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  1. Article ; Online: Identification of Genes Predicting Poor Response of Trastuzumab in Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer.

    Dong, Xinrui / Dai, Huijuan / Sun, Aijun / Yu, Zhenfeng / Du, Yueyao

    Journal of immunology research

    2022  Volume 2022, Page(s) 9529114

    Abstract: Objective: To identify trastuzumab-resistant genes predicting drug response and poor prognosis in human epidermal growth factor receptor 2 positive (HER2+) breast cancer.: Methods: Gene expression profiles from the GEO (Gene Expression Omnibus) ... ...

    Abstract Objective: To identify trastuzumab-resistant genes predicting drug response and poor prognosis in human epidermal growth factor receptor 2 positive (HER2+) breast cancer.
    Methods: Gene expression profiles from the GEO (Gene Expression Omnibus) database were obtained and analyzed. Differentially expressed genes (DEGs) between the pathological complete response (pCR) group and non-pCR group in a trastuzumab neoadjuvant therapy cohort and DEGs between Herceptin-resistant and wild-type cell lines were detected and evaluated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses were performed to select the functional hub genes. The hub genes' prognostic power was validated by another trastuzumab adjuvant treatment cohort.
    Results: Fifty upregulated overlapping DEGs were identified by analyzing two trastuzumab resistance-related GEO databases. Functional analysis picked out ten hub genes enriched in mitochondrial function and metabolism pathways:
    Conclusion: Ten novel trastuzumab resistance-related genes were discovered, of which
    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Receptor, ErbB-2 ; Trastuzumab/pharmacology ; Trastuzumab/therapeutic use
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2022-07-27
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2022/9529114
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  2. Article: Correction: Yu et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: There was an error in the original publication [ ... ]. ...

    Abstract There was an error in the original publication [...].
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010091
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  3. Article: Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics.

    Yu, Zhenfeng / Eich, Christina / Cruz, Luis J

    Frontiers in chemistry

    2020  Volume 8, Page(s) 496

    Abstract: Fluorescence imaging in the second near infrared window (NIR-II, 1,000-1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial resolution and deep tissue penetration depths. In this work, recent advances in rare-earth- ... ...

    Abstract Fluorescence imaging in the second near infrared window (NIR-II, 1,000-1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial resolution and deep tissue penetration depths. In this work, recent advances in rare-earth-doped nanoparticles (RENPs)-a novel kind of NIR-II nanoprobes-are presented. The main focus of this study is on the modification of RENPs and their applications in NIR-II
    Language English
    Publishing date 2020-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2020.00496
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  4. Article ; Online: Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer.

    Sun, Aijun / Sheng, Xiaonan / Tang, Jinhai / Yu, Zhenfeng / Zhang, Jian

    Journal of immunology research

    2021  Volume 2021, Page(s) 7876489

    Abstract: Breast cancer is the ... ...

    Abstract Breast cancer is the 3
    MeSH term(s) Animals ; Atrial Natriuretic Factor/genetics ; Atrial Natriuretic Factor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Computational Biology/methods ; Extracellular Matrix/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; MCF-7 Cells ; Mice, Nude ; Promoter Regions, Genetic/genetics ; Protein Binding ; Transplantation, Heterologous ; Tumor Burden/genetics ; Mice
    Chemical Substances Kruppel-Like Transcription Factors ; MZF1 protein, human ; NPPA protein, human ; Atrial Natriuretic Factor (85637-73-6)
    Language English
    Publishing date 2021-09-27
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2021/7876489
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  5. Article: Correction: Yu et al. Rare-Earth-Metal (Nd

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy.

    Hao, Yang / Chung, Chih Kit / Yu, Zhenfeng / Huis In 't Veld, Ruben V / Ossendorp, Ferry A / Ten Dijke, Peter / Cruz, Luis J

    Pharmaceutics

    2022  Volume 14, Issue 1

    Abstract: Photodynamic therapy (PDT), in which a light source is used in combination with a photosensitizer to induce local cell death, has shown great promise in therapeutically targeting primary tumors with negligible toxicity and minimal invasiveness. However, ... ...

    Abstract Photodynamic therapy (PDT), in which a light source is used in combination with a photosensitizer to induce local cell death, has shown great promise in therapeutically targeting primary tumors with negligible toxicity and minimal invasiveness. However, numerous studies have shown that noninvasive PDT alone is not sufficient to completely ablate tumors in deep tissues, due to its inherent shortcomings. Therefore, depending on the characteristics and type of tumor, PDT can be combined with surgery, radiotherapy, immunomodulators, chemotherapy, and/or targeted therapy, preferably in a patient-tailored manner. Nanoparticles are attractive delivery vehicles that can overcome the shortcomings of traditional photosensitizers, as well as enable the codelivery of multiple therapeutic drugs in a spatiotemporally controlled manner. Nanotechnology-based combination strategies have provided inspiration to improve the anticancer effects of PDT. Here, we briefly introduce the mechanism of PDT and summarize the photosensitizers that have been tested preclinically for various cancer types and clinically approved for cancer treatment. Moreover, we discuss the current challenges facing the combination of PDT and multiple cancer treatment options, and we highlight the opportunities of nanoparticle-based PDT in cancer therapies.
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14010120
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  7. Article: Rare-Earth-Metal (Nd

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: Here, we describe the synthesis of a novel type of rare-earth-doped nanoparticles (NPs) for multimodal imaging, by combining the rare-earth elements Ce, Gd and Nd in a crystalline host lattice consisting of ... ...

