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  1. Article ; Online: Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ

    Li, Bin / Xie, Pei-Jun / Hao, Yan-Wei / Guo, Yu / Yu, Jun-Rong / Gong, Dao-Yin / Guo, Jing / Zeng, Jin-Hao / Zhang, Yi

    Molecular medicine reports

    2021  Volume 23, Issue 4

    Abstract: Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported to aid in the treatment of Alzheimer's disease (AD). The present study aimed to investigate the effects of YZS on tau protein aggregation, a hallmark of AD ... ...

    Abstract Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported to aid in the treatment of Alzheimer's disease (AD). The present study aimed to investigate the effects of YZS on tau protein aggregation, a hallmark of AD pathology, and its possible mechanisms. The results demonstrated that YZS improved learning and memory abilities, and decreased the severity of AD pathology in β‑amyloid (Aβ
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Peptide Fragments/genetics ; Phosphorylation/drug effects ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/genetics ; Protein Aggregates/drug effects ; Rats ; Ubiquitin/genetics ; tau Proteins/genetics
    Chemical Substances Amyloid beta-Peptides ; Drugs, Chinese Herbal ; Peptide Fragments ; Protein Aggregates ; Ubiquitin ; amyloid beta-protein (1-40) ; tau Proteins ; yuan zhi ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2021-02-19
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2021.11918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) interpenetrating polymer network beads as potential capsules for biomedical use

    Tang, Qi / Yu, Jun-Rong / Chen, Lei / Zhu, Jing / Hu, Zu-Ming

    Current applied physics. 2011 May, v. 11, no. 3

    2011  

    Abstract: Silicone hydrogels represent a series of novel materials designed for extensive applications especially in the biomedical field. In the current work, a method to obtain poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) (PDMS/PHEMA) ... ...

    Abstract Silicone hydrogels represent a series of novel materials designed for extensive applications especially in the biomedical field. In the current work, a method to obtain poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) (PDMS/PHEMA) interpenetrating polymer network (IPN) beads was developed. With further optimization, up to 43% PHEMA was incorporated into size controllable PDMS microspheres, offers an improved hydrophilicity and thus a reduced protein adsorption for long-term use. Furthermore, we found the PDMS/PHEMA IPN beads possess a hollow capsule-like structure, proposing their application as novel drug delivery vehicles. In vitro release studies have demonstrated two release patterns of these IPN beads for water-soluble drugs just by modulating the drug concentration, suggesting their possible applications in different delivery systems.
    Keywords adsorption ; drugs ; hydrocolloids ; hydrophilicity ; physics ; silicone
    Language English
    Dates of publication 2011-05
    Size p. 945-950.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1567-1739
    DOI 10.1016/j.cap.2010.12.035
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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  3. Article: Effects of three parameters on the diameter of electrospun poly(ethylene oxide) nanofibers.

    He, Su-Wen / Li, Shan-Shan / Hu, Zu-Ming / Yu, Jun-Rong / Chen, Lei / Zhu, Jing

    Journal of nanoscience and nanotechnology

    2011  Volume 11, Issue 2, Page(s) 1052–1059

    Abstract: The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning, which produces the diameter of polymer fibers range from nanometer to sub-micron. In this work, we have studied ... ...

    Abstract The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning, which produces the diameter of polymer fibers range from nanometer to sub-micron. In this work, we have studied effects of adding LiCl on the morphology and diameter of electrospun poly(ethylene oxide), and we have also evaluated systematically the effect of three important solution parameters on the morphology of electrospun poly(ethylene oxide): molecular weight, solution viscosity and electrical conductivity. We find that molecular weight is strongly correlated with the formation of bead defects in the fibers, the smaller molecular weight, the more beads defect density. As a result, the fibers have beads-in-string structures. Electrical conductivity increases, then decreases as molecular weight increases. Solution viscosity has been found to most strongly affect fiber size, with fibers diameter increasing with increasing solution viscosity according to a power law relationship. In addition, we find evidence that solution viscosity and electrical conductivity affect the interesting morphology of the electrospun nanofibers, and result in doubling and forming membrances phenomena.
    Language English
    Publishing date 2011-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 1533-4880
    ISSN 1533-4880
    DOI 10.1166/jnn.2011.3080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Study on morphology and characterization of poly(mphenylene isophtalamide)/multi-walled carbon nanotubes composite nanofibers by electrospinning.

    He, Su-Wen / Liu, Li-Qi / Gaol, Bao-Shan / Chen, Lei / Hu, Zu-Ming / Yu, Jun-Rong / Zhu, Jing

    Journal of nanoscience and nanotechnology

    2011  Volume 11, Issue 5, Page(s) 4004–4010

    Abstract: Electrospinning technique is the main method of preparing polymer nanofiber simply, directly and continuously at present. In this work, electrospinning blend solution was prepared by in-situ polymerization using acid-modified multi-walled carbon ... ...

    Abstract Electrospinning technique is the main method of preparing polymer nanofiber simply, directly and continuously at present. In this work, electrospinning blend solution was prepared by in-situ polymerization using acid-modified multi-walled carbon nanotubes (MWNTs), m-phenylenediamine (MPD) and isophthaloyl chloride (IPC). And then composite nanofibers were prepared by electrospinning. MWNTs played an important role in nanofiber's properties. The effects of MWNTs on the morphology and characterization of the MWNTs/PMIA composite nanofibers were investigated. Scanning electron microscopy (SEM), thermal gravimetric analyzer (TGA), and X-ray diffraction (XRD) were utilized to characterize the MWNTs/PMIA nanofibers morphology and properties. The experimental results indicated that the nanofibers diameter decreased and solution dynamic viscosity increased with increasing MWNTs contents. XRD data demonstrated that PMIA composite nanofibers had the same crystal type as the pure PMIA nanofiber, and crystallinity was improved with increasing MWNTs loading. Transmission electron microscopy (TEM) was used to confirm MWNTs aligned along the axis of composite nanofibers.
    Language English
    Publishing date 2011-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 1533-4880
    ISSN 1533-4880
    DOI 10.1166/jnn.2011.3827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  5. Article: Poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) interpenetrating polymer network beads as potential capsules for biomedical use

    Tang, Qi / Yu, Jun-Rong / Chen, Lei / Zhu, Jing / Hu, Zu-Ming

    Current applied physics

    Volume v. 11,, Issue no. 3

    Abstract: Silicone hydrogels represent a series of novel materials designed for extensive applications especially in the biomedical field. In the current work, a method to obtain poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) (PDMS/PHEMA) ... ...

    Abstract Silicone hydrogels represent a series of novel materials designed for extensive applications especially in the biomedical field. In the current work, a method to obtain poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) (PDMS/PHEMA) interpenetrating polymer network (IPN) beads was developed. With further optimization, up to 43% PHEMA was incorporated into size controllable PDMS microspheres, offers an improved hydrophilicity and thus a reduced protein adsorption for long-term use. Furthermore, we found the PDMS/PHEMA IPN beads possess a hollow capsule-like structure, proposing their application as novel drug delivery vehicles. In vitro release studies have demonstrated two release patterns of these IPN beads for water-soluble drugs just by modulating the drug concentration, suggesting their possible applications in different delivery systems.
    Keywords hydrophilicity ; physics ; silicone ; drugs ; adsorption ; hydrocolloids
    Language English
    Document type Article
    ISSN 1567-1739
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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