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Article ; Online: Socioeconomic Inequalities in Oral Health among Adults in Guangxi, China.

Li, Andi / Zhang, Tingting / Liu, Qiulin / Yu, Xueting / Zeng, Xiaojuan

2024 Volume 22, Issue 1, Page(s) 31–38

Abstract: Purpose: To examine the relationship between socioeconomic inequalities and oral health among adults in the Guangxi province of China.: Materials and methods: The present work was designed as a cross-sectional study, and comprises a secondary ... ...

Abstract	Purpose: To examine the relationship between socioeconomic inequalities and oral health among adults in the Guangxi province of China. Materials and methods: The present work was designed as a cross-sectional study, and comprises a secondary analysis of the Fourth National Oral Health Survey from 2015-2016. A multistage cluster sampling method was adopted for this survey, conducted in three urban and three rural districts Guangxi province. Dental examinations were conducted to determine oral health indicators: decayed teeth (DT), clinical attachment loss (CAL) and missing teeth (MT). The outcome measures were DT, CAL and MT. A structured questionnaire was used to collect data on demographic characteristics and socioeconomic status (SES). Multiple logistic regression models were used to analyse the relationship between SES and oral health by adjusting covariates. Results: The sample consisted of 651 participants aged 35-74 years. Logisitic analysis showed a statistically significant association between SES and oral health indicators. In the fully adjusted model, participants with primary education were more likely to suffer more DT (OR = 2.67, 95% CI: 1.17-6.10), teeth with CAL ≥ 4 mm (OR = 2.15, 95% CI: 1.25-3.67) and MT (OR = 3.04, 95% CI: 1.65-5.60) compared to the higher education group. Participants with secondary education exhibited a higher likelihood of experiencing increased MT compared to those in the higher education group in the fully adjusted model (OR = 3.21, 95% CI: 1.78-5.76). Household income was associated with DT and MT in the unadjusted model only. Conclusions: There was strong relationship between SES and oral health of adults. The survey suggested a relationship between low educational attainment and oral health.
MeSH term(s)	Adult ; Humans ; Oral Health ; Cross-Sectional Studies ; China/epidemiology ; Social Class ; Tooth Loss/epidemiology ; Socioeconomic Factors
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2136786-3
ISSN	1757-9996 ; 1602-1622
ISSN (online)	1757-9996
ISSN	1602-1622
DOI	10.3290/j.ohpd.b4836051
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Article ; Online: Common risk factors for dental caries and impaired glucose regulation in Guangxi, China.

Chen, Shaoyong / Liu, Qiulin / Yu, Xueting / Zeng, Xiaojuan

International journal of dental hygiene

2023 Volume 22, Issue 1, Page(s) 219–228

Abstract: Objectives: To assess the prevalence of caries and impaired glucose regulation (IGR) and try to investigate their common risk factors among adult residents in Guangxi province.: Methods: A cross-sectional study was conducted on a sample of 2993 ... ...

Abstract	Objectives: To assess the prevalence of caries and impaired glucose regulation (IGR) and try to investigate their common risk factors among adult residents in Guangxi province. Methods: A cross-sectional study was conducted on a sample of 2993 adults from five different areas of Guangxi province. The sociodemographic data, history of personal habits such as diet and physical activities, physical measurements, oral examination results and biochemical laboratory test data were collected to establish a database and prepare a sound research model. Chi-square test and multiple logistic regression were used to analyse the risk factors for dental caries and IGR. Results: The prevalence rate for caries was 85.9%, and the mean DMFT score was 7.35. In multiple logistic regression, after adjustment, education level, occupation, daily consumption of vegetables, weekly consumption of carbonated beverages and weekly exercise were associated with caries (odds ratio [OR]: 2.10, OR: 1.80, OR: 1.40, OR: 2.45, OR: 2.38). The prevalence of IGR was 33.5%, and after adjustment, results showed that occupation, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, high-density lipoprotein-C levels and low-density lipoprotein-C levels were significantly associated with IGR (OR: 0.80, OR: 1.70, OR: 1.56, OR: 1.88, OR: 1.60, OR: 1.43, OR: 1.48). The strength of association between caries/IGR and risk factors was a weak association or moderate association. Conclusions: We have not found common risk factors between dental caries and IGR. Therefore, further studies are needed to explore these common risk factors to prevent caries and IGR.
MeSH term(s)	Adult ; Humans ; China/epidemiology ; Dental Caries/etiology ; Dental Caries/complications ; Glucose ; Cross-Sectional Studies ; DMF Index ; Risk Factors ; Prevalence
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-09-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2252118-5
ISSN	1601-5037 ; 1601-5029
ISSN (online)	1601-5037
ISSN	1601-5029
DOI	10.1111/idh.12730
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Article ; Online: Autoantigenic Peptide and Immunomodulator Codelivery System for Rheumatoid Arthritis Treatment by Reestablishing Immune Tolerance.

