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Article ; Online: Human infection with avian-origin H5N6 influenza a virus after exposure to slaughtered poultry.

Li, Jun / Fang, Yezhen / Qiu, Xiaofeng / Yu, Xinfen / Cheng, Shi / Li, Na / Sun, Zhou / Ni, Zhimin / Wang, Haoqiu

2022 Volume 11, Issue 1, Page(s) 807–810

Abstract: Exposure to poultry in live poultry markets is strongly associated with human infection with avian influenza virus. To effectively prevent the transmission of viruses from live poultry to humans, people have been forced to change their living habits from ...

Abstract	Exposure to poultry in live poultry markets is strongly associated with human infection with avian influenza virus. To effectively prevent the transmission of viruses from live poultry to humans, people have been forced to change their living habits from purchasing live poultry for consumption to purchasing freshly slaughtered poultry after the permanent closure of live poultry markets in China. In this study, we reported a case of human infection by the H5N6 virus in Hangzhou after exposure to a freshly slaughtered chicken, defying the traditional hypothesis that human infection requires a history of exposure to live poultry and indicating a novel route of infection. Rapid genomic characterization of H5N6 influenza A variants from the patient and the associated environment suggested that these viral variants were of avian origin, belonged to clade 2.3.4.4b H5 and were adapting to the human host after infection. Comparative analysis of the local H5N6 genomes showed that viral contamination in the associated environment and the poultry market was complex. Considering this case of H5N6 infection, conducting surveillance for any possible new avian influenza virus reassortment spillover to humans or other animal species is critical, and awareness of the risk of exposure to possible viral variants from infected slaughtered poultry or the associated environment must be seriously improved.
MeSH term(s)	Animals ; Chickens ; China/epidemiology ; Humans ; Influenza A virus/genetics ; Influenza in Birds ; Influenza, Human ; Phylogeny ; Poultry ; Poultry Diseases
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2022.2048971
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Protective Effects of

Shi, Yueyue / Tian, Chongmei / Yu, Xinfen / Fang, Yuejuan / Zhao, Xinyu / Zhang, Xiaoxi / Xia, Daozong

Frontiers in pharmacology

2020 Volume 11, Page(s) 556248

Abstract: Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. ...

Abstract	Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage.
Language	English
Publishing date	2020-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.556248
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Article: Composition and Dynamics of H1N1 and H7N9 Influenza A Virus Quasispecies in a Co-infected Patient Analyzed by Single Molecule Sequencing Technology.

Lin, Peng / Jin, Tao / Yu, Xinfen / Liang, Lifeng / Liu, Guang / Jovic, Dragomirka / Sun, Zhou / Yu, Zhe / Pan, Jingcao / Fan, Guangyi

Frontiers in genetics

2021 Volume 12, Page(s) 754445

Abstract: A human co-infected with H1N1 and H7N9 subtypes influenza A virus (IAV) causes a complex infectious disease. The identification of molecular-level variations in composition and dynamics of IAV quasispecies will help to understand the pathogenesis and ... ...

Abstract	A human co-infected with H1N1 and H7N9 subtypes influenza A virus (IAV) causes a complex infectious disease. The identification of molecular-level variations in composition and dynamics of IAV quasispecies will help to understand the pathogenesis and provide guidance for precision medicine treatment. In this study, using single-molecule real-time sequencing (SMRT) technology, we successfully acquired full-length IAV genomic sequences and quantified their genotypes abundance in serial samples from an 81-year-old male co-infected with H1N1 and H7N9 subtypes IAV. A total of 26 high diversity nucleotide loci was detected, in which the A-G base transversion was the most abundant substitution type (67 and 64%, in H1N1 and H7N9, respectively). Seven significant amino acid variations were detected, such as NA:H275Y and HA: R222K in H1N1 as well as PB2:E627K and NA: K432E in H7N9, which are related to viral drug-resistance or mammalian adaptation. Furtherly, we retrieved 25 H1N1 and 22 H7N9 genomic segment haplotypes from the eight samples based on combining high-diversity nucleotide loci, which provided a more concise overview of viral quasispecies composition and dynamics. Our approach promotes the popularization of viral quasispecies analysis in a complex infectious disease, which will boost the understanding of viral infections, pathogenesis, evolution, and precision medicine.
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.754445
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Article ; Online: The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.

