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Article: Total-system innovation management

Yu, Oliver

Quality innovation : knowledge, theory, and practices , p. 143-157

concepts and applications

2014 , Page(s) 143–157

Author's details	Oliver Yu
Keywords	Innovation ; Innovationsmanagement
Language	English
Size	graph. Darst.
Publisher	Information Science Reference
Publishing place	Hershey, Pa.
Document type	Article
ISBN	978-1-4666-4769-5 ; 1-4666-4769-8
Database	ECONomics Information System

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Article: Transgenic Rice Expressing Isoflavone Synthase Gene from Soybean Shows Resistance Against Blast Fungus (Magnaporthe oryzae)

Pokhrel, Suresh / Ponniah, Sathish K. / Jia, Yulin / Yu, Oliver / Manoharan, Muthusamy

Plant disease. 2021 Oct. 29, v. 105, no. 10

2021

Abstract: The isoflavones are a group of plant secondary metabolites primarily synthesized in legumes and are known for their role in improving human health and plant disease resistance. The isoflavones, especially genistein, act as precursors for the production ... ...

Abstract	The isoflavones are a group of plant secondary metabolites primarily synthesized in legumes and are known for their role in improving human health and plant disease resistance. The isoflavones, especially genistein, act as precursors for the production of phytoalexins, which may induce broad-spectrum disease resistance in plants. In this study, we screened transgenic rice lines expressing the isoflavone synthase (GmIFS1) gene from soybean for rice blast (Magnaporthe oryzae) resistance. Two homozygous transgenic lines (I2 and I10), based on single copy gene integration, were identified. The expression of GmIFS1 in transgenic lines was confirmed by quantitative real-time PCR. Genistein was detected in the transgenic lines using liquid chromatography with tandem mass spectrometry. Subsequently, the transgenic lines were evaluated against the rice blast pathogen, isolate YJ54 (race IB-54). The results indicated that >60% of the plants in both the lines (I2 and I10) showed resistance against the blast pathogen. The progenies of one of the resistant transgenic lines (I10) also showed >65% resistance against rice blast. The resistance of these transgenic lines against rice blast may be attributed to the synthesis of isoflavone (genistein) in rice.
Keywords	Magnaporthe oryzae ; blast disease ; fungi ; genes ; genistein ; homozygosity ; human health ; liquid chromatography ; pathogens ; phytoalexins ; plant disease resistance ; quantitative polymerase chain reaction ; rice ; secondary metabolites ; soybeans ; tandem mass spectrometry
Language	English
Dates of publication	2021-1029
Size	p. 3141-3146.
Publishing place	The American Phytopathological Society
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-08-20-1777-RE
Database	NAL-Catalogue (AGRICOLA)

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Article: Transgenic Rice Expressing Isoflavone Synthase Gene from Soybean Shows Resistance Against Blast Fungus (

Pokhrel, Suresh / Ponniah, Sathish K / Jia, Yulin / Yu, Oliver / Manoharan, Muthusamy

Plant disease

2021 Volume 105, Issue 10, Page(s) 3141–3146

Abstract	The isoflavones are a group of plant secondary metabolites primarily synthesized in legumes and are known for their role in improving human health and plant disease resistance. The isoflavones, especially genistein, act as precursors for the production of phytoalexins, which may induce broad-spectrum disease resistance in plants. In this study, we screened transgenic rice lines expressing the isoflavone synthase (
MeSH term(s)	Ascomycota ; Fabaceae ; Magnaporthe/genetics ; Oryza/genetics ; Oxygenases ; Plants, Genetically Modified/genetics ; Glycine max/genetics
Chemical Substances	Oxygenases (EC 1.13.-) ; isoflavone synthase (EC 1.14.13.-)
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-08-20-1777-RE
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Article ; Online: Molecular basis for branched steviol glucoside biosynthesis.

Lee, Soon Goo / Salomon, Eitan / Yu, Oliver / Jez, Joseph M

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 26, Page(s) 13131–13136

Abstract: Steviol glucosides, such as stevioside and rebaudioside A, are natural products roughly 200-fold sweeter than sugar and are used as natural, noncaloric sweeteners. Biosynthesis of rebaudioside A, and other related stevia glucosides, involves formation of ...

