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  1. Article: A Review of the Pharmacokinetic Characteristics of Immune Checkpoint Inhibitors and Their Clinical Impact Factors.

    Liu, Jun-Chen / Yu, Hong-Jing

    Pharmacogenomics and personalized medicine

    2023  Volume 16, Page(s) 29–36

    Abstract: Immune checkpoint inhibitors (ICIs) have been shown to be significant in improving the overall survival rate in certain malignancies with poor prognoses. However, only 20-40% of patients achieve long-term benefits, highlighting the relevance of the ... ...

    Abstract Immune checkpoint inhibitors (ICIs) have been shown to be significant in improving the overall survival rate in certain malignancies with poor prognoses. However, only 20-40% of patients achieve long-term benefits, highlighting the relevance of the factors that influence the treatment, which can help clinicians improve their results and guide the development of new immune checkpoint therapies. In this study, the current pharmacokinetic aspects associated with the ICIs and the factors influencing clinical efficacy were characterised, including in terms of drug metabolism, drug clearance, hormonal effects and immunosuppressive effects.
    Language English
    Publishing date 2023-01-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S391756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effectiveness of pressure support ventilation and T-piece in differing duration among weaning patients: A systematic review and network meta-analysis.

    Ye, Xiaomei / Waters, David / Yu, Hong-Jing

    Nursing in critical care

    2022  Volume 28, Issue 1, Page(s) 120–132

    Abstract: Background: A spontaneous breathing trial (SBT) is recommended to help patients to liberate themselves from mechanical ventilation as soon as possible in the ICU. The respiratory workload in SBT, which depends on being with or without respiratory ... ...

    Abstract Background: A spontaneous breathing trial (SBT) is recommended to help patients to liberate themselves from mechanical ventilation as soon as possible in the ICU. The respiratory workload in SBT, which depends on being with or without respiratory support and a specific time, is more accurate to reflect how much support the weaning patients need compared with only considering SBT technologies.
    Aim: To compare and rank the effectiveness of different respiratory workloads during SBT via differing technologies (Pressure Support Ventilation and T-piece) and differing duration (30 and 120 min) in SBTs.
    Study design: A comprehensive literature search was performed in six English electronic databases to identify eligible randomized controlled trials (RCTs) published before September 2020. The pooled risk ratio (RR) with 95% confidence interval (CI) was calculated by Markov chain Monte Carlo methods. A Bayesian network meta-analysis was conducted using "gemtc" version 0.8.2 of R software. Each intervention's ranking possibilities were calculated using the surface under the cumulative ranking analysis (SUCRA).
    Results: A total of nine RCTs including 3115 participants were eligible for this network meta-analysis involving four different commonly used SBT strategies and four outcomes. The only statistically significant difference was between Pressure Support Ventilation (PSV) 30 min and T-piece 120 min in the outcome of the rate of success in SBTs (RR = 0.91; 95% CI, 0.84-0.98). The cumulative rank probability showed that the rate of success in SBT from best to worst was PSV 30 min, PSV 120 min, T-piece 30 min and T-piece 120 min. PSV 30 min and PSV 120 min are more likely to have a higher rate of extubation (SUCRA values of 82.5% for 30 min PSV, 70.7% for 120 min PSV, 36.4% for T-piece 30 min, 10.4% for T-piece 120). Meanwhile, T-piece 120 min (SUCRA, 62.9%) and PSV 120 min (SUCRA, 60.9%) may result in lower reintubation rates, followed by T-piece 30 min (SUCRA, 41.8%) and PSV 30 min (SUCRA, 34.4%).
    Conclusions and relevance to clinical practice: In comprehensive consideration of four outcomes, regarding SBT strategies, 30-min PSV was superior in simple-to-wean patients. Besides, 120-min T-piece and 120-min PSV are more likely to achieve a lower reintubation rate. Thus, the impact of duration is more significant among patients who have a high risk of reintubation. It is still unclear whether the SBTs affect the outcome of mortality; further studies may need to explore the underlying mechanism.
    MeSH term(s) Humans ; Network Meta-Analysis ; Respiration, Artificial/methods ; Positive-Pressure Respiration/methods ; Ventilator Weaning/methods ; Intubation, Intratracheal
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2011956-2
    ISSN 1478-5153 ; 1362-1017
    ISSN (online) 1478-5153
    ISSN 1362-1017
    DOI 10.1111/nicc.12781
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  3. Article ; Online: Genome Sequence of Oxalobacter formigenes Strain SSYG-15.

