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  1. Article ; Online: Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning

    Taiyi Wang / Weiwei Xie / Jiahui Yu / Clive Ellory / Robert Wilkins / Yan Zhu / Yu-ling Ma

    Frontiers in Pharmacology, Vol

    2019  Volume 10

    Abstract: Xin Su Ning (XSN) is a China patented and certified herbal medicine used to treat premature ventricular contractions (PVCs) since 2005. A recent completed clinical trial of 861 patients showed that XSN had similar PVC inhibition rate to the class I ... ...

    Abstract Xin Su Ning (XSN) is a China patented and certified herbal medicine used to treat premature ventricular contractions (PVCs) since 2005. A recent completed clinical trial of 861 patients showed that XSN had similar PVC inhibition rate to the class I antiarrhythmic drug mexiletine, at 65.85% for XSN and 63.10% for mexiletine. We have previously reported that XSN prolongs action potential duration (APD) and suppresses action potential amplitude (APA) of the cardiac ventricular myocytes. In this report we aim to reveal the effect of XSN on the ionic channels that govern APD and APA, which would help to explain the cellular electrophysiological mechanism of XSN. Our main findings are: (1) On ECG recorded in isolated rat, in the presence of XSN the amplitude of R wave was significantly decreased and the amplitude of T wave was increased significantly; (2) XSN blocked hNaV1.5 channel stably transfected cell line in a dose-dependent manner with an IC50 of 0.18 ± 0.02 g/L; and (3) XSN suppresses hERG channels in a dose-dependent manner with an IC50 of 0.34 ± 0.01 g/L. In conclusion, the clinical antiarrhythmic efficacy of XSN is based on its class I and Class III antiarrhythmic properties by suppression hNaV1.5 channel and hERG channels, which are directly responsible for XSN’s effect on APA suppression and APD prolongation.
    Keywords anti-arrhythmic drugs ; premature ventricular contractions ; Xin Su Ning ; Chinese Herbal Medicine ; electrophysiology ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Corrigendum

    Taiyi Wang / Weiwei Xie / Jiahui Yu / Clive Ellory / Robert Wilkins / Yan Zhu / Yu-ling Ma

    Frontiers in Pharmacology, Vol

    Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning

    2019  Volume 10

    Keywords anti-arrhythmic drugs ; premature ventricular contractions ; Xin Su Ning ; Chinese Herbal Medicine ; electrophysiology ; Therapeutics. Pharmacology ; RM1-950
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Investigation on prescription screening of a polyherbal preparation based on splenocyte proliferation activity and its preparation method

    Ahmed Attia Ahmed Abdelmoaty / Yu-Ling Ma / Ruibin Bai / Xiao-Ping Zheng / Fang-Di Hu / Ying-Dong Li

    World Journal of Traditional Chinese Medicine, Vol 3, Iss 4, Pp 7-

    2017  Volume 14

    Abstract: Objective: The present study aims to optimize the extraction conditions of polysaccharides and flavonoids from a polyherbal preparation consisting of three kinds of Chinese medicinal herbs, Codonopsis pilosula, Crataegus pinnatifida, and Lycium barbarum, ...

    Abstract Objective: The present study aims to optimize the extraction conditions of polysaccharides and flavonoids from a polyherbal preparation consisting of three kinds of Chinese medicinal herbs, Codonopsis pilosula, Crataegus pinnatifida, and Lycium barbarum, and evaluation of its immunomodulatory activity in immunosuppressed mice. Materials and Methods: An orthogonal design (L9 [3]4) was constructed to achieve the optimal extraction conditions. The immunomodulatory action of the polyherbal preparation was studied at three doses of 10, 20, and 40 mL/kg/day orally by measuring splenocyte proliferation in mice model of cyclophosphamide-induced immunosuppression. Results: The chosen parameters, including the ratio of solvent-to-raw material, duration of extraction, and extraction times, were the fundamental variables that influenced the extract yields. The highest yield of total polysaccharides content was 54.3 mg/mL when the ratio of solvent-to-raw material, duration of extraction, and number of extractions were 12:1, 1.5 h, and 3, respectively. The maximum extraction yield of the flavonoids was 3.5 mg/mL when the ratio of solvent-to-raw material was 12:1, the extraction time was 2 h, and the number of extractions was 3. The prescription screening showed that the impact of the polyherbal preparation on the splenocyte proliferation capacity was more pronounced than its disassembled components. Oral administration of the polyherbal preparation could significantly increase the concanavalin A-stimulated mouse spleen cells proliferation in a dose-dependent manner. Conclusion: These findings suggested that the polyherbal preparation possesses potential for augmenting the immune activity due to the polysaccharide and flavonoid content in these herbal medicines.
    Keywords Codonopsis pilosula ; Crataegus pinnatifida ; flavonoids ; Lycium barbarum ; polysaccharides ; Medicine (General) ; R5-920
    Subject code 660
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The effects of different compatibilities of Qing'e formula on scopolamine-induced learning and memory impairment in the mouse

    Xiao-Ping Zheng / Fang-Di Hu / Li Yang / Yu-Ling Ma / Bo-Lu Sun / Chang-Hong Wang / Zheng-Tao Wang

    World Journal of Traditional Chinese Medicine, Vol 3, Iss 3, Pp 12-

    2017  Volume 17

    Abstract: Background: The Qing'e formula (QEF) is a well-known traditional Chinese prescription that has been clinically employed for treatment of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different ... ...