Mai, Yaping / Yu, Xueting / Gao, Ting / Wei, Yaya / Meng, Tingting / Zuo, Wenbao / Yang, Jianhong

ACS applied materials & interfaces

2024

Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by abnormal activation of ... ...

Abstract	Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by abnormal activation of CD4
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c00296
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Article ; Online: Association Between the

Liu, Li / Ma, Fei / Liu, Qiulin / Yu, Xueting / Zeng, Xiaojuan

Genetic testing and molecular biomarkers

2023 Volume 27, Issue 5, Page(s) 149–156

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Child ; Humans ; Asian People ; China/epidemiology ; Dental Caries/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Glucose Transporter Type 2/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Glucose Transporter Type 2 ; SLC2A2 protein, human
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2486664-7
ISSN	1945-0257 ; 1945-0265
ISSN (online)	1945-0257
ISSN	1945-0265
DOI	10.1089/gtmb.2022.0201
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Article ; Online: GAPDH: A common housekeeping gene with an oncogenic role in pan-cancer

Wang, Jin / Yu, Xueting / Cao, Xiyuan / Tan, Lirong / Jia, Beibei / Chen, Rui / Li, Jianxiang

Computational and Structural Biotechnology Journal. 2023 Aug. 09,

2023

Abstract: Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is one of the most prominent housekeeping proteins and is widely used as an internal control in some semi-quantitative assays. In addition to glycolysis, GAPDH is involved in several cancer-related ... ...

Abstract	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is one of the most prominent housekeeping proteins and is widely used as an internal control in some semi-quantitative assays. In addition to glycolysis, GAPDH is involved in several cancer-related biological processes and has been reported to be commonly dysregulated in multiple cancer types. Therefore, its role in the physiological process of cancer needs to be urgently elucidated. Pan-cancer analysis indicated that GAPDH is ubiquitously highly expressed in most cancer types, and that patients with a high GAPDH expression of in tumor tissues have a poor prognosis. The concordance of GAPDH expression in tumors with the infiltration of immune cells and immune checkpoints implies a certain association between GAPDH and the tumor microenvironment as well as tumor development. Gene Set Enrichment Analysis revealed that GAPDH may contribute to multiple important cancer-related pathways and biological processes. Multi-omics analysis and in vitro cell experiments revealed that GAPDH overexpression is regulated by DNA copy number amplification and promoter methylation modification. Importantly, a transcription factor, forkhead box M1 (FOXM1), which is capable of regulating GAPDH expression, was also identified and was confirmed to be an oncogene and ubiquitously highly expressed in multiple cancer types. Semi-quantitative chromatin immunoprecipitation, quantitative PCR, and dual-luciferase assays showed that FOXM1 mainly binds to the promoter region of GAPDH in two cancer cell lines. The present findings revealed the implication of GAPDH in tumor development, thus bringing attention to this important molecule and casting doubts on its role as an internal reference gene in cancer studies.
Keywords	DNA ; biotechnology ; chromatin immunoprecipitation ; glyceraldehyde-3-phosphate dehydrogenase ; glycolysis ; methylation ; multiomics ; neoplasm cells ; neoplasms ; oncogenes ; prognosis ; promoter regions ; quantitative polymerase chain reaction ; transcription factors ; GAPDH ; Pan-cancer ; Immunological ; Prognostic ; FOXM1 ; DNA methylation
Language	English
Dates of publication	2023-0809
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2023.07.034
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Therapeutic potential of tolerance-based peptide vaccines in autoimmune diseases.

Yu, Xueting / Mai, Yaping / Wei, Yaya / Yu, Na / Gao, Ting / Yang, Jianhong

International immunopharmacology

2023 Volume 116, Page(s) 109740

Abstract: Autoimmune diseases are caused by the dysfunction of the body's immune regulatory system, which leads to the recognition of self-antigens and the destruction of self-tissues and is mediated by immune cells such as T and B cells, and affects 5-10% of the ... ...

