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Article: [Theory and Practice of Empowerment for Family Members of Patients Under Custodial Protection Sentence].

Kuo, Yu-Heng

Hu li za zhi The journal of nursing

2024 Volume 71, Issue 1, Page(s) 99–104

Abstract: Empowerment not only benefits patients but also provides support and assistance to their family members, especially in cases when patients are subject to custodial protection sentences. The positive effects of empowerment on patients' family members may ... ...

Abstract	Empowerment not only benefits patients but also provides support and assistance to their family members, especially in cases when patients are subject to custodial protection sentences. The positive effects of empowerment on patients' family members may be summarized into three main aspects, including: enhancing their engagement in healthcare, alleviating their anxiety, and enhancing their caregiving skills. With regard to enhancing engagement in healthcare, family members receive health education that provides an overview of the illness, treatment options, prognosis, and key nursing points and allows them to better understand the patient's condition and actively participate in decision-making. With regard to alleviating anxiety, patients under custodial protection sentences are involved in legal problems, which results in higher levels of stress for family members compared to their peers caring for general patients. Through emotional support and active listening, nurses provide opportunities for family members to express their concerns and offer comfort and encouragement, helping them cope with difficulties and pressures. With regard to enhancing caregiving skills, the purpose of custodial protection sentences is to prevent recidivism, and family members bear significant responsibility for caregiving after discharge. Nurses can share similar caregiving experiences from their ward, educate family members about observing symptoms, and provide guidance, thereby strengthening their caregiving capabilities. In addition, with regard to the disposition of patients, nurses assist family members to understand the medical process and provide necessary guidance, ensuring family members have a clear understanding and are respected during the preparations for discharge. Based on related theoretical frameworks and practical experiences, this research highlights the positive role of empowerment in enhancing the caregiving abilities and satisfaction of the family members of patients, particularly those subject to custodial protection sentences.
MeSH term(s)	Humans ; Anxiety ; Family ; Health Education ; Hospitals ; Patient Discharge
Language	Chinese
Publishing date	2024-01-22
Publishing country	China (Republic : 1949- )
Document type	English Abstract ; Journal Article
ISSN	0047-262X
ISSN	0047-262X
DOI	10.6224/JN.202402_71(1).12
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Article ; Online: Taiwan ended third COVID-19 community outbreak as forecasted.

Wu, Yu-Heng / Nordling, Torbjörn E M

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6596

Abstract: Accurate forecasting of community outbreaks is crucial for governments to allocate healthcare resources correctly and implement suitable non-pharmaceutical interventions. Additionally, companies must address critical questions about stock and staff ... ...

Abstract	Accurate forecasting of community outbreaks is crucial for governments to allocate healthcare resources correctly and implement suitable non-pharmaceutical interventions. Additionally, companies must address critical questions about stock and staff management. Society's key concern is when businesses and organizations can resume normal operations. Between December 31st 2019 and 2021, Taiwan experienced three separate COVID-19 community outbreaks with significant time intervals in between, suggesting that each outbreak eventually came to an end. We identified the ratio of the 7-day average of local & unknown confirmed to suspected cases as the key control variable and forecasted the end of the third outbreak by the exponential model. We forecasted the end of the third outbreak on Aug. 16th with threshold ratios of
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Taiwan/epidemiology ; Disease Outbreaks ; Contact Tracing
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56692-0
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Article ; Online: The damage-associated molecular pattern cellotriose alters the phosphorylation pattern of proteins involved in cellulose synthesis and trans-Golgi trafficking in Arabidopsis thaliana

Akanksha Gandhi / Yu-Heng Tseng / Ralf Oelmüller

Plant Signaling & Behavior, Vol 18, Iss

2023 Volume 1

Abstract: We have recently demonstrated that the cellulose breakdown product cellotriose is a damage-associated molecular pattern (DAMP) which induces responses related to the integrity of the cell wall. Activation of downstream responses requires the Arabidopsis ... ...