Wang, Siwei / Fang, Yuejuan / Yu, Xinfen / Guo, Lu / Zhang, Xiaoxi / Xia, Daozong

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2018 Volume 111, Page(s) 162–168

Abstract: Uric acid metabolic disorder is considered to be the main pathogenesis of uric acid nephropathy (UN). Smilax glabra Roxb. is a traditional Chinese herb which has been used in the treatment of gout, but the mechanism was unclear. In this study, we ... ...

Abstract	Uric acid metabolic disorder is considered to be the main pathogenesis of uric acid nephropathy (UN). Smilax glabra Roxb. is a traditional Chinese herb which has been used in the treatment of gout, but the mechanism was unclear. In this study, we investigated the protective effects of the flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. (SGF) on uric acid nephropathy rats and its underlying mechanisms of promoting uric acid excretion. Sprague Dawley (SD) rats were induced by high purine diet (yeast pellets + adenine) for 5 weeks. Rats were orally treated with SGF or allopurinol daily. The biochemical parameters and enzymes in different treated rats were determined by commercial kits. Kidney pathology was visualized using optical microscopy and electron microscopy. Renal inflammatory factors were detected by ELISA. Renal fibrosis factors and uric acid transporters were analyzed by real time RT-PCR and western blot. The results showed that SGF significantly improved kidney function. Histopathologic examination revealed that urate-induced renal damage was markedly reversed by SGF. Meanwhile, SGF treatment was also found to significantly inhibit renal oxidative stress. SGF treatment obviously suppressed the inflammatory factors of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2) and the profibrotic factors of basic fibroblast growth factor (bFGF), transforming growth factor-β
MeSH term(s)	Animals ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Kidney Diseases/chemically induced ; Kidney Diseases/drug therapy ; Kidney Diseases/metabolism ; Male ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Rhizome ; Smilax ; Uric Acid/metabolism ; Uric Acid/toxicity
Chemical Substances	Flavonoids ; Inflammation Mediators ; Plant Extracts ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2018-12-20
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2018.12.050
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Article ; Online: Multiple Lineages of Dengue Virus Serotype 2 Cosmopolitan Genotype Caused a Local Dengue Outbreak in Hangzhou, Zhejiang Province, China, in 2017.

Yu, Hua / Kong, Qingxin / Wang, Jing / Qiu, Xiaofeng / Wen, Yuanyuan / Yu, Xinfen / Liu, Muwen / Wang, Haoqiu / Pan, Jingcao / Sun, Zhou

Scientific reports

2019 Volume 9, Issue 1, Page(s) 7345

Abstract: During July to November 2017, a large dengue outbreak involving 1,138 indigenous cases occurred in Hangzhou, Zhejiang Province, China. All patients were clinically diagnosed as mild dengue. Epidemiology investigation and phylogenetic analysis of ... ...

Abstract	During July to November 2017, a large dengue outbreak involving 1,138 indigenous cases occurred in Hangzhou, Zhejiang Province, China. All patients were clinically diagnosed as mild dengue. Epidemiology investigation and phylogenetic analysis of circulating viruses revealed that at least three lineages of dengue virus serotype 2 (DENV-2) Cosmopolitan genotype initiated the outbreak during a short time. The analysis of the time to most recent common ancestor estimated that the putative ancestor of these DENV-2 lineages might rise no later than March, 2017, suggesting independent introductions of these lineages into Hangzhou. We presumed that group travelers visiting dengue-endemic areas gave rise to multiple introductions of these lineages during so short a time. Co-circulating of multiple DENV-2 lineages, emerging of disease in urban areas, hot and humid weather in Hangzhou adequate for mosquito breeding, and limited dengue diagnosis abilities of local hospitals, were the reasons causing the large local outbreak in Hangzhou.
MeSH term(s)	China/epidemiology ; Dengue/epidemiology ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Disease Outbreaks ; Female ; Humans ; Male ; Middle Aged ; Phylogeny ; Serogroup
Language	English
Publishing date	2019-05-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-43560-5
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Article ; Online: Reverse transcription recombinase-aided amplification assay for rapid detection of the influenza A(H1N1)pdm09 H275Y mutation that confers oseltamivir resistance.

Li, Jun / Yang, Zi / Mao, Ling-Feng / Chen, Ren-Hua / Yu, Xin-Fen / Yang, Xu-Hui / Zhang, Guo-Zhong / Wang, Hao-Qiu / Chen, Shu-Chang / Zhao, Gang

Molecular and cellular probes

2021 Volume 60, Page(s) 101771

Abstract: The emergence of the influenza A(H1N1)pdm09 virus with the NA-H275Y mutation, which confers oseltamivir resistance, must be monitored, especially in patients undergoing neuraminidase inhibitor treatment. In this study, we developed a reverse ... ...

