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  1. Article ; Online: N-allyl quinoxaline derivative exhibited potent and selective cytotoxicity through EGFR/VEGFR-mediated apoptosis: In vitro and in vivo studies.

    Nafie, Mohamed S / Ali, Mohab A / Youssef, Magdy M

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 4, Page(s) e23690

    Abstract: The cytotoxic activity, EGFR/VEGFR2 target inhibition, apoptotic activity, RT-PCR gene expression, in vivo employing a solid-Ehrlich carcinoma model, and in silico investigations for highlighting the binding affinity of eight quinoxaline derivatives were ...

    Abstract The cytotoxic activity, EGFR/VEGFR2 target inhibition, apoptotic activity, RT-PCR gene expression, in vivo employing a solid-Ehrlich carcinoma model, and in silico investigations for highlighting the binding affinity of eight quinoxaline derivatives were tested for anticancer activities. The results showed that compound 8 (N-allyl quinoxaline) had potent cytotoxicity against A594 and MCF-7 cancer cells with IC
    MeSH term(s) Humans ; Structure-Activity Relationship ; Sorafenib/pharmacology ; Molecular Docking Simulation ; Quinoxalines/pharmacology ; Apoptosis ; Antineoplastic Agents/chemistry ; ErbB Receptors/metabolism ; Cell Proliferation ; Molecular Structure ; Drug Screening Assays, Antitumor ; Protein Kinase Inhibitors/pharmacology
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; Quinoxalines ; Antineoplastic Agents ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23690
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    Zs.A 2201: Show issues Location:
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  2. Article ; Online: The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.

    Al-Adl, Menna / Youssef, Magdy M / El-Sebaie, Ahmed / Refaat, Sherif / El-Said, Afaf

    Oncology research

    2024  Volume 32, Issue 4, Page(s) 785–797

    Abstract: Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of ... ...

    Abstract Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of CYPs are variable between individuals, which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics, as well as differences in the efficacy and toxicity of clinically used drugs. This research aimed to examine the presence of the
    MeSH term(s) Humans ; Cytochrome P-450 CYP2B6/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Incidence ; Egypt/epidemiology ; Cytochrome P-450 Enzyme System/genetics ; Genotype ; Cyclophosphamide/adverse effects
    Chemical Substances Cytochrome P-450 CYP2B6 (EC 1.14.14.1) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Cyclophosphamide (8N3DW7272P) ; CYP2B6 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1114699-0
    ISSN 1555-3906 ; 0965-0407
    ISSN (online) 1555-3906
    ISSN 0965-0407
    DOI 10.32604/or.2024.047021
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    Zs.A 3087: Show issues Location:
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  3. Article ; Online: The Effect of Iron Oxide Nanoparticles of

    Moustafa, Amal Mahmoud Youssef / Abd El-Hamid El-Damrany, Maha Mohamed / Youssef, Magdy Mahfouz

    Anti-cancer agents in medicinal chemistry

    2023  Volume 23, Issue 14, Page(s) 1652–1669

    Abstract: Background: Nanoparticles' precise targeting properties are becoming increasingly important in treating cancer and starting to outweigh cancer therapies.: Methods: The : Results: The value of the median lethal dose LD: Conclusion: ... ...

    Abstract Background: Nanoparticles' precise targeting properties are becoming increasingly important in treating cancer and starting to outweigh cancer therapies.
    Methods: The
    Results: The value of the median lethal dose LD
    Conclusion: Histopathology tests showed anticancer activity against (EAC) in both the preventive group and therapeutic group, especially in the preventive group in kidney organs showed no pathology with normal glomeruli and normal tubules, it also showed in liver foci of lobular inflammation with mild development of a portal tract accompanied by inflammation, but in the therapeutic group showed less activity than the preventive group as in the kidney many tubules displayed appearances of slight tubular injury with mild acute tubular injury and in the liver, the therapeutic group becomes a more effective representation in normal liver architecture, with no detected lobular or portal inflammation or confluent necrosis. So the preventive group was considered as protecting agent for the kidney organ. However, the therapeutic group is supposed to be the treatment agent for the liver organ. This is due to the fact that it has a defensive effect rather than a curative effect. There is a possibility that it is a favorable anticancer agent. Green synthesis of Fe
    MeSH term(s) Humans ; Animals ; Acalypha ; Ascites ; bcl-2-Associated X Protein ; Inflammation ; Magnetic Iron Oxide Nanoparticles ; Carcinoma ; Carcinoma, Ehrlich Tumor/drug therapy ; Carcinoma, Ehrlich Tumor/pathology ; Apoptosis
    Chemical Substances ethyl acetate (76845O8NMZ) ; bcl-2-Associated X Protein
    Language English
    Publishing date 2023-05-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520623666230517100427
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    Zs.A 5583: Show issues Location:
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  4. Article ; Online: Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population.

