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  1. Article: Endoscopic transnasal optic canal decompression for pediatric traumatic optic neuropathy with no light perception.

    Ning, Yuan / Wang, Chun-Xia / Yu, Zi-Yan / Wang, Yong

    International journal of ophthalmology

    2023  Volume 16, Issue 12, Page(s) 2136–2138

    Language English
    Publishing date 2023-12-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2023.12.29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Insights on the possibility of SARS-CoV-2 transmission through the eyes.

    Zhu, Rui / Yu, Zi-Yan / Han, Lin

    International journal of ophthalmology

    2022  Volume 15, Issue 11, Page(s) 1857–1863

    Abstract: A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCOV), causing coronavirus disease 2019 (COVID-19), has rapidly spread to most countries and regions worldwide since it broke out at the end of 2019. Epidemic ... ...

    Abstract A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCOV), causing coronavirus disease 2019 (COVID-19), has rapidly spread to most countries and regions worldwide since it broke out at the end of 2019. Epidemic of the virus produces a tremendous pressure on the global health systems. With progressive insight into SARS-CoV-2, the role of eye tissue has attracted wide attention in the spread of COVID-19. Whether SARS-CoV-2 can enter the human body through eyes and cause infection? The fact that unprotected exposure of the eyes to 2019-nCoV might have allowed the virus to infect the body implies that 2019-nCOV can invade eye tissue and set foot in organism. Facing the severe challenge of preventing spread of the COVID-19, combined with the high-risk environment of ophthalmology, it is crucial to investigate ocular tropism of coronavirus. This paper explores the possibility of coronavirus transmission through the eye from aspects of probable mechanisms, clinical cases, detection of coronavirus; and puts forward precautions for ophthalmologists and nurses. Consequently, this review reveals our understanding of ocular tropism of coronavirus and contributes to determining risk of ocular transmission, raising awareness of necessary eye protection among medical workers and reducing further prevalence of SARS-CoV-2.
    Language English
    Publishing date 2022-11-18
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2022.11.18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Changes in corneal endothelial cell density in patients with primary open-angle glaucoma.

    Yu, Zi-Yan / Wu, Ling / Qu, Bo

    World journal of clinical cases

    2019  Volume 7, Issue 15, Page(s) 1978–1985

    Abstract: Background: Glaucoma is a group of diseases characterized by a specific pattern of optic nerve neuropathy and retinopathy. Increasing evidence demonstrates glaucoma associated corneal endothelium loss. Direct-compression mechanism due to elevated ... ...

    Abstract Background: Glaucoma is a group of diseases characterized by a specific pattern of optic nerve neuropathy and retinopathy. Increasing evidence demonstrates glaucoma associated corneal endothelium loss. Direct-compression mechanism due to elevated intraocular pressure (IOP), cell toxicity after long term exposure to preservatives and glaucoma surgery have been reported to be the possible mechanism. Herein, we compare the specular endothelial microscopy in primary open-angle glaucoma (POAG) patients and healthy controls of the same age group to observe the corneal endothelium changes and the correlations to the mean IOP in a Chinese case control study.
    Aim: To investigate corneal endothelial cell density in Chinese patients with POAG.
    Methods: A case control study was performed on 60 eyes of 60 patients with POAG. Exclusion criteria included history of corneal diseases, intraocular diseases, contact lens use, ocular trauma or surgery (including intraocular surgery and laser treatment), congenital abnormalities or systemic diseases such as diabetes. Intraocular pressure was measured using Goldmann tonometry. Indirect specular microscopy (TOPCON SP-2000P) was performed on central corneas and endothelial images were acquired. Endothelial cell density, area and cell counts were analyzed.
    Results: Endothelial cell density was 2959 ± 236 cells/mm
    Conclusion: Patients with POAG have lower corneal endothelial cell density than healthy controls of the same age. This may be attributed to mechanical damage from elevated IOP and toxicity of glaucoma medications.
    Language English
    Publishing date 2019-05-30
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v7.i15.1978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparison of measurements of anterior chamber angle

    Yu, Zi-Yan / Huang, Ting / Lu, Lu / Qu, Bo

    World journal of clinical cases

    2020  Volume 8, Issue 15, Page(s) 3249–3258

    Abstract: Background: Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. The variable clinical manifestations may result in differential diagnostic difficulties. The early screening and diagnosis of glaucoma are ... ...

