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Book ; Online: On Duplication-Free Codes for Disjoint or Equal-Length Errors

Yu, Wenjun / Schwartz, Moshe

2024

Abstract: Motivated by applications in DNA storage, we study a setting in which strings are affected by tandem-duplication errors. In particular, we look at two settings: disjoint tandem-duplication errors, and equal-length tandem-duplication errors. We construct ... ...

Abstract	Motivated by applications in DNA storage, we study a setting in which strings are affected by tandem-duplication errors. In particular, we look at two settings: disjoint tandem-duplication errors, and equal-length tandem-duplication errors. We construct codes, with positive asymptotic rate, for the two settings, as well as for their combination. Our constructions are duplication-free codes, comprising codewords that do not contain tandem duplications of specific lengths. Additionally, our codes generalize previous constructions, containing them as special cases.
Keywords	Computer Science - Information Theory ; Mathematics - Combinatorics
Publishing date	2024-01-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [The neural basis underlying primary dysmenorrhea: evidence from neuroimaging and animal model studies].

Yu, Wen-Jun / Yuan, Jin-Hua / Liu, Pei-Wen

Sheng li xue bao : [Acta physiologica Sinica

2023 Volume 75, Issue 3, Page(s) 465–474

Abstract: Primary dysmenorrhea (PDM), cyclic menstrual pain in the absence of pelvic anomalies, is characterized by acute and chronic gynecological pain disorders in childbearing age women. PDM strongly affects the quality of life of patients and leads to economic ...

Abstract	Primary dysmenorrhea (PDM), cyclic menstrual pain in the absence of pelvic anomalies, is characterized by acute and chronic gynecological pain disorders in childbearing age women. PDM strongly affects the quality of life of patients and leads to economic losses. PDM generally do not receive radical treatment and often develop into other chronic pain disorders later in life. The clinical treatment status of PDM, the epidemiology of PDM and chronic pain comorbidities, and the abnormal physiological and psychological characteristics of patients with PDM suggest that PDM not only is related to the inflammation around the uterus, but also may be related to the abnormal pain processing and regulation function of patients' central system. Therefore, exploring the brain neural mechanism of PDM is indispensable and important to understand the pathological mechanism of PDM, and is also a hotspot of brain science research in recent years, which will bring new inspiration to explore the target of PDM intervention. Based on the progress of the neural mechanism of PDM, this paper systematically summarizes the evidence from neuroimaging and animal model studies.
MeSH term(s)	Animals ; Humans ; Female ; Dysmenorrhea ; Brain Mapping ; Chronic Pain ; Quality of Life ; Neuroimaging ; Models, Animal
Language	Chinese
Publishing date	2023-02-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Drug development advances in human genetics-based targets.

Zhang, Xiaoxia / Yu, Wenjun / Li, Yan / Wang, Aiping / Cao, Haiqiang / Fu, Yuanlei

MedComm

2024 Volume 5, Issue 2, Page(s) e481

Abstract: Drug development is a long and costly process, with a high degree of uncertainty from the identification of a drug target to its market launch. Targeted drugs supported by human genetic evidence are expected to enter phase II/III clinical trials or be ... ...

Abstract	Drug development is a long and costly process, with a high degree of uncertainty from the identification of a drug target to its market launch. Targeted drugs supported by human genetic evidence are expected to enter phase II/III clinical trials or be approved for marketing more quickly, speeding up the drug development process. Currently, genetic data and technologies such as genome-wide association studies (GWAS), whole-exome sequencing (WES), and whole-genome sequencing (WGS) have identified and validated many potential molecular targets associated with diseases. This review describes the structure, molecular biology, and drug development of human genetics-based validated beneficial loss-of-function (LOF) mutation targets (target mutations that reduce disease incidence) over the past decade. The feasibility of eight beneficial LOF mutation targets (PCSK9, ANGPTL3, ASGR1, HSD17B13, KHK, CIDEB, GPR75, and INHBE) as targets for drug discovery is mainly emphasized, and their research prospects and challenges are discussed. In conclusion, we expect that this review will inspire more researchers to use human genetics and genomics to support the discovery of novel therapeutic drugs and the direction of clinical development, which will contribute to the development of new drug discovery and drug repurposing.
Language	English
Publishing date	2024-02-09
Publishing country	China
Document type	Journal Article ; Review
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.481
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage.