    Al-Adl, Menna / El-Said, Afaf / El-Sebaie, Ahmed / Refaat, Sherif / Youssef, Magdy M

    Gene

    2023  Volume 883, Page(s) 147673

    Abstract: Background: The frequency of hematological malignancies is increasing universally, and over the last few decades, a significant increase in the incidence of B-chronic lymphocytic leukemia (B-CLL) has been observed. Many studies have revealed the ... ...

    Abstract Background: The frequency of hematological malignancies is increasing universally, and over the last few decades, a significant increase in the incidence of B-chronic lymphocytic leukemia (B-CLL) has been observed. Many studies have revealed the involvement of genetic predisposition along with environmental exposure to genotoxic xenobiotics in the leukemogenesis process of B-CLL. CYP1A1 is a vital member of the cytochromes P450 (CYPs) superfamily, which is involved in pro-carcinogens activation into reactive intermediates during phase I xenobiotic biotransformation.
    Aim: This study aimed to determine the possible role of the CYP1A1*2A (T3801C, rs4646903) single nucleotide polymorphism (SNP) as a risk factor for developing B-CLL, as well as the impact of this SNP on the disease progression and the clinical outcome.
    Patients and methods: The study was conducted on 100 patients newly diagnosed with B-CLL, and 100 healthy individuals with matched ages and sex, served as the control group. CYP1A1 (T3801C) genotyping of all patient and control samples was performed using the PCR-based Restriction Fragment Length Polymorphism (RFLP-PCR) method. In addition, serum levels of both IL-6 and TNF-α were estimated by the ELISA technique.
    Results: Higher frequencies of the heterozygous carrier (TC) and homozygous variant (CC) genotypes of the CYP1A1 (T3801C) variant were observed in B-CLL patients compared to the controls (P < 0.001 for both). The frequencies of the CYP1A1 (T3801C) variant indicated a significant elevated risk of B-CLL under various genetic models, including allelic (OR = 8.8, P < 0.001) and dominant (OR = 9.3, P < 0.001) models. In addition, the median IL-6 level was significantly higher in patients with (TC) and (CC) genotypes than in patients with (TT) genotype (P = 0.001 and P < 0.001, respectively). Also, the median TNF-α level was significantly higher in patients with (TC) and (CC) genotypes than in patients with (TT) genotype (P < 0.001 for both).
    Conclusion: Our results showed that the CYP1A1*2A (T3801C, rs4646903) SNP increases the susceptibility to B-CLL incidence and is associated with poor disease progression.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Cytochrome P-450 CYP1A1/genetics ; Egypt ; Interleukin-6/genetics ; Tumor Necrosis Factor-alpha/genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide ; Disease Progression
    Chemical Substances Cytochrome P-450 CYP1A1 (EC 1.14.14.1) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; CYP1A1 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2023-07-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2023.147673
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    Zs.A 1357: Show issues Location:
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  5. Article: Diminished CCl4‐induced hepatocellular carcinoma, oxidative stress, and apoptosis by co‐administration of curcumin or selenium in mice

    Elkhamesy, Asmaa / Refaat, Manar / Gouida, Mona S. O. / Alrdahe, Salma S. / Youssef, Magdy M.

    Journal of food biochemistry. 2022 Apr., v. 46, no. 4

    2022  

    Abstract: Hepatocellular carcinoma (HCC) is a lethal disease, and in HCC advanced stages, there is limited therapeutic efficacy. HCC results in a complication of fibrosis or cirrhosis. In this study, the protective effect of curcumin and selenium versus ... ...