    Sun, Ning-Yun / Gao, Yuan / Yu, Hong-Jing

    Microbiology resource announcements

    2019  Volume 8, Issue 42

    Abstract: Colonization of the intestine ... ...

    Abstract Colonization of the intestine with
    Language English
    Publishing date 2019-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01059-19
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  4. Article ; Online: Attitudes and beliefs towards implementation of nurse prescribing among general nurses and nurse specialists in China: A cross-sectional survey study.

    Ling, Dong-Lan / Hu, Jiale / Zhong, Mei-Yun / Li, Wan-Ting / Yu, Hong-Jing

    Nursing open

    2021  Volume 8, Issue 5, Page(s) 2760–2772

    Abstract: Aims: To investigate the attitudes and beliefs towards the implementation of nurse prescribing among general nurses and nurse specialists.: Design: A cross-sectional survey among general nurses and nurse specialists was conducted in seven provinces ... ...

    Abstract Aims: To investigate the attitudes and beliefs towards the implementation of nurse prescribing among general nurses and nurse specialists.
    Design: A cross-sectional survey among general nurses and nurse specialists was conducted in seven provinces and one autonomous region in mainland China using convenience sampling method.
    Methods: The attitudes and beliefs towards nurse prescribing were assessed using the Nurse Attitudes and Beliefs towards Nurse prescribing scale, of which Cronbach's coefficient was 0.902, retest reliability was 0.808. Respondents from eight hospitals across the country were employed to complete an online questionnaire.
    Results: Nurse specialists (n = 399) had statistically significantly more favourable intentions towards nurse prescribing than general nurses (n = 415; 105.64 ± 12.83 vs. 96.39 ± 13.16; p < .001). The years of clinical work experience, professional title, education degree were positively correlated with general nurses' and nurse specialists' attitudes and beliefs towards nurse prescribing (p < .05). Among nurse specialists, the variety of specialties and whether they work in nurse-led clinics on an outpatient basis have positively influence on their intentions towards nurse prescribing (p < .05).
    MeSH term(s) Attitude of Health Personnel ; Cross-Sectional Studies ; Humans ; Nurse Specialists ; Nurses ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2021-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2809556-X
    ISSN 2054-1058 ; 2054-1058
    ISSN (online) 2054-1058
    ISSN 2054-1058
    DOI 10.1002/nop2.852
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  5. Article: The use of fluorescent techniques in combination with flow cytometry for fast counting of Bifidobacterium longum ATCC BAA-2753 in BIFICO capsule

    Gao, Yuan / Yu, Hong-jing / Wen, Bin

    Food science and biotechnology. 2018 Oct., v. 27, no. 5

    2018  

    Abstract: BIFICO is a main microecological drug that the main ingredient is Bifidobacterium longum ATCC BAA-2753. It’s necessary to detect the number of Bifidobacterium longum ATCC BAA-2753 for quality control during the production of BIFICO. Plate count assay ( ... ...

    Abstract BIFICO is a main microecological drug that the main ingredient is Bifidobacterium longum ATCC BAA-2753. It’s necessary to detect the number of Bifidobacterium longum ATCC BAA-2753 for quality control during the production of BIFICO. Plate count assay (PCA) is the most commonly used method for counting microbial cells. However, not all microorganisms can be counted by PCA. (e.g. uncultured microorganisms under specific growth conditions). In this study, a method of fluorescent techniques in combination with flow cytometry (FCM) was established for the counting of Bifidobacterium longum BAA-2753. Using SYTO9 and PI stain, flow cytometric analysis could easily differentiate live bacteria and dead bacteria. The number of live bacteria determined by FCM was about fourfold higher than that counted by PCA. Therefore, the FCM method could be a practical tool for the quality control of Bifidobacterium longum BAA-2753 in the industrial production of BIFICO.
    Keywords Bifidobacterium longum ; bacteria ; flow cytometry ; fluorescence ; ingredients ; microbial ecology ; plate count ; probiotics ; quality control
    Language English
    Dates of publication 2018-10
    Size p. 1405-1410.
    Publishing place Springer Singapore
    Document type Article
    ZDB-ID 2000008-X
    ISSN 1226-7708
    ISSN 1226-7708
    DOI 10.1007/s10068-018-0388-z
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: The use of fluorescent techniques in combination with flow cytometry for fast counting of

