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Article ; Online: Uveitis in pediatric inflammatory bowel disease.

Yu, Kimberley / Davidson, Stefanie / Binenbaum, Gil

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

2023 Volume 27, Issue 3, Page(s) 153–155

Abstract: There are currently no official uveitis screening guidelines for children with inflammatory bowel disease (IBD). In this retrospective cohort study of children with IBD with at least 1 ophthalmologist examination over 12 years, we investigated the ... ...

Abstract	There are currently no official uveitis screening guidelines for children with inflammatory bowel disease (IBD). In this retrospective cohort study of children with IBD with at least 1 ophthalmologist examination over 12 years, we investigated the prevalence and characteristics of uveitis in pediatric IBD. Outcomes included prevalence of uveitis, age at onset, and clinical characteristics of uveitis. A total of 315 children with IBD (mean age, 11.7 ± 4.3) had 974 eye examinations. Five children (1.6%; 95% CI, 0.7%-3.7%) had uveitis, with mean age at onset of 14.3 ± 5.6 years. Three of 209 children with Crohn's disease (1.4%; 95% CI, 0.5%-4.1%), 2 of 55 with IBD-unclassified (3.6%; 95% CI, 1.0%-12.3%) and 0 of 51 with ulcerative colitis (95% CI, 0.0%-7.0%) had uveitis. All uveitis was symptomatic. In our study cohort, uveitis was rare and symptomatic in pediatric IBD.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Adult ; Retrospective Studies ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/epidemiology ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/epidemiology ; Crohn Disease/diagnosis ; Uveitis/diagnosis ; Uveitis/epidemiology ; Uveitis/etiology
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	1412476-2
ISSN	1528-3933 ; 1091-8531
ISSN (online)	1528-3933
ISSN	1091-8531
DOI	10.1016/j.jaapos.2023.02.013
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Article: A rare pediatric case of cluster headaches after cardiac catheterization in a patient with an isolated innominate artery.

Yu, Kimberley / Chadehumbe, Madeline

SAGE open medical case reports

2021 Volume 9, Page(s) 2050313X211023679

Abstract: While cluster headaches are classified and considered a primary headache disorder, secondary causes of cluster headaches have been reported and may provide insight into cluster headaches' potential pathophysiology. The mechanisms underlying this headache ...

Abstract	While cluster headaches are classified and considered a primary headache disorder, secondary causes of cluster headaches have been reported and may provide insight into cluster headaches' potential pathophysiology. The mechanisms underlying this headache phenotype are poorly understood, and several theories have been proposed that range from the activation within the posterior hypothalamus to autonomic tone dysfunction. We provide a review of reported cases in the literature describing secondary causes after cardiac procedures. We will present a novel pediatric case report of a 16-year-old boy with an isolated innominate artery who presented with acute new-onset headaches 8 h following cardiac catheterization of the aortic arch with arteriography and left pulmonary artery stent placement. The headaches were characterized by attacks of excruciating pain behind the left eye and jaw associated with ipsilateral photophobia, conjunctival injection, rhinorrhea, with severe agitation and restlessness. These met the
Language	English
Publishing date	2021-06-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X211023679
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Article ; Online: Dry Eye Subtypes in the Dry Eye Assessment and Management (DREAM) Study: A Latent Profile Analysis.

Yu, Kimberley / Asbell, Penny A / Shtein, Roni M / Ying, Gui-Shuang

Translational vision science & technology

2022 Volume 11, Issue 11, Page(s) 13

Abstract: Purpose: Dry eye disease (DED) is a heterogeneous condition with poorly characterized subtypes. The DREAM study was a large multicenter randomized clinical trial that did not find omega-3 to be more effective than placebo in treating symptomatic DED. We ...