    Abstract Hepatocellular carcinoma (HCC) is a lethal disease, and in HCC advanced stages, there is limited therapeutic efficacy. HCC results in a complication of fibrosis or cirrhosis. In this study, the protective effect of curcumin and selenium versus hepatocellular carcinoma caused by CCl₄ in experimental animals was investigated. In all, 70 mice were divided into seven groups to study the effect of curcumin and selenium on CCl₄‐induced hepatocellular carcinoma. After treatment time, different animal groups were sacrificed, serum and liver samples were collected and processed for assay of biochemical and molecular parameters. Our results showed that CCl₄ administration induced various alterations such as significant elevation in the serum levels of ALT, AST, and hepatic contents of malondialdehyde (MDA), and depletion in the levels of antioxidant parameters. CCl₄ induced apoptosis in the hepatic cells indicated by an increased level of p53, CD4, CD8, Bax, and Annexin V/PI in addition to significant decrease in the level of Bcl‐2. Administration of curcumin and selenium restored this abnormal variation in these biochemical parameters to normal values. Our study addressed that curcumin or selenium may be helpful in the protection against liver damage induced by CCl₄. The hepatoprotective impact of curcumin or selenium might be mediated primarily by its potent antioxidant activity. PRACTICAL APPLICATIONS: Hepatocellular carcinoma (HCC) ranked third common cause of death, primary liver cancer. Exposure to CCl₄ was found to induce significant hepatotoxicity, characterized by fibrosis, bile duct proliferation, cirrhosis, and reduced hepatic function The work was prepared to investigate the protecting capacity of curcumin, selenium alone, and in combination against HCC induced by CCl₄ in the experimental animal model. This study proved the protective effect of curcumin and selenium, alone and in combination with each other, where curcumin showed multiple pharmacological activities, including anti‐inflammation and antioxidant, and have an essential role in inhibiting the progression of HCC.
    Keywords animal models ; antioxidant activity ; antioxidants ; apoptosis ; bile ducts ; blood serum ; curcumin ; death ; fibrosis ; hepatoma ; hepatotoxicity ; laboratory animals ; liver ; liver function ; malondialdehyde ; oxidative stress ; protective effect ; selenium ; therapeutics
    Language English
    Dates of publication 2022-04
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13845
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  6. Article ; Online: Prunus Armeniaca L

    Hosny, Samar / Sahyon, Heba / Youssef, Magdy / Negm, Amr

    Anti-cancer agents in medicinal chemistry

    2020  Volume 21, Issue 5, Page(s) 621–629

    Abstract: Background: Despite significant advances in therapeutic interventions, liver cancer is the leading cause of cancer mortality in the world. Potential phytochemicals have shown to be promising agents against many life-threatening diseases because of their ...

    Abstract Background: Despite significant advances in therapeutic interventions, liver cancer is the leading cause of cancer mortality in the world. Potential phytochemicals have shown to be promising agents against many life-threatening diseases because of their low toxicity and potential effectiveness.
    Objective: The current study aims to conduct an in vitro investigation of the anticancer activity of Apricot Extract (AE) and Amygdalin Containing Fraction (ACF), additionally studying their therapeutic effects on DMBAinduced liver carcinogenesis mice model to highlight their related biochemical and molecular mechanisms.
    Methods and results: Amygdalin was isolated from the seeds of P. armeniaca L. Male mice received AE or ACF, DMBA, DMBA+AE, DMBA+ACF, and vehicles. The oxidative stress and antioxidant markers, cell proliferation by flow cytometric analysis of Proliferating Cell Nuclear Antigen (PCNA) expression, angiogenesis marker (VEGF), inflammatory marker (TNF-α), apoptotic, anti-apoptotic and autophagy genes expression (caspase-3, Bcl-2, and Beclin-1) were investigated. AE and ACF were found to stimulate the apoptotic process by up-regulating caspase-3 expression and down-regulating Bcl-2 expression. They also reduced VEGF and PCNA levels and increased the antioxidant defense system. Moreover, AE and ACF treatments also inhibited HepG2 and EAC cell proliferation and up-regulated Beclin-1 expression.
    Conclusion: This study provides evidence that, in DMBA-induced hepatocarcinogenesis, the key proteins involved in the proliferation, angiogenesis, autophagy, and apoptosis are feasible molecular targets for hepatotherapeutic potential using AE and ACF.
    MeSH term(s) Amygdalin/chemical synthesis ; Amygdalin/chemistry ; Amygdalin/pharmacology ; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Prunus armeniaca/chemistry ; Seeds/chemistry ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents, Phytogenic ; Plant Extracts ; Amygdalin (214UUQ9N0H)
    Language English
    Publishing date 2020-06-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520620666200608124003
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    Zs.A 5583: Show issues Location:
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  7. Article ; Online: Oleanolic Acid Suppressed DMBA-Induced Liver Carcinogenesis through Induction of Mitochondrial-Mediated Apoptosis and Autophagy.