Abstract	Autoimmune diseases are caused by the dysfunction of the body's immune regulatory system, which leads to the recognition of self-antigens and the destruction of self-tissues and is mediated by immune cells such as T and B cells, and affects 5-10% of the population worldwide. Current treatments such as non-steroidal anti-inflammatory drugs and glucocorticoids can only relieve symptoms of the disease and are accompanied by serious side effects that affect patient quality of life. The recent rise in antigen-specific therapies, especially vaccines carrying autoantigenic peptides, promises to change this disadvantage, where research has increased dramatically in the last decade. This therapy established specific immune tolerance by delivering peptide fragments containing disease-specific self-antigen epitopes to suppress excessive immune responses, thereby exerting a therapeutic effect, with high safety and specificity. This article presents the latest progress on the treatment of autoimmune diseases with autoantigen peptide vaccines. It includes the construction of peptide vaccine delivery system, the mechanism of inducing immune tolerance and its application.
MeSH term(s)	Humans ; Quality of Life ; Autoimmune Diseases ; Immune Tolerance ; Vaccines/therapeutic use ; Autoantigens ; Vaccines, Subunit/therapeutic use
Chemical Substances	Vaccines ; Autoantigens ; Vaccines, Subunit
Language	English
Publishing date	2023-01-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109740
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Article: GAPDH: A common housekeeping gene with an oncogenic role in pan-cancer.

Wang, Jin / Yu, Xueting / Cao, Xiyuan / Tan, Lirong / Jia, Beibei / Chen, Rui / Li, Jianxiang

Computational and structural biotechnology journal

2023 Volume 21, Page(s) 4056–4069

Abstract	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is one of the most prominent housekeeping proteins and is widely used as an internal control in some semi-quantitative assays. In addition to glycolysis, GAPDH is involved in several cancer-related biological processes and has been reported to be commonly dysregulated in multiple cancer types. Therefore, its role in the physiological process of cancer needs to be urgently elucidated. Pan-cancer analysis indicated that
Language	English
Publishing date	2023-08-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2023.07.034
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Article ; Online: Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.

Ma, Fei / He, Haoyu / Chen, Shaoyong / Yu, Xueting / Liu, Qiulin / Zeng, Xiaojuan

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 6

Abstract: Objective: The aim of this study was to assess associations of PART1 rs27565 and DEFB1 rs11362 polymorphisms with the prevalence of dental caries in twelve-year-old children in Nandan County, Guangxi, China.: Methods: A total of 1,061 children were ... ...

Abstract	Objective: The aim of this study was to assess associations of PART1 rs27565 and DEFB1 rs11362 polymorphisms with the prevalence of dental caries in twelve-year-old children in Nandan County, Guangxi, China. Methods: A total of 1,061 children were included in this cross-sectional study and divided into two groups based on the Decayed, Missing and Filled teeth (DMFT) index: caries-free children (DMFT score = 0) and children with caries (DMFT score ≥ 1). Demographic characteristics, oral hygiene behaviour and dietary habits were collected through household records and questionnaires. Genomic DNA was extracted from buccal cells, and PART1 rs27565 and DEFB1 rs11362 polymorphisms were genotyped using a custom-designed 48-Plex single nucleotide polymorphism-scan kit. Results: Carriers of the PART1 rs27565 C allele (odds ratio [OR] = 1.338, 95% confidence interval (CI) = 1.015-1.764, P value = 0.039) and carriers of the DEFB1 rs11362 T allele (OR = 1.364, 95% CI = 1.056-1.762, P value = 0.017) had a higher risk of caries. Carriers of the PART1 rs27565 TC or CC genotype who ate sugary food more than once a week had a 1.6-fold higher risk of caries than TT carriers who ate sugary food at most once a week (OR = 1.579, 95% CI = 1.032-2.414, P value = 0.035). Carriers of the DEFB1 rs11362 CT or TT genotype who ate sugary food more than once a week had a 2.1-fold higher risk of caries than CC carriers who ate sugary food at most once a week (OR = 2.057, 95% CI = 1.438-2.940, P value < 0.001). Conclusion: PART1 rs27565 and DEFB1 rs11362 polymorphisms were associated with caries in 12-year-old children in Nandan County, Guangxi, China. Carriers of the PART1 rs27565 TC or CC genotype and the DEFB1 rs11362 CT or TT genotype who ate sugary food more than once a week had a high probability of having caries.
MeSH term(s)	Humans ; Child ; Cross-Sectional Studies ; Dental Caries/epidemiology ; Dental Caries/genetics ; Mouth Mucosa ; China/epidemiology ; Polymorphism, Single Nucleotide ; Prevalence ; DMF Index ; beta-Defensins/genetics
Chemical Substances	DEFB1 protein, human ; beta-Defensins
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03678-4
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Article ; Online: Mapping RNA-seq reads to transcriptomes efficiently based on learning to hash method.