Abstract	We have recently demonstrated that the cellulose breakdown product cellotriose is a damage-associated molecular pattern (DAMP) which induces responses related to the integrity of the cell wall. Activation of downstream responses requires the Arabidopsis malectin domain-containing CELLOOLIGOMER RECEPTOR KINASE1 (CORK1). The cellotriose/CORK1 pathway induces immune responses, including NADPH oxidase-mediated reactive oxygen species production, mitogen-activated protein kinase 3/6 phosphorylation-dependent defense gene activation, and the biosynthesis of defense hormones. However, apoplastic accumulation of cell wall breakdown products should also activate cell wall repair mechanisms. We demonstrate that the phosphorylation pattern of numerous proteins involved in the accumulation of an active cellulose synthase complex in the plasma membrane and those for protein trafficking to and within the trans-Golgi network (TGN) are altered within minutes after cellotriose application to Arabidopsis roots. The phosphorylation pattern of enzymes involved in hemicellulose or pectin biosynthesis and the transcript levels for polysaccharide-synthesizing enzymes responded barely to cellotriose treatments. Our data show that the phosphorylation pattern of proteins involved in cellulose biosynthesis and trans-Golgi trafficking is an early target of the cellotriose/CORK1 pathway.
Keywords	cell wall ; protein phosphorylation ; arabidopsis ; membrane protein trafficking ; malectin domain ; Plant ecology ; QK900-989 ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spontaneous spinal epidural hematoma leading to acute paraplegia

Yu Liu / Rajeesh George / Gamaliel Yu Heng Tan

Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-

a case report

2023 Volume 4

Abstract: Abstract Background Spontaneous spinal epidural hematoma is an infrequent yet potentially debilitating condition characterized by blood accumulation in the epidural space, with only 300 documented cases globally. Although the exact etiology of ... ...

Abstract	Abstract Background Spontaneous spinal epidural hematoma is an infrequent yet potentially debilitating condition characterized by blood accumulation in the epidural space, with only 300 documented cases globally. Although the exact etiology of spontaneous spinal epidural hematoma remains poorly understood, theories suggest arteriovenous malformations, rupture of epidural vessels, or epidural veins as possible causes. Case presentation This study presents a 58-year-old Malay woman patient from Singapore with well-controlled hypertension, hyperlipidemia, type II diabetes mellitus, and microscopic hematuria. Despite a prior cystoscopy revealing no abnormalities, she presented to the emergency department with sudden-onset back pain, weakness, and numbness in both lower limbs. Rapidly progressing symptoms prompted imaging, leading to the diagnosis of a spinal epidural hematoma from thoracic (T) 9 to lumbar (L) 1. Prompt decompressive surgery was performed, and the patient is currently undergoing postoperative rehabilitation for paralysis. Conclusion This case emphasizes the severity and life-altering consequences of spontaneous spinal epidural hematomas. Despite various proposed causative factors, a definitive consensus remains elusive in current literature. Consequently, maintaining a low threshold of suspicion for patients with similar presentations is crucial. The findings underscore the urgent need for swift evaluation and surgical intervention in cases of acute paraplegia.
Keywords	Spinal hematoma ; Spontaneous ; Decompression ; Paraplegia ; Case report ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homogeneous Water Oxidation Catalyzed by First-Row Transition Metal Complexes: Unveiling the Relationship between Turnover Frequency and Reaction Overpotential.

Hsu, Wan-Chi / Wang, Yu-Heng

ChemSusChem

2022 Volume 15, Issue 5, Page(s) e202102378

Abstract: The utilization of earth-abundant low-toxicity metal ions in the construction of highly active and efficient molecular catalysts promoting the water oxidation reaction is important for developing a sustainable artificial energy cycle. However, the ... ...

Abstract	The utilization of earth-abundant low-toxicity metal ions in the construction of highly active and efficient molecular catalysts promoting the water oxidation reaction is important for developing a sustainable artificial energy cycle. However, the kinetic and thermodynamic properties of the currently available molecular water oxidation catalysts (MWOCs) have not been comprehensively investigated. This Review summarizes the current status of MWOCs based on first-row transition metals in terms of their turnover frequency (TOF, a kinetic property) and overpotential (η, a thermodynamic property) and uses the relationship between log(TOF) and η to assess catalytic performance. Furthermore, the effects of the same ligand classes on these MWOCs are discussed in terms of TOF and η, and vice versa. The collective analysis of these relationships provides a metric for the direct comparison of catalyst systems and identifying factors crucial for catalyst design.
MeSH term(s)	Catalysis ; Coordination Complexes ; Oxidation-Reduction ; Transition Elements ; Water
Chemical Substances	Coordination Complexes ; Transition Elements ; Water (059QF0KO0R)
Language	English
Publishing date	2022-01-14
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202102378
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Article ; Online: Assessing the evolution of hypertension management in Gansu, China: A comparative study of prevalence, awareness, treatment, and control in 2012 and 2022.

