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  1. AU="Yu, Zhi-Gao"
  2. AU="Camelia-Maria Monoranu"
  3. AU="Zanette, Dalila Lucíola"
  4. AU="Beaumont, Vahri"
  5. AU="Sorrentino, Gregorio"
  6. AU="Matulionyte, Raimonda"
  7. AU="Afshar, Sabereh"
  8. AU=Armstrong James PK AU=Armstrong James PK
  9. AU="Leshem, Shahaf"
  10. AU="García-García, Ana"
  11. AU="Terrón, Alberto"
  12. AU=Hanel Martin
  13. AU="Saro-Buendía, Miguel"
  14. AU="John R. Kouvaris"
  15. AU="Tripathy, Ashutosh"
  16. AU="Sharpley, Ann L"
  17. AU="Kragt, Lea"
  18. AU="Cui, Yanyan"
  19. AU="Morton, Jennifer P"

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  1. Artikel ; Online: Phenanthroline-Decorated Covalent Organic Framework for Catalytic Synthesis of 2-Aminobenzothiazoles in Water.

    Wang, Jian-Cheng / Yu, Zhi-Gao / Yang, Wen-Ting / Du, Jia-Qi / Chen, Zhi / Kan, Jing-Lan / Dong, Ying / Dong, Yu-Bin

    ChemPlusChem

    2023  Band 89, Heft 4, Seite(n) e202300494

    Abstract: 2-Aminobenzothiazoles are widely used in the fields of pharmaceuticals and pesticides. Herein, we report a metal-free protocol for the preparation of 2-aminobenzothiazoles by a covalent organic framework (COF) catalyzed tandem reaction. In the presence ... ...

    Abstract 2-Aminobenzothiazoles are widely used in the fields of pharmaceuticals and pesticides. Herein, we report a metal-free protocol for the preparation of 2-aminobenzothiazoles by a covalent organic framework (COF) catalyzed tandem reaction. In the presence of catalytic amount of phenanthroline-decorated COF (Phen-COF), a variety of 2-aminobenzothiazoles are obtained in excellent yields by the cross-coupling of 2-iodoanilines with isothiocyanates at room temperature in water. In addition, the COF-catalyst is very stable and can be reused at least seven times without loss of its catalytic activity.
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202300494
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Establishment of a swine model of traumatic cardiac arrest induced by haemorrhage and ventricular fibrillation

    Peng Shen / Jie-Feng Xu / Yu-Zhi Gao / Sen-Lin Xia / Shao-Yun Liu / Mao Zhang

    Journal of International Medical Research, Vol

    2020  Band 48

    Abstract: Objective To establish and evaluate a swine model of traumatic cardiac arrest (TCA) induced by haemorrhage and ventricular fibrillation. Methods Thirteen male pigs were divided into a sham group ( n = 5) and TCA group ( n = 8). Animals in the sham- ... ...

    Abstract Objective To establish and evaluate a swine model of traumatic cardiac arrest (TCA) induced by haemorrhage and ventricular fibrillation. Methods Thirteen male pigs were divided into a sham group ( n = 5) and TCA group ( n = 8). Animals in the sham-operated group underwent intubation and monitoring but not haemorrhage and resuscitation, while animals in the TCA group underwent 40% blood volume haemorrhage over 20 min followed by 5 min of ventricular fibrillation and 5 min of cardiopulmonary resuscitation with fluid resuscitation. Results Restoration of spontaneous circulation was achieved in seven of eight animals in the TCA group. After resuscitation, the heart rate was significantly increased while the mean arterial pressure and ejection fraction were significantly decreased in the TCA group. The TCA group had significant cardiac and neurological injuries post-resuscitation and had higher serum creatinine and blood lactic acid levels and lower PaO 2 than the sham group. Animals in the TCA group also exhibited significantly higher apoptotic indices and caspase-3 protein levels in the heart, brain and kidney than the sham group. Conclusion Animals in this swine model of TCA exhibited high rates of successful resuscitation, significant vital organ injury and prolonged survival. The model is suitable for use in further TCA research.
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Metalloporphyrin and Ionic Liquid-Functionalized Covalent Organic Frameworks for Catalytic CO

    Ding, Luo-Gang / Yao, Bing-Jian / Wu, Wen-Xiu / Yu, Zhi-Gao / Wang, Xiao-Yu / Kan, Jing-Lan / Dong, Yu-Bin

    Inorganic chemistry

    2021  Band 60, Heft 16, Seite(n) 12591–12601

    Abstract: We report the construction of a porphyrin and imidazolium-ionic liquid (IL)-decorated and quinoline-linked covalent organic framework (COF, abbreviated ... ...

