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Article ; Online: Transarterial embolization for enoxaparin-induced massive abdominal wall hematoma: A case report and literature review.

He, Qifan / Xiong, Yue / Yu, Yihui / Chen, Zhonghua

2024 Volume 47, Issue 4, Page(s) 1865–1866

MeSH term(s)	Humans ; Enoxaparin/adverse effects ; Abdominal Wall ; Hematoma/chemically induced ; Hematoma/diagnostic imaging ; Embolization, Therapeutic/adverse effects ; Vascular Surgical Procedures ; Gastrointestinal Hemorrhage/complications
Chemical Substances	Enoxaparin
Language	English
Publishing date	2024-01-06
Publishing country	Netherlands
Document type	Review ; Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.12.155
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Article ; Online: Oral abrocitinib in the treatment of granuloma annulare: a case report.

Liu, Wenyan / Chen, Weifeng / Tian, Xin / Yu, Yihui / Zhu, Junhui / Liang, Jingyao / Zhang, Xibao

The Journal of dermatological treatment

2024 Volume 35, Issue 1, Page(s) 2313090

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Granuloma Annulare/drug therapy ; Granuloma Annulare/pathology ; Pyrimidines/therapeutic use ; Sulfonamides/therapeutic use ; Janus Kinase Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	abrocitinib (73SM5SF3OR) ; Pyrimidines ; Sulfonamides ; Janus Kinase Inhibitors
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2024.2313090
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Zs.A 2627: Show issues

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Article ; Online: Predicting cancer-specific mortality in T1/2 hepatocellular carcinoma after radiofrequency ablation by competing risk nomogram: A population-based analysis.

He, Qifan / Xiong, Yue / Xia, Pengcheng / Yang, Xiaoyu / Yu, Yihui / Chen, Zhonghua

Clinics and research in hepatology and gastroenterology

2024 Volume 48, Issue 2, Page(s) 102283

Abstract: Background: Radiofrequency ablation (RFA) is one of the primary treatment methods for T1/2 hepatocellular carcinoma (HCC), but the risk factors after RFA remain controversial. This study aims to identify the key factors associated with cancer-specific ... ...

Abstract	Background: Radiofrequency ablation (RFA) is one of the primary treatment methods for T1/2 hepatocellular carcinoma (HCC), but the risk factors after RFA remain controversial. This study aims to identify the key factors associated with cancer-specific mortality (CSM) in patients with T1/2 HCC after RFA using competing risk analysis and to establish a prognostic nomogram for improved clinical management. Methods: A total of 2,135 T1/2 HCC patients treated with RFA were obtained from the Surveillance, Epidemiology, and End Results (SEER) database and randomly categorized into training and validation sets. Univariate and multivariable competing risk analyses were performed to identify risk factors associated with CSM and construct a competing risk nomogram. Receiver operating characteristic (ROC) curves, concordance indices (C-indexes), calibration plots, and decision curve analysis (DCA) were conducted to evaluate the predictive efficiency and clinical applicability of the nomogram in the training and validation sets. Patients were stratified according to their nomogram score, and the different risk groups were compared using cumulative incidence function (CIF) curves and Gray's validation . Results: The 5-year CSM rate for HCC patients treated with RFA was 30.1 %. Grade, tumor size, tumor number, cirrhosis, and AFP level were identified as independent risk factors for CSM. A prognostic nomogram was developed based on these risk factors. The time-dependent C-indexes (0.65) were greater than those of the AJCC stage model (0.55) during the 12 to 60 months of follow-up. The calibration plots of the competing risk nomograms demonstrated excellent consistency between actual survival and nomogram predictions. ROC analyses showed that the 1-, 3-, and 5-year AUC values in both the training and validation cohorts were all greater than 0.63 and exceeded those of the AJCC stage model. DCA demonstrated the clinical usefulness of the nomogram. Patients were classified into low-, moderate-, and high-risk groups based on the nomogram scores, with the high-risk group showing significantly higher CSM rates after RFA compared to the other two groups. Conclusions: We identified Grade, AFP, cirrhosis, tumor size, and tumor number as independent risk factors associated with CSM. The competing risk nomogram exhibited high performance in predicting the probability of CSM for HCC patients undergoing RFA.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/surgery ; Nomograms ; alpha-Fetoproteins ; Liver Neoplasms/surgery ; Radiofrequency Ablation ; Liver Cirrhosis ; Prognosis
Chemical Substances	alpha-Fetoproteins
Language	English
Publishing date	2024-01-12
Publishing country	France
Document type	Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2024.102283
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Article ; Online: A successful endovascular intervention for massive hemorrhage due to a ruptured gastric artery aneurysm in a patient with microscopic polyangiitis: A case report

Chen, Zhonghua / Zhu, Chuanfang / Zhao, Peng / Tang, Congsheng / Xiong, Yue / Yu, Yihui / Chen, Feng

Heliyon. 2023 Apr. 05, p.e15240-

2023

Abstract: The formation of left gastric artery aneurysms (LGAAs) is a very rare complication of microscopic polyangiitis (MPA). Hemorrhage due to ruptured LGAAs is life threatening. In this case report, an 81-year-old female patient diagnosed with MPA developed ... ...