Liang, Wei / Zhang, Xiaowei / Wang, Qiongying / Yu, Heng / Yu, Jing

Journal of clinical hypertension (Greenwich, Conn.)

2024

Abstract: The aim of this study is to evaluate the developments in the treatment and prevalence of hypertension by demographic subgroups in least developed area of China in 2012 and 2022. This population-based cross-sectional study was conducted in 2012 and 2022, ... ...

Abstract	The aim of this study is to evaluate the developments in the treatment and prevalence of hypertension by demographic subgroups in least developed area of China in 2012 and 2022. This population-based cross-sectional study was conducted in 2012 and 2022, we applied stratified multistage random sampling to investigate residents aged 18 years or older in Gansu, the least developed province in the northwest of China. Questionnaires and anthropometric measurements were given to all respondents. The standardized prevalence of hypertension in adults in Gansu increased from 26.1% in 2012 to 28.8% in 2022. Compared with 2012, the control rate remains decreased despite the significantly improved awareness and treatment rates of hypertension in 2022. Apart from the reversal of the control rate, the trend of higher prevalence in men and higher awareness and treatment rates in women has not changed. There was an obviously increase in the proportion of participants who had received health education and hypertension management services from medical workers. The treatment was still primarily monotherapy, and there was no significant improvement in the prescription of medication. The prevalence of hypertension has increased mildly in the least developed region of China over the past decade, and the challenge of hypertension management has shifted from increasing awareness and treatment rates to increasing control rates. The onset and control of hypertension are affected by education methods, BMI, local economic conditions and other factors, and targeted strategies can be adopted to strengthen the management of hypertension in economically underdeveloped areas of China.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.14809
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Zs.A 5723: Show issues

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Article ; Online: Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review.

Woon, Ting Hui / Tan, Melissa Jia Hui / Kwan, Yu Heng / Fong, Warren

Complementary therapies in medicine

2024 Volume 80, Page(s) 103017

Abstract: Objectives: Chinese herbal medicine (CHM) has been shown to be effective in autoimmune rheumatic diseases, but harmful herb-drug interactions might be inherent. We aim to review the evidence regarding herb-drug interactions between immunosuppressive ... ...

Abstract	Objectives: Chinese herbal medicine (CHM) has been shown to be effective in autoimmune rheumatic diseases, but harmful herb-drug interactions might be inherent. We aim to review the evidence regarding herb-drug interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and CHM. Methods: We searched PubMed, EMBASE and CINAHL from inception till 30 April 2023 using keywords that encompassed 'herb-drug interactions', 'herbs' and 'immunosuppressants'. Articles were included if they contained reports about interactions between immunosuppressive drugs used in the treatment of rheumatic diseases with CHM. Level of evidence for each pair of interaction was graded using the algorithm developed by Colalto. Results: A total of 65 articles and 44 unique pairs of interactions were identified. HDIs were reported for cyclophosphamide, cyclosporine, tacrolimus, methotrexate, mycophenolic acid, glucocorticoids, sulfasalazine, tofacitinib and biologic disease-modifying antirheumatic drugs. Among these, cyclosporine (n = 27, 41.5%) and tacrolimus (n = 19, 29.2%) had the highest number of documented interactions. Hypericum perforatum had the highest level of evidence of interaction with cyclosporine and tacrolimus. Consumption reduced the bioavailability and therapeutic effects of the drugs. Schisandra sphenanthera had the highest level of evidence of interaction with tacrolimus and increased the bioavailability of the drug. Majority of the articles were animal studies. Conclusion: Overall level of evidence for the included studies were low, though interactions between cyclosporine, tacrolimus, Hypericum perforatum and Schisandra sphenanthera were the most and well-documented. Healthcare professionals should actively enquire about the concurrent use of CHM in patients, especially when drugs with a narrow therapeutic index are consumed.
MeSH term(s)	Animals ; Humans ; Tacrolimus ; Drugs, Chinese Herbal/adverse effects ; Immunosuppressive Agents/therapeutic use ; Herb-Drug Interactions ; Plant Oils ; Cyclosporins
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Drugs, Chinese Herbal ; Immunosuppressive Agents ; Plant Oils ; Cyclosporins
Language	English
Publishing date	2024-01-11
Publishing country	Scotland
Document type	Review ; Journal Article
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2024.103017
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Zs.A 3726: Show issues

