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Article ; Online: Electromagnetic characteristics of antisymmetric toroidal dipole array of plasmonic metasurfaces.

Yu, Yingying / Sun, B O

2023 Volume 31, Issue 20, Page(s) 32311–32321

Abstract: An antisymmetric toroidal dipole array of plasmonic metasurfaces, whose unit cell consisted of a pair of physically connected asymmetric split-ring resonators, is presented in this study. Moreover, a new paradigm was established to control toroidal ... ...

Abstract	An antisymmetric toroidal dipole array of plasmonic metasurfaces, whose unit cell consisted of a pair of physically connected asymmetric split-ring resonators, is presented in this study. Moreover, a new paradigm was established to control toroidal electric dipole properties. Toroidal electric dipoles and electric and magnetic hybrid pseudo-anapole states are excited owing to imperfect and perfect destructive interference, respectively, which leads to the spatial separation of the electric and magnetic fields and a distinct asymmetric Fano line shape in the transmission spectrum. The imperfect destructive interference was further modified by adjusting the relative position between the even and odd layers of the metasurfaces. The scattered power of the toroidal electric dipole is tuned continuously and linearly, which enables the tailoring of the electromagnetic response. The displacement sensitivity is approximately 0.13 GHz/mm over the range 0-8 mm. The modulation depth of the scattered power of the toroidal electric dipole can reach 740%, realising a toroidal electric-dipole-to-electric-dipole transition. The proposed plasmonic metasurfaces provide a platform to efficiently control near-field enhancement, far-field radiation, and electric-magnetic separation and find potential applications in frequency-selective surfaces, sensors, filters, spectroscopic tests, and many other areas.
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.500058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Examining coordination and equilibrium: an analysis of supply index and spatial evolution characteristics for older adult services in Zhejiang Province.

Ji, Hao / Yu, Yingying

Frontiers in public health

2023 Volume 11, Page(s) 1222424

Abstract: Objective: This study aims to analyze the spatial distribution and dynamic evolution of older adult service supply in Zhejiang Province from 2010 to 2019. Additionally, this research seeks to propose an optimized resource allocation strategy for older ... ...

Abstract	Objective: This study aims to analyze the spatial distribution and dynamic evolution of older adult service supply in Zhejiang Province from 2010 to 2019. Additionally, this research seeks to propose an optimized resource allocation strategy for older adult care services, promoting regional fairness and coordinated development. Methods: To evaluate the older adult service supply capacity, this research first constructed an evaluation index system based on the Chinese modernization development pattern. Then, an empirical analysis was carried out using a combination of the entropy-TOPSIS method, kernel density estimation, Markov chain analysis, Dagum Gini coefficient, and panel regression model. Results: The results show an overall upward trend in the supply and service capacity of older adult care in the whole province. However, the spatial distribution of older adult service supply capacity in Zhejiang Province still exhibits a gradient effect, even in the most recent year of 2019. Furthermore, the supply capacity of older adult services shifted to a higher level in the whole province, and regions with high supply capacity had a positive spillover effect on adjacent regions. The overall difference in the older adult service supply capacity of the province showed a decreasing trend. The level of economic development, urbanization rate, transportation capacity, the level of opening up, and the proportion of employees in the tertiary industry had a significant impact on the supply capacity and spatial difference of older adult services. Conclusion: From the findings, this study puts forth countermeasures and suggestions to optimize the spatial distribution of older adult care services. This includes giving full play to the regional spatial linkage effect, promoting new-type urbanization construction, upgrading the transportation network, and expanding the opening up of the industrial structure. By implementing these measures, a more equitable and coordinated older adult services system can be developed in Zhejiang Province.
MeSH term(s)	Aged ; Humans ; Asian People ; China ; Economic Development ; Industry ; Markov Chains ; Resource Allocation ; Health Services for the Aged/supply & distribution ; Spatial Analysis
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1222424
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Article ; Online: Advances of Olfactory Design and Its Applications in Library Studies

YU Yingying, SU Wencheng, WU Junru

Nongye tushu qingbao xuebao, Vol 34, Iss 12, Pp 45-

2022 Volume 54

Abstract: Purpose/Significance] The olfactory experience can influence human emotion and cognition. Space olfactory design enhances our overall activity experience and satisfaction with the whole space environment by awakening our positive emotional feelings and ... ...