Abstract	The emergence of the influenza A(H1N1)pdm09 virus with the NA-H275Y mutation, which confers oseltamivir resistance, must be monitored, especially in patients undergoing neuraminidase inhibitor treatment. In this study, we developed a reverse transcription recombinase-aided amplification assay that has high sensitivity (detection limit: 1.0 × 10
MeSH term(s)	Drug Resistance, Viral/genetics ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza, Human/diagnosis ; Influenza, Human/drug therapy ; Mutation ; Mutation, Missense ; Neuraminidase/genetics ; Oseltamivir/pharmacology ; Recombinases ; Reverse Transcription
Chemical Substances	Recombinases ; Oseltamivir (20O93L6F9H) ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2021-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639082-1
ISSN	1096-1194 ; 0890-8508
ISSN (online)	1096-1194
ISSN	0890-8508
DOI	10.1016/j.mcp.2021.101771
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Zs.A 2230: Show issues

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Article: Reverse transcription recombinase-aided amplification assay for rapid detection of the influenza A(H1N1)pdm09 H275Y mutation that confers oseltamivir resistance

Li, Jun / Yang, Zi / Mao, Ling-feng / Chen, Ren-hua / Yu, Xin-fen / Yang, Xu-hui / Zhang, Guo-zhong / Wang, Hao-qiu / Chen, Shu-chang / Zhao, Gang

Molecular and cellular probes. 2021 Dec., v. 60

2021

Abstract	The emergence of the influenza A(H1N1)pdm09 virus with the NA-H275Y mutation, which confers oseltamivir resistance, must be monitored, especially in patients undergoing neuraminidase inhibitor treatment. In this study, we developed a reverse transcription recombinase-aided amplification assay that has high sensitivity (detection limit: 1.0 × 10¹ copies/μL) and specificity for detecting the oseltamivir-resistant H275Y mutation; the assay is performed within 30 min at a constant temperature of 39° Celsius using an isothermal device. This method is suitable for the clinical application of targeted testing, thereby providing technical support for precision medicine in individual drug applications for patients with severe infection or immunosuppression.
Keywords	detection limit ; drugs ; immunosuppression ; influenza ; mutation ; oseltamivir ; precision medicine ; rapid methods ; reverse transcription ; sialidase ; temperature ; viruses
Language	English
Dates of publication	2021-12
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	639082-1
ISSN	1096-1194 ; 0890-8508
ISSN (online)	1096-1194
ISSN	0890-8508
DOI	10.1016/j.mcp.2021.101771
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2230: Show issues

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Article ; Online: Rapid genomic characterization of SARS-CoV-2 viruses from clinical specimens using nanopore sequencing.

Li, Jun / Wang, Haoqiu / Mao, Lingfeng / Yu, Hua / Yu, Xinfen / Sun, Zhou / Qian, Xin / Cheng, Shi / Chen, Shuchang / Chen, Junfang / Pan, Jingcao / Shi, Jueliang / Wang, Xuchu

Scientific reports

2020 Volume 10, Issue 1, Page(s) 17492

Abstract: The novel SARS-CoV-2 outbreak has swiftly spread worldwide. The rapid genome sequencing of SARS-CoV-2 strains has become a helpful tool for better understanding the genomic characteristics and origin of the virus. To obtain virus whole-genome sequences ... ...

Abstract	The novel SARS-CoV-2 outbreak has swiftly spread worldwide. The rapid genome sequencing of SARS-CoV-2 strains has become a helpful tool for better understanding the genomic characteristics and origin of the virus. To obtain virus whole-genome sequences directly from clinical specimens, we performed nanopore sequencing using a modified ARTIC protocol in a portable nanopore sequencer and validated a routine 8-h workflow and a 5-h rapid pipeline. We conducted some optimization to improve the genome sequencing workflow. The sensitivity of the workflow was also tested by serially diluting RNA from clinical samples. The optimized pipeline was finally applied to obtain the whole genomes of 29 clinical specimens collected in Hangzhou from January to March 2020. In the 29 obtained complete genomes of SARS-CoV-2, 33 variations were identified and analyzed. The genomic variations and phylogenetic analysis hinted at multiple sources and different transmission patterns during the COVID-19 epidemic in Hangzhou, China. In conclusion, the genomic characteristics and origin of the virus can be quickly determined by nanopore sequencing following our workflows.
MeSH term(s)	Adolescent ; Adult ; Betacoronavirus/classification ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Female ; Genetic Variation ; Genome, Viral ; Humans ; Male ; Middle Aged ; Mutation, Missense ; Nanopore Sequencing/methods ; Pandemics ; Phylogeny ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sequence Analysis, DNA ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-74656-y
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Article: [Genetic Diversity and Evolution of the M Gene of Human Influenza A Viruses from 2009 to 2013 in Hangzhou, China].

