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Article: Machine learning-enhanced insights into sphingolipid-based prognostication: revealing the immunological landscape and predictive proficiency for immunomotherapy and chemotherapy responses in pancreatic carcinoma.

Shi, Ting / Li, Minmin / Yu, Yabin

2023 Volume 10, Page(s) 1284623

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1284623
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Voluntary Environmental Behavior and Innovation Quality of Chinese Textile Enterprises Based on Grounded Theory and Propensity Score Matching.

Yu, Yabin / Cheng, Hua / Xu, Qian

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 9736667

Abstract: At a new stage of "carbon peak" and "carbon neutral," we need to strengthen the internal impetus of institutions and policies to promote ecological civilization construction. The initiative implementation of voluntary environmental behavior (VEB) is an ... ...

Abstract	At a new stage of "carbon peak" and "carbon neutral," we need to strengthen the internal impetus of institutions and policies to promote ecological civilization construction. The initiative implementation of voluntary environmental behavior (VEB) is an effective way for enterprises to achieve high quality sustainable development. The VEB of enterprises include but are not limited to compliance with voluntary environmental regulations (VER). Different from the existing literature on enterprise VER, most of which are just the verification of ISO14001, the study conducts a comprehensive exploratory research on the theoretical framework of what is driving the VEB of Chinese textile enterprises. First, based on grounded theory, the paper coded the hand-collected environmental text information of Chinese listed textile enterprises from 2004 to 2018 and constructed a complete theoretical analysis framework from motivation to performance evaluation of enterprise VEB. Second, PSM method is taken to verify the conceptual model. As a result, we find the following: (1) in addition to ISO14001, the textile enterprises involve many industry-specific VER. (2) The VEB and VER of Chinese textile enterprises promote each other. (3) Either following VER or implementing VEB can effectively increase the innovation input and then actively improve the innovation quality of Chinese textile enterprises. In this way, the conclusion not only provides analysis ideas for future empirical research, but also offers practical suggestions to Chinese textile enterprises and policy makers for environmental management.
MeSH term(s)	Carbon ; China ; Grounded Theory ; Propensity Score ; Textiles
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/9736667
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Defect Removal and Rearrangement of Wood Board Based on Genetic Algorithm

Yang, Yutu / Zhuang, Zilong / Yu, Yabin

Forests. 2021 Dec. 25, v. 13, no. 1

2021

Abstract: Defects on a solid wood board have a great influence on the aesthetics and mechanical properties of the board. After removing the defects, the board is no longer the standard size; manual drawing lines and cutting procedure is time-consuming and ... ...

Abstract	Defects on a solid wood board have a great influence on the aesthetics and mechanical properties of the board. After removing the defects, the board is no longer the standard size; manual drawing lines and cutting procedure is time-consuming and laborious; and an optimal solution is not necessarily obtained. Intelligent cutting of the board can be realized using a genetic algorithm. However, the global optimal solution of the whole machining process cannot be obtained by separately considering the sawing and splicing of raw materials. The integrated consideration of wood board cutting and board splicing can improve the utilization rate of the solid wood board. The effective utilization rate of the board with isolated consideration of raw material sawing with standardized dimensions of wood pieces and board splicing is 79.1%, while the shortcut splicing optimization with non-standardized dimensions for the final board has a utilization rate of 88.6% (which improves the utilization rate by 9.5%). In large-scale planning, the use of shortcut splicing optimization also increased the utilization rate by 12.14%. This has certain guiding significance for actual production.
Keywords	aesthetics ; algorithms ; raw materials ; wood
Language	English
Dates of publication	2021-1225
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f13010026
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway.

Lin, Kai / Zhou, Endi / Shi, Ting / Zhang, Siqing / Zhang, Jinfan / Zheng, Ziruo / Pan, Yuetian / Gao, Wentao / Yu, Yabin

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 217

Abstract: Background: Gemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mutation has been shown to have a significant regulatory role in chemosensitivity; however, it is not apparent whether ... ...

