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  1. AU="Yu-Heng Cheng"
  2. AU=Freeman Richard B Jr
  3. AU="Wang, Qi-En"
  4. AU="Mallamaci, M"
  5. AU="Turk, Yael R"
  6. AU="Tinto, Monica"
  7. AU="Selvendiran, Karuppaiyah" AU="Selvendiran, Karuppaiyah"
  8. AU="Enns, Murray W"
  9. AU="Yaohua Yang" AU="Yaohua Yang"

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  1. Artikel: The effects of salt concentration and foulant surface charge on hydrocarbon fouling of a poly(vinylidene fluoride) microfiltration membrane

    He, Zhengwang / Alon Y. Kirschner / Benny D. Freeman / Donald R. Paul / Sirirat Kasemset / Yu-Heng Cheng

    Water research. 2017 June 15, v. 117

    2017  

    Abstract: The effects of inorganic salts and organic hydrocarbons on membrane fouling are often investigated independently. However, in many cases, these foulants are commonly found together, and such mixtures are rarely the subject of fouling studies. In this ... ...

    Abstract The effects of inorganic salts and organic hydrocarbons on membrane fouling are often investigated independently. However, in many cases, these foulants are commonly found together, and such mixtures are rarely the subject of fouling studies. In this study, crude oil-in-water emulsions were formulated at three different added NaCl concentrations, 0, 10-3 and 10−1 M. Surface properties, such as surface tension and surface charge, of these emulsions and a poly(vinylidene fluoride) (PVDF) microfiltration (MF) membrane were characterized. The Derjaguin-Landau-Verwey-Overbeek (DLVO) model was utilized to simulate membrane-oil droplet and oil layer-oil droplet surface interactions. The DLVO model qualitatively predicted increasing fouling propensity with increasing emulsion salt concentration. The PVDF MF membrane was challenged with crude oil-in-water emulsions in constant permeate flux crossflow fouling tests to characterize the fouling propensity of the various emulsions, and the results were consistent with the model predictions.
    Schlagwörter emulsions ; fluorides ; fouling ; hydrocarbons ; microfiltration ; models ; oils ; prediction ; salt concentration ; sodium chloride ; surface interactions ; surface tension
    Sprache Englisch
    Erscheinungsverlauf 2017-0615
    Umfang p. 230-241.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2017.03.051
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer

    Yu-Chih Chen / Maria E. Gonzalez / Boris Burman / Xintao Zhao / Talha Anwar / Mai Tran / Natasha Medhora / Ayse B. Hiziroglu / Woncheol Lee / Yu-Heng Cheng / Yehyun Choi / Euisik Yoon / Celina G. Kleer

    Cell Reports, Vol 27, Iss 13, Pp 3916-3926.e

    2019  Band 5

    Abstract: Summary: Twenty percent of breast cancer (BC) patients develop distant metastasis for which there is no cure. Mesenchymal stem/stromal cells (MSCs) in the tumor microenvironment were shown to stimulate metastasis, but the mechanisms are unclear. Here, we ...

    Abstract Summary: Twenty percent of breast cancer (BC) patients develop distant metastasis for which there is no cure. Mesenchymal stem/stromal cells (MSCs) in the tumor microenvironment were shown to stimulate metastasis, but the mechanisms are unclear. Here, we identified and quantified cancer cells engulfing stromal cells in clinical samples of BC metastasis by dual immunostaining for EZH2 and ALDH1 expression. Using flow cytometry and a microfluidic single-cell paring and retrieval platform, we show that MSC engulfment capacity is associated with BC cell metastatic potential and generates cells with mesenchymal-like, invasion, and stem cell traits. Whole-transcriptome analyses of selectively retrieved engulfing BC cells identify a gene signature of MSC engulfment consisting of WNT5A, MSR1, ELMO1, IL1RL2, ZPLD1, and SIRPB1. These results delineate a mechanism by which MSCs in the tumor microenvironment promote metastasis and provide a microfluidic platform with the potential to predict BC metastasis in clinical samples. : How MSCs in the tumor microenvironment promote breast cancer progression is unclear. Chen et al. find that aggressive breast cancer cells are able to engulf MSCs. Through the development of a microfluidic cell pairing platform, they discover that this process induces transcriptome changes in breast cancer cells and enhances distant metastasis. Keywords: breast cancer, metastasis, mesenchymal stem cell, MSC, cell fusion, cell engulfment, EZH2, microfluidics, microenvironment, single cell retrieval
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Hydro-Seq enables contamination-free high-throughput single-cell RNA-sequencing for circulating tumor cells