Abstract	The formation of left gastric artery aneurysms (LGAAs) is a very rare complication of microscopic polyangiitis (MPA). Hemorrhage due to ruptured LGAAs is life threatening. In this case report, an 81-year-old female patient diagnosed with MPA developed massive bleeding from a ruptured LGAA and hemorrhagic shock during hospitalization. The patient underwent endovascular therapy to successfully embolize the aneurysm with microcoils and recovered postoperatively.
Keywords	aneurysm ; case studies ; females ; hemorrhage ; patients ; therapeutics ; Microscopic polyangiitis ; Interventional radiology
Language	English
Dates of publication	2023-0405
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15240
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Article ; Online: Efficacy of adalimumab in the treatment of refractory livedoid vasculopathy: Case report and literature review.

Dong, Liangjiao / Li, Qian / Yu, Yihui / Liang, Jingyao / Zhang, Xibao

Dermatologic therapy

2022 Volume 35, Issue 9, Page(s) e15666

MeSH term(s)	Adalimumab/therapeutic use ; Humans ; Livedo Reticularis/therapy ; Livedoid Vasculopathy
Chemical Substances	Adalimumab (FYS6T7F842)
Language	English
Publishing date	2022-07-09
Publishing country	United States
Document type	Case Reports ; Letter ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15666
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Article ; Online: A systematic review and meta-analysis on the efficacy and safety of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer.

Yu, Yihui / Fu, Jinman / Xia, Pengcheng / Chu, Chunyan

Translational cancer research

2021 Volume 11, Issue 5, Page(s) 1297–1308

Abstract: Background: Transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) intervention in prolonging the long-term survival and prognosis of patients with liver cancer are still controversy compared with the traditional ... ...

Abstract	Background: Transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) intervention in prolonging the long-term survival and prognosis of patients with liver cancer are still controversy compared with the traditional interventional therapy of RFA alone. This meta-analysis aimed to compare the efficacy and safety of combination therapy versus RFA alone. Methods: The related articles were searched in PubMed, Embase, MEDLINE, Science Direct, The Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Science and Technology Journal Database, and China Biomedical Literature Database (CBM). The Chinese and English search keywords included transcatheter arterial chemoembolization, TACE, radiofrequency ablation, RFA, primary liver cancer, and liver tumor. The five evaluation criteria of randomized controlled trials (RCTs) in Cochrane RoB 2.0 repeatedly independently evaluated the bias risks involved in the study and cross-checked the results. Results: A total of 7 articles were included, and the results of bias risk assessment show that 6 articles described the generation of random sequences in detail; There were 3 articles describing allocation concealment in detail; Operator blindness was used in 4 articles; The outcome indicators of 7 documents were complete. The 3-year overall survival rate of the RFA combined with TACE group was significantly better than that of the RFA group [odds ratio (OR) =1.97, 95% confidence interval (CI): 1.42-2.74, Z=4.05, P<0.0001]. The 1-year and 3-year tumor recurrence-free survival rates in the RFA combined with TACE group were significantly better than those in the RFA group (OR =1.88, 95% CI: 1.28-2.76, Z=3.23, P=0.001; OR =2.11, 95% CI: 1.37-3.24, Z=3.38, P=0.0007). There was no significant difference in the complication rate of patients with primary liver cancer between the RFA combined with TACE group and the RFA group (OR =0.79, 95% CI: 0.45-1.39, Z=0.81, P=0.42). Discussion: Meta-analysis results confirmed that TACE combined with RFA was safe and effective in the treatment of primary liver cancer, and can improve the overall survival and recurrence-free survival of patients with primary liver cancer.
Language	English
Publishing date	2021-06-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-22-816
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Article: A successful endovascular intervention for massive hemorrhage due to a ruptured gastric artery aneurysm in a patient with microscopic polyangiitis: A case report.

Chen, Zhonghua / Zhu, Chuanfang / Zhao, Peng / Tang, Congsheng / Xiong, Yue / Yu, Yihui / Chen, Feng

Heliyon

2023 Volume 9, Issue 4, Page(s) e15240

Abstract	The formation of left gastric artery aneurysms (LGAAs) is a very rare complication of microscopic polyangiitis (MPA). Hemorrhage due to ruptured LGAAs is life threatening. In this case report, an 81-year-old female patient diagnosed with MPA developed massive bleeding from a ruptured LGAA and hemorrhagic shock during hospitalization. The patient underwent endovascular therapy to successfully embolize the aneurysm with microcoils and recovered postoperatively.
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15240
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Article ; Online: Sanguinarine, similar to the MICs of spectinomycin, exhibits good anti-Neisseria gonorrhoeae activity in vitro.

Liang, Jingyao / Li, Xiaodong / Bi, Chao / Yu, Yihui / Liu, Wenyan / Zhang, Xibao / Cao, Wenling

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 29, Issue 9, Page(s) 927–929

Abstract: The increasing antibiotic resistance of Neisseria gonorrhoeae (NG) is an urgent need to explore new and effective drugs. The antibacterial activities of spectinomycin and sanguinarine against 117 clinical NG isolates and time-kill curve of sanguinarine ... ...