    Hosny, Samar / Sahyon, Heba / Youssef, Magdy / Negm, Amr

    Nutrition and cancer

    2020  Volume 73, Issue 6, Page(s) 968–982

    Abstract: Phytochemicals appeared as a rich source of efficient and safe agents against many diseases like cancer. Various herbal sources are rich in oleanolic acid (OA). The scope of this study was to assess the biochemical and molecular mechanisms implicated in ... ...

    Abstract Phytochemicals appeared as a rich source of efficient and safe agents against many diseases like cancer. Various herbal sources are rich in oleanolic acid (OA). The scope of this study was to assess the biochemical and molecular mechanisms implicated in the ameliorative potency of OA against DMBA-induced liver carcinogenesis. Forty-eight male albino mice were assigned randomly to five groups (eight mice each) as follows: control healthy group, olive oil group, OA group, DMBA group, and DMBA with OA. Apoptosis, autophagy, inflammation, proliferation, and angiogenesis were investigated in the tissue samples. Histopathological examination was carried out as well as liver enzymes activity and other hepatic antioxidant and inflammatory biomarkers. The treatment with OA effectively suppressed the DMBA-initiated liver carcinogenesis via modulation of antioxidant status, induction of apoptosis and autophagy through modulating the expression of Caspase-3, Bcl-2 and Beclin-1, inhibiting angiogenesis (VEGF), proliferation (PCNA), and improved liver function and histological picture with a reduction in AFP level. Additionally, OA applies its antitumor effects by inhibition of proinflammatory transcription factor NF-κB and inflammatory markers (TNF-α and Cox-2) associated with DMBA administration. The present study shows that OA treatment efficiently suppressed the DMBA-initiated liver carcinogenesis through induction of mitochondrial-mediated apoptosis and autophagy and modulating inflammation.
    MeSH term(s) 9,10-Dimethyl-1,2-benzanthracene/toxicity ; Animals ; Apoptosis ; Autophagy ; Carcinogenesis ; Liver ; Male ; Mice ; Oleanolic Acid/pharmacology
    Chemical Substances 9,10-Dimethyl-1,2-benzanthracene (57-97-6) ; Oleanolic Acid (6SMK8R7TGJ)
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2020.1776887
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    Zs.A 1496: Show issues Location:
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  8. Article: PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus.

    Shawki, Hadeel Ahmed / Abo-Hashem, Ekbal M / Youssef, Magdy M / Shahin, Maha / Elzehery, Rasha

    Journal of diabetes and metabolic disorders

    2022  Volume 21, Issue 1, Page(s) 241–250

    Abstract: Purpose: Diabetes mellitus (DM) is a growing global health concern. Genetic factors play a pivotal role in the development of diabetes. Therefore, the present work aimed to study the relation between peroxisome proliferator-activate receptors (PPARɣ2) ( ... ...

    Abstract Purpose: Diabetes mellitus (DM) is a growing global health concern. Genetic factors play a pivotal role in the development of diabetes. Therefore, the present work aimed to study the relation between peroxisome proliferator-activate receptors (PPARɣ2) (rs3856806), aldose reductase (AR) (rs759853), transcription factor 7 like 2 (TCF7L2) (rs7903146) gene polymorphism with diabetes in the Egyptian population.
    Methods: The study included 260 diabetics and 120 healthy subjects. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism.
    Results: Regression analysis revealed that PPARɣ2 TT, TCF7L2 TT were suggested to be independent risk predictors for T1DM and TCF7L2 TC, CC genotype were suggested to be independent protective factors against T1DM development. On the other hand, PPARɣ2 TT, AR TT genotypes were suggested to be independent risk predictors for T2DM susceptibility, and PPARɣ2 CT genotypes were suggested to be independent protective factors against T2DM development.
    Conclusion: The present study revealed that PPARγ2 (rs3856806), TCF7L2 (rs7903146) and AR (rs759853) gene polymorphism may play an important role in the susceptibility of diabetes. Therefore, these polymorphisms may have a prognostic value for diabetes in the Egyptian population. Further work is required to confirm the role of these polymorphisms in diabetes.
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-021-00963-4
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  9. Article ; Online: The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence.