Abstract	[Purpose/Significance] The olfactory experience can influence human emotion and cognition. Space olfactory design enhances our overall activity experience and satisfaction with the whole space environment by awakening our positive emotional feelings and promoting the positive nature of behavioral activities. It provides reference and inspiration for the application of spatial olfactory design in public cultural service institutions such as libraries. Therefore, the utility of the olfactory experience for users can be applied to library architectural spaces, so as to increase the loyalty of library users. [Method/Process] This paper used literature research and content analysis method to collect, screen, organize and analyze the related literature on space olfactory design at home and abroad, to review the domestic and international research on the role of space olfactory, and to summarize the research progress and application trends of space olfactory design at home and abroad. The practical application of space olfactory design and the utility of space olfactory experience were analyzed, including the role of space odor design on emotional arousal, memory utility of space-related events and on other sensory behavioral efficiency enhancement, behavioral performance improvement and learning memory capacity improvement. [Results/Conclusions] The study found that international research scenarios on the design of space olfactory were focused mainly on the olfactory experience in special contexts such as learning scenarios and commercial shopping scenarios. In contrast, domestic research on space olfactory design is still at the stage of theoretical exploration, and the empirical research is yet to be explored. Scent marketing in commercial field provides theoretical and practical guidance for library space scent environment design. In addition, in order to create future learning centers based on the perspective of the user's olfactory experience, public libraries need to pay more attention to the consistency of ...
Keywords	space olfactory\|olfactory experience\|olfactory design\|library space ; Bibliography. Library science. Information resources ; Z ; Agriculture ; S
Subject code	027
Language	Chinese
Publishing date	2022-12-01T00:00:00Z
Publisher	Editorial Department of Journal of Library and Information Science in Agriculture
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations between digital literacy, health literacy, and digital health behaviors among rural residents: evidence from Zhejiang, China.

Ji, Hao / Dong, Junqiang / Pan, Weiguang / Yu, Yingying

International journal for equity in health

2024 Volume 23, Issue 1, Page(s) 68

Abstract: Objective: Within the digital society, the limited proficiency in digital health behaviors among rural residents has emerged as a significant factor intensifying health disparities between urban and rural areas. Addressing this issue, enhancing the ... ...

Abstract	Objective: Within the digital society, the limited proficiency in digital health behaviors among rural residents has emerged as a significant factor intensifying health disparities between urban and rural areas. Addressing this issue, enhancing the digital literacy and health literacy of rural residents stands out as a crucial strategy. This study aims to investigate the relationship between digital literacy, health literacy, and the digital health behaviors of rural residents. Methods: Initially, we developed measurement instruments aimed at assessing the levels of digital literacy and health literacy among rural residents. Subsequently, leveraging micro survey data, we conducted assessments on the digital literacy and health literacy of 968 residents in five administrative villages in Zhejiang Province, China. Building upon this foundation, we employed Probit and Poisson models to empirically scrutinize the influence of digital literacy, health literacy, and their interaction on the manifestation of digital health behaviors within the rural population. This analysis was conducted from a dual perspective, evaluating the participation of digital health behaviors among rural residents and the diversity to which they participate in such behaviors. Results: Digital literacy exhibited a notably positive influence on both the participation and diversity of digital health behaviors among rural residents. While health literacy did not emerge as a predictor for the occurrence of digital health behavior, it exerted a substantial positive impact on the diversity of digital health behaviors in the rural population. There were significant interaction effects between digital literacy and health literacy concerning the participation and diversity of digital health behaviors among rural residents. These findings remained robust even after implementing the instrumental variable method to address endogeneity issues. Furthermore, the outcomes of robust analysis and heterogeneity analysis further fortify the steadfastness of the aforementioned conclusions. Conclusion: The findings suggest that policymakers should implement targeted measures aimed at enhancing digital literacy and health literacy among rural residents. This approach is crucial for improving rural residents' access to digital health services, thereby mitigating urban-rural health inequality.
MeSH term(s)	Humans ; Health Literacy ; Rural Population ; Digital Health ; Health Status Disparities ; Health Behavior ; China/epidemiology
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2092056-8
ISSN	1475-9276 ; 1475-9276
ISSN (online)	1475-9276
ISSN	1475-9276
DOI	10.1186/s12939-024-02150-2
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Article ; Online: Nanomedicine sheds new light on cancer immunotherapy