Abstract	The increasing antibiotic resistance of Neisseria gonorrhoeae (NG) is an urgent need to explore new and effective drugs. The antibacterial activities of spectinomycin and sanguinarine against 117 clinical NG isolates and time-kill curve of sanguinarine were evaluated. Almost all isolates were resistant to penicillin (91.5%) and ciprofloxacin (96.5%), 8.5% showed resistance to azithromycin, 10.3% and 10.3% had decreased susceptibility/resistance to ceftriaxone and cefixime, respectively, whereas 100% were susceptible to spectinomycin. The minimum inhibitory concentration (MIC) ranges, MIC
MeSH term(s)	Humans ; Spectinomycin/pharmacology ; Spectinomycin/therapeutic use ; Neisseria gonorrhoeae ; Gonorrhea/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Ceftriaxone/therapeutic use ; Ciprofloxacin/pharmacology ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial
Chemical Substances	Spectinomycin (93AKI1U6QF) ; sanguinarine (AV9VK043SS) ; Anti-Bacterial Agents ; Azithromycin (83905-01-5) ; Ceftriaxone (75J73V1629) ; Ciprofloxacin (5E8K9I0O4U)
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.05.022
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Article ; Online: LC-MS metabolomics reveal skin metabolic signature of psoriasis vulgaris.

Xiong, Qiying / Zhong, Daoqing / Li, Qian / Yu, Yihui / Zhang, Sanquan / Liang, Jingyao / Zhang, Xibao

Experimental dermatology

2023 Volume 32, Issue 6, Page(s) 889–899

Abstract: Recent metabolic studies have indicated that several metabolites in blood and urine of psoriasis functionally involved in the pathogenesis of psoriasis, but the skin metabonomics research of psoriasis is limited. We aimed to investigate the metabolic ... ...

Abstract	Recent metabolic studies have indicated that several metabolites in blood and urine of psoriasis functionally involved in the pathogenesis of psoriasis, but the skin metabonomics research of psoriasis is limited. We aimed to investigate the metabolic profiling of lesional and nonlesional skin and screen out potential biomarkers for psoriasis. We performed liquid chromatography-mass spectrometry (LC-MS)-based nontargeted metabolomic analysis to compare metabolic profile between lesional and nonlesional skin from 12 patients with psoriasis vulgaris. A total of 3463 metabolites were detected, of which 769 (346 named and 423 unnamed) in positive ion mode and 179 (80 named and 99 unnamed) in negative ion mode were significantly different between lesional and nonlesional skin. These different metabolites were mainly derived from amino acid, lipid and nucleotide metabolism, and involved in cell proliferation and apoptosis regulation. Fourteen metabolites (10 upregulated and 4 downregulated) were identified as the most potentially significant biomarkers. Interestingly, seven of them were positively (l-gamma-glutamyl-l-leucine, 2-methylcitric acid, l-palmitoylcarnitine, inosine, eicosapentaenoic acid and 13-hydroxy-octadecaenoic acid) or negatively (l-serine) correlated with disease severity. Significant differences of metabolic characteristics were found between lesional and nonlesional skin, which may contribute to assess the severity of psoriasis and therapeutic responses.
MeSH term(s)	Humans ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Psoriasis/metabolism ; Metabolomics/methods ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-03-31
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14796
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Zs.A 3508: Show issues

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Article ; Online: Review of secukinumab-induced adverse events of special interest and its potential pathogenesis.

Liang, Jingyao / Zhang, Sanquan / Li, Qian / Yu, Yihui / Chen, Xiaoyin / Zhang, Xibao

Dermatologic therapy

2022 Volume 35, Issue 8, Page(s) e15599

Abstract: Although secukinumab has demonstrated high efficacy and favorable safety in moderate-to-severe psoriasis and psoriatic arthritis, patients developing adverse events of special interest (AESI) were reported increasingly in real-world practice. A ... ...

Abstract	Although secukinumab has demonstrated high efficacy and favorable safety in moderate-to-severe psoriasis and psoriatic arthritis, patients developing adverse events of special interest (AESI) were reported increasingly in real-world practice. A systematic literature search of the PubMed database was conducted to identify clinical studies or case reports on secukinumab-induced AESI. More than 1077 patients (aged 18-74 years) from 55 studies were reported to have 24 AESI 3 days to 96 weeks after secukinumab treatment. The four most common AESI was inflammatory bowel disease (n > 1000), eczematous drug eruption (n > 30), drug-associated vasculitis (n = 8), and drug-induced lupus erythematosus (n = 4). Most of these AESI were only mild to moderately severe and resolved after secukinumab discontinuation without or with symptomatic treatment. Secukinumab has the potential to develop a number of AESI by probably dysregulating the different expression of polar T-cell axes (Th1, Th2, Th17, Th22, and/or Treg) and driving various cytokines in some patients. Physicians should be aware of these AESI for timely diagnosis and proper treatment.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Arthritis, Psoriatic/drug therapy ; Humans ; Psoriasis/chemically induced ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; secukinumab (DLG4EML025)
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15599
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