    Hassan, Eglal A / Elsaid, Afaf M / Abou-Elzahab, M M / El-Refaey, Ahmed M / Elmougy, Rehab / Youssef, Magdy M

    Biochemical genetics

    2023  Volume 62, Issue 2, Page(s) 1304–1324

    Abstract: The kidney lost a lot of protein in the urine when you have nephrotic syndrome (NS). Clinical manifestations mostly common in NS include massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Idiopathic nephrotic syndrome is currently ... ...

    Abstract The kidney lost a lot of protein in the urine when you have nephrotic syndrome (NS). Clinical manifestations mostly common in NS include massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Idiopathic nephrotic syndrome is currently classified into steroid-dependent (SDNS) and steroid-resistant (SRNS) based on the initial response to corticosteroid therapy at presentation. Several reports examined the association of the MYH9 gene (rs3752462, C > T) variant and ELMO1 gene (rs741301 G > A) variant as risk factors for Nephrotic Syndrome. This study aimed to determine the potential effect of the MYH9 gene (rs3752462, C > T) and ELMO1 gene (rs741301) variant on the risk of (NS) among Egyptian Children. This study included two hundred participants involving 100 nephrotic syndrome (NS) cases and 100 healthy controls free from nephrotic syndrome (NS). The MYH9 gene (rs3752462, C > T) variant and ELMO1 gene (rs G > A741301) variant were analyzed by ARMS-PCR technique. Nephrotic syndrome cases include 74% SRNS and 26% SDNS. Higher frequencies of the heterozygous carrier (CT) and homozygous variant (TT) genotypes of the MYH9 (rs3752462, C > T) variant were observed in NS patients compared to the controls with p-value < 0.001. The frequencies of the MYH9 (rs3752462, C > T variant indicated a statistically significant elevated risk of NS under various genetic models, including allelic model (OR 2.85, p < 0.001), dominant (OR 3.97, p < 0.001) models, and the recessive model OR 5.94, p < 0.001). Higher frequencies of the heterozygous carrier (GA) and homozygous variant (AA) genotypes of ELMO1gene (rs G > A741301) variant were observed in NS patients compared to the controls with p-value < 0.001. The frequencies of the ELMO1 (rs G > A741301) variant indicated a statistically significant elevated risk of NS under various genetic models, including allelic model (OR 2.15, p < 0.001), dominant models (OR 2.8, p < 0.001), and the recessive model (OR 4.17, p = 0.001). Both MYH9 and ELMO1 gene variants are significantly different in NS in comparison with the control group (p < 0.001). The MYH9 gene (rs3752462, C > T) and ELMO1gene (rs G > A741301) variants were considered independent risk factors for NS among Egyptian Children.
    MeSH term(s) Child ; Humans ; Nephrotic Syndrome/genetics ; Nephrotic Syndrome/drug therapy ; Incidence ; Genotype ; Proteinuria ; Steroids/therapeutic use ; Adaptor Proteins, Signal Transducing/genetics ; Myosin Heavy Chains/genetics
    Chemical Substances Steroids ; ELMO1 protein, human ; Adaptor Proteins, Signal Transducing ; MYH9 protein, human ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2168-4
    ISSN 1573-4927 ; 0006-2928
    ISSN (online) 1573-4927
    ISSN 0006-2928
    DOI 10.1007/s10528-023-10481-y
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    Zs.A 578: Show issues Location:
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  10. Article ; Online: Diminished CCl

    Elkhamesy, Asmaa / Refaat, Manar / Gouida, Mona S O / Alrdahe, Salma S / Youssef, Magdy M

    Journal of food biochemistry

    2021  Volume 46, Issue 4, Page(s) e13845

    Abstract: Hepatocellular carcinoma (HCC) is a lethal disease, and in HCC advanced stages, there is limited therapeutic efficacy. HCC results in a complication of fibrosis or cirrhosis. In this study, the protective effect of curcumin and selenium versus ... ...

    Abstract Hepatocellular carcinoma (HCC) is a lethal disease, and in HCC advanced stages, there is limited therapeutic efficacy. HCC results in a complication of fibrosis or cirrhosis. In this study, the protective effect of curcumin and selenium versus hepatocellular carcinoma caused by CCl
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis ; Carcinoma, Hepatocellular/drug therapy ; Curcumin/pharmacology ; Liver Cirrhosis ; Liver Neoplasms/drug therapy ; Mice ; Oxidative Stress ; Selenium
    Chemical Substances Antioxidants ; Selenium (H6241UJ22B) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13845
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