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Article ; Online: Establishing a novel ternary complex of soybean protein isolated-tannic acid-magnesium ion and its properties.

Xu, Qian-Da / Yu, Zhi-Long / He, Qiang / Zeng, Wei-Cai

2024 Volume 446, Page(s) 138861

Abstract: A ternary complex composed of soybean protein isolated (SPI), tannic acid (TA) and magnesium ion (M) was established to enhance the capability of protein carriers for TA delivery. SPI was firstly covalently bind with TA (TA-SPI) and then M was employed ... ...

Abstract	A ternary complex composed of soybean protein isolated (SPI), tannic acid (TA) and magnesium ion (M) was established to enhance the capability of protein carriers for TA delivery. SPI was firstly covalently bind with TA (TA-SPI) and then M was employed to form the ternary complex (M-TA-SPI). Their structures, gel and digestion properties were further investigated. TA was observed to covalently bind with SPI. TA-SPI and M-TA-SPI complexes showed different molecule size and spatial structures after binding with M and TA. The increasing of TA amount changed the intramolecular interactions, microstructure and texture properties of M-TA-SPI gels. Compared with TA-SPI, M retarded the gastric digestion of M-TA-SPI and caused higher TA release amount in intestinal tract. In this study, M-TA-SPI was determined to be a good carrier to protect and release TA in gastrointestinal digestion. This kind of complex may have potential applications for loading polyphenols in nutraceuticals.
MeSH term(s)	Soybean Proteins/chemistry ; Magnesium ; Polyphenols
Chemical Substances	Soybean Proteins ; Tannic Acid ; Magnesium (I38ZP9992A) ; Polyphenols
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138861
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Article ; Online: Therapeutic potentials of FexMoyS-PEG nanoparticles in colorectal cancer: a multimodal approach via ROS-ferroptosis-glycolysis regulation.

Yu, Zhilong / Wang, Chenyi / Ye, Yingjiang / Wang, Shan / Jiang, Kewei

Journal of nanobiotechnology

2024 Volume 22, Issue 1, Page(s) 253

Abstract: Improving cancer therapy by targeting the adverse tumor microenvironment (TME) rather than the cancer cells presents a novel and potentially effective strategy. In this study, we introduced ... ...

Abstract	Improving cancer therapy by targeting the adverse tumor microenvironment (TME) rather than the cancer cells presents a novel and potentially effective strategy. In this study, we introduced Fe
MeSH term(s)	Animals ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/drug therapy ; Reactive Oxygen Species/metabolism ; Humans ; Mice ; Polyethylene Glycols/chemistry ; Ferroptosis/drug effects ; Glycolysis/drug effects ; Cell Line, Tumor ; Tumor Microenvironment/drug effects ; Nanoparticles/chemistry ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C ; Mice, Nude ; Apoptosis/drug effects ; Cell Survival/drug effects ; Female ; Glutathione/metabolism
Language	English
Publishing date	2024-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-024-02515-3
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Article: Flexible cellulose nanocrystal-based bionanocomposite film as a smart photonic material responsive to humidity

Yu, Zhilong / Wang, Kaidi / Lu, Xiaonan

International journal of biological macromolecules. 2021 Oct. 01, v. 188

2021

Abstract: A flexible bionanocomposite film with a visible structural color was developed by co-assembling cellulose nanocrystals with glycerol, glucose, and poly(vinyl alcohol), and its application as a photonic humidity-responsive material was investigated. This ... ...

Abstract	A flexible bionanocomposite film with a visible structural color was developed by co-assembling cellulose nanocrystals with glycerol, glucose, and poly(vinyl alcohol), and its application as a photonic humidity-responsive material was investigated. This chiral nematic film exhibited an indigo, cyan, olive green, orange, pink, and transparent color when exposed to relative humidity of 33%, 75%, 85%, 89%, 96%, and 100%, respectively. The color change was caused by reversible change in chiral nematic pitch due to hydration and dehydration. The nanocomposite displayed a stable structural color after alternatively conditioned at 33% and 100% relative humidity for ten cycles. Notably, material cost for a piece of such a smart film with an area of 28 cm² is less than $0.1 USD. This flexible, uniform bionanocomposite film has great potential to be used as a smart photonic material responsive to humidity.
Keywords	cellulose ; color ; glucose ; glycerol ; indigo ; nanocomposites ; nanocrystals ; photons ; relative humidity
Language	English
Dates of publication	2021-1001
Size	p. 385-390.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.08.049
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Article ; Online: Application of Raman Spectroscopic Methods in Food Safety: A Review.

Petersen, Marlen / Yu, Zhilong / Lu, Xiaonan

Biosensors

2021 Volume 11, Issue 6

Abstract: Food detection technologies play a vital role in ensuring food safety in the supply chains. Conventional food detection methods for biological, chemical, and physical contaminants are labor-intensive, expensive, time-consuming, and often alter the food ... ...