Abstract	Steviol glucosides, such as stevioside and rebaudioside A, are natural products roughly 200-fold sweeter than sugar and are used as natural, noncaloric sweeteners. Biosynthesis of rebaudioside A, and other related stevia glucosides, involves formation of the steviol diterpenoid followed by a series of glycosylations catalyzed by uridine diphosphate (UDP)-dependent glucosyltransferases. UGT76G1 from
MeSH term(s)	Biosynthetic Pathways/genetics ; Coenzymes/metabolism ; Crystallography, X-Ray ; Diterpenes, Kaurane/chemistry ; Diterpenes, Kaurane/metabolism ; Enzyme Assays ; Glucosides/biosynthesis ; Glucosides/chemistry ; Glucosyltransferases/genetics ; Glucosyltransferases/isolation & purification ; Glucosyltransferases/metabolism ; Glucosyltransferases/ultrastructure ; Metabolic Engineering/methods ; Mutagenesis, Site-Directed ; Plant Proteins/metabolism ; Plant Proteins/ultrastructure ; Plants, Genetically Modified/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Stevia/enzymology ; Sweetening Agents/chemistry ; Sweetening Agents/metabolism ; Uridine Diphosphate/metabolism
Chemical Substances	Coenzymes ; Diterpenes, Kaurane ; Glucosides ; Plant Proteins ; Recombinant Proteins ; Sweetening Agents ; steviol (4741LYX6RT) ; Uridine Diphosphate (58-98-0) ; Glucosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2019-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1902104116
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Article ; Online: Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells.

Wang, Yechun / Yu, Oliver

Journal of biotechnology

2012 Volume 157, Issue 1, Page(s) 258–260

Abstract: Resveratrol is a polyphenolic compound produced by a few higher plants when under attack by pathogens such as bacteria or fungi. Besides antioxidant benefits to humans, this health-promoting compound has been reported to extend longevity in yeasts, flies, ...

Abstract	Resveratrol is a polyphenolic compound produced by a few higher plants when under attack by pathogens such as bacteria or fungi. Besides antioxidant benefits to humans, this health-promoting compound has been reported to extend longevity in yeasts, flies, worms, fishes and obesity mice. Here we utilized the synthetic scaffolds strategy to improve resveratrol production in Saccharomyces cerevisiae. We observed a 5.0-fold improvement over the non-scaffolded control, and a 2.7-fold increase over the previous reported with fusion protein. This work demonstrated the synthetic scaffolds can be used for the optimization of engineered metabolic pathway.
MeSH term(s)	Acyltransferases/chemistry ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Coenzyme A Ligases/chemistry ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Genetic Vectors/genetics ; PDZ Domains ; Protein Engineering/methods ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Stilbenes/metabolism ; src Homology Domains
Chemical Substances	Recombinant Fusion Proteins ; Stilbenes ; Acyltransferases (EC 2.3.-) ; stilbene synthase (EC 2.3.1.-) ; Coenzyme A Ligases (EC 6.2.1.-) ; 4-coumarate-CoA ligase (EC 6.2.1.12) ; resveratrol (Q369O8926L)
Language	English
Publishing date	2012-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2011.11.003
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Article: Comparison of technology forecasting methods for multi-national enterprises

Yu, Oliver

Challenges in the management of new technologies , p. 409-423

scenario approach

2007 , Page(s) 409–423

Author's details	Oliver Yu
Keywords	Multinationales Unternehmen ; Innovationsmanagement ; Technischer Fortschritt ; Prognose ; Szenariotechnik
Language	English
Publisher	World Scientific
Publishing place	Singapore [u.a.]
Document type	Article
ISBN	978-981-270-855-7 ; 981-270-855-3
Database	ECONomics Information System

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Article: Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells

Wang, Yechun / Yu, Oliver

Journal of biotechnology. 2012 Jan., v. 157, no. 1

2012

Abstract	Resveratrol is a polyphenolic compound produced by a few higher plants when under attack by pathogens such as bacteria or fungi. Besides antioxidant benefits to humans, this health-promoting compound has been reported to extend longevity in yeasts, flies, worms, fishes and obesity mice. Here we utilized the synthetic scaffolds strategy to improve resveratrol production in Saccharomyces cerevisiae. We observed a 5.0-fold improvement over the non-scaffolded control, and a 2.7-fold increase over the previous reported with fusion protein. This work demonstrated the synthetic scaffolds can be used for the optimization of engineered metabolic pathway.
MeSH term(s)	Acyltransferases/chemistry/genetics/metabolism ; Coenzyme A Ligases/chemistry/genetics/metabolism ; Genetic Vectors/genetics ; PDZ Domains ; Protein Engineering/methods ; Recombinant Fusion Proteins/biosynthesis/chemistry/genetics ; Saccharomyces cerevisiae/genetics/metabolism ; src Homology Domains ; Stilbenes/metabolism
Keywords	antioxidants ; bacteria ; biochemical pathways ; biosynthesis ; cells ; Diptera ; fish ; genetically engineered microorganisms ; humans ; longevity ; mice ; obesity ; pathogens ; plants (botany) ; recombinant fusion proteins ; resveratrol ; Saccharomyces cerevisiae ; yeasts
Language	English
Dates of publication	2012-01
Size	p. 258-260.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2011.11.003
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Engineering an ABC Transporter for Enhancing Resistance to Caffeine in Saccharomyces cerevisiae.