Yu Yingying / Feng Liangzhu / Liu Zhuang

Medical Review, Vol 3, Iss 2, Pp 188-

2023 Volume 192

Abstract: Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective ... ...

Abstract	Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective response rates, particularly against most solid tumors, are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens, limited tumor infiltration of effector immune cells, acquired tumor immunosuppression and some other factors. In recent years, various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms, presenting new promises in many published studies. This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.
Keywords	cancer immunotherapy ; in situ cancer vaccine ; nanomedicine ; nanovaccine ; tumor microenvironment ; Medicine ; R
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determination of Tumor Marker Screening for Lung Cancer Using ROC Curves.

Dou, Xiaofeng / Lu, Jiachen / Yu, Yingying / Yi, Yaohui / Zhou, Ling

Disease markers

2024 Volume 2024, Page(s) 4782618

Abstract: Introduction: Lung cancer ranks first among malignant tumors worldwide and is a leading cause of cancer-related mortality in both men and women. Combining tumor marker testing is a strategy to screen individuals at high risk of pulmonary cancer and ... ...

Abstract	Introduction: Lung cancer ranks first among malignant tumors worldwide and is a leading cause of cancer-related mortality in both men and women. Combining tumor marker testing is a strategy to screen individuals at high risk of pulmonary cancer and minimize pulmonary cancer mortality. Therefore, tumor marker screening is crucial. In this study, we analyzed combinations of tumor markers for lung cancer screening using receiver operating characteristic (ROC) curve analysis. Methods: A retrospective descriptive study was conducted on patients diagnosed with lung cancer, as well as healthy and benign lung diseases, using data from the China Huludao Central Hospital database between January 2016 and July 2022. The Results: In this study, 267 healthy participants, 385 patients with benign lesions, and 296 patients with lung cancer underwent tumor marker screening. The sensitivity of five tumor markers-CEA, CYFRA21-1, NSE, pro-GRP, and CA125-was found to be <55%. This study revealed that a single tumor marker had limited value in lung cancer screening. However, combining two or more markers yielded varying area under the curves (AUC), with no significant impact on screening accuracy. The combination of CEA + CA125 demonstrated the highest accuracy for lung cancer screening in healthy participants. At a cutoff of 0.447 for CEA + CA125, the combination showed a sensitivity of 0.676 and specificity of 0.846 for lung cancer screening. Conversely, for patients with benign lung lesions, the optimal combination was CEA + NSE, with a cutoff of 0.393, yielding a sensitivity of 0.645 and specificity of 0.766 for lung cancer screening. Conclusion: The five tumor markers-CEA, CA125, CY211, NSE, GRP-show promising results in screening healthy individuals and patients with lung cancer. However, only CEA, NSE, and GRP effectively differentiate patients with benign lung lesions from those with lung cancer. A single tumor marker has limited utility in detecting and screening for lung cancer and should be combined with other tumor markers. CEA + CA125 emerges as a superior tumor marker for distinguishing healthy individuals from those with lung cancer, whereas the CEA + NSE combination is more effective in identifying tumor markers in patients with benign lung lesions and lung cancer.
MeSH term(s)	Male ; Humans ; Female ; Lung Neoplasms/diagnosis ; Biomarkers, Tumor ; ROC Curve ; Carcinoembryonic Antigen ; Retrospective Studies ; Early Detection of Cancer ; Antigens, Neoplasm ; Keratin-19
Chemical Substances	Biomarkers, Tumor ; antigen CYFRA21.1 ; Carcinoembryonic Antigen ; Antigens, Neoplasm ; Keratin-19
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2024/4782618
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Prevalence and Determinants of Anxiety and Depression Among Healthcare Workers in Liaoning Province, China.