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Article ; Online: Ideal adaptive control in biological systems: an analysis of

Ashyani, Akram / Wu, Yu-Heng / Hsu, Huan-Wei / Nordling, Torbjörn E M

BMC bioinformatics

2024 Volume 25, Issue 1, Page(s) 95

Abstract: Background: Dynamical compensation (DC) provides robustness to parameter fluctuations. As an example, DC enables control of the functional mass of endocrine or neuronal tissue essential for controlling blood glucose by insulin through a nonlinear ... ...

Abstract	Background: Dynamical compensation (DC) provides robustness to parameter fluctuations. As an example, DC enables control of the functional mass of endocrine or neuronal tissue essential for controlling blood glucose by insulin through a nonlinear feedback loop. Researchers have shown that DC is related to the structural unidentifiability and the Results: We initiate our analysis by introducing a simplified two-dimensional dynamical model with DC, fostering experimentation and understanding of the system's behavior. We explore the system's behavior with time-varying input and disturbance signals, with a focus on illustrating the system's Conclusions: We show that DC can be seen as a case of ideal adaptive control since the system is invariant to the compensated parameter.
MeSH term(s)	Empirical Research ; Insulin ; Research Design ; Uncertainty
Chemical Substances	Insulin
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-024-05718-5
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Article ; Online: The damage-associated molecular pattern cellotriose alters the phosphorylation pattern of proteins involved in cellulose synthesis and

Gandhi, Akanksha / Tseng, Yu-Heng / Oelmüller, Ralf

Plant signaling & behavior

2023 Volume 18, Issue 1, Page(s) 2184352

Abstract	We have recently demonstrated that the cellulose breakdown product cellotriose is a damage-associated molecular pattern (DAMP) which induces responses related to the integrity of the cell wall. Activation of downstream responses requires the Arabidopsis malectin domain-containing CELLOOLIGOMER RECEPTOR KINASE1 (CORK1)
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Phosphorylation ; Cellulose/metabolism ; trans-Golgi Network/metabolism ; Cell Wall/metabolism ; Carrier Proteins/metabolism
Chemical Substances	cellotriose ; Arabidopsis Proteins ; Cellulose (9004-34-6) ; Carrier Proteins
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1559-2324
ISSN (online)	1559-2324
DOI	10.1080/15592324.2023.2184352
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Article ; Online: Structural polymorphism in protein cages and virus-like particles.

Lie, Felicia / Szyszka, Taylor N / Lau, Yu Heng

Journal of materials chemistry. B

2023 Volume 11, Issue 28, Page(s) 6516–6526

Abstract: Protein cages and virus-like particles are often thought of as highly uniform structures that obey strict geometric rules for self-assembly. Yet, there is a growing number of examples where different architectures can emerge from the same native cage ... ...

Abstract	Protein cages and virus-like particles are often thought of as highly uniform structures that obey strict geometric rules for self-assembly. Yet, there is a growing number of examples where different architectures can emerge from the same native cage system through minor changes in experimental conditions or protein sequence. Access to diverse architectures can help tune the engineering of protein cages for biotechnology applications where shape and symmetry often affects function. In this review, we highlight the underappreciated diversity of polymorphic architectures that can be formed by protein cages and virus-like particles, categorising examples by their method of formation.
MeSH term(s)	Proteins/chemistry ; Biotechnology
Chemical Substances	Proteins
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb00991b
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