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  1. AU="Yu-Chin, Lin"
  2. AU=Badri Shirinsadat AU=Badri Shirinsadat
  3. AU="Giudici, Carolina"
  4. AU="Mahmoudi, Hassan"
  5. AU="Catharine Sturgeon"
  6. AU=Bhardwaj Neeru
  7. AU=Hamdani Muhammad Afzal
  8. AU="Wen, O"
  9. AU="de Oliveira, Luciana Maia Nogueira"
  10. AU="Sanabria, Mauricio"
  11. AU="Tronnier, Michael"
  12. AU="Yu, Yaonan"
  13. AU="Gradl, W"
  14. AU="Grossklags, Jens"
  15. AU="Andreas M. Köster"
  16. AU="Diana Karolina Maniak"
  17. AU="Cahuana-Hurtado, Lucero"
  18. AU="Ebert, Christoph"
  19. AU="Köhler, Matthias"
  20. AU=Fitzgerald Amelia Lucy AU=Fitzgerald Amelia Lucy
  21. AU="Yang, Charles"
  22. AU="Fraser, Alice j"
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  24. AU=Guettari Moez AU=Guettari Moez
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  26. AU="Patel P.M"
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  28. AU="Naganawa, Mika"
  29. AU="Viecelli, Claudio"
  30. AU=Valls Joan
  31. AU="Yang, Qizhang"
  32. AU=Wilt Timothy J
  33. AU="Dene R. Littler" AU="Dene R. Littler"
  34. AU="Petrenko, Andrei"
  35. AU=Valentino Kristin
  36. AU=Swash M
  37. AU="Adedipe, Ifeoluwa"
  38. AU=Shen Hongcheng
  39. AU="Padhy, Biswajit"
  40. AU="Kruglikov, Alibek"
  41. AU="Tasu, Jean Pierre"
  42. AU="Floate, Kevin D"
  43. AU="Mark Rijpkema"
  44. AU="Gjeloshi, Klodian"
  45. AU="Lucie Beaudoin"

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  1. Artikel ; Online: H 2 S- and Redox-State-Mediated PTP1B S-Sulfhydration in Insulin Signaling

    Yu-Chin Lin / Wan-Ting Zeng / Der-Yen Lee

    International Journal of Molecular Sciences, Vol 24, Iss 2898, p

    2023  Band 2898

    Abstract: Because hydrogen sulfide (H 2 S) is classified as a gaseous signaling molecule, protein S-sulfhydration is known to be one of the mechanisms by which H 2 S signals are conducted. PTP1B, a negative regulator in insulin signaling, has been found to be S- ... ...

    Abstract Because hydrogen sulfide (H 2 S) is classified as a gaseous signaling molecule, protein S-sulfhydration is known to be one of the mechanisms by which H 2 S signals are conducted. PTP1B, a negative regulator in insulin signaling, has been found to be S-sulfhydrated at Cys215-SH to form Cys215-SSH in response to endoplasmic reticulum (ER) stress. Therefore, we aimed to understand the change in PTP1B S-sulfhydration and cellular redox homeostasis in response to insulin stimulation. We demonstrated a feasible PEG-switch method to determine the levels of PTP1B S-sulfhydration. According to the results obtained from HEK293T and MDA-MB-231 cells, insulin induced a change in PTP1B S-sulfhydration that was similar to the change in Insulin receptor substrate 1 (IRS1) phosphorylation in both cell lines. However, insulin-induced PTP1B S-sulfhydration and IRS1 phosphorylation were only significantly affected by metformin in HEK293T cells. Insulin also induced an increase in reactive oxygen species (ROS) in both cell lines. However, the level of H 2 S, GSH, and GSSG was only significantly affected by insulin and metformin in HEK293T cells. HEK293T cells maintained high levels of H 2 S and cysteine, but low levels of GSSG and GSH in general compared to MDA-MB-231 cells. From these findings, we suggest that PTP1B activity is modulated by H 2 S and redox-regulated S-sulfhydration during insulin signaling.
    Schlagwörter H 2 S ; S-sulfhydration ; PEG-switch ; PTP1B ; insulin ; glutathione ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Is the goal of 12,000 steps per day sufficient for improving body composition and metabolic syndrome? The necessity of combining exercise intensity

    Tsung-Lin Chiang / Chu Chen / Chih-Hsiang Hsu / Yu-Chin Lin / Huey-June Wu

    BMC Public Health, Vol 19, Iss 1, Pp 1-

    a randomized controlled trial

    2019  Band 9

    Abstract: Abstract Background To investigate the differences in body composition and metabolic syndrome (MS) under a daily 12,000-step strategy with or without moderate-intensity walking exercise in college students with obesity. Methods Thirty-two adults with ... ...