    Abstract Here, we describe the synthesis of a novel type of rare-earth-doped nanoparticles (NPs) for multimodal imaging, by combining the rare-earth elements Ce, Gd and Nd in a crystalline host lattice consisting of CaF
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122796
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  8. Article: Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2022  Volume 14, Issue 4

    Abstract: Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result in a waste of healthcare resources but can even lead to delays in diagnosis and treatment, consequently reducing cure rates. Therefore, it is ...

    Abstract Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result in a waste of healthcare resources but can even lead to delays in diagnosis and treatment, consequently reducing cure rates. Therefore, it is crucial to develop an imaging probe that can provide diagnostic information precisely and rapidly. Here, we used a simple hydrothermal method to design a multimodal imaging probe based on the excellent properties of rare-earth ions. Calcium fluoride co-doped with ytterbium, gadolinium, and neodymium (CaF
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14040840
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  9. Article ; Online: Upconversion nanoparticle platform for efficient dendritic cell antigen delivery and simultaneous tracking.

    Yu, Zhenfeng / Vepris, Olena / Eich, Christina / Feng, Yansong / Que, Ivo / Camps, Marcel G M / Zhang, Hong / Ossendorp, Ferry A / Cruz, Luis J

    Mikrochimica acta

    2022  Volume 189, Issue 10, Page(s) 368

    Abstract: Upconversion nanoparticles (UCNPs) represent a group of NPs that can convert near-infrared (NIR) light into ultraviolet and visible light, thus possess deep tissue penetration power with less background fluorescence noise interference, and do not induce ... ...

    Abstract Upconversion nanoparticles (UCNPs) represent a group of NPs that can convert near-infrared (NIR) light into ultraviolet and visible light, thus possess deep tissue penetration power with less background fluorescence noise interference, and do not induce damage to biological tissues. Due to their unique optical properties and possibility for surface modification, UCNPs can be exploited for concomitant antigen delivery into dendritic cells (DCs) and monitoring by molecular imaging. In this study, we focus on the development of a nano-delivery platform targeting DCs for immunotherapy and simultaneous imaging. OVA 254-267 (OVA24) peptide antigen, harboring a CD8 T cell epitope, and Pam3CysSerLys4 (Pam3CSK4) adjuvant were chemically linked to the surface of UCNPs by amide condensation to stimulate DC maturation and antigen presentation. The OVA24-Pam3CSK4-UCNPs were thoroughly characterized and showed a homogeneous morphology and surface electronegativity, which promoted a good dispersion of the NPs. In vitro experiments demonstrated that OVA24-Pam3CSK4-UCNPs induced a strong immune response, including DC maturation, T cell activation, and proliferation, as well as interferon gamma (IFN-γ) production. In vivo, highly sensitive upconversion luminescence (UCL) imaging of OVA24-Pam3CSK4-UCNPs allowed tracking of UCNPs from the periphery to lymph nodes. In summary, OVA24-Pam3CSK4-UCNPs represent an effective tool for DC-based immunotherapy.
    MeSH term(s) Dendritic Cells ; Light ; Luminescence ; Molecular Imaging ; Nanoparticles/chemistry
    Language English
    Publishing date 2022-09-03
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-022-05441-z
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  10. Article: Photodynamic Therapy in Combination with the Hepatitis B Core Virus-like Particles (HBc VLPs) to Prime Anticancer Immunity for Colorectal Cancer Treatment.

    Hao, Yang / Gu, Zili / Yu, Zhenfeng / Schomann, Timo / Sayedipour, Sana / Aguilar, Julio C / Ten Dijke, Peter / Cruz, Luis J

    Cancers

    2022  Volume 14, Issue 11

    Abstract: Photodynamic therapy (PDT), which combines light and oxygen with a photosensitizer to induce reactive oxygen species (ROS)-mediated killing of primary tumor cells, benefits from non-invasive properties and its negligible toxicity to surrounding healthy ... ...

    Abstract Photodynamic therapy (PDT), which combines light and oxygen with a photosensitizer to induce reactive oxygen species (ROS)-mediated killing of primary tumor cells, benefits from non-invasive properties and its negligible toxicity to surrounding healthy tissues. In this study, we have shown that the second-generation photosensitizer FOSCAN can be internalized by tumor cells and effectively induce tumor cell death when exposed to laser irradiation in vitro. In addition, these dying tumor cells can be phagocytosed by dendritic cells and lead to their activation and maturation as assessed by in vitro co-culture models. While PDT induces immunogenic tumor cell apoptosis, its application for the treatment of tumors located in deep tissues and advanced malignancies has been limited. In this study, we demonstrate that hepatitis B core virus-like particles (HBc VLPs) can serve as a vaccine to enhance PDT-induced anti-cancer immunity by priming humoral immune responses and inducing CD8
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112724
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