Guo, Fan / Li, Yan / Yu, Wenjun / Fu, Yuanlei / Zhang, Jing / Cao, Haiqiang

Molecular pharmaceutics

2024

Abstract: Small interfering RNAs (siRNAs) are promising therapeutic strategies, and five siRNA drugs have been approved by the Food and Drug Administration (FDA) and the European Commission (EC). This marks a significant milestone in the development of siRNA for ... ...

Abstract	Small interfering RNAs (siRNAs) are promising therapeutic strategies, and five siRNA drugs have been approved by the Food and Drug Administration (FDA) and the European Commission (EC). This marks a significant milestone in the development of siRNA for clinical applications. The approved siRNA agents can effectively deliver siRNAs to the liver and treat liver-related diseases. Currently, researchers have developed diverse delivery platforms for transporting siRNAs to different tissues such as the brain, lung, muscle, and others, and a large number of siRNA drugs are undergoing clinical trials. Here, these delivery technologies and the latest advancements in clinical applications are summarized, and this Review provides a concise overview of the strategies employed for siRNA delivery to both hepatic and extrahepatic tissues.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c01158
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Article: The Impact of Firm's Unethical Behavior in Investment Decisions Among Young Investors in China.

Tang, Xuelian / Yu, Keyi / Yu, Wenjun

Psychology research and behavior management

2022 Volume 15, Page(s) 3427–3443

Abstract: Purpose: There is ample evidence that investors respond negatively to firm's unethical behavior. However, researchers cannot explain investors' reactions and the mechanisms of change when faced with firm's unethical behavior. By collecting and analyzing ...

Abstract	Purpose: There is ample evidence that investors respond negatively to firm's unethical behavior. However, researchers cannot explain investors' reactions and the mechanisms of change when faced with firm's unethical behavior. By collecting and analyzing data from questionnaires, this study investigated the effects of firm's unethical behavior on investors' willingness to invest and further focused on different targets involved in unethical events. Moreover, this study explored the roles of firm development stages and the moderation effect of investors' moral support level. It aims to reveal investors' decisions on firm's unethical behaviors in different situations. Methods: This study employed a 2 (behavioral ethics: unethical behavior versus normal behavior) X 2 (stages of firm development: startups versus mature firms) X 4 (targets involved in the events: employees, peers, customers, and society) mixed design. Two hundred and fifty-seven participants were finally recruited for final analysis, and then repeated-measures ANOVAs were adopted to assess the valid data collected from 257 participants. Results: The results showed that disclosure of unethical behavior in due diligence reports significantly decreased investors' willingness to invest. However, investor willingness was higher for startups with unethical behavior than for unethical mature firms. Investors' willingness to invest decreased most significantly when evaluating firms with unethical behavior toward employees, followed by society and peers. Their willingness to invest decreased the least when evaluating firms exhibiting unethical behavior toward customers. The level of investors' moral support moderated the above effects, that is, the higher the moral support, the more considerable the decrease in investment willingness in unethical firms. Conclusion: Current results demonstrated that when facing firms with unethical behaviors, investors would make investment decisions after considering the firm's stage of development and the stakeholder of the unethical event. This study provides a valuable theoretical basis for decision-making by government, institutional investors, and firm managers.
Language	English
Publishing date	2022-11-28
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S384377
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Article: Effects of the Interactive Use of Performance Measurement Systems on Job Performance: Mediation Effect of Organizational Learning.

Zhang, Lu / Yu, Wenjun

Frontiers in psychology

2020 Volume 10, Page(s) 3059

Abstract: Interactive controls that focus on communication and continuous learning are very important to achieve a competitive advantage. To better understand the underlying mechanism of how performance measurement systems (PMSs) improve job performance, a ... ...