Abstract	Background: Gemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mutation has been shown to have a significant regulatory role in chemosensitivity; however, it is not apparent whether gemcitabine resistance can be regulated by fat mass and obesity-associated protein (FTO). Methods: Cells with established gemcitabine resistance and tissues from pancreatic cancer patients were used to evaluate FTO expression. The biological mechanisms of the effects of FTO on gemcitabine resistant cells were investigated using CCK-8, colony formation assay, flow cytometry, and inhibitory concentration 50. Immunoprecipitation/mass spectrometry, MeRIP-seq, RNA sequencing and RIP assays, RNA stability, luciferase reporter, and RNA pull down assays were employed to examine the mechanism of FTO affecting gemcitabine resistant pancreatic cancer cells. Results: The results revealed that FTO was substantially expressed in cells and tissues that were resistant to gemcitabine. Functionally, the gemcitabine resistance of pancreatic cancer could be enhanced by FTO, while its depletion inhibited the growth of gemcitabine resistant tumor cells in vivo. Immunoprecipitation/mass spectrometry showed that the FTO protein can be bound to USP7 and deubiquitinated by USP7, leading to the upregulation of FTO. At the same time, FTO knockdown significantly decreased the expression level of NEDD4 in an m6A-dependent manner. RNA pull down and RNA immunoprecipitation verified YTHDF2 as the reader of NEDD4, which promoted the chemoresistance of gemcitabine resistant cells. FTO knockdown markedly increased the PTEN expression level in an NEDD4-dependent manner and influenced the chemosensitivity to gemcitabine through the PI3K/AKT pathway in pancreatic cancer cells. Conclusion: In conclusion, we found that gemcitabine resistance in pancreatic cancer can be influenced by FTO that demethylates NEDD4 RNA in a m6A-dependent manner, which then influences the PTEN expression level and thereby affects the PI3K/AKT pathway. We also identified that the FTO level can be upregulated by USP7.
MeSH term(s)	Humans ; Gemcitabine ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Ubiquitin-Specific Peptidase 7 ; RNA Stability ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; PTEN Phosphohydrolase/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Pancreatic Neoplasms
Chemical Substances	Gemcitabine ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ubiquitin-Specific Peptidase 7 (EC 3.4.19.12) ; USP7 protein, human (EC 3.4.19.12) ; PTEN protein, human (EC 3.1.3.67) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33)
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02792-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ultrasonic Signal Transmission Performance in Bolted Connections of Wood Structures under Different Preloads

Zhuang, Zilong / Yu, Yabin / Liu, Ying / Chen, Jiawei / Wang, Zhengguang

Forests. 2021 May 21, v. 12, no. 6

2021

Abstract: In industrial applications, bolt connections are simple and economical, contributing to their popularity for use in wood packing boxes. However, they can easily fail when subjected to a continuous vibrational load under usual working conditions such as ... ...

Abstract	In industrial applications, bolt connections are simple and economical, contributing to their popularity for use in wood packing boxes. However, they can easily fail when subjected to a continuous vibrational load under usual working conditions such as transportation and hoisting. Based on an ultrasonic technique, nondestructive evaluation can be used to quickly detect large-scale structures, but the complex propagation properties in wood limit its application. To solve this problem, a time-reversal method was adopted to predict the residual preload on bolted connections by focusing on the signals collected by wood structures, which helps to assess the structures’ reliability. In this study, the residual preload of bolted connections in wood structures was predicted using the deep-learning method, LSTM, one-dimensional Resnet and Densenet, and tree classification models. It was confirmed that the use of the time-reversal method for ultrasonic detection focused on the signals transmitted in bolted connections of wood structures and deep-learning methods are a feasible way to predict an ultrasonic transmission model.
Keywords	models ; transportation ; trees ; ultrasonics ; wood
Language	English
Dates of publication	2021-0521
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f12060652
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Detection Method for Bolted Connection Looseness at Small Angles of Timber Structures based on Deep Learning.

