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  1. Book: Special issue: Mushroom and health

    Yu, Zhiling

    (Current topics in nutraceutical research ; 10,1)

    2012  

    Title variant Mushroom and health
    Author's details guest ed. Zhiling Yu
    Series title Current topics in nutraceutical research ; 10,1
    Collection
    Language English
    Size VI, 86 S. : Ill., graph. Darst.
    Publisher New Century Health Publ
    Publishing place New Orleans, LA
    Publishing country United States
    Document type Book
    HBZ-ID HT017256895
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  2. Article ; Online: A critical review on intestinal mucosal barrier protection effects of dietary polysaccharides.

    Yan, Weiqi / Luo, Jinhai / Yu, Zhiling / Xu, Baojun

    Food & function

    2024  Volume 15, Issue 2, Page(s) 481–492

    Abstract: Studies have shown that dietary polysaccharides, which are widely present in natural foods, have an important impact on the intestinal mucosal barrier. Dietary polysaccharides can maintain the intestinal barrier function through multiple mechanisms. The ... ...

    Abstract Studies have shown that dietary polysaccharides, which are widely present in natural foods, have an important impact on the intestinal mucosal barrier. Dietary polysaccharides can maintain the intestinal barrier function through multiple mechanisms. The intestinal barrier is composed of mechanical, chemical, immune, and biological barriers, and dietary polysaccharides, as a bioactive component, can promote and regulate these four barriers. Dietary polysaccharides can enhance the expression of tight junction proteins and mucins such as occludin-1 and zonula occludens-1 (ZO-1) between intestinal epithelial cells, inhibit inflammatory response and oxidative stress, increase the growth of beneficial bacteria, produce beneficial metabolites such as short chain fatty acids (SCFAs), and promote the proliferation and metabolism of immune cells. Given the critical role of the intestinal mucosal system in health and disease, the protective effects of dietary polysaccharides may be potentially valuable for the prevention and treatment of gut-related diseases. Therefore, it is of great significance to further study the mechanism and application prospects of the intestinal mucosal barrier derived from plant, animal, fungal and bacterial sources.
    MeSH term(s) Animals ; Polysaccharides/pharmacology ; Polysaccharides/metabolism ; Intestinal Mucosa/metabolism ; Epithelial Cells ; Tight Junction Proteins/genetics ; Tight Junction Proteins/metabolism ; Occludin/genetics ; Occludin/metabolism
    Chemical Substances Polysaccharides ; Tight Junction Proteins ; Occludin
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03412g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Insights into prevention mechanisms of bioactive components from healthy diets against Alzheimer's disease.

    Wang, Jingwen / Yu, Zhiling / Peng, Ye / Xu, Baojun

    The Journal of nutritional biochemistry

    2023  Volume 119, Page(s) 109397

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease in which senile plaques, neurofibrillary tangles, insulin resistance, oxidative stress, chronic neuroinflammation, and abnormal neurotransmission are the potential mechanisms involved in ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease in which senile plaques, neurofibrillary tangles, insulin resistance, oxidative stress, chronic neuroinflammation, and abnormal neurotransmission are the potential mechanisms involved in its onset and development. Although it is still an intractable disorder, diet intervention has been developed as an innovative strategy for AD prevention. Some bioactive compounds and micronutrients from food, including soy isoflavones, rutin, vitamin B1, etc., have exhibited numerous neuronal health-promoting effects in both in vivo and in vitro studies. It is well known that their antiapoptotic, antioxidative, and anti-inflammatory properties prevent the neuronal or glial cells from injury or death, minimize oxidative damage, inhibit the production of proinflammatory cytokines by modulating typical signaling pathways of MAPK, NF-kβ, and TLR, and further reduce Aβ genesis and tau hyperphosphorylation. However, parts of the dietary components trigger AD-related proteins productions and inflammasome as well as inflammatory gene upregulation. This review summarized the neuroprotective or nerve damage-promoting role and underlying molecular mechanisms of flavonoids, vitamins, and fatty acids via the data from library databases, PubMed, and journal websites, which provides a comprehensive analysis of the prevention potential of these dietary components against AD.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Neurodegenerative Diseases ; Diet, Healthy ; Antioxidants/metabolism ; Oxidative Stress
    Chemical Substances Antioxidants
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2023.109397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Two New Isoprenylated Flavones from Roots of Artocarpus styracifolius