Abstract	Purpose: Dry eye disease (DED) is a heterogeneous condition with poorly characterized subtypes. The DREAM study was a large multicenter randomized clinical trial that did not find omega-3 to be more effective than placebo in treating symptomatic DED. We performed secondary analysis of DREAM data to characterize DED subtypes and their omega-3 response. Methods: A total of 535 patients with moderate-to-severe DED were randomized to omega-3 or placebo treatment for one year. We used latent profile analysis to identify subtypes based on baseline Ocular Surface Disease Index, tear break-up time (TBUT), anesthetized Schirmer's test, corneal and conjunctival staining, and meibomian gland dysfunction (MGD). We evaluated omega-3's effect for each subtype using generalized linear regression. Results: Five clinically meaningful DED subtypes were identified. They differed significantly in sex (P < 0.001) and race (P = 0.02). Subtype 1 had the most severe DED signs yet milder symptoms and was associated with more Sjögren's syndrome (21%, P < 0.001). Subtype 2 had the mildest DED signs except MGD. Subtype 3 had the most severe symptoms, out of proportion to DED signs. Subtype 4 had relatively milder symptoms and MGD. Subtype 5 had severe MGD and TBUT and was associated with rosacea (29%, P = 0.04). Omega-3 was not significantly more beneficial than placebo for any subtype. Conclusions: Five clinically meaningful DED subtypes differed significantly in demographics, symptoms, signs, and systemic disease associations. Omega-3 was not significantly more effective than placebo for any subtype. Translational relevance: T3 translational research identifying subtypes in the DREAM study can improve DED clinical classification and targeted management.
MeSH term(s)	Humans ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/drug therapy ; Tears ; Meibomian Gland Dysfunction ; Cornea ; Fatty Acids, Omega-3/therapeutic use
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.11.11.13
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Article ; Online: Otorhinolaryngology, head and neck surgery practice during the COVID-19 pandemic.

Yu, Kimberley / Wei, Jun-Min / Li, Da-Qing / Fang, Yu-Xin

World journal of otorhinolaryngology - head and neck surgery

2020 Volume 6, Page(s) S1

Keywords	covid19
Language	English
Publishing date	2020-06-06
Publishing country	China
Document type	Editorial
ISSN	2589-1081
ISSN (online)	2589-1081
DOI	10.1016/j.wjorl.2020.06.001
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Article: Machine Learning Applications in the Evaluation and Management of Psoriasis: A Systematic Review.

Yu, Kimberley / Syed, Maha N / Bernardis, Elena / Gelfand, Joel M

Journal of psoriasis and psoriatic arthritis

2020 Volume 5, Issue 4, Page(s) 147–159

Abstract: Background: Machine learning (ML), a subset of artificial intelligence (AI) that aims to teach machines to automatically learn tasks by inferring patterns from data, holds significant promise to aid psoriasis care. Applications include evaluation of ... ...

Abstract	Background: Machine learning (ML), a subset of artificial intelligence (AI) that aims to teach machines to automatically learn tasks by inferring patterns from data, holds significant promise to aid psoriasis care. Applications include evaluation of skin images for screening and diagnosis as well as clinical management including treatment and complication prediction. Objective: To summarize literature on ML applications to psoriasis evaluation and management and to discuss challenges and opportunities for future advances. Methods: We searched MEDLINE, Google Scholar, ACM Digital Library, and IEEE Xplore for peer-reviewed publications published in English through December 1, 2019. Our search queries identified publications with any of the 10 computing-related keywords and "psoriasis" in the title and/or abstract. Results: Thirty-three studies were identified. Articles were organized by topic and synthesized as evaluation- or management-focused articles covering 5 content categories: (A) Evaluation using skin images: (1) identification and differential diagnosis of psoriasis lesions, (2) lesion segmentation, and (3) lesion severity and area scoring; (B) clinical management: (1) prediction of complications and (2) treatment. Conclusion: Machine learning has significant potential to aid psoriasis evaluation and management. Current topics popular in ML research on psoriasis are the evaluation of medical images, prediction of complications, and treatment discovery. For patients to derive the greatest benefit from ML advancements, it is helpful for dermatologists to have an understanding of ML and how it can effectively aid their assessments and decision-making.
Language	English
Publishing date	2020-08-31
Publishing country	United States
Document type	Journal Article
ISSN	2475-5303
ISSN	2475-5303
DOI	10.1177/2475530320950267
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Article ; Online: Systemic Conditions Associated with Severity of Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management Study.

Yu, Kimberley / Bunya, Vatinee / Maguire, Maureen / Asbell, Penny / Ying, Gui-Shuang

Ophthalmology

2021 Volume 128, Issue 10, Page(s) 1384–1392

Abstract: Purpose: Certain systemic conditions are reported to be risk factors for dry eye disease (DED), but their associations with DED severity are not well studied. We evaluated whether systemic conditions reported to be DED risk factors are associated with ... ...