    Abstract Abstract Background To investigate the differences in body composition and metabolic syndrome (MS) under a daily 12,000-step strategy with or without moderate-intensity walking exercise in college students with obesity. Methods Thirty-two adults with obesity (mean (s.d.) age: 19.72 (0.80) years; height: 165.38 (3.99) cm; wt: 83.31 (4.66) kg; body mass index: 30.38 (0.83) kg m− 2) were recruited and randomly assigned to the walking step goal group (WSG; achieving 12,000 steps per day), walking exercise group (WEG; achieving 12,000 steps per day, including 3 days per week on which walking at a step rate of over 103 steps min− 1 was required), or control group (CG; maintaining a free-living life style). Each participant’s accumulated daily steps from daily activities and walking exercises were monitored using a smartwatch for 8 weeks. The variables of body composition and MS were measured before and after intervention. Results Average daily steps over 8 weeks did not significantly differ between the WSG and WEG (11,677.67 (480.24) vs. 12,131.90 (527.14) steps per day, respectively, P > .05). Although the CG and WSG showed no improvement in body composition, the WEG exhibited significant improvements in terms of hip circumference and visceral fat area (VFA) (∆ − 2.28 (3.27) cm and ∆ − 13.11 (9.83) cm2, respectively, P < .05); high-density lipoprotein cholesterol (HDL-C), fasting glucose (FG), and triglycerides (TG) (∆ 16.36 (8.39), ∆ − 2.53 (3.73), and ∆ − 10.52 (36.26) mg dL− 1, respectively, P < .05). The WSG exhibited improvements only in HDL-C (∆ 14.24 (16.13) mg dL− 1, P < .05). Conclusion The combination of walking exercise program and daily step goal is a more time efficient strategy in improving body composition and MS than simply establishing a daily step goal. Furthermore, this strategy may also include a potential reduction effect on the risk factors of cardiovascular diseases. Trial registration Australian New Zealand Clinical Trials Registry, number ACTRN12618001237279 (Retrospectively registered).
    Schlagwörter Walking ; Daily step goal ; Step rate ; Moderate intensity ; Cardiovascular disease risk factor ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
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  3. Artikel: Geology and zircon U-Pb geochronology of the Mtkvari pyroclastic flow and evaluation of destructive processes affecting Vardzia rock-cut city, Georgia

    Okrostsvaridze, Avtandil / Sun-Lin Chung / Yu-Chin Lin / Irakli Skhirtladze

    Quaternary international. 2019 Mar. 25,

    2019  

    Abstract: Late Cenozoic subaerial volcanic highland crop out in Eastern Anatolia and the western part of the Lesser Caucasus, part of which, located in Georgia, is known as Samtskhe-Javakheti. The Samtskhe-Javakheti highland (∼4500 km2) is cut by the Mtkvari river ...

