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  1. Article ; Online: A new clip-type nailing device for rapid wound closure and hemostasis.

    Fang, Yongchao / Qiu, Jinwei / Yu, Shiya / Wang, Yu

    Asian journal of surgery

    2023  Volume 47, Issue 4, Page(s) 1803–1804

    MeSH term(s) Humans ; Fracture Fixation, Intramedullary ; Surgical Instruments ; Hemostatic Techniques ; Hemostasis ; Treatment Outcome ; Equipment Design
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The prevalence of social frailty among older adults: A systematic review and meta-analysis.

    Yu, Shiya / Wang, Jialin / Zeng, Li / Yang, Pengyu / Tang, Ping / Su, Sihui

    Geriatric nursing (New York, N.Y.)

    2022  Volume 49, Page(s) 101–108

    Abstract: Social frailty is a geriatric public health problem that deeply affects healthy aging. Currently, evidence on the prevalence and factors associated with social frailty in older adults remains unclear. Our study aims to estimate the prevalence and related ...

    Abstract Social frailty is a geriatric public health problem that deeply affects healthy aging. Currently, evidence on the prevalence and factors associated with social frailty in older adults remains unclear. Our study aims to estimate the prevalence and related factors of social frailty in older adults. This study retrieved nine electronic databases searched through July 5th, 2022. The prevalence of social frailty was pooled using Stata software. It was found that older adults suffered from a "moderate" level of social frailty. We found a higher prevalence of social frailty in the United Kingdom, Greece, Croatia, The Netherlands, and Spain, in people over 75 years, in hospitals, and during the Coronavirus Disease 2019 (COVID-19). We believed that countries, age, research sites, and the pandemic of COVID-19 were influencing factors of social frailty among older adults. These findings may provide a theoretical basis for the development of ameliorating social frailty among older adults.
    MeSH term(s) Humans ; Aged ; Frailty/epidemiology ; Prevalence ; COVID-19/epidemiology ; Hospitals ; Netherlands/epidemiology ; Frail Elderly
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632559-2
    ISSN 1528-3984 ; 0197-4572
    ISSN (online) 1528-3984
    ISSN 0197-4572
    DOI 10.1016/j.gerinurse.2022.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2789: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq.

    Li, Hui / Liu, Hongyi / Liu, Yifei / Wang, Xuefei / Yu, Shiya / Huang, Hongwen / Shen, Xiangru / Zhang, Qi / Hong, Ni / Jin, Wenfei

    iScience

    2023  Volume 26, Issue 9, Page(s) 107588

    Abstract: T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the ... ...

    Abstract T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the factors affecting T cell activation. We found a stimulated T subset (HSP
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer

    Zheng, Shiyao / Chen, Yongyuan / Yu, Shiya / Weng, Caiming / Lin, Nan / Luo, Ziqiang / Wang, Yuanzhao / Xiong, Ping / Teng, Zhun / Wang, Yu / Zhao, Hu / Xiao, Chunhong

    Heliyon. 2023 Apr., v. 9, no. 4 p.e15058-

    2023  

    Abstract: Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas ( ... ...

    Abstract Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenocarcinoma (STAD) patients, which revealed that DISC1 overexpression was closely associated with tumor histological type (mucinous vs. tubular, OR = 2.860, CI = 1.423-5.872, p = 0.004), as well as tumor stage and grade. Furthermore, the higher the DISC1 expression, the lower the overall 10-year survival rate. Patients with low DISC1 expression had a significantly longer progression-free interval (PFI) and disease-specific survival (DSS) than patients with high DISC1 expression. However, patients with higher DISC1 expression in the T3&T4, N0&N1 and M0 subgroups had poorer prognosis in terms of OS, DSS and PFI, as could be seen in the subgroup survival analysis. Public datasets were used to predict lncRNA-miRNA-DISC1 regulation. DISC1 was significantly up-regulated in GC(gastric cancer), and its expression levels showed a moderate to strong positive correlation with infiltration levels of effector memory T cells (Tem) and central memory T cells (Tcm), and a negative correlation was observed with Th17 cells and NK CD56bright cells. In addition, concomitant with the high expression of the DISC1 gene was a decrease in MHC-I (Major Histocompatibility Complex-I)expression and an increase in MHC-II expression, and altered chemokine expression. The upregulation of CXCL12 and CXCR4 expression could be caused by an increase in DISC1 expression. The above expression variability and correlation suggest a role for DISC1 in regulating tumor immunity in GC. These findings suggest that high expression of DISC1 could be an independent prognostic factor for GC.
    Keywords adenocarcinoma ; biomarkers ; chemokines ; data collection ; genes ; histology ; immunity ; memory ; prognosis ; schizophrenia ; stomach ; stomach neoplasms ; survival rate ; DISC1 ; Gastric cancer ; Tumor infiltrating lymphocytes ; Bioinformatics ; TSA ; miRNAs ; GC ; STAD ; TCGA ; FPKM ; TPM ; ROC ; FDR ; KEGG ; GO ; CCs ; BPs ; MFs ; GSEA ; NES ; PPI ; PD ; SD ; PR ; CR ; DEG
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15058
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer.

    Zheng, Shiyao / Chen, Yongyuan / Yu, Shiya / Weng, Caiming / Lin, Nan / Luo, Ziqiang / Wang, Yuanzhao / Xiong, Ping / Teng, Zhun / Wang, Yu / Zhao, Hu / Xiao, Chunhong

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e15058

    Abstract: Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas ( ... ...

    Abstract Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenocarcinoma (STAD) patients, which revealed that DISC1 overexpression was closely associated with tumor histological type (mucinous vs. tubular, OR = 2.860, CI = 1.423-5.872, p = 0.004), as well as tumor stage and grade. Furthermore, the higher the DISC1 expression, the lower the overall 10-year survival rate. Patients with low DISC1 expression had a significantly longer progression-free interval (PFI) and disease-specific survival (DSS) than patients with high DISC1 expression. However, patients with higher DISC1 expression in the T3&T4, N0&N1 and M0 subgroups had poorer prognosis in terms of OS, DSS and PFI, as could be seen in the subgroup survival analysis. Public datasets were used to predict lncRNA-miRNA-DISC1 regulation. DISC1 was significantly up-regulated in GC(gastric cancer), and its expression levels showed a moderate to strong positive correlation with infiltration levels of effector memory T cells (Tem) and central memory T cells (Tcm), and a negative correlation was observed with Th17 cells and NK CD56bright cells. In addition, concomitant with the high expression of the DISC1 gene was a decrease in MHC-I (Major Histocompatibility Complex-I)expression and an increase in MHC-II expression, and altered chemokine expression. The upregulation of CXCL12 and CXCR4 expression could be caused by an increase in DISC1 expression. The above expression variability and correlation suggest a role for DISC1 in regulating tumor immunity in GC. These findings suggest that high expression of DISC1 could be an independent prognostic factor for GC.
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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