Shao, Tiejuan / Li, Jun / Pu, Xiaoying / Yu, Xinfen / Kou, Yu / Zhou, Yinyan / Qian, Xin

Bing du xue bao = Chinese journal of virology

2015 Volume 31, Issue 2, Page(s) 145–151

Abstract: We investigated the genetic diversity and evolution of the M gene of human influenza A viruses in Hangzhou (Zhejiang province, China) from 2009 to 2013, including subtypes of A(H1N1) pdm09 strains and seasonal A(H3N2) strains. Subtypes of analyzed ... ...

Abstract	We investigated the genetic diversity and evolution of the M gene of human influenza A viruses in Hangzhou (Zhejiang province, China) from 2009 to 2013, including subtypes of A(H1N1) pdm09 strains and seasonal A(H3N2) strains. Subtypes of analyzed viruses were identified by cell culture and real-time reverse transcription-polymerase chain reaction, followed by cloning, sequencing and phylogenetic analyses of the M gene. Assessment of 5675 throat swabs revealed a positive rate for the influenza virus of 20.46%, and 827 cases were diagnosed as. infections due to influenza A viruses. Seventy-six influenza-A strains were selected randomly from nine stages during six phases of a virus epidemic. Sequences of the M gene showed high homology among six epidemics with identities of amino-acid sequences of 98.98-100%. All strains contained the adamantine-resistant mutation S31N in its M2 protein. Two of the A(H1N1)pdm09 strains had double mutants of V27A/S31N or V271/S31N. One of the seasonal A(H3N2) viruses had another form of double-mutant R45H/S31N. Evolutionary rate of the M gene was much lower than that of the HA gene and NA gene. Compared with A(H3N2) strains, higher positive pressure on the M1 and M2 proteins of A(H1N1) pdm09 viruses was observed. Separate analyses of M1 and M2 proteins revealed very different selection pressures. Knowledge of the genetic diversity and evolution of the M gene of human influenza-A viruses will be valuable for the control and prevention of diseases.
MeSH term(s)	Amino Acid Substitution ; China/epidemiology ; Evolution, Molecular ; Genetic Variation ; Humans ; Influenza A Virus, H1N1 Subtype/classification ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Influenza A Virus, H3N2 Subtype/classification ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/isolation & purification ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Phylogeny ; Selection, Genetic ; Viral Matrix Proteins/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics
Chemical Substances	M1 protein, Influenza A virus ; M2 protein, Influenza A virus ; Viral Matrix Proteins ; Viral Proteins
Language	Chinese
Publishing date	2015-03
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1158410-5
ISSN	1000-8721
ISSN	1000-8721
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Zs.A 4131: Show issues

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Article ; Online: Outbreak of coinfection with human metapneumovirus and measles virus resulting in the death of a child at a hospital in China.

Kou, Yu / Sun, Zhou / Li, Feng / Yu, Xinfen / Yang, Xuhui / Li, Jun / Pan, Jingcao

American journal of infection control

2015 Volume 43, Issue 4, Page(s) 365–367

Abstract: Two children with different digestive diseases were admitted to the gastroenterology department of a children's hospital in Hangzhou, Zhejiang Province, China, in May 2010. They manifested successively acute lower respiratory tract infection symptoms ... ...

Abstract	Two children with different digestive diseases were admitted to the gastroenterology department of a children's hospital in Hangzhou, Zhejiang Province, China, in May 2010. They manifested successively acute lower respiratory tract infection symptoms during their stay in the hospital. The epidemiologic and experimental evidence supports that one child acquired nosocomial coinfection with measles virus and human metapneumovirus from another child while they shared the same ward.
MeSH term(s)	Acute Disease ; China/epidemiology ; Coinfection/diagnosis ; Coinfection/virology ; Cross Infection/diagnosis ; Cross Infection/transmission ; Cross Infection/virology ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/virology ; Fatal Outcome ; Gastroenterology ; Hospitalization ; Humans ; Infant ; Measles virus/isolation & purification ; Metapneumovirus/isolation & purification ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/transmission ; Respiratory Tract Infections/virology
Keywords	covid19
Language	English
Publishing date	2015-02-14
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2015.01.002
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