Yu, Yabin / Liu, Ying / Chen, Jiawei / Jiang, Dong / Zhuang, Zilong / Wu, Xiaoli

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 9

Abstract: Bolted connections are widely used in timber structures. Bolt looseness is one of the most important factors leading to structural failure. At present, most of the detection methods for bolt looseness do not achieve a good balance between cost and ... ...

Abstract	Bolted connections are widely used in timber structures. Bolt looseness is one of the most important factors leading to structural failure. At present, most of the detection methods for bolt looseness do not achieve a good balance between cost and accuracy. In this paper, the detection method of small angle of bolt loosening in a timber structure is studied using deep learning and machine vision technology. Firstly, three schemes are designed, and the recognition targets are the nut's own specification number, rectangular mark, and circular mark, respectively. The Single Shot MultiBox Detector (SSD) algorithm is adopted to train the image datasets. The scheme with the smallest identification angle error is the one identifying round objects, of which the identification angle error is 0.38°. Then, the identification accuracy was further improved, and the minimum recognition angle reached 1°. Finally, the looseness in a four-bolted connection and an eight-bolted connection are tested, confirming the feasibility of this method when applied on multi-bolted connection, and realizing a low operating costing and high accuracy.
Language	English
Publishing date	2021-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21093106
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Loosening of Bolted Connections under Transverse Loading in Timber Structures

Chen, Jiawei / Wang, Honghong / Yu, Yabin / Liu, Ying / Jiang, Dong

Forests. 2020 July 28, v. 11, no. 8

2020

Abstract: Bolted joints are widely used in timber structures, and the loosening of bolt connections will reduce the structural performance. In this paper, a mechanical model of bolt connection for timber structures is established, and the process of bolt loosening ...

Abstract	Bolted joints are widely used in timber structures, and the loosening of bolt connections will reduce the structural performance. In this paper, a mechanical model of bolt connection for timber structures is established, and the process of bolt loosening under a transverse load is investigated. By using the finite element method to construct an accurate thread model with a helix angle, the thread contact state during the bolt loosening procedure was analyzed in detail, and the factors such as load amplitude, load frequency, load location, and different timber materials on bolt loosening are also studied. In the timber structure, the load amplitude is the main factor affecting the bolt loosening, the decay rate of the preload in the bolted joint is positively correlated with the amplitude of the cyclic transverse load. The frequency of the loading has a smaller effect on the looseness, the preload decreases as the frequency increases. When the load is applied to the smooth rod part of the bolt, the preload force will decrease rapidly, and the distance between the load position and the bolt has no effect on the change in looseness. The decreasing range of the preload is different with different timber material, but the decreasing law is the same. The model can be applied to analyze the loosening rule of bolted connections in timber structures.
Keywords	finite element analysis ; forestry ; mechanical models
Language	English
Dates of publication	2020-0728
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f11080816
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Overexpression of long noncoding RNA CUDR promotes hepatic differentiation of human umbilical cord mesenchymal stem cells.

Yu, Yabin / Li, Meng / Song, Yan / Xu, Jianbo / Qi, Fuzhen

Molecular medicine reports

2019 Volume 21, Issue 3, Page(s) 1051–1058

Abstract: Previous studies have shown that long noncoding RNAs (lncRNAs) are capable of regulating cell differentiation and pluripotency. The objective of the present study was to explore the effect of lncRNA cancer upregulated drug resistant (CUDR) on the hepatic ...