Yu, Xueting / Liu, Xuejun

Computers in biology and medicine

2019 Volume 116, Page(s) 103539

Abstract: Accurate and efficient read-alignment is one of the fundamental challenges in RNA-seq analysis. Due to the increasingly large number of reads generated from the RNA-seq experiments, read-alignment is a time-consuming task. Many mappers adopted various ... ...

Abstract	Accurate and efficient read-alignment is one of the fundamental challenges in RNA-seq analysis. Due to the increasingly large number of reads generated from the RNA-seq experiments, read-alignment is a time-consuming task. Many mappers adopted various strategies to look for potential alignment locations for reads in a tolerable time, and provide adequate information for downstream analysis. But in some transcript analysis tasks, such as transcriptome quantification, the mapping information about the transcripts and positions for reads is sufficient. Thus the original alignment problem can be simplified to a string searching problem since the reads can be mapped contiguously to the transcriptome. Some models for transcript analysis adopt more efficient strategies to solve this simplified problem, but the efficiency is still restricted by handling RNA-seq data in the original read space. We propose a method, bit-mapping, based on learning to hash algorithm for mapping reads to the transcriptome. It learns hash functions from the transcriptome and generates binary hash codes of the sequences, then maps reads to the transcriptome according to their hash codes. Bit-mapping accelerates mapping problems in RNA-seq analysis by reducing the dimension of the read. We evaluate the performance of bit-mapping based on simulated data and real data, and compare it with other popular and state-of-the-art methods, STAR, RapMap, Bowtie 2 and HISAT 2. The comparative results of simulated and real data show that the accuracy of our method is competitive to the existing mappers in terms of mapping efficiency, especially for longer reads (¿ 100 bp).
MeSH term(s)	Algorithms ; Humans ; RNA-Seq/methods ; Sequence Alignment/methods ; Software ; Transcriptome/genetics
Language	English
Publishing date	2019-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2019.103539
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Article ; Online: Academic grit scale for Chinese middle- and upper-grade primary school students: testing its factor structure and measurement invariance.

Lin, Rongmao / Chen, Yanping / Shen, Yilin / Hu, Ting / Huang, Ying / Yang, Yishan / Yu, Xueting / Ding, Jinliang

BMC psychology

2024 Volume 12, Issue 1, Page(s) 149

Abstract: The Academic Grit Scale (AGS) is a novel measure of academic-specific grit. However, its factor structure and measurement invariance have yet to be thoroughly supported. The present study tested the factor structure and measurement invariance of the AGS ... ...

Abstract	The Academic Grit Scale (AGS) is a novel measure of academic-specific grit. However, its factor structure and measurement invariance have yet to be thoroughly supported. The present study tested the factor structure and measurement invariance of the AGS with a large sample of early adolescents (aged 9-14 years) from China (N = 1,894). The bifactor model showed that the AGS was predominately accounted for by the general factor rather than the domain-specific factors; the parallel model from the AGS's one-factor model showed good fit indices; thus, the AGS should be described as a univocal solution and reported as the total score. Gender and grade measurement invariance were supported at a scalar level, warranting further mean difference comparisons. In addition, academic grit was significantly associated with positive academic emotions and academic achievement, yielding evidence of good criteria-related validity. The current study contributes additional evidence to the construct validity of the Chinese version of the AGS among middle- and upper-grade primary school students in China.
MeSH term(s)	Adolescent ; Humans ; China ; Psychometrics ; Schools ; Students/psychology ; Child ; East Asian People ; Academic Success
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-024-01622-y
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