    Abstract Late Cenozoic subaerial volcanic highland crop out in Eastern Anatolia and the western part of the Lesser Caucasus, part of which, located in Georgia, is known as Samtskhe-Javakheti. The Samtskhe-Javakheti highland (∼4500 km2) is cut by the Mtkvari river canyon, where, into the thick pyroclastic flow in twelfth-century is hewn the unique city Vardzia. Despite this, characteristics of the pyroclastic flow, such as scale, source, type, genesis, isotopic age and evaluation of destructive geological processes of the Vardzia rock-cut city have not been well studied. Our research has shown that the Mtkvari pyroclastic flow is exposed at a distance of about 35 km from the Karzameti fortress to the Khertvisi fortress, it is inclined northward by 2-4°, and its thickness increases to the north from 40 m up to 80 m. These rocks represent welded, weakly welded and non-welded ignimbrites of the andesitic-dacitic composition. Isotopic parameters of these rocks (ɛNd varies between +3 and + 4, and 87Sr/88Sr between 0,70341 and 0.70450) indicate that they originated as a result of fractionation of mantle derived melts. As a result of field work, we interpret the Mtkvari ignimbrites as products of megacaldera collapse (modern Niala fields), which nowadays is filled by postcaldera domes of andesitic composition and Quaternary sediments. The result of zircon dating using the U-Pb method with LA-ICP-MS technology is 7.52 ± 0.21 Ma, which corresponds to the Late Miocene epoch. Geological research of the Vardzia rock-cut city has revealed that it is hewn into weakly welded ignimbrites and for which reason these rocks are under the intensive affecting of weathering and erosion processes. At the same time, the city is completely included in a tectonic block of 900 m length which is detached from the main body of rocks and is gradually subsiding towards the Mtkvari canyon. Nowadays Vardzia block is lowered by 30.6 m in comparison with bordering blocks. In addition, this block is split into several micro-blocks by a joint set, thus reducing its stability. The situation is worsened by the active deep fault running along the Vardzia rock-cut city, which represents a potential earthquake source.
    Schlagwörter Miocene epoch ; earthquakes ; fractionation ; melting ; rivers ; rocks ; sediments ; tectonics ; weathering ; zircon ; Caucasus region ; Turkey (country)
    Sprache Englisch
    Erscheinungsverlauf 2019-0325
    Umfang p. .
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ISSN 1040-6182
    DOI 10.1016/j.quaint.2019.03.026
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  4. Artikel ; Online: Effects of Para-Toluenesulfonamide on Canine Melanoma Xenotransplants in a BALB/c Nude Mouse Model

    Chien-Teng Lin / Chuen-Fu Lin / Jui-Te Wu / Hsiao-Pei Tsai / Shu-Ying Cheng / Huei-Jyuan Liao / Tzu-Chun Lin / Chao-Hsuan Wu / Yu-Chin Lin / Jiann-Hsiung Wang / Geng-Ruei Chang

    Animals, Vol 12, Iss 2272, p

    2022  Band 2272

    Abstract: The pharmacological pathway of para-toluenesulfonamide (PTS) restricts the kinase activity of the mammalian target of rapamycin, potentially leading to reductions in cell division, cell growth, cell proliferation, and inflammation. These pathways have a ... ...

    Abstract The pharmacological pathway of para-toluenesulfonamide (PTS) restricts the kinase activity of the mammalian target of rapamycin, potentially leading to reductions in cell division, cell growth, cell proliferation, and inflammation. These pathways have a critical effect on tumorigenesis. We aimed to examine the antitumor effect of PTS or PTS combined with cisplatin on canine melanoma implanted in BALB/c nude mice by estimating tumor growth, apoptosis expression, inflammation, and metastasis. The mice were randomly divided into four groups: control, cisplatin, PTS, and PTS combined with cisplatin. Mice treated with PTS or PTS combined with cisplatin had retarded tumor growth and increased tumor apoptosis through the enhanced expression of cleaved caspase 3 and extracellular signal-regulated kinase phosphorylation, decreased inflammatory cytokine levels, reduced inflammation-related factors, enhanced anti-inflammation-related factors, and inhibition of metastasis-related factors. Mice treated with PTS combined with cisplatin exhibited significantly retarded tumor growth, reduced tumor size, and increased tumor inhibition compared with those treated with cisplatin or PTS alone. PTS or PTS combined with cisplatin could retard canine melanoma growth and inhibit tumorigenesis. PTS and cisplatin were found to have an obvious synergistic tumor-inhibiting effect on canine melanoma. PTS alone and PTS combined with cisplatin may be antitumor agents for canine melanoma treatment.
    Schlagwörter apoptosis ; canine melanoma ; cisplatin ; inflammation ; metastasis ; para-toluenesulfonamide ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  5. Artikel: Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice

    Huang, Chung-Hsiung / Tong-Rong Jan / Yu-Chin Lin

    Journal of functional foods. 2017 Apr., v. 31

    2017  

    Abstract: The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell ... ...