Abstract	Interactive controls that focus on communication and continuous learning are very important to achieve a competitive advantage. To better understand the underlying mechanism of how performance measurement systems (PMSs) improve job performance, a mediation model was constructed in the current study to examine organizational learning as a possible mediating variable. Data were collected using a questionnaire in China with a sample size of 191 managers. Structural equation model and Smart-PLS methods were used to test the hypotheses. Results yielded significant direct effects between the interactive use of PMS on organizational learning and job performance. Additionally, organizational learning was found to play a mediating role in the relationship between interactive use of PMS and job performance. These findings highlight the importance of interactive PMS use, as well as the underlying mechanisms among PMS, organizational learning, and job performance, and further help the management clarify how organizational learning affects performance, providing a framework for building a sustainable competitive advantage.
Language	English
Publishing date	2020-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2019.03059
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Article ; Online: The Preparation and Potential Bioactivities of Modified Pectins: A Review

Jiao, Xu / Li, Fei / Zhao, Jing / Wei, Yunlu / Zhang, Luyao / Yu, Wenjun / Li, Quanhong

Foods. 2023 Feb. 27, v. 12, no. 5

2023

Abstract: Pectins are complex polysaccharides that are widely found in plant cells and have a variety of bioactivities. However, the high molecular weights (Mw) and complex structures of natural pectins mean that they are difficult for organisms to absorb and ... ...

Abstract	Pectins are complex polysaccharides that are widely found in plant cells and have a variety of bioactivities. However, the high molecular weights (Mw) and complex structures of natural pectins mean that they are difficult for organisms to absorb and utilize, limiting their beneficial effects. The modification of pectins is considered to be an effective method for improving the structural characteristics and promoting the bioactivities of pectins, and even adding new bioactivities to natural pectins. This article reviews the modification methods, including chemical, physical, and enzymatic methods, for natural pectins from the perspective of their basic information, influencing factors, and product identification. Furthermore, the changes caused by modifications to the bioactivities of pectins are elucidated, including their anti-coagulant, anti-oxidant, anti-tumor, immunomodulatory, anti-inflammatory, hypoglycemic, and anti-bacterial activities and the ability to regulate the intestinal environment. Finally, suggestions and perspectives regarding the development of pectin modification are provided.
Keywords	anticoagulants ; antioxidants ; intestines ; pectins
Language	English
Dates of publication	2023-0227
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12051016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quantifying seasonal ground deformation in Taiyuan basin, China, by Sentinel-1 InSAR time series analysis

Tang, Wei / Zhao, Xiangjun / Bi, Gang / Chen, Mingjie / Cheng, Siyu / Liao, Mingsheng / Yu, Wenjun

Journal of Hydrology. 2023 July, v. 622 p.129654-

2023

Abstract: The presence of seasonal surface deformation in areas that are subsiding/uplifting due to groundwater pumping/recovery can indicate aquifer recharge. Understanding seasonal surface deformation and the existing relationship between triggering factors and ... ...

Abstract	The presence of seasonal surface deformation in areas that are subsiding/uplifting due to groundwater pumping/recovery can indicate aquifer recharge. Understanding seasonal surface deformation and the existing relationship between triggering factors and the deformation supports effective groundwater management and subsidence mitigation. Here, we investigated seasonal ground displacement in response to the aquifer compaction and expansion due to groundwater extraction and recharge within the Taiyuan basin, Northern China. We obtained Sentinel-1 InSAR displacement time series data from 2017 to 2020 and quantitatively analyzed relationships between triggering factors (e.g., groundwater level and precipitation) and the associated displacements using wavelet-based methods. The results show that the seasonal deformation is concentrated in the irrigated areas within the central basin, with a 1-year periodicity. The annual peak-to-peak amplitude was up to 2 cm, peaking in March with troughs in August. This seasonality present in the displacement time series is found to be ‘in-phase’ with respect to groundwater levels and ‘anti-phase’ in relation to natural precipitation. These results are consistent with the irrigation pumping practices in the basin, with increased groundwater withdrawals to meet irrigation water demand prior to the monsoon precipitation season, resulting in water level decline and land subsidence from mid-March to mid-August. During the non-irrigated season, groundwater extraction decreases, and the aquifer systems are replenished by precipitation, causing water levels to recover and the ground to uplift from late August to mid-March. A geological analysis indicates that the seasonal deformation is controlled by the thickness of Quaternary strata and fault systems, which play a critical role in forming the earth fissures in the basin. The elastic and inelastic deformation was separated; the estimated elastic/inelastic ratio was about 0.6–0.7, indicating that the inelastic component dominates the main aquifer compaction in the central basin. Our analysis is of hydrologic importance which could be used to guide groundwater management and subsidence mitigation, given the inter-basin water diversion projects in this arid basin.
Keywords	aquifers ; basins ; deformation ; groundwater ; groundwater extraction ; irrigation ; irrigation water ; monsoon season ; periodicity ; quantitative analysis ; subsidence ; time series analysis ; water management ; water table ; China ; InSAR ; Land subsidence ; Seasonal deformation ; Wavelet analysis ; Elastic/inelastic deformation
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2023.129654
Database	NAL-Catalogue (AGRICOLA)