Wang, Min / Deng, Wei-Wei / Zhang, Zheng-Zhu / Yu, Oliver

Journal of agricultural and food chemistry

2016 Volume 64, Issue 42, Page(s) 7973–7978

Abstract: In addressing caffeine toxicity to the producing cells, engineering a transporter that can move caffeine from cytoplasm across the cell membrane to the extracellular space, thus enhancing caffeine resistance and potentially increasing the yield in yeast, ...

Abstract	In addressing caffeine toxicity to the producing cells, engineering a transporter that can move caffeine from cytoplasm across the cell membrane to the extracellular space, thus enhancing caffeine resistance and potentially increasing the yield in yeast, is important. An ABC-transporter bfr1 from Schizosaccharomyces pombe was cloned and transformed into S. cerevisiae, resulting in enhancing caffeine resistance. Afterward, a library of randomly mutagenized bfr1 mutants through error-prone PCR was generated. One mutant was identified with drastically increased caffeine resistance (15 mg/mL). Sequencing and structural analysis illustrated that many of the mutations occurred at the cytosolic domain. Site-directed mutagenesis of these mutations confirmed at least one amino acid that conferred enhancing caffeine resistance in the mutated bfr1. These data demonstrated engineering ABC-transporters can be an efficient way to reduce product toxicity in heterologous systems.
Language	English
Publishing date	2016-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.6b03980
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Article ; Online: A plant malonyl-CoA synthetase enhances lipid content and polyketide yield in yeast cells.

Wang, Yechun / Chen, Hui / Yu, Oliver

Applied microbiology and biotechnology

2014 Volume 98, Issue 12, Page(s) 5435–5447

Abstract: Malonyl-CoA is the essential building block of natural products such as fatty acids, polyketides, and flavonoids. Engineering the biosynthesis of fatty acids is important for biofuel production while that of polyketides provides precursors of medicines ... ...

Abstract	Malonyl-CoA is the essential building block of natural products such as fatty acids, polyketides, and flavonoids. Engineering the biosynthesis of fatty acids is important for biofuel production while that of polyketides provides precursors of medicines and nutritional supplements. However, microorganisms maintain a small amount of cellular malonyl-CoA, which could limit production of lipid and polyketides under certain conditions. Malonyl-CoA concentration is regulated by multiple pathways and signals, and changes in intracellular malonyl-CoA often lead to complex alterations in metabolism. In the present work, overexpression of a plant malonyl-CoA synthetase gene (AAE13) in Saccharomyces cerevisiae resulted in 1.6- and 2.4-fold increases in lipid and resveratrol accumulation simultaneously. We also demonstrated that AAE13 partially complemented the temperature-sensitive acc1 mutant, replacing this key enzyme in central metabolism. Mechanistic analysis by CoA quantification and transcriptomic measurement suggested that increases in malonyl-CoA concentration were coupled with drastic reductions in other major CoA compounds and clear suppression of tricarboxylic acid cycle-related genes. These results suggest that malonyl-CoA is a critical target for fatty acid and polyketide engineering and that overexpression of malonyl-CoA synthetic enzymes needs to be combined with upregulation of CoA synthesis to maintain metastasis of central metabolism.
MeSH term(s)	Arabidopsis/enzymology ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Lipids/biosynthesis ; Metabolic Engineering ; Polyketides/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Chemical Substances	Arabidopsis Proteins ; Bacterial Proteins ; Lipids ; Polyketides ; Coenzyme A Ligases (EC 6.2.1.-) ; malonyl-CoA synthetase (EC 6.2.1.-)
Language	English
Publishing date	2014-06
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-014-5612-z
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Article ; Online: miR393 and miR164 influence indeterminate but not determinate nodule development.

Mao, Guohang / Turner, Marie / Yu, Oliver / Subramanian, Senthil

Plant signaling & behavior

2014 Volume 8, Issue 10, Page(s) doi: 10.4161/psb.26753

Abstract: The roles of auxin in the regulation of symbiotic legume nodule formation are unclear. We recently showed that enhanced sensitivity to auxin resulting from overexpression of miR160 inhibits determinate nodule formation in soybean. We examined the roles ... ...

Abstract	The roles of auxin in the regulation of symbiotic legume nodule formation are unclear. We recently showed that enhanced sensitivity to auxin resulting from overexpression of miR160 inhibits determinate nodule formation in soybean. We examined the roles of miR393 and miR164 in soybean (that forms determinate nodules) and Medicago truncatula (that forms indeterminate nodules). Our results together with previous studies suggest that indeterminate nodule formation requires a higher, but narrow window of auxin sensitivity and that miR164 regulation is not crucial for determinate nodule formation.
MeSH term(s)	Medicago truncatula/growth & development ; Medicago truncatula/metabolism ; MicroRNAs/metabolism ; Root Nodules, Plant/growth & development ; Root Nodules, Plant/metabolism ; Glycine max/growth & development ; Glycine max/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2014-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1559-2324
ISSN (online)	1559-2324
DOI	10.4161/psb.26753
Database	MEDical Literature Analysis and Retrieval System OnLINE

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