    Abstract The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell activation, and serum IgE production in allergic mice. The production of signature T helper (Th)1 and 2 cytokines, namely IFN-γ and IL-4, by splenocytes was suppressed by L. reuteri. Concordantly, the intestinal expression of IFN-γ, IL-4, T-bet and GATA3 was down-regulated. However, L. reuteri augmented the expression of IL-10, TGF-β and Foxp3, and the number of IL-10-secreting CD11c+CD103+ mesenteric lymph node (MLN) cells. Furthermore, direct exposure to heat-killed L. reuteri attenuated OVA-induced cell proliferation and IL-2 secretion by MLN cells. These results demonstrate that L. reuteri possesses anti-allergic activities via modulating enteric flora and promoting tolerogenic immune responses, and suggest L. reuteri as a functional probiotic against food allergy.
    Schlagwörter blood serum ; CD4-positive T-lymphocytes ; cell proliferation ; diarrhea ; direct contact ; flora ; food allergies ; GATA transcription factors ; immune response ; immunoglobulin E ; immunosuppression ; interferon-gamma ; interleukin-10 ; interleukin-2 ; interleukin-4 ; Lactobacillus reuteri ; lymph nodes ; mast cells ; mice ; oral administration ; ovalbumin ; probiotics ; secretion ; splenocytes ; transforming growth factor beta
    Sprache Englisch
    Erscheinungsverlauf 2017-04
    Umfang p. 44-51.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2017.01.034
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  6. Artikel ; Online: p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models.

    Ching-Wen, Chang / Yun-Chieh, Chen / Yu-Chin, Lin / Wen-Huang, Peng

    Journal of natural medicines

    2017  Band 71, Heft 2, Seite(n) 422–432

    Abstract: p-Hydroxyacetophenone (HAP) is a crucial chemical compound present in plants of the genus Artemisia, which are used in traditional therapies for treating jaundice, hepatitis, and inflammatory diseases. Nevertheless, the bioactivity of HAP remains to be ... ...

    Abstract p-Hydroxyacetophenone (HAP) is a crucial chemical compound present in plants of the genus Artemisia, which are used in traditional therapies for treating jaundice, hepatitis, and inflammatory diseases. Nevertheless, the bioactivity of HAP remains to be identified in order to prove its importance in the plants of genus Artemisia. This study investigated the antioxidative, antinociceptive, and anti-inflammatory effects of HAP, and probed its possible molecular mechanisms. Our results revealed that HAP (80 mg/kg, intraperitoneally) in vivo reduced the acetic acid-induced writhing response and formalin-induced licking time. Moreover, in the λ-carrageenan-induced acute-inflammatory paw edema model in mice, HAP significantly improved hind paw swelling and neutrophil infiltration. In a homogenized paw tissue examination, HAP attenuated pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, and interleukin-6. Simultaneously, HAP also inhibited the production of nuclear factor kappa B, cyclooxygenase-2, and nitric oxide (NO). Another examination revealed that HAP exerted anti-inflammatory activity by decreasing malondialdehyde levels in the edematous paw through increasing the activities of superoxide dismutase, glutathione peroxidase, and glutathione reductase in the liver. These findings may be beneficial in understanding the therapeutic effects of some plants of the genus Artemisia in the pretreatment of inflammation-associated diseases.
    Mesh-Begriff(e) Acetophenones/therapeutic use ; Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Artemisia/chemistry ; Biological Products/therapeutic use ; Disease Models, Animal ; Inflammation/drug therapy ; Liver/drug effects ; Male ; Mice ; NF-kappa B/chemistry ; Nitric Oxide ; Plant Extracts/chemistry
    Chemische Substanzen Acetophenones ; Analgesics ; Anti-Inflammatory Agents ; Biological Products ; NF-kappa B ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; 4-hydroxyacetophenone (G1L3HT4CMH)
    Sprache Englisch
    Erscheinungsdatum 2017-02-01
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-017-1074-9
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  7. Artikel ; Online: Corrigendum to “Degradation of Epidermal Growth Factor Receptor Mediates Dasatinib-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma Cells” [Neoplasia 14 (2012) 463–475]

    Yu-Chin Lin / Meng-Hsuan Wu / Tzu-Tang Wei / Shu-Hui Chuang / Kuen-Feng Chen / Ann-Lii Cheng / Ching-Chow Chen

    Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 3, Pp 252-

    2017  Band 254

    Schlagwörter Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag Elsevier
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  8. Artikel ; Online: Subclinical abnormalities in workers with continuous low-level toluene exposure.