Abstract	Food detection technologies play a vital role in ensuring food safety in the supply chains. Conventional food detection methods for biological, chemical, and physical contaminants are labor-intensive, expensive, time-consuming, and often alter the food samples. These limitations drive the need of the food industry for developing more practical food detection tools that can detect contaminants of all three classes. Raman spectroscopy can offer widespread food safety assessment in a non-destructive, ease-to-operate, sensitive, and rapid manner. Recent advances of Raman spectroscopic methods further improve the detection capabilities of food contaminants, which largely boosts its applications in food safety. In this review, we introduce the basic principles of Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), and micro-Raman spectroscopy and imaging; summarize the recent progress to detect biological, chemical, and physical hazards in foods; and discuss the limitations and future perspectives of Raman spectroscopic methods for food safety surveillance. This review is aimed to emphasize potential opportunities for applying Raman spectroscopic methods as a promising technique for food safety detection.
MeSH term(s)	Dietary Supplements ; Food Contamination ; Food Safety/methods ; Spectrum Analysis, Raman/methods
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios11060187
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Article ; Online: Low power consumption grating magneto-optical trap based on planar elements.

Yu, Zhilong / Zhu, Yumeng / Yao, Minghao / Qi, Feng / Chen, Liang / Zou, Chang-Ling / Duan, Junyi / Liu, Xiaochi

Optics express

2024 Volume 32, Issue 6, Page(s) 8919–8928

Abstract: The grating-based magneto-optical trap (GMOT) is a promising approach for miniaturizing cold-atom systems. However, the power consumption of a GMOT system dominates its feasibility in practical applications. In this study, we demonstrated a GMOT system ... ...

Abstract	The grating-based magneto-optical trap (GMOT) is a promising approach for miniaturizing cold-atom systems. However, the power consumption of a GMOT system dominates its feasibility in practical applications. In this study, we demonstrated a GMOT system based on planar elements that can operate with low power consumption. A high-diffraction-efficiency grating chip was used to cool atoms with a single incident beam. A planar coil chip was designed and fabricated with a low power consumption nested architecture. The grating and coil chips were adapted to a passive pump vacuum chamber, and up to 10
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.518268
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Article ; Online: Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma.

Xia, Fei / Yu, Zhilong / Deng, Aijun / Gao, Guohong

Experimental biology and medicine (Maywood, N.J.)

2021 Volume 247, Issue 3, Page(s) 246–262

Abstract: Immunotherapy is the most promising treatment for uveal melanoma patients with metastasis. Tumor microenvironment plays an essential role in tumor progression and greatly affects the efficacy of immunotherapy. This research constructed an immune-related ... ...

Abstract	Immunotherapy is the most promising treatment for uveal melanoma patients with metastasis. Tumor microenvironment plays an essential role in tumor progression and greatly affects the efficacy of immunotherapy. This research constructed an immune-related subtyping system and discovered immune prognostic genes to further understand the immune mechanism in uveal melanoma. Immune-related genes were determined from literature. Gene expression profiles of uveal melanoma were clustered using consensus clustering based on immune-related genes. Subtypes were further divided by applying immune landscape, and weighted correlation network analysis was performed to construct immune gene modules. Univariate Cox regression analysis was conducted to generate a prognostic model. Enriched immune cells were determined after gene set enrichment analysis. Three major immune subtypes (IS1, IS2, and IS3) were identified, and IS2 could be further divided into IS2A and IS2B. The subtypes were closely associated with uveal melanoma prognosis. IS3 group had the most favorable prognosis and was sensitive to PD-1 inhibitor. Immune genes in IS1 group showed an overall higher expression than IS3 group. Six immune gene modules were identified, and the enrichment score of immune genes varied within immune subtypes. Four immune prognostic genes (
MeSH term(s)	Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Cluster Analysis ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks ; Humans ; Immunotherapy ; Interferon Regulatory Factor-1/genetics ; Interleukins/genetics ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/mortality ; Melanoma/therapy ; Mutation ; Prognosis ; Proto-Oncogene Proteins c-vav/genetics ; Sorting Nexins/genetics ; Transcriptome ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Uveal Neoplasms/genetics ; Uveal Neoplasms/immunology ; Uveal Neoplasms/mortality ; Uveal Neoplasms/therapy
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; IL32 protein, human ; IRF1 protein, human ; Interferon Regulatory Factor-1 ; Interleukins ; Proto-Oncogene Proteins c-vav ; SNX20 protein, human ; Sorting Nexins ; VAV1 protein, human
Language	English
Publishing date	2021-11-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702211053801
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Article ; Online: Structural and functional modifications of myofibrillar protein by natural phenolic compounds and their application in pork meatball.

Xu, Qian-Da / Yu, Zhi-Long / Zeng, Wei-Cai

Food research international (Ottawa, Ont.)

2021 Volume 148, Page(s) 110593

Abstract: Effects of different phenolic compounds on the structural and functional properties of myofibrillar protein (MP) were investigated, and the phenolic compounds were applied as natural modifiers in pork meatball. Interactions between MP and phenolic ... ...