Lu, Jiachen / Dou, Xiaofeng / Yi, Yaohui / Yu, Yingying / Zhou, Ling

Risk management and healthcare policy

2024 Volume 17, Page(s) 983–993

Abstract: Purpose: To assess the anxiety and depression and their predictors among healthcare workers in Liaoning Province, China.: Methods: In order to explore the influencing factors and prevalence of anxiety and depression among healthcare workers, a cross- ... ...

Abstract	Purpose: To assess the anxiety and depression and their predictors among healthcare workers in Liaoning Province, China. Methods: In order to explore the influencing factors and prevalence of anxiety and depression among healthcare workers, a cross-sectional research design was used to survey 500 healthcare workers using the 14-item Hospital Anxiety Depression Scale (HADS), the Rosenberg Self-Esteem Scale (RSES), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Survey of Perceived Organizational Support (SPOS). Results: About 47.12% of the healthcare workers suffered from anxiety and 71.63% suffered from depression. In our study, we found that the health status (OR: 0.540, 95% CI: 0.298-0.976), self-esteem (OR: 0.395, 95% CI: 0.251-0.619), PSS (OR: 0.621, 95% CI: 0.388-0.994), organizational support (OR: 0.533, 95% CI. 0.333-0.854) were protective factors for healthcare workers suffering from anxiety, and resistance to COVID-19 (OR: 1.703, 95% CI: 1.082-2.681) was a risk factor for healthcare workers suffering from anxiety, while good quality of life (OR: 0.385, 95% CI: 0.206-0.719) self-esteem (OR: 0.187, 95% CI: 0.110-0.317), and PSS (OR: 0.475, 95% CI: 0.267-0.847) were protective factors for healthcare workers suffering from depression, and at the age of 35-40 years (OR: 2.475, 95% CI: 1.140-5.369) and resistance to COVID-19 (OR: 2.219, 95% CI: 1.313-3.751) were risk factors for healthcare workers suffering from depression. Conclusion: The anxiety and depression status of healthcare workers in China is poor, and hospital administrators should take positive measures to support healthcare workers and give positive expectations to alleviate negative emotions such as anxiety and depression.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S460118
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Article ; Online: Spatial distribution and influencing factors of CDC health resources in China: a study based on panel data from 2016-2021.

Yu, Yingying / Lu, Jiachen / Dou, Xiaofeng / Yi, Yaohui / Zhou, Ling

Frontiers in public health

2024 Volume 12, Page(s) 1331522

Abstract: Background: Measuring the development of Chinese centers for disease control and prevention only by analyzing human resources for health seems incomplete. Moreover, previous studies have focused more on the quantitative changes in healthcare resources ... ...

Abstract	Background: Measuring the development of Chinese centers for disease control and prevention only by analyzing human resources for health seems incomplete. Moreover, previous studies have focused more on the quantitative changes in healthcare resources and ignored its determinants. Therefore, this study aimed to analyze the allocation of healthcare resources in Chinese centers for disease control and prevention from the perspective of population and spatial distribution, and to further explore the characteristics and influencing factors of the spatial distribution of healthcare resources. Methods: Disease control personnel density, disease control and prevention centers density, and health expenditures density were used to represent human, physical, and financial resources for health, respectively. First, health resources were analyzed descriptively. Then, spatial autocorrelation was used to analyze the spatial distribution characteristics of healthcare resources. Finally, we used spatial econometric modeling to explore the influencing factors of healthcare resources. Results: The global Moran index for disease control and prevention centers density decreased from 1.3164 to 0.2662 ( Conclusion: There were obvious differences in the spatial distribution of healthcare resources in Chinese centers for disease control and prevention. Social, economic and policy factors can affect healthcare resources. The government should consider the rational allocation of healthcare resources at the macro level.
MeSH term(s)	China ; Humans ; Health Resources/statistics & numerical data ; Health Resources/economics ; Spatial Analysis ; Health Expenditures/statistics & numerical data
Language	English
Publishing date	2024-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1331522
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Article ; Online: Light-Triggered Signal Enhancement Strategy Integrated with a CRISPR/Cas13a-Based Assay for Ultrasensitive and Specific miRNA Detection