    Yu-Heng Cheng / Yu-Chih Chen / Eric Lin / Riley Brien / Seungwon Jung / Yu-Ting Chen / Woncheol Lee / Zhijian Hao / Saswat Sahoo / Hyun Min Kang / Jason Cong / Monika Burness / Sunitha Nagrath / Max S. Wicha / Euisik Yoon

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 11

    Abstract: Transcriptome analysis of circulating tumor cells (CTCs) provides insights into monitoring target therapeutics and underlying tumor metastasis. Here the authors present Hydro-Seq, a contamination-free high-throughput hydrodynamic scRNA-seq barcoding ... ...

    Abstract Transcriptome analysis of circulating tumor cells (CTCs) provides insights into monitoring target therapeutics and underlying tumor metastasis. Here the authors present Hydro-Seq, a contamination-free high-throughput hydrodynamic scRNA-seq barcoding technique for rare CTCs.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Hydro-Seq enables contamination-free high-throughput single-cell RNA-sequencing for circulating tumor cells

    Yu-Heng Cheng / Yu-Chih Chen / Eric Lin / Riley Brien / Seungwon Jung / Yu-Ting Chen / Woncheol Lee / Zhijian Hao / Saswat Sahoo / Hyun Min Kang / Jason Cong / Monika Burness / Sunitha Nagrath / Max S. Wicha / Euisik Yoon

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 11

    Abstract: Transcriptome analysis of circulating tumor cells (CTCs) provides insights into monitoring target therapeutics and underlying tumor metastasis. Here the authors present Hydro-Seq, a contamination-free high-throughput hydrodynamic scRNA-seq barcoding ... ...

    Abstract Transcriptome analysis of circulating tumor cells (CTCs) provides insights into monitoring target therapeutics and underlying tumor metastasis. Here the authors present Hydro-Seq, a contamination-free high-throughput hydrodynamic scRNA-seq barcoding technique for rare CTCs.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator

    Yu-Chih Chen / Brock Humphries / Riley Brien / Anne E. Gibbons / Yu-Ting Chen / Tonela Qyli / Henry R. Haley / Matthew E. Pirone / Benjamin Chiang / Annie Xiao / Yu-Heng Cheng / Yi Luan / Zhixiong Zhang / Jason Cong / Kathryn E. Luker / Gary D. Luker / Euisik Yoon

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Band 13

    Abstract: Abstract Isolation of tumor-initiating cells currently relies on markers that do not reflect essential biologic functions of these cells. We proposed to overcome this limitation by isolating tumor-initiating cells based on enhanced migration, a function ... ...

    Abstract Abstract Isolation of tumor-initiating cells currently relies on markers that do not reflect essential biologic functions of these cells. We proposed to overcome this limitation by isolating tumor-initiating cells based on enhanced migration, a function tightly linked to tumor-initiating potential through epithelial-to-mesenchymal transition (EMT). We developed a high-throughput microfluidic migration platform with automated cell tracking software and facile recovery of cells for downstream functional and genetic analyses. Using this device, we isolated a small subpopulation of migratory cells with significantly greater tumor formation and metastasis in mouse models. Whole transcriptome sequencing of migratory versus non-migratory cells from two metastatic breast cancer cell lines revealed a unique set of genes as key regulators of tumor-initiating cells. We focused on phosphatidylserine decarboxylase (PISD), a gene downregulated by 8-fold in migratory cells. Breast cancer cells overexpressing PISD exhibited reduced tumor-initiating potential in a high-throughput microfluidic mammosphere device and mouse xenograft model. PISD regulated multiple aspects of mitochondria, highlighting mitochondrial functions as therapeutic targets against cancer stem cells. This research establishes not only a novel microfluidic technology for functional isolation of tumor-initiating cells regardless of cancer type, but also a new approach to identify essential regulators of these cells as targets for drug development.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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