    Zhu, Lingzhi / Yu, Zhiling / Zhong, Guoyue / Ren, Gang

    Chemistry of natural compounds. 2022 May, v. 58, no. 3

    2022  

    Abstract: Two new isoprenylated flavones, named styracifolins E and F (1 and 2), were isolated from the roots of Artocarpus styracifolius. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, UV, IR, and HR-ESI-MS. ...

    Abstract Two new isoprenylated flavones, named styracifolins E and F (1 and 2), were isolated from the roots of Artocarpus styracifolius. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, UV, IR, and HR-ESI-MS.
    Keywords Artocarpus ; chemistry ; flavones
    Language English
    Dates of publication 2022-05
    Size p. 426-428.
    Publishing place Springer US
    Document type Article
    ZDB-ID 213866-9
    ISSN 0009-3130
    ISSN 0009-3130
    DOI 10.1007/s10600-022-03701-1
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway.

    Luo, Jinhai / Yu, Zhiling / Tovar, Juscelino / Nilsson, Anne / Xu, Baojun

    Pharmacological research

    2022  Volume 184, Page(s) 106461

    Abstract: Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by ... ...

    Abstract Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex, and the up-regulation of Wnt ligands, its cell surface receptor and Wnt antagonist. In this review, the literature on the anti-obesity effect of phytochemicals through Wnt/β-catenin signaling pathway is collected from Google Scholar, Scopus, PubMed, and Web of Science, and summarizes the regulation mechanism of phytochemicals in this pathway. As one of the alternative methods of weight loss drugs, Phytochemicals inhibit adipogenesis through Wnt/β-catenin signaling pathway. More progress in relevant fields may pose phytochemicals as the main source of anti-obesity treatment.
    MeSH term(s) 3T3-L1 Cells ; Adipocytes/metabolism ; Adipogenesis ; Animals ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use ; Cell Differentiation ; Lipids ; Mice ; Obesity/drug therapy ; Obesity/metabolism ; PPAR gamma/metabolism ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Saponins/pharmacology ; Terpenes/metabolism ; Terpenes/pharmacology ; Transcription Factors/metabolism ; Wnt Signaling Pathway ; beta Catenin/metabolism
    Chemical Substances Anti-Obesity Agents ; Lipids ; PPAR gamma ; Phytochemicals ; Saponins ; Terpenes ; Transcription Factors ; beta Catenin
    Language English
    Publishing date 2022-09-21
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficacy and safety of Si-Jun-Zi-Tang-based therapies for functional (non-ulcer) dyspepsia: a meta-analysis of randomized controlled trials.

    Wang, Yaping / Liu, Bin / Fu, Xiuqiong / Tong, Tiejun / Yu, Zhiling

    BMC complementary medicine and therapies

    2021  Volume 21, Issue 1, Page(s) 11

    Abstract: Background: The traditional Chinese medicine formula Si-Jun-Zi-Tang (SJZT) has a long history of application in the treatment of functional dyspepsia (non-ulcer dyspepsia, FD)-like symptoms. SJZT-based therapies have been claimed to be beneficial in ... ...