    Shih, Hsu-Tzu / Yu, Chin-Lin / Wu, Ming-Tsang / Liu, Chiu-Shong / Tsai, Chon-Haw / Hung, Dong-Zong / Wu, Chun-Shing / Kuo, Hisen-Wen

    Toxicology and industrial health

    2011  Band 27, Heft 8, Seite(n) 691–699

    Abstract: Short-term exposure to a high concentration (TWA > 100 ppm) of toluene can cause hepatotocixity and neurotoxicity in humans. Data on the effects of exposure to low levels of toluene, however, are controversial. In addition, few studies on the effects of ... ...

    Abstract Short-term exposure to a high concentration (TWA > 100 ppm) of toluene can cause hepatotocixity and neurotoxicity in humans. Data on the effects of exposure to low levels of toluene, however, are controversial. In addition, few studies on the effects of toluene exposure on the autonomic nervous system have been conducted. Urine samples from 34 male factory workers in Taiwan who were exposed to low levels of toluene either intermittently (n = 13) or continuously (n = 21) were taken on a Monday morning after a 2-day hiatus and at the end of the workweek on Friday evening. Urinary hippuric acid levels were measured using high-performance liquid chromatography (HPLC). A complete blood work-up was also performed for each subject. The prevalence and severity of neurotoxic symptoms were investigated by a self-reported questionnaire, a neuropsychiatric battery, and sympathetic and peripheral nerve function tests. The mean value of urinary hippuric acid corrected for creatinine (Cr) was 0.34 ± 0.18 g/g Cr on Monday morning and 0.43 ± 0.26 g/g Cr on Friday evening. The difference in the mean value of urinary hippuric acid between the two periods (p < 0.01) and the odds ratio of impairment of sympathetic (OR = 4.13, p = 0.11) and peripheral nerves (OR = 6.94, p = 0.074) were higher in workers continuously exposed to toluene. In addition, workers who were continuously exposed to toluene had a lower mean platelet count (216 ± 41 × 10(6) /µL) than workers who were intermittently exposed (252 ± 40 × 10(6)/µL), (p = 0.018). Furthermore, there was a positive relationship between neurological abnormalities and a self-reported neuropsychiatric measurement (r = 0.35-0.66, p < 0.05) in all workers. These data suggest that continuous exposure to low levels of toluene may be associated with sympathetic and peripheral nerve dysfunction and sub-clinical hematological damage. Further research needs to be carried out regarding how chronic exposure to low-levels of toluene affects workers.
    Mesh-Begriff(e) Adult ; Chemical Industry ; Chromatography, High Pressure Liquid ; Hematologic Tests ; Hippurates/urine ; Humans ; Male ; Neuropsychological Tests ; Occupational Diseases/chemically induced ; Occupational Diseases/urine ; Occupational Exposure/adverse effects ; Surveys and Questionnaires ; Taiwan ; Toluene/poisoning
    Chemische Substanzen Hippurates ; Toluene (3FPU23BG52) ; hippuric acid (TE0865N2ET)
    Sprache Englisch
    Erscheinungsdatum 2011-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/0748233710395348
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  9. Artikel: Subclinical abnormalities in workers with continuous low-level toluene exposure

    Shih, Hsu-Tzu / Yu, Chin-Lin / Wu, Ming-Tsang / Liu, Chiu-Shong / Tsai, Chon-Haw / Hung, Dong-Zong / Wu, Chun-Shing / Kuo, Hisen-Wen

    Toxicol Ind Health. 2011 Sept., v. 27, no. 8

    2011  

    Abstract: Short-term exposure to a high concentration (TWA > 100 ppm) of toluene can cause hepatotocixity and neurotoxicity in humans. Data on the effects of exposure to low levels of toluene, however, are controversial. In addition, few studies on the effects of ... ...