Abstract	Previous studies have shown that long noncoding RNAs (lncRNAs) are capable of regulating cell differentiation and pluripotency. The objective of the present study was to explore the effect of lncRNA cancer upregulated drug resistant (CUDR) on the hepatic differentiation of human umbilical cord mesenchymal stem cells (HuMSCs). HuMSCs were subjected to a hepatogenic differentiation protocol. The level of CUDR was monitored by reverse transcription‑quantitative PCR (RT‑qPCR) following certain stages of hepatic differentiation. Lentivirus transfection was used to achieve CUDR overexpression. The hepatocyte‑related proteins and mRNAs were then examined by immunofluorescence, ELISA and RT‑qPCR analyses. The results showed that CUDR was upregulated during the hepatic differentiation of HuMSCs. Upregulation of CUDR can improve hepatic differentiation of HuMSCs, including hepatocyte‑related genes and proteins. In addition, it was also found that liver‑enriched transcription factors were upregulated after CUDR overexpression. Moreover, there was an association between the Wnt/β‑catenin pathway and CUDR. In summary, these results demonstrated that the overexpression of CUDR could improve the hepatic differentiation of HuMSCs, therefore it could be an ideal source for regenerative therapy.
MeSH term(s)	Cell Differentiation ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; RNA, Long Noncoding/biosynthesis ; RNA, Long Noncoding/genetics ; Umbilical Cord/cytology ; Umbilical Cord/metabolism ; Up-Regulation
Chemical Substances	RNA, Long Noncoding ; UCA1 RNA, human
Language	English
Publishing date	2019-12-19
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2019.10897
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bouveret's syndrome: A rare presentation of gastric outlet obstruction.

Yu, Ya-Bin / Song, Yan / Xu, Jian-Bo / Qi, Fu-Zhen

Experimental and therapeutic medicine

2019 Volume 17, Issue 3, Page(s) 1813–1816

Abstract: Bouveret's syndrome refers to gastric outlet obstruction caused by the formation of a cholecystoduodenal fistula with subsequent migration and impaction of a large gallstone into the duodenum. A case of a 59-year-old male who presented to our institution ...

Abstract	Bouveret's syndrome refers to gastric outlet obstruction caused by the formation of a cholecystoduodenal fistula with subsequent migration and impaction of a large gallstone into the duodenum. A case of a 59-year-old male who presented to our institution with consistent abdominal pain and nausea is reported herein. Bouveret's syndrome was diagnosed after conducting a computed tomography scan. Surgery was performed wherein gallstone removal was followed by cholecystectomy and fistula repair associated with a pyloric bypass via gastro-jejunostomy. The patient recovered well following surgery and has remained free of symptoms for the last year.
Language	English
Publishing date	2019-01-03
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2019.7150
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical analysis of hepatic angioleiomyoma: Two case reports.

Jiang, Bin / Chen, Qiu-Ni / Qi, Fu-Zhen / Xu, Jian-Bo / Yu, Ya-Bin / Song, Yan

Medicine

2019 Volume 98, Issue 11, Page(s) e14661

Abstract: Rationale: Angioleiomyoma is an uncommon benign tumor that originates from the vascular smooth muscle cells and contains thick-walled vessels. It can appear anywhere in the body but more frequently in the extremities (especially in the lower limbs) and ... ...

Abstract	Rationale: Angioleiomyoma is an uncommon benign tumor that originates from the vascular smooth muscle cells and contains thick-walled vessels. It can appear anywhere in the body but more frequently in the extremities (especially in the lower limbs) and rarely invades the internal organs. Patient concerns: A 52-year-old Chinese woman was referred to our hospital because of finding liver neoplasm 2 weeks ago (case first) and a 64-year-old Chinese woman was admitted to hospital with enlargement of the hepatic neoplasm revealed in follow-up, who was diagnosed with angioleiomyoma of left kidney 2 years ago (case second). Diagnosis: All patients were diagnosed with hepatic angioleiomyoma by pathological results. Interventions: All patients received surgical treatment, with laparoscopic hepatectomy of the IVb segment in case 1 and laparoscopic hepatic left lateral lobectomy in case 2. Outcomes: The 2 patients have eventually recovered, and no recurrences or other complications have been observed so far. Lessons: Because of atypical clinical symptoms, no specificity in laboratory examination, and lack of characteristic imaging findings, angioleiomyoma is easily misdiagnosed for another disease of the liver. But with complete resection, the prognosis is generally good.
MeSH term(s)	Angiomyoma/diagnostic imaging ; Angiomyoma/pathology ; Angiomyoma/surgery ; Female ; Hepatectomy/methods ; Humans ; Laparoscopy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging ; Middle Aged ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-03-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000014661
Database	MEDical Literature Analysis and Retrieval System OnLINE

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