    Abstract Background: The traditional Chinese medicine formula Si-Jun-Zi-Tang (SJZT) has a long history of application in the treatment of functional dyspepsia (non-ulcer dyspepsia, FD)-like symptoms. SJZT-based therapies have been claimed to be beneficial in managing FD. This study aimed to assess the efficacy and safety of SJZT-based therapies in treating FD by meta-analysis.
    Methods: Systematic searches for RCTs were conducted in seven databases (up to February 2019) without language restrictions. Data were analyzed using Cochrane RevMan software version 5.3.0 and Stata software version 13.1, and reported as relative risk (RR) or odds ratio (OR) with 95% confidence intervals (CIs). The primary outcome was response rate and the secondary outcomes were gastric emptying, quality of life, adverse effects and relapse rate. The quality of evidence was evaluated according to criteria from the Cochrane risk of bias.
    Results: A total of 341 potentially relevant publications were identified, and 12 RCTs were eligible for inclusion. For the response rate, there was a statically significant benefit in favor of SJZT-based therapies (RR = 1.23; 95% CI 1.17 to 1.30). However, the benefit was limited to modified SJZT (MSJZT). The relapse rate of FD patients received SJZT-based therapies was lower than that of patients who received conventional medicines (OR = 0.23; 95% CI 0.10 to 0.51). No SJZT-based therapies-related adverse effect was reported.
    Conclusion: SJZT-based prescriptions may be effective in treating FD and no serious side-effects were identified, but the effect on response rate appeared to be limited to MSJZT. The results should be interpreted with caution as all the included studies were considered at a high risk of bias. Standardized, large-scale and strictly designed RCTs are needed to further validate the benefits of SJZT-based therapies for FD management.
    Trial registration: Systematic review registration: [PROSPERO registration: CRD42019139136 ].
    MeSH term(s) Drugs, Chinese Herbal/therapeutic use ; Dyspepsia/drug therapy ; Humans ; Phytotherapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Drugs, Chinese Herbal ; si-jun-zi-tang
    Language English
    Publishing date 2021-01-06
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-020-03176-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis.

    Khan, Shakeel Ahmad / Wu, Ying / Li, Amy Sze-Man / Fu, Xiu-Qiong / Yu, Zhi-Ling

    BMC complementary medicine and therapies

    2022  Volume 22, Issue 1, Page(s) 275

    Abstract: Background: Atopic dermatitis (AD) is a common inflammatory skin disease that compromises the skin's barrier function and capacity to retain moisture. Cnidii Fructus (CF), the dried fruits of Cnidium monnieri, has long been used to treat atopic ... ...

    Abstract Background: Atopic dermatitis (AD) is a common inflammatory skin disease that compromises the skin's barrier function and capacity to retain moisture. Cnidii Fructus (CF), the dried fruits of Cnidium monnieri, has long been used to treat atopic dermatitis (AD) in China. However, the anti-AD compounds and mechanisms of CF are not fully understood. In this study, we evaluated the active compounds and molecular targets of CF in treating AD.
    Methods: The Traditional Chinese Medicine Systems Pharmacology database was used to acquire information regarding the compounds that occur in the herb. Targets of these compounds were predicted using the SwissTargetPrediction website tool. AD-related genes were collected from the GeneCards database. Gene ontology (GO) enrichment analysis and KEGG pathway analysis of proteins that are targeted by active compounds of CF and encoded by AD-related genes were performed using Database for Annotation, Visualization, and Integrated Discovery Bioinformatics Resources. A "compound-target" network was constructed and analyzed using Cytoscape Software. Molecular docking was performed using BIOVIA Discovery Studio Visualizer and AutoDock Vina.
    Results: We identified 19 active compounds in CF, 532 potential targets for these compounds, and 1540 genes related to AD. Results of GO enrichment indicated that CF affects biological processes and molecular functions, such as inflammatory response and steroid hormone receptor activity, which may be associated with its anti-AD effects. KEGG pathway analyses showed that PI3K-Akt signaling, calcium signaling, Rap1 signaling, and cAMP signaling pathways are the main pathways involved in the anti-AD effects of CF. Molecular docking analyses revealed that the key active compounds in CF, such as (E)-2,3-bis(2-keto-7-methoxy-chromen-8-yl)acrolein, ar-curcumene, and diosmetin, can bind the main therapeutic targets AKT1, SRC, MAPK3, EGFR, CASP3, and PTGS2.
    Conclusions: Results of the present study establish a foundation for further investigation of the anti-AD compounds and mechanisms of CF and provide a basis for developing modern anti-AD agents based on compounds that occur in CF.
    MeSH term(s) Molecular Docking Simulation ; Caspase 3 ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Fruit ; Dermatitis, Atopic/drug therapy ; Cyclooxygenase 2 ; Network Pharmacology ; Acrolein ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Steroids ; Hormones ; ErbB Receptors
    Chemical Substances Caspase 3 (EC 3.4.22.-) ; Drugs, Chinese Herbal ; Cyclooxygenase 2 (EC 1.14.99.1) ; Acrolein (7864XYD3JJ) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Steroids ; Hormones ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-022-03734-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.