    Abstract Background: The Qing'e formula (QEF) is a well-known traditional Chinese prescription that has been clinically employed for treatment of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different compatibilities of QEF on the scopolamine-induced learning and memory impairment in the mouse, and further to explore its action mechanisms and compatibility rationality. Materials and Methods: The learning and memory alterations in the mouse were evaluated using the step-down test and Morris water maze (MWM) test; the acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF) expression in the hippocampus were measured using colorimetric method or immunohistochemistry. Results: The results showed that different compatibilities of QEF significantly prolonged latency in the step-down test, shortened escape latency in the navigation test, increased the percentage of residence time, and the percentage of swimming distance in the target quadrant in the probe trial session. In addition, our results also found that different compatibilities of QEF remarkably inhibited AChE activity and increased BDNF expression in the hippocampus of mice. What's more, the group after being treated with whole recipe (QF) showed the highest level of improvement. Conclusions: These findings not only suggest that QEF may effectively ameliorate cognitive deficits through inhibiting AChE activity and increasing BDNF expression in the hippocampus but also elucidate the rationality of QEF.
    Keywords Acetylcholinesterase ; brain-derived factor ; Learning and memory ; Qing'e formula ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Deciphering the Active Compounds and Mechanisms of Qixuehe Capsule on Qi Stagnation and Blood Stasis Syndrome

    Yu-Xi Huang / Ding-Qiao Xu / Shi-Jun Yue / Yan-Yan Chen / Hui-Juan Tao / Rui-jia Fu / Li-Ming Xing / Taiyi Wang / Yu-ling Ma / Bao-An Wang / Yu-Ping Tang / Jin-Ao Duan

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Network Pharmacology Study

    2020  Volume 2020

    Abstract: Background. Qixuehe capsule (QXH), a Chinese patent medicine, has been demonstrated to be effective in the treatment of menstrual disorders. In traditional Chinese medicine (TCM) theory, qi stagnation and blood stasis syndrome (QS-BSS) is the main ... ...

    Abstract Background. Qixuehe capsule (QXH), a Chinese patent medicine, has been demonstrated to be effective in the treatment of menstrual disorders. In traditional Chinese medicine (TCM) theory, qi stagnation and blood stasis syndrome (QS-BSS) is the main syndrome type of menstrual disorders. However, the pharmacodynamic effect of QXH in treating QS-BSS is not clear, and the main active compounds and underlying mechanisms remain unknown. Methods. A rat model of QS-BSS was established to evaluate the pharmacodynamic effect of QXH. Thereafter, a network pharmacology approach was performed to decipher the active compounds and underlying mechanisms of QXH. Results. QXH could significantly reduce the rising whole blood viscosity (WBV) and plasma viscosity (PV) but also normalize prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB) content in QS-BSS rats. Based on partial least-squares-discriminant analysis (PLS-DA), the low-dose QXH-intervened (QXH-L) and the high-dose QXH-intervened (QXH-H) groups seemed the most effective by calculating the relative distance to normality. Through network pharmacology, QXH may improve hemorheological abnormality mainly via 185 compounds-51 targets-28 pathways, whereas 184 compounds-68 targets-28 pathways were associated with QXH in improving coagulopathy. Subsequently, 25 active compounds of QXH were verified by UPLC-Q/TOF-MS. Furthermore, 174 active compounds of QXH were shared in improving hemorheological abnormality and coagulopathy in QS-BSS, each of which can act on multiple targets to be mainly involved in complement and coagulation cascades, leukocyte transendothelial migration, PPAR signaling pathway, VEGF signaling pathway, and arachidonic acid metabolism. The attribution of active compounds indicated that Angelicae Sinensis Radix (DG), Paeoniae Radix Rubra (CS), Carthami Flos (HH), Persicae Semen (TR), and Corydalis Rhizoma (YHS) were the vital herbs of QXH in treating QS-BSS. Conclusion. QXH can improve the hemorheology ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 540
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Chemical Characteristics Combined with Bioactivity for Comprehensive Evaluation of Tumuxiang Based on HPLC-DAD and Multivariate Statistical Methods

    Xia Gao / Yu-Ling Ma / Pei Zhang / Xiao-Ping Zheng / Bo-Lu Sun / Fang-Di Hu

    World Journal of Traditional Chinese Medicine, Vol 2, Iss 2, Pp 36-

    2016  Volume 47

    Abstract: Background: The dried roots of Inula helenium L. (IH) and Inula racemosa Hook f. (IR) are used commonly as folk medicine under the name of “tumuxiang (TMX)”. Phenolic acid compounds and their derivatives, as main active constituents in IH and IR, exhibit ...