    Abstract We report the construction of a porphyrin and imidazolium-ionic liquid (IL)-decorated and quinoline-linked covalent organic framework (COF, abbreviated as
    Sprache Englisch
    Erscheinungsdatum 2021-08-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c01975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Antitumor effect of capsaicin on colorectal carcinoma xenograft in nude mice].

    Zhu, Li-li / Hu, Wan-le / Zhang, Lin-jun / Yu, Zhi-gao / Huang, Chong-jie / Jiang, Ming-zhe / Teng, Ming-xing / Liu, Jian-lu / Liu, Chang-bao

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2013  Band 35, Heft 4, Seite(n) 256–261

    Abstract: Objective: To evaluate the effect of capsaicin on nude mice xenografted with colorectal carcinoma cells, and to explore its mechanism of action.: Methods: A nude mouse model of colorectal cancer was established by subcutaneous inoculation of human ... ...

    Abstract Objective: To evaluate the effect of capsaicin on nude mice xenografted with colorectal carcinoma cells, and to explore its mechanism of action.
    Methods: A nude mouse model of colorectal cancer was established by subcutaneous inoculation of human colorectal carcinoma HT-29 cells. Terminal deoxynucleotidyl transferase-mediated nicked labeling assay (TUNEL) was undertaken to detect the cell proliferation and apoptosis in the xenograft tissue in nude mice. Immunohistochemical (IHC) staining and Western blot were used to detect the expression of HSP27, Cyt-C and active caspase-3.
    Results: The tumor growth of the groups C10 and C20 was significantly slower than that of the group NS. The integrated optical density (IOD) of both the group C5 (2532.14 ± 578.11) and group C10 (6364.03 ± 1137.98) was significantly higher than that of the group NS (760.12 ± 238.05), (P < 0.05). The integrated optical density (IOD) of the group C20 was (15743.96 ± 1855.95), significantly higher than that of the groups C10, C5 and NS (all were P < 0.01). Immunohistochemistry showed that the cytoplasmic expression of HSP27 was strongly positive in the group NS, and significantly reduced with the increasing dose of capsaicin in the treated groups. The expression of active caspase-3 and Cyt-C in the group NS was weakly positive, and was significantly increased with the increasing dose of capsaicin in the groups C5 and C10 (P < 0.05), and the expression of active caspase-3 and Cyt-C of the group C20 was significantly higher than that of the groups C5, C10 and NS (P < 0.01). Western blot analysis showed that both the expressions of HSP27 of the group C5 (0.73 ± 0.05) and the group C10 (0.41 ± 0.03) were significantly lower than that of the group NS (P < 0.05). The expression of HSP27 of the group C20 (0.22 ± 0.06) was significantly lower than that of the groups C5, C10 and NS (P < 0.01). The expressions of active-caspase-3 and Cyt-C in the group C5 were (2.57 ± 0.34) and (2.03 ± 0.38), significantly higher than those of the group NS (P < 0.05). The expressions of active-caspase-3 and Cyt-C in the group C10 were (4.23 ± 0.45) and (3.13 ± 0.44), also significantly higher than those of the group NS (P < 0.05). The expressions of active-caspase-3 and Cyt-C in the group C20 were (5.78 ± 0.48) and (4.92 ± 0.52), significantly higher than those of the group C5, C10 and NS (P < 0.01). TUNEL analysis showed that there was a significant difference of cell apoptosis in comparison of each two groups. The higher dose of capsaicin was used, the more apoptosis was observed.
    Conclusions: Capsaicin can significantly inhibit the tumor growth and induce cell apoptosis in the colorectal carcinoma xenograft in nude mice. Its mechanism of action is possibly related with the down-regulation of HSP27 expression and up-regulation of expression of active caspase-3 and Cyt-C in the colorectal carcinoma xenograft in nude mice.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Capsaicin/administration & dosage ; Capsaicin/pharmacology ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Cytochrome c Group/metabolism ; Dose-Response Relationship, Drug ; Female ; HSP27 Heat-Shock Proteins/metabolism ; HT29 Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Transplantation ; Random Allocation ; Tumor Burden ; Xenograft Model Antitumor Assays
    Chemische Substanzen Antineoplastic Agents, Phytogenic ; Cytochrome c Group ; HSP27 Heat-Shock Proteins ; HSPB1 protein, human ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Capsaicin (S07O44R1ZM)
    Sprache Chinesisch
    Erscheinungsdatum 2013-04
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.issn.0253-3766.2013.04.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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