Abstract	Purpose: Certain systemic conditions are reported to be risk factors for dry eye disease (DED), but their associations with DED severity are not well studied. We evaluated whether systemic conditions reported to be DED risk factors are associated with severity of DED signs and symptoms. Design: Secondary analysis of data from the Dry Eye Assessment and Management Study, a large-scale multicenter randomized clinical trial of patients with moderate to severe DED. Participants: Five hundred thirty-five adult patients with moderate to severe DED from 27 United States centers. Methods: Patients reported their medical history at baseline. They underwent ocular surface examinations and symptom evaluation using standardized protocols at baseline, 6 months, and 12 months. We analyzed the associations of systemic conditions (a systemic disease or smoking history) reported as potential DED risk factors with the severity of DED signs and symptoms using generalized linear regression models adjusted by age, gender, race, and visit. Main outcome measures: Dry eye disease symptoms assessed using the Ocular Surface Disease Index (OSDI), 6 DED signs (tear film break-up time, anesthetized Schirmer testing, corneal fluorescein staining, conjunctival lissamine green staining, tear osmolarity, and meibomian gland dysfunction), and a composite signs severity score from 0 to 1 (1 = most severe). Results: The mean age was 58 years; 81% were women. More severe DED signs were associated significantly with Sjögren syndrome (mean composite signs severity score 0.52 with disease vs. 0.43 without disease; P < 0.001), facial rosacea (0.47 vs. 0.43; P = 0.002), rheumatoid arthritis (0.47 vs. 0.42; P = 0.002), peripheral artery disease (0.50 vs. 0.43; P < 0.001), and daily smoking history (0.45 vs. 0.43; P = 0.047). Thyroid dysfunction, osteoarthritis, diabetes, irritable bowel syndrome, hypercholesterolemia, hypertension, and hypertriglyceridemia were not associated significantly with DED signs. No conditions were associated significantly with OSDI. Conclusions: In this large, well-characterized cohort of patients with DED assessed under standardized procedures, patients with certain systemic diseases and smoking history showed more severe DED signs compared with patients without the conditions. The profile of significant DED signs varied by systemic condition, reflecting different DED causes. Understanding the systemic conditions and underlying causes that predispose some patients to severe DED can improve management.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Conjunctiva/pathology ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/etiology ; Female ; Humans ; Male ; Middle Aged ; Osmolar Concentration ; Rheumatic Diseases/complications ; Risk Factors ; Severity of Illness Index ; Surveys and Questionnaires ; Tears/chemistry ; Young Adult
Language	English
Publishing date	2021-03-27
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2021.03.030
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Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 533: Show issues

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Article ; Online: Preliminary Screening Questionnaire for Sjögren's Syndrome in the Rheumatology Setting.

Yu, Kimberley / Ying, Gui-Shuang / Vivino, Frederick B / Gonzales, John A / Massaro-Giordano, Mina / Bunya, Vatinee Y

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2021 Volume 28, Issue 2, Page(s) e456–e461

Abstract: Objective: Sjögren's syndrome (SS) is frequently undetected or misdiagnosed as other rheumatologic diseases. We aimed to develop an SS screening questionnaire for the rheumatology practice.: Methods: We developed the Sjögren's Syndrome Screening ... ...

Abstract	Objective: Sjögren's syndrome (SS) is frequently undetected or misdiagnosed as other rheumatologic diseases. We aimed to develop an SS screening questionnaire for the rheumatology practice. Methods: We developed the Sjögren's Syndrome Screening Questionnaire (SSSQ) via secondary analysis of data from 974 participants referred by rheumatologists to the Sjögren's International Collaborative Clinical Alliance (SICCA) study. Participants answered 88 questions regarding symptoms, medical history, and demographics. They underwent ocular, dental, and serologic tests and were classified as SS or non-SS using the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria. We conducted univariate and multivariate logistic regression to identify questions most discriminative of SS, from which we derived an individual's likelihood of SS ("SSSQ score"). Results: Five questions were significantly discriminative of SS in the multivariate analysis (p < 0.05): (1) Can you eat a cracker without drinking a fluid/liquid? (no: odds ratio [OR], 1.39; 95% confidence interval [CI], 1.06-1.82]); (2) How would you describe your dental and oral health in general? (fair/poor: OR, 1.68; 95% CI, 1.04-2.75); (3) During the last week, have you experienced tearing? (none of the time: OR, 2.26; 95% CI, 1.23-4.34); (4) Are you able to produce tears? (no: OR, 1.62; 95% CI, 1.12-2.37); and (5) Do you currently smoke cigarettes? (no: OR, 2.83; 95% CI, 1.69-4.91). SSSQ score ≥7 (possible range, 0-11) distinguishes SS from non-SS patients with 64% sensitivity and 58% specificity (area under receiver operating characteristic curve, 0.65). Conclusions: The SSSQ is a simple 5-item questionnaire designed to screen for SS in clinical practice, with a potential impact to reduce delays in diagnosis.
MeSH term(s)	Humans ; Odds Ratio ; ROC Curve ; Rheumatology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000001760
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Zs.A 4815: Show issues