Abstract	Effects of different phenolic compounds on the structural and functional properties of myofibrillar protein (MP) were investigated, and the phenolic compounds were applied as natural modifiers in pork meatball. Interactions between MP and phenolic compounds were determined via molecular docking to elucidate the modification mechanisms. Tannic acid, gallic acid, (-)-epigallocatechin gallate, and epigallocatechin interacted with MP primarily through hydrogen bonds, which unfolded the secondary structures of MP and lowered surface hydrophobicity. Accordingly, the solubility, gel properties, and oxidation stability of MP were improved, while the emulsifying properties significantly decreased. Quercetin and quercitrin showed electrostatic interactions with MP, which preserved α-helix structures and increased surface hydrophobicity. While, the modifications lent MP the enhanced emulsifying properties, thermal stability, and oxidation stability, but the gel properties and solubility were mitigated. In addition, the incorporation of phenolic compounds prevented MP oxidation based upon their antioxidant abilities deriving from hydroxyl groups. Once the phenolic compounds were used in pork meatball, a minced meat model, they significantly improved the quality of meatball by bettering the texture properties and controlling the oxidation level. The results suggest that phenolic compounds have great potential to be employed as natural additives in minced meat products for the modification of functional properties.
MeSH term(s)	Animals ; Molecular Docking Simulation ; Muscle Proteins ; Oxidation-Reduction ; Pork Meat ; Red Meat/analysis ; Swine
Chemical Substances	Muscle Proteins
Language	English
Publishing date	2021-07-10
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2021.110593
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Article ; Online: Flexible cellulose nanocrystal-based bionanocomposite film as a smart photonic material responsive to humidity.

Yu, Zhilong / Wang, Kaidi / Lu, Xiaonan

International journal of biological macromolecules

2021 Volume 188, Page(s) 385–390

Abstract	A flexible bionanocomposite film with a visible structural color was developed by co-assembling cellulose nanocrystals with glycerol, glucose, and poly(vinyl alcohol), and its application as a photonic humidity-responsive material was investigated. This chiral nematic film exhibited an indigo, cyan, olive green, orange, pink, and transparent color when exposed to relative humidity of 33%, 75%, 85%, 89%, 96%, and 100%, respectively. The color change was caused by reversible change in chiral nematic pitch due to hydration and dehydration. The nanocomposite displayed a stable structural color after alternatively conditioned at 33% and 100% relative humidity for ten cycles. Notably, material cost for a piece of such a smart film with an area of 28 cm
MeSH term(s)	Cellulose/chemistry ; Chemical Phenomena ; Humidity ; Nanocomposites/chemistry ; Nanoparticles/chemistry ; Optics and Photonics ; Smart Materials/chemistry
Chemical Substances	Smart Materials ; Cellulose (9004-34-6)
Language	English
Publishing date	2021-08-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.08.049
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Article: Corrigendum: PPy@Fe

Yu, Zhilong / Tong, Shanshi / Wang, Chenyi / Wu, Zizhen / Ye, Yingjiang / Wang, Shan / Jiang, Kewei

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1148674

Abstract: This corrects the article DOI: 10.3389/fbioe.2022.1001994.]. ...

Abstract	[This corrects the article DOI: 10.3389/fbioe.2022.1001994.].
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1148674
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Article ; Online: Superflexible Artificial Soft Wood.

Gao, Yu-Cheng / Yu, Zhi-Long / Qin, Bing / Chen, Cheng / Ma, Zhi-Yuan / Yu, Shu-Hong

Advanced materials (Deerfield Beach, Fla.)

2023 Volume 35, Issue 39, Page(s) e2303518

Abstract: Soft woods have attracted enormous interest due to their anisotropic cellular microstructure and unique flexibility. The conventional wood-like materials are usually subject to the conflict between the superflexibility and robustness. Inspired by the ... ...

Abstract	Soft woods have attracted enormous interest due to their anisotropic cellular microstructure and unique flexibility. The conventional wood-like materials are usually subject to the conflict between the superflexibility and robustness. Inspired by the synergistic compositions of soft suberin and rigid lignin of cork wood which has good flexibility and mechanical robustness, an artificial soft wood is reported by freeze-casting the soft-in-rigid (rubber-in-resin) emulsions, where the carboxy nitrile rubber confers softness and rigid melamine resin provides stiffness. The subsequent thermal curing induces micro-scale phase inversion and leads to a continuous soft phase strengthened by interspersed rigid ingredients. The unique configuration ensures crack resistance, structural robustness and superb flexibility, including wide-angle bending, twisting, and stretching abilities in various directions, as well as excellent fatigue resistance and high strength, overwhelming the natural soft wood and most wood-inspired materials. This superflexible artificial soft wood represents a promising substrate for bending-insensitive stress sensors.
Language	English
Publishing date	2023-07-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202303518
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