    Abstract Background: Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. The variable clinical manifestations may result in differential diagnostic difficulties. The early screening and diagnosis of glaucoma are currently experiencing a demand for anterior segment analysis tools that can gather more information with one short measurement. Therefore, we analyzed the agreement, difference, and correlation of chamber angle parameters such as angel opening distance at 500 μm (AOD500) and trabeculo-iris space area at 500 μm
    Aim: To compare the differences, correlation, and agreement in measuring AOD500 and TISA500 by AS-OCT and UBM.
    Methods: Both AS-OCT and UBM were performed to measure AOD500 and TISA500 in 45 subjects (72 eyes). All subjects without glaucoma were collected from October 2015 to August 2016 at the Ophthalmology Department of the Fourth Affiliated Hospital of China Medical University. Data of the two groups (AOD500 and TISA500) were compared by nonparametric tests. Pearson correlative analysis and Bland-Altman analysis were used to compare the correlation and agreement.
    Results: There were no significant differences between AS-OCT and UBM in measuring AOD500 (
    Conclusion: There is a high correlation and agreement between AOD500 and TISA500 measurements by AS-OCT and UBM. They are interchangeable under some circumstances. AS-OCT proves to be a better early screening tool for glaucoma.
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Clinical Trial
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i15.3249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Bibliometric analysis and mapping knowledge domain of pterygium: 2000-2019.

    Wang, Yu-Chi / Zhao, Fang-Kun / Liu, Qian / Yu, Zi-Yan / Wang, Jing / Zhang, Jin-Song

    International journal of ophthalmology

    2021  Volume 14, Issue 6, Page(s) 903–914

    Abstract: Aim: To track the knowledge structure, topics in focus, and trends in emerging research in pterygium in the past 20y.: Methods: Base on the Web of Science Core Collection (WoSCC), studies related to pterygium in the past 20y from 2000-2019 have been ... ...

    Abstract Aim: To track the knowledge structure, topics in focus, and trends in emerging research in pterygium in the past 20y.
    Methods: Base on the Web of Science Core Collection (WoSCC), studies related to pterygium in the past 20y from 2000-2019 have been included. With the help of VOSviewer software, a knowledge map was constructed and the distribution of countries, institutions, journals, and authors in the field of pterygium noted. Meanwhile, using co-citation analysis of references and co-occurrence analysis of keywords, we identified basis and hotspots, thereby obtaining an overview of this field.
    Results: The search retrieved 1516 publications from WoSCC on pterygium published between 2000 and 2019. In the past two decades, the annual number of publications is on the rise and fluctuated a little. Most productive institutions are from Singapore but the most prolific and active country is the United States. Journal
    Conclusion: This study demonstrates that the research of pterygium is gradually attracting the attention of scholars and researchers. The interaction between authors, institutions, and countries is lack of. Even though, the research hotspot, distribution, and research status in pterygium in this study could provide valuable information for scholars and researchers.
    Language English
    Publishing date 2021-06-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2021.06.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation.

    Yang, Zi-Jie / Yu, Zi-Yan / Cai, Yi-Ming / Du, Rong-Rong / Cai, Liang

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 116

    Abstract: Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific ... ...

    Abstract Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific extracellular signal. Recent advancement of synNotch has shown promise for future use in cellular engineering to treat cancers. However, synNotch from Morsut et al. (2016) has a high level of ligand-independent activation, which limits its application. Here we show that adding an intracellular hydrophobic sequence (QHGQLWF, named as RAM7) present in native Notch, significantly reduced ligand-independent activation. Our enhanced synthetic Notch receptor (esNotch) demonstrates up to a 14.6-fold reduction in ligand-independent activation, without affecting its antigen-induced activation efficiency. Our work improves a previously reported transmembrane receptor and provides a powerful tool to develop better transmembrane signaling transduction modules for further advancement of eukaryotic synthetic biology.
    MeSH term(s) Amino Acid Sequence ; Antigens/metabolism ; Cell Engineering/methods ; Cell Membrane/metabolism ; Cloning, Molecular/methods ; HEK293 Cells ; Humans ; Ligands ; Plasmids/genetics ; Protein Domains ; Proteolysis ; Receptors, Artificial/chemistry ; Receptors, Artificial/metabolism ; Receptors, Notch/chemistry ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction/genetics ; Single-Chain Antibodies ; Synthetic Biology/methods ; Transfection
    Chemical Substances Antigens ; Ligands ; Receptors, Artificial ; Receptors, Notch ; Single-Chain Antibodies
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0848-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Trends in research related to high myopia from 2010 to 2019: a bibliometric and knowledge mapping analysis.

    Zhang, Xiao-Dan / Wang, Chun-Xia / Jiang, Hong-Hu / Jing, Shuo-Lan / Zhao, Jiang-Yue / Yu, Zi-Yan

    International journal of ophthalmology

    2021  Volume 14, Issue 4, Page(s) 589–599

    Abstract: Aim: To evaluate the global trends in and explore hotspots of high myopia (HM) research.: Methods: This bibliometric analysis was used to reveal the publication trends in HM research field based on the Web of Science Core Collection (WoSCC). ... ...