    Gao, Yuan / Yu, Hong-Jing / Wen, Bin

    Food science and biotechnology

    2018  Volume 27, Issue 5, Page(s) 1405–1410

    Abstract: BIFICO is a main microecological drug that the main ingredient ... ...

    Abstract BIFICO is a main microecological drug that the main ingredient is
    Language English
    Publishing date 2018-05-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-018-0388-z
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  7. Article ; Online: Truth-telling, decision-making, and ethics among cancer patients in nursing practice in China.

    Ling, Dong-Lan / Yu, Hong-Jing / Guo, Hui-Ling

    Nursing ethics

    2017  Volume 26, Issue 4, Page(s) 1000–1008

    Abstract: Background: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling ... ...

    Abstract Background: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling of terminal illness and the role of nurses thus is not explicit when encountering this issue.
    Objectives: The intention of this paper is to provide ethical guidelines or strategies with regards to decision-making on truth-telling of terminal illness for Chinese nurses.
    Methods: This paper initially present a case scenario and then critically discuss the ethical issue in association with ethical principles and philosophical theories. Instead of focusing on attitudes toward truth disclosure, it aims to provide strategies regarding this issue for nurses. It highlights and discusses some of the relevant ethical assumptions around the perceived role of nurses in healthcare settings by focusing on nursing ethical virtues, nursing codes of ethics, and philosophical perspectives. And Confucian culture is discussed to explicate that deontology does not consider family-oriented care in China.
    Conclusion: Treating each family individually to explore the family's beliefs and values on this issue is essential in healthcare practice and nurses should tailor their own approach to individual needs regarding truth-telling in different situations. Moreover, the Chinese Code of Ethics should be modified to be more specific and applicable. Finally, a narrative ethics approach should be applied and teamwork between nurses, physicians and families should be established to support cancer patients and to ensure their autonomy and hope.
    Ethical considerations: This paper was approved by the Ethics Committee of The Second Affiliated Hospital of Guangzhou Medical University. The authors have obtained consent to use the case study and it has been anonymised to preserve the patient's confidentiality.
    MeSH term(s) Aged ; China ; Decision Making ; Ethics, Nursing ; Humans ; Male ; Neoplasms/complications ; Neoplasms/psychology ; Nursing Process/ethics ; Philosophy ; Truth Disclosure/ethics
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1200467-4
    ISSN 1477-0989 ; 0969-7330
    ISSN (online) 1477-0989
    ISSN 0969-7330
    DOI 10.1177/0969733017739783
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    Zs.A 4041: Show issues Location:
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  8. Article ; Online: Implementation of a motivational programme based on existence- relatedness-growth theory in nursing undergraduate interns: A quasi-experimental study.

    Yang, Shuai / Zhang, Xiao-Die / Guo, Wei / Ho, Ka Yan / Lam, Katherine Ka Wai / Dong, Yan-Yan / Pan, Jing-Da / Liu, Qi / Xu, Ri-Di / Ling, Dong-Lan / Yu, Hong-Jing

    Nurse education today

    2023  Volume 129, Page(s) 105894

    Abstract: Background: Currently, a paramount issue in nursing education is to motivate nursing undergraduate interns to develop self-directed learning skills and improve their practice satisfaction and professional identity, so as to meet the growing demands in ... ...