Niuyuetaohua / Yu, Yingying / Lin, Yu / Chen, Chuanxia

Analytical Chemistry. 2023 Dec. 11, v. 95, no. 50, p. 18587–18594

2023 , Page(s) 18587

Abstract: The development of facile, accurate, and affordable assays for microRNAs (miRNAs) in early cancer is greatly desirable but encounters an obstacle due to low cellular abundance in biofuids. In this study, we present a novel approach called a light- ... ...

Abstract	The development of facile, accurate, and affordable assays for microRNAs (miRNAs) in early cancer is greatly desirable but encounters an obstacle due to low cellular abundance in biofuids. In this study, we present a novel approach called a light-triggered exponential amplification strategy coupled with a CRISPR/Cas13a-based diagnostic system (LEXPA-CRISPR), which directly transduces rare miRNA targets into photocontrolled signal enhancement response. This innovative platform leverages trans-cleavage of CRISPR/Cas13a, activated by the miRNA target, to cleave specific RNA fragments within the MB@PC-NAC assembly, thus releasing free PC-single-stranded DNA (PC-ssDNA) that is modified by a photocleavable linker (PC linker). UV irradiation is further employed toward the photoresponsive PC-ssDNA, resulting in instantaneous generation of oligo with a new 5′ phosphate group (Pho-ssDNA). The Pho-ssDNA serves as a trigger for rolling circle amplification (RCA) reaction, which generates thousands of long ssDNA repeats of diverse lengths with a strong fluorescence signal. Through optimization, we achieved a detection limit of 1 fM for miR21 without the need for target amplification. Moreover, the programmable versatility of LEXPA-CRISPR is also demonstrated for miR17 determination only with simple modification of CRISPR RNA (crRNA) sequences. This proposed biosensor successfully monitored the levels of miR21 and miR17 in tumor cells, showing a satisfactory consistency with the standard qRT-PCR method. Conclusively, LEXPA-CRISPR represents a promising strategy for ultrasensitive miRNA detection. It combines the advantages of light-triggered signal amplification and robust collateral cleavage activity of Cas13a, making it an attractive tool for practical CRISPR-based diagnostics.
Keywords	DNA ; analytical chemistry ; biosensors ; detection limit ; diagnostic techniques ; fluorescence ; microRNA ; neoplasms ; phosphates ; ultraviolet radiation
Language	English
Dates of publication	2023-1211
Size	p. 18587–18594
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04487
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Light-Triggered Signal Enhancement Strategy Integrated with a CRISPR/Cas13a-Based Assay for Ultrasensitive and Specific miRNA Detection.

Hu, Tao / Yu, Yingying / Lin, Yu / Chen, Chuanxia

Analytical chemistry

2023 Volume 95, Issue 50, Page(s) 18587–18594

Abstract	The development of facile, accurate, and affordable assays for microRNAs (miRNAs) in early cancer is greatly desirable but encounters an obstacle due to low cellular abundance in biofuids. In this study, we present a novel approach called a
MeSH term(s)	Humans ; Biological Assay ; Biosensing Techniques ; DNA, Single-Stranded/genetics ; MicroRNAs/genetics ; Phosphates
Chemical Substances	DNA, Single-Stranded ; MicroRNAs ; Phosphates
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04487
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ab Jg. 2022: Lesesaal (EG)

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