    Abstract Background: The dried roots of Inula helenium L. (IH) and Inula racemosa Hook f. (IR) are used commonly as folk medicine under the name of “tumuxiang (TMX)”. Phenolic acid compounds and their derivatives, as main active constituents in IH and IR, exhibit prominent anti-inflammation effect.
    Keywords Inula helenium L. ; Inula racemosa Hook f. ; HPLC fingerprints ; Spectrum-efficacy relationship ; Multivariate statistical methods ; Medicine (General) ; R5-920
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Oat products modulate the gut microbiota and produce anti-obesity effects in obese rats

    Dong, Ji-lin / Qi-sen Xiang / Rui-ling Shen / Yan-qi Liu / Ying-ying Zhu / Yu-ling Ma

    Journal of functional foods. 2016 Aug., v. 25

    2016  

    Abstract: Three oat products were supplemented into high fat diets and fed to obese rats for 8 weeks. Each oat product decreased body weight, epididymal fat accumulation, and serum inflammatory factor levels and significantly regulated serum lipid levels. Oat bran ...

    Abstract Three oat products were supplemented into high fat diets and fed to obese rats for 8 weeks. Each oat product decreased body weight, epididymal fat accumulation, and serum inflammatory factor levels and significantly regulated serum lipid levels. Oat bran significantly reduced mean adipocyte size and TNF-α mRNA expression levels. Principal components analysis showed that the oat products shifted the overall structure of gut microbiota in DIO rats. The relative abundances of Bacteroidetes and Firmicutes and the Bacteroidetes/Firmicutes ratio were altered towards that of normal rats. Spearman's correlation analysis showed that changes in the overall microbiota composition were significantly correlated with total cholesterol, triacylglycerol, endotoxin, and tumour cell necrosis factor-α levels in serum, and mRNA expression levels. Oat products significantly increased the total short-chain fatty acids (SCFA) concentration in colonic digesta. These results suggest that oat products attenuate obesity and related metabolic disorders while modifying the gut microbiota composition in high fat diet-induced obese rats.
    Keywords adipocytes ; Bacteroidetes ; blood lipids ; blood serum ; cholesterol ; digesta ; endotoxins ; epididymis ; Firmicutes ; gene expression ; high fat diet ; intestinal microorganisms ; messenger RNA ; metabolic diseases ; necrosis ; neoplasm cells ; oat bran ; oats ; obesity ; principal component analysis ; rats ; short chain fatty acids ; triacylglycerols ; tumor necrosis factor-alpha
    Language English
    Dates of publication 2016-08
    Size p. 408-420.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2016.06.025
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning

    Yu-ling Ma / Rou-Mu Hu / Xinchun Yang / Taiyi Wang / Penelope J. Noble / Robert Wilkins / Clive Ellory / Carolyn Carr / Denis Noble / Jiefu Yang / Weixing Lu / Junhua Zhang / Hongde Hu / Xiaomei Guo / Min Chen / Yang Wu / Meng Wei / Jingyuan Mao / Xiaochang Ma /
    Ling Qin / Huanlin Wu / Feng Lu / Ying Cao / Sheng Gao / Wanli Gu

    Frontiers in Pharmacology, Vol

    2020  Volume 11

    Abstract: Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse ... ...

    Abstract Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Conventional electrophysiological techniques were used to study the cellular antiarrhythmic mechanism of XSN. Data was then modeled with computational simulation of human action potential (AP) of the cardiac ventricular myocytes. The clinical trial was conducted with a total of 861 eligible participants randomly assigned in a ratio of 2:2:1 to receive XSN, mexiletine, or the placebo for 4 weeks. The primary and secondary endpoint was the change of premature ventricular contraction (PVC) counts and PVC-related symptoms, respectively. This trial was registered in the Chinese Clinical Trial Register Center (ChiCTR-TRC-14004180). We found that XSN prolonged AP duration of the ventricular myocytes in a dose-dependent, reversible manner and blocked potassium channels. Patients in XSN group exhibited significant total effective responses in the reduction of PVCs compared to those in the placebo group (65.85% vs. 27.27%, P < 0.0001). No severe adverse effects attributable to XSN were observed. In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular ...
    Keywords Xin Su Ning ; traditional Chinese medicine ; multicomponent antiarrhythmic medicine ; cellular electrophysiology ; premature ventricular contraction ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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