    Abstract Background: Currently, a paramount issue in nursing education is to motivate nursing undergraduate interns to develop self-directed learning skills and improve their practice satisfaction and professional identity, so as to meet the growing demands in healthcare.
    Objectives: This study aimed to examine the effectiveness of a motivational programme based on the Existence-Relatedness-Growth (ERG) theory in developing self-directed learning skills, improving practice satisfaction and promoting the professional identity of nursing undergraduate interns in China.
    Design: A quasi-experimental study design.
    Setting: A government-funded tertiary teaching hospital in Guangzhou, Guangdong province, China.
    Methods: This study was conducted with 99 nursing undergraduate interns in a hospital between June 2020 and April 2022. The interns in the experimental group (n = 50) participated in the motivational programme based on ERG theory, while those in the control group (n = 49) underwent a traditional training programme. The interns in the two groups were compared in terms of their degree of self-directed learning, practice satisfaction and professional identity after the training, using independent samples t-test.
    Results: After the internship, interns in the experimental group showed a statistically significantly higher level of self-directed learning and practice satisfaction than those in the control group (p < 0.05). However, no significant difference was observed in professional identity between the two groups after the internship.
    Conclusions: The motivational programme based on ERG theory was shown to be effective in improving self-directed learning and practice satisfaction in nursing undergraduate interns. A large-scale randomized controlled trial is warranted to confirm the results.
    MeSH term(s) Humans ; Education, Nursing ; Internship and Residency ; Learning ; Delivery of Health Care ; Students, Nursing
    Language English
    Publishing date 2023-07-05
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1062570-7
    ISSN 1532-2793 ; 0260-6917
    ISSN (online) 1532-2793
    ISSN 0260-6917
    DOI 10.1016/j.nedt.2023.105894
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  9. Article: Truth-telling, decision-making, and ethics among cancer patients in nursing practice in China

    Ling, Dong-Lan / Yu, Hong-Jing / Guo, Hui-Ling

    Nursing ethics : an international journal for health care professionals

    2019  Volume 26, Issue 4, Page(s) 1000–1008

    Keywords Autonomie ; China ; Ethische Entscheidungsfindung ; Kommunikation ; Krebskranker
    Language English
    Document type Article
    ZDB-ID 1200467-4
    ISSN 1477-0989 ; 0969-7330
    ISSN (online) 1477-0989
    ISSN 0969-7330
    DOI 10.1177/0969733017739783
    Database bibnet.org

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  10. Article ; Online: The necessity and possibility of implementation of nurse prescribing in China: An international perspective.

    Ling, Dong-Lan / Lyu, Chun-Mei / Liu, Hui / Xiao, Xiao / Yu, Hong-Jing

    International journal of nursing sciences

    2017  Volume 5, Issue 1, Page(s) 72–80

    Abstract: Background: The number of countries where nurses are legally permitted to prescribe has grown rapidly due to a variety of external and internal forces. Despite its international popularity, nurse prescribing has not yet been implemented in China widely.! ...

    Abstract Background: The number of countries where nurses are legally permitted to prescribe has grown rapidly due to a variety of external and internal forces. Despite its international popularity, nurse prescribing has not yet been implemented in China widely.
    Objective: The intent of this paper is to review the current international literature regarding nurse prescribing so as to explore the necessity and possibility of implementation of nurse prescribing in China and classify the research gap.
    Methods: Eight electronic databases including Embase, SpringerLink, EBSCO, CINAHL, Medline, Wiley, Science Direct, CochraneLibrary were electronically searched to identify related peer-review articles published in the English language only from 2007 to 2017. Relative references found from the identified studies were traced back to ensure that potentially eligible articles were included.
    Results: Thirty-three publications which met the inclusion criteria were included in this literature review. The literature shows that not only could nurse prescribing provide quicker service, improvements in quality, but also could make better utilization of the nurses' professional skills and increase nurses' autonomy. Moreover, the barriers of nurse prescribing are explored to identify the factors that may facilitate the success of its implementation.
    Conclusion: The review advises that nurses' views towards nurse prescribing have played a significant role in the success of nurse prescribing. While no literature regarding Chinese nurses' attitudes towards nurse prescribing could be identified, it is imperative to examine their attitudes on it. This would help Chinese healthcare policymakers ascertain the necessity of the introduction of nurse prescribing and provide them with valuable information for service planning.
    Language English
    Publishing date 2017-12-29
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2800296-9
    ISSN 2352-0132 ; 2352-0132
    ISSN (online) 2352-0132
    ISSN 2352-0132
    DOI 10.1016/j.ijnss.2017.12.011
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