    Amin, Aftab / Wu, Rentian / Khan, Muhammad Ajmal / Cheung, Man Hei / Liang, Yanting / Liu, Changdong / Zhu, Guang / Yu, Zhi-Ling / Liang, Chun

    Life science alliance

    2023  Volume 6, Issue 3

    Abstract: Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (pre-RCs). ORC ... ...

    Abstract Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (pre-RCs). ORC and Noc3p bind replication origins throughout the cell cycle, providing a platform for pre-RC assembly. We previously reported that cell cycle-dependent ORC dimerization is essential for the chromatin loading of the symmetric MCM double-hexamers. Here, we used
    MeSH term(s) Cell Cycle/genetics ; Dimerization ; DNA Replication/genetics ; Origin Recognition Complex/genetics ; Origin Recognition Complex/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Protein Multimerization/genetics ; Protein Multimerization/physiology ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/physiology ; Nuclear Proteins/genetics ; Nuclear Proteins/physiology
    Chemical Substances Origin Recognition Complex ; Saccharomyces cerevisiae Proteins ; NOC3 protein, S cerevisiae ; Nucleocytoplasmic Transport Proteins ; Nuclear Proteins
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sea bass (Lateolabrax maculatus) accelerates wound healing: A transition from inflammation to proliferation.

    Chen, Jiali / Jayachandran, Muthukumaran / Xu, Baojun / Yu, Zhiling

    Journal of ethnopharmacology

    2019  Volume 236, Page(s) 263–276

    Abstract: Ethnopharmacological relevance: Sea bass (Lateolabrax maculatus) has been used for dietary therapy practice for wound healing of puerperal or surgery patients in China. Traditional Chinese medicinal books also documented that sea bass can be used to ... ...

    Abstract Ethnopharmacological relevance: Sea bass (Lateolabrax maculatus) has been used for dietary therapy practice for wound healing of puerperal or surgery patients in China. Traditional Chinese medicinal books also documented that sea bass can be used to manage inflammation-associated conditions such as wound, miscarriage and cough. Some studies also proved that dietary supplement with fish benefited for treating many inflammatory - associated conditions, such as cardiovascular disease, ulcerative colitis and hyperlipidemia. However, the studies on the pharmacological mechanisms of wound healing efficacy of sea bass remain lack of investigation.
    Aim of the study: The aim of this study is to investigate the molecular mechanisms of sea bass on wound healing efficacy. Establishing a further justification for clinical application of aqueous extract of sea bass (ASB) in treating wound healing.
    Materials and methods: Transition from inflammation to proliferation phase treated as the critical step in wound repair which were investigated via in vitro and in vivo study. A series of inflammatory mediators associated with wound healing and proliferation effects of fibroblasts upon treatments were studied via Western blotting, enzyme-linked immunosorbent assay (ELISA), real time reverse transcription-polymerase chain reaction (RT-PCR) and scratch assay. The cutaneous wound model was applied on skin wound healing study to observe the healing process in C57BL/6 mice upon ASB treatments. Hematological parameters and tumor necrosis factor-α (TNF-α) secretions in serum were determined. Histopathological examinations were conducted by hematoxylin and eosin (H&E) staining and Masson staining. Immunofluorescence were performed to identify infiltrating neutrophils (MPO) and α-smooth muscle actin (α-SMA).
    Results: Results showed that ASB significantly reduced the production of inflammatory mediators cyclooxygenase-2 (COX-2), nitrite oxide (NO) production and TNF-α. The phosphorylation and nuclear protein levels of transcription factor nuclear factor-κB (NF-ĸB) in toll-like receptor 4 (TLR4) signaling were decreased by ASB treatment as well. Wound closure rate and cyclin D1 expression level of fibroblasts were significantly increased by ASB treatments. Moreover, cutaneous wound model in C57BL/6 mice presented many similarities in appearance to the process of wound healing.
    Conclusions: The in vitro study demonstrated an inhibitory effect of ASB on the inflammatory mediators regulated by TLR4 signaling pathways, providing evidence that ASB treatment potentially accelerate the wound healing through migration and proliferation enhancement. Additionally, the in vivo study suggested that ASB treatment has a potential in accelerating the proliferation phase of wound healing via well-organized abundant collagen deposition, angiogenesis and re-epithelialization in wounds. The present findings can be treated as a pharmacological basis for the folk use of sea bass and further studies in biological and medical fields.
    MeSH term(s) Animals ; Bass ; Cell Proliferation/physiology ; Collagen/metabolism ; Disease Models, Animal ; Humans ; Inflammation/blood ; Inflammation/diet therapy ; Male ; Medicine, Chinese Traditional/methods ; Mice ; Mice, Inbred C57BL ; Neovascularization, Physiologic/physiology ; RAW 264.7 Cells ; Seafood ; Signal Transduction/physiology ; Skin/blood supply ; Skin/injuries ; Skin/metabolism ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/blood ; Wound Healing/physiology
    Chemical Substances Tlr4 protein, mouse ; Tnf protein, mouse ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; Collagen (9007-34-5)
    Language English
    Publishing date 2019-03-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis

    Khan, Shakeel Ahmad / Wu, Ying / Li, Amy Sze-Man / Fu, Xiu-Qiong / Yu, Zhi-Ling

    BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.275-275

    2022  

    Abstract: BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease that compromises the skin's barrier function and capacity to retain moisture. Cnidii Fructus (CF), the dried fruits of Cnidium monnieri, has long been used to treat atopic ... ...

    Abstract BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease that compromises the skin's barrier function and capacity to retain moisture. Cnidii Fructus (CF), the dried fruits of Cnidium monnieri, has long been used to treat atopic dermatitis (AD) in China. However, the anti-AD compounds and mechanisms of CF are not fully understood. In this study, we evaluated the active compounds and molecular targets of CF in treating AD. METHODS: The Traditional Chinese Medicine Systems Pharmacology database was used to acquire information regarding the compounds that occur in the herb. Targets of these compounds were predicted using the SwissTargetPrediction website tool. AD-related genes were collected from the GeneCards database. Gene ontology (GO) enrichment analysis and KEGG pathway analysis of proteins that are targeted by active compounds of CF and encoded by AD-related genes were performed using Database for Annotation, Visualization, and Integrated Discovery Bioinformatics Resources. A “compound-target” network was constructed and analyzed using Cytoscape Software. Molecular docking was performed using BIOVIA Discovery Studio Visualizer and AutoDock Vina. RESULTS: We identified 19 active compounds in CF, 532 potential targets for these compounds, and 1540 genes related to AD. Results of GO enrichment indicated that CF affects biological processes and molecular functions, such as inflammatory response and steroid hormone receptor activity, which may be associated with its anti-AD effects. KEGG pathway analyses showed that PI3K-Akt signaling, calcium signaling, Rap1 signaling, and cAMP signaling pathways are the main pathways involved in the anti-AD effects of CF. Molecular docking analyses revealed that the key active compounds in CF, such as (E)-2,3-bis(2-keto-7-methoxy-chromen-8-yl)acrolein, ar-curcumene, and diosmetin, can bind the main therapeutic targets AKT1, SRC, MAPK3, EGFR, CASP3, and PTGS2. CONCLUSIONS: Results of the present study establish a foundation for further investigation of the anti-AD compounds and mechanisms of CF and provide a basis for developing modern anti-AD agents based on compounds that occur in CF.
    Keywords Cnidium monnieri ; Internet ; Oriental traditional medicine ; acrolein ; atopic dermatitis ; bioinformatics ; calcium ; complement ; computer software ; gene ontology ; inflammation ; pharmacology ; prediction ; steroid hormone receptors ; therapeutics ; China
    Language English
    Dates of publication 2022-12
    Size p. 275.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2662-7671
    DOI 10.1186/s12906-022-03734-7
    Database NAL-Catalogue (AGRICOLA)

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