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Article: Genome architecture plasticity underlies DNA replication timing dynamics in cell differentiation.

Yu, Wenjun / Zhong, Quan / Wen, Zi / Zhang, Weihan / Huang, Yanrong

Frontiers in genetics

2022 Volume 13, Page(s) 961612

Abstract: During the S-phase of eukaryotic cell cycle, DNA is replicated in a dedicatedly regulated temporal order, with regions containing active and inactive genes replicated early and late, respectively. Recent advances in sequencing technology allow us to ... ...

Abstract	During the S-phase of eukaryotic cell cycle, DNA is replicated in a dedicatedly regulated temporal order, with regions containing active and inactive genes replicated early and late, respectively. Recent advances in sequencing technology allow us to explore the connection between replication timing (RT), histone modifications, and three-dimensional (3D) chromatin structure in diverse cell types. To characterize the dynamics during cell differentiation, corresponding sequencing data for human embryonic stem cells and four differentiated cell types were collected. By comparing RT and its extent of conservation before and after germ layer specification, the human genome was partitioned into distinct categories. Each category is then subject to comparisons on genomic, epigenetic, and chromatin 3D structural features. As expected, while constitutive early and late replication regions showed active and inactive features, respectively, dynamic regions with switched RT showed intermediate features. Surprisingly, although early-to-late replication and late-to-early replication regions showed similar histone modification patterns in hESCs, their structural preferences were opposite. Specifically, in hESCs, early-to-late replication regions tended to appear in the B compartment and large topologically associated domains, while late-to-early replication regions showed the opposite. Our results uncover the coordinated regulation of RT and 3D genome structure that underlies the loss of pluripotency and lineage commitment and indicate the importance and potential roles of genome architecture in biological processes.
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.961612
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Article ; Online: Side channel analysis based on feature fusion network.

Ni, Feng / Wang, Junnian / Tang, Jialin / Yu, Wenjun / Xu, Ruihan

PloS one

2022 Volume 17, Issue 10, Page(s) e0274616

Abstract: Various physical information can be leaked while the encryption algorithm is running in the device. Side-channel analysis exploits these leakages to recover keys. Due to the sensitivity of deep learning to the data features, the efficiency and accuracy ... ...

Abstract	Various physical information can be leaked while the encryption algorithm is running in the device. Side-channel analysis exploits these leakages to recover keys. Due to the sensitivity of deep learning to the data features, the efficiency and accuracy of side channel analysis are effectively improved with the application of deep learning algorithms. However, a considerable part of existing reserches are based on traditional neural networks. The effectiveness of key recovery is improved by increasing the size of the network. However, the computational complexity of the algorithm increases accordingly. Problems such as overfitting, low training efficiency, and low feature extraction ability also occur. In this paper, we construct an improved lightweight convolutional neural network based on the feature fusion network. The new network and the traditional neural networks are respectively applied to the side-channel analysis for comparative experiments. The results show that the new network has faster convergence, better robustness and higher accuracy. No overfitting has occurred. A heatmap visualization method was introduced for analysis. The new network has higher heat value and more concentration in the key interval. Side-channel analysis based on feature fusion network has better performance, compared with the ones based on traditional neural networks.
MeSH term(s)	Algorithms ; Neural Networks, Computer
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274616
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