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Article: Otorhinolaryngology, head and surgery practice during the COVID-19 pandemic

Yu, Kimberley / Wei, Jun-Min / Li, Da-Qing / Fang, Yu-Xin

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #548039
Database	COVID19

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Article ; Online: Otorhinolaryngology, head and surgery practice during the COVID-19 pandemic

Yu, Kimberley / Wei, Jun-Min / Li, Da-Qing / Fang, Yu-Xin

World Journal of Otorhinolaryngology - Head and Neck Surgery ; ISSN 2095-8811

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.wjorl.2020.06.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.

Chen, Xi / Chang, Jianjun / Deng, Qiudong / Xu, Jie / Nguyen, Thi A / Martens, Lauren H / Cenik, Basar / Taylor, Georgia / Hudson, Kathryn F / Chung, Jaegwon / Yu, Kimberley / Yu, Phillip / Herz, Joachim / Farese, Robert V / Kukar, Thomas / Tansey, Malú G

The Journal of neuroscience : the official journal of the Society for Neuroscience

2013 Volume 33, Issue 21, Page(s) 9202–9213

Abstract: Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is implicated in neuronal survival on the basis that mutations in the GRN gene causing haploinsufficiency result in a familial form of frontotemporal dementia (FTD). ... ...

Abstract	Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is implicated in neuronal survival on the basis that mutations in the GRN gene causing haploinsufficiency result in a familial form of frontotemporal dementia (FTD). Recently, a direct interaction between PGRN and tumor necrosis factor receptors (TNFR I/II) was reported and proposed to be a mechanism by which PGRN exerts anti-inflammatory activity, raising the possibility that aberrant PGRN-TNFR interactions underlie the molecular basis for neuroinflammation in frontotemporal lobar degeneration pathogenesis. Here, we report that we find no evidence for a direct physical or functional interaction between PGRN and TNFRs. Using coimmunoprecipitation and surface plasmon resonance (SPR) we replicated the interaction between PGRN and sortilin and that between TNF and TNFRI/II, but not the interaction between PGRN and TNFRs. Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize TNF-dependent NFκB, Akt, and Erk1/2 pathway activation; inflammatory gene expression; or secretion of inflammatory factors in BV2 microglia and bone marrow-derived macrophages (BMDMs). Moreover, PGRN did not antagonize TNF-induced cytotoxicity on dopaminergic neuroblastoma cells. Last, co-addition or pre-incubation with various N- or C-terminal-tagged recombinant PGRNs did not alter lipopolysaccharide-induced inflammatory gene expression or cytokine secretion in any cell type examined, including BMDMs from Grn+/- or Grn-/- mice. Therefore, the neuroinflammatory phenotype associated with PGRN deficiency in the CNS is not a direct consequence of the loss of TNF antagonism by PGRN, but may be a secondary response by glia to disrupted interactions between PGRN and Sortilin and/or other binding partners yet to be identified.
MeSH term(s)	Adaptor Proteins, Vesicular Transport/metabolism ; Analysis of Variance ; Animals ; Cell Line ; Cell Proliferation/drug effects ; Culture Media, Conditioned/pharmacology ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; Granulins ; Humans ; Immunoprecipitation ; Intercellular Signaling Peptides and Proteins/deficiency ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Isoquinolines/metabolism ; Lipopolysaccharides/pharmacology ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/drug effects ; Microglia/metabolism ; NF-kappa B/metabolism ; Progranulins ; Protein Binding/genetics ; Receptors, Tumor Necrosis Factor/genetics ; Receptors, Tumor Necrosis Factor/metabolism ; Recombinant Proteins/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Surface Plasmon Resonance ; Transfection
Chemical Substances	Adaptor Proteins, Vesicular Transport ; Culture Media, Conditioned ; Cytokines ; Granulins ; Grn protein, mouse ; Intercellular Signaling Peptides and Proteins ; Isoquinolines ; Lipopolysaccharides ; NF-kappa B ; Progranulins ; Receptors, Tumor Necrosis Factor ; Recombinant Proteins ; lucifer yellow (9654F8OVKE) ; sortilin (Z020Y8WIJ4)
Language	English
Publishing date	2013-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.5336-12.2013
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