    Abstract Short-term exposure to a high concentration (TWA > 100 ppm) of toluene can cause hepatotocixity and neurotoxicity in humans. Data on the effects of exposure to low levels of toluene, however, are controversial. In addition, few studies on the effects of toluene exposure on the autonomic nervous system have been conducted. Urine samples from 34 male factory workers in Taiwan who were exposed to low levels of toluene either intermittently (n = 13) or continuously (n = 21) were taken on a Monday morning after a 2-day hiatus and at the end of the workweek on Friday evening. Urinary hippuric acid levels were measured using high-performance liquid chromatography (HPLC). A complete blood work-up was also performed for each subject. The prevalence and severity of neurotoxic symptoms were investigated by a self-reported questionnaire, a neuropsychiatric battery, and sympathetic and peripheral nerve function tests. The mean value of urinary hippuric acid corrected for creatinine (Cr) was 0.34 ± 0.18 g/g Cr on Monday morning and 0.43 ± 0.26 g/g Cr on Friday evening. The difference in the mean value of urinary hippuric acid between the two periods (p < 0.01) and the odds ratio of impairment of sympathetic (OR = 4.13, p = 0.11) and peripheral nerves (OR = 6.94, p = 0.074) were higher in workers continuously exposed to toluene. In addition, workers who were continuously exposed to toluene had a lower mean platelet count (216 ± 41 x 106 /µL) than workers who were intermittently exposed (252 ± 40 x 106/µL), (p = 0.018). Furthermore, there was a positive relationship between neurological abnormalities and a self-reported neuropsychiatric measurement (r = 0.35-0.66, p < 0.05) in all workers. These data suggest that continuous exposure to low levels of toluene may be associated with sympathetic and peripheral nerve dysfunction and sub-clinical hematological damage. Further research needs to be carried out regarding how chronic exposure to low-levels of toluene affects workers.
    Schlagwörter autonomic nervous system ; blood ; blood platelet count ; chronic exposure ; high performance liquid chromatography ; hippuric acid ; humans ; labor ; neurotoxicity ; odds ratio ; peripheral nerves ; questionnaires ; toluene ; urine ; Taiwan
    Sprache Englisch
    Erscheinungsverlauf 2011-09
    Umfang p. 691-699.
    Erscheinungsort SAGE Publications
    Dokumenttyp Artikel
    ZDB-ID 56831-4
    ISSN 0748-2337
    ISSN 0748-2337
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  10. Artikel ; Online: Degradation of Epidermal Growth Factor Receptor Mediates Dasatinib-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma Cells

    Yu-Chin Lin / Meng-Hsuan Wu / Tzu-Tang Wei / Shu-Hui Chung / Kuen-Feng Chen / Ann-Lii Cheng / Ching-Chow Chen

    Neoplasia : An International Journal for Oncology Research, Vol 14, Iss 6, Pp 463-

    2012  Band 475

    Abstract: Epidermal growth factor receptor (EGFR) is an important oncoprotein that promotes cell growth and proliferation. Dasatinib, a bcr-abl inhibitor, has been approved clinically for the treatment of chronic myeloid leukemia and demonstrated to be effective ... ...

    Abstract Epidermal growth factor receptor (EGFR) is an important oncoprotein that promotes cell growth and proliferation. Dasatinib, a bcr-abl inhibitor, has been approved clinically for the treatment of chronic myeloid leukemia and demonstrated to be effective against solid tumors in vitro through Src inhibition. Here, we disclose that EGFR degradation mediated dasatinib-induced apoptosis in head and neck squamous cell carcinoma (HNSCC) cells. HNSCC cells, including Ca9-22, FaDu, HSC3, SAS, SCC-25, and UMSCC1, were treated with dasatinib, and cell viability, apoptosis, and underlying signal transduction were evaluated. Dasatinib exhibited differential sensitivities against HNSCC cells. Growth inhibition and apoptosis were correlated with its inhibition on Akt, Erk, and Bcl-2, irrespective of Src inhibition. Accordingly, we found that down-regulation of EGFR was a determinant of dasatinib sensitivity. Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation. Increased EGFR activation by ligand administration rescued cells from dasatinib-induced apoptosis, whereas inhibition of EGFR enhanced its apoptotic effect. Estrogen receptor α (ERα) was demonstrated to play a role in Bcl-2 expression, and dasatinib inhibited ERα at the pretranslational level. ERα was associated with EGFR in dasatinib-treated HNSCC cells. Furthermore, the xenograft model showed that dasatinib inhibited HSC3 tumor growth through in vivo down-regulation of EGFR and ERα. In conclusion, degradation of EGFR is a novel mechanism responsible for dasatinib-induced apoptosis in HNSCC cells.
    Schlagwörter Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 616 ; 610
    Erscheinungsdatum 2012-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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