    Abstract Aim: To evaluate the global trends in and explore hotspots of high myopia (HM) research.
    Methods: This bibliometric analysis was used to reveal the publication trends in HM research field based on the Web of Science Core Collection (WoSCC). VOSviewer version 1.6.13 software was used to analyze the data and construct a knowledge map including the yearly publication number, journals, countries, international collaborations, authors, research hotspots, and intellectual base in HM.
    Results: The search engine found 3544 peer-reviewed publications on HM between 2010 and 2019, and the yearly research output substantially elevated over the past decade. China is the top publishing country, and Sun Yat-sen University was the most active academic institution. Jonas JB is the top publishing scientist, and
    Conclusion: The evaluation of development trends based on the data extracted from WoSCC can provide valuable information and guidance for ophthalmologists and public health researchers to improve management procedures in HM field.
    Language English
    Publishing date 2021-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2021.04.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Polarization independent quasi-phase-matched sum frequency generation for single photon detection.

    Song, Xiao-shi / Yu, Zi-yan / Wang, Qin / Xu, Fei / Lu, Yan-qing

    Optics express

    2011  Volume 19, Issue 1, Page(s) 380–386

    Abstract: Polarization independent sum frequency generation (SFG) is proposed in an electro-optic (EO) tunable periodically poled Lithium Niobate (PPLN). The PPLN consists of four sections. External electric field could be selectively applied to them to induce ... ...

    Abstract Polarization independent sum frequency generation (SFG) is proposed in an electro-optic (EO) tunable periodically poled Lithium Niobate (PPLN). The PPLN consists of four sections. External electric field could be selectively applied to them to induce polarization rotation between the ordinary and extraordinary waves. If the domain structure is well designed, the signal wave with an arbitrary polarization state could realize efficient frequency up-conversion as long as a z-polarized pump wave is selected. The applications in single photon detection and optical communications are discussed.
    Language English
    Publishing date 2011-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.19.000380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Broadband and highly efficient quadratic interactions in double-slot lithium niobate waveguides through phase matching.

    Kou, Jun-long / Wang, Qin / Yu, Zi-yan / Xu, Fei / Lu, Yan-qing

    Optics letters

    2011  Volume 36, Issue 13, Page(s) 2533–2535

    Abstract: We propose and study in detail a phase-matched quadratic optical interaction in a realizable 2D double-slot lithium niobate (LN) waveguide. As opposed to the single-slot waveguide, the field can be well confined in the nanometric nonlinear material, and ... ...

    Abstract We propose and study in detail a phase-matched quadratic optical interaction in a realizable 2D double-slot lithium niobate (LN) waveguide. As opposed to the single-slot waveguide, the field can be well confined in the nanometric nonlinear material, and it is also more flexible for birefringence and dispersion design. The proposed compact double-slot structure could not only achieve form birefringence phase matching but also effectively enhance the modal overlap integral and expand the working wavelength. The calculated results on second harmonic generation show an extremely large bandwidth of ~40 nm. The modal overlap integral up to 0.035 W(3/2)/V can be realized by optimizing the waveguide geometry, and it is much better than previous results on single-slot waveguides. Its temperature dependence is low--around 25 °C. The geometry is practical considering the current micromachining technique of LN.
    Language English
    Publishing date 2011-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.36.002533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acousto-optic tunable second harmonic generation in periodically poled LiNbO3.

    Yu, Zi-yan / Xu, Fei / Leng, Fei / Qian, Xiao-Shi / Chen, Xiang-fei / Lu, Yan-qing

    Optics express

    2009  Volume 17, Issue 14, Page(s) 11965–11971

    Abstract: Acousto-optic (AO) tunable second harmonic generation (SHG) was proposed in periodically poled lithium niobate (PPLN). The acoustic wave could either be induced from an external transducer or self-generated in PPLN driving with a cross-field radio ... ...

    Abstract Acousto-optic (AO) tunable second harmonic generation (SHG) was proposed in periodically poled lithium niobate (PPLN). The acoustic wave could either be induced from an external transducer or self-generated in PPLN driving with a cross-field radio frequency field. The reciprocal vector of PPLN compensates the SHG wave-vector mismatch when quasi-phase- matching (QPM) condition is satisfied, while phonons with suitable frequencies may affect it by scattering photons to different polarization state. The QPM SHG and AO polarization rotation are coupled together. Second harmonic waves' intensities, polarization states and even phases thus could be manipulated instantly through AO interaction.
    MeSH term(s) Acoustics ; Crystallization ; Equipment Design ; Niobium/chemistry ; Optical Devices ; Optics and Photonics ; Oxides/chemistry ; Photons
    Chemical Substances Oxides ; Niobium (05175J654G) ; lithium niobate (12031-63-9)
    Language English
    Publishing date 2009-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/oe.17.011965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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