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Book ; Online ; E-Book: Towards Holistic Medicine

Yuan, Bing

2022

Abstract: This book outlines the method and theoretical framework of holistic medicine, and gives the method of constructing the theoretical system and using it to achieve the best regulation of diseases. It can be expected that holistic medicine will become the ... ...

Abstract	This book outlines the method and theoretical framework of holistic medicine, and gives the method of constructing the theoretical system and using it to achieve the best regulation of diseases. It can be expected that holistic medicine will become the mainstream medicine in the 21st century.
Subject code	615.5
Language	English
Size	1 online resource (281 pages)
Edition	1st ed.
Publisher	Taylor & Francis Group
Publishing place	Milton
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-429-03219-6 ; 0-429-62913-3 ; 0-367-14534-0 ; 978-0-429-03219-6 ; 978-0-429-62913-6 ; 978-0-367-14534-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: What Personalized Medicine Humans Need and Way to It --also on the Practical Significance and Scientific Limitations of Precision Medicine.

Yuan, Bing

Pharmacogenomics and personalized medicine

2022 Volume 15, Page(s) 927–942

Abstract: The rise of precision medicine has opened up a broad space for the development of modern medicine and has also given practical significance to the concept of personalised medicine. Precision medicine is establishing a personalized disease classification ... ...

Abstract	The rise of precision medicine has opened up a broad space for the development of modern medicine and has also given practical significance to the concept of personalised medicine. Precision medicine is establishing a personalized disease classification system that differs from the traditional system. However, the research progress of precision medicine in recent years is far from satisfactory: There are few disease types that can be attributed to the abnormality of a single target; the effects of current'precision' medications are not ideal, and various side effects remain unavoidable. The methodology of precision medicine is still reductionist, and it would not solve the integration problem of clinical treatment but rather would increase the difficulty of integration. Therefore, the precision medicine approach is not a feasible way to build a personalised medicine system. Based on the analysis and demonstration of the scientific limitations of precision medicine and the consistency of traditional Chinese medicine (TCM) and complexity science methods, this paper draws on the concepts and methods of cybernetics and complexity science, and proposes a fresh set of ideas and methods for the development of personalised medicine. The conclusion is as follows: Along the path of precision medicine, ideal personalised medicine cannot be achieved; what people ultimately need is personalised medicine that can achieve holistic integration. On the basis of TCM with the characteristics of holistic integration and personalisation, and according to scientific norms and the principle of evidence, building a theoretical model and state description system grounded in empirical evidence is the best way to establish a personalised medicine system.
Language	English
Publishing date	2022-11-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508173-1
ISSN	1178-7066
ISSN	1178-7066
DOI	10.2147/PGPM.S380767
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Towards a Clinical Efficacy Evaluation System Adapted for Personalized Medicine.

Yuan, Bing

Pharmacogenomics and personalized medicine

2021 Volume 14, Page(s) 487–496

Abstract: The rise of precision medicine (PM) has initiated the transition of mainstream medicine from disease-based medicine to personalized medicine, alongside which the US FDA has begun to establish a clinical trial and efficacy evaluation (CTEE) system ... ...

Abstract	The rise of precision medicine (PM) has initiated the transition of mainstream medicine from disease-based medicine to personalized medicine, alongside which the US FDA has begun to establish a clinical trial and efficacy evaluation (CTEE) system compatible with personalized medicine based on biological markers. Outside of modern medicine, however, there has always existed a personalized medical system, traditional Chinese medicine (TCM), that is, a personalized medical system built at the organism level with a similar concept and method to today's complexity science. However, under the current CTEE system, TCM has not usually been shown to be effective. The CTEE system of modern medicine has now begun to embrace personalized medicine at the microlevel. Therefore, there is no reason to continue to reject TCM, which is a type of personalized medicine at the organism level. This paper analyzes and compares the commonality and differences between a personalized medical system based on biomarkers established by PM and a personalized medical system based on syndromes in TCM; the results clearly reveal structural relationships between the two medical systems. On this basis, through rigorous logical reasoning, the feasibility of applying the CTEE method which is used in PM to evaluate the efficacy of TCM treatments is demonstrated. The relationship among biomarkers by which PM describes personalized states and modern medical diseases and the relationship among TCM syndromes and diseases are completely consistent. Because of this consistency, the new CTEE system established by the US FDA to promote the development of PM is fully applicable to the clinical trial and efficacy evaluation of TCM treatment methods. Clinical trials and efficacy evaluations based on this system can scientifically prove the effectiveness of TCM, and TCM is expected to be incorporated into the modern medical system based on scientific norms.
Language	English
Publishing date	2021-04-28
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508173-1
ISSN	1178-7066
ISSN	1178-7066
DOI	10.2147/PGPM.S304420
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chinese Medicine, Which Targets Body's Response State, Is An Effective Way to Treat Epidemic Infectious Diseases.

Yuan, Bing

Chinese journal of integrative medicine

2020 Volume 28, Issue 2, Page(s) 168–175

Abstract: In the fight against epidemic infectious diseases in the past 2,000 years, Chinese medicine (CM) has gradually developed a complete response system including diagnosis and treatment. The focal point of CM in the treatment of infectious diseases is the ... ...

Abstract	In the fight against epidemic infectious diseases in the past 2,000 years, Chinese medicine (CM) has gradually developed a complete response system including diagnosis and treatment. The focal point of CM in the treatment of infectious diseases is the personalized response state to pathogen, which is a treatment method consistent with the personalized concept of precision medicine. Compared with the methods of directly killing or inactivating pathogens, which are used in modern medicine, CM is an effective treatment modality that has a wider range of points of action in the human body. The remarkable effects achieved while treating SARS in 2003 and the current coronavirus disease 2019 (COVID-19) pneumonia and the history of the effective responses to epidemics in the past 2,000 years have fully demonstrated the effectiveness of CM in treating infectious diseases. This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods, which will reacquaint the world with CM. The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases.
MeSH term(s)	COVID-19 ; Communicable Diseases/epidemiology ; Communicable Diseases/therapy ; Drugs, Chinese Herbal ; Epidemics ; Humans ; Medicine, Chinese Traditional ; SARS-CoV-2
Chemical Substances	Drugs, Chinese Herbal
Keywords	covid19
Language	English
Publishing date	2020-10-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-020-3324-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Energy and Speed Landscapes of the Membrane Internalization Behavior of Soft Nanoparticles.

Zhang, Zhenyu / Ou, Luping / Yang, Kai / Yuan, Bing

The journal of physical chemistry. B

2024 Volume 128, Issue 11, Page(s) 2632–2639

Abstract: The cellular endocytosis of nanoparticles (NPs) is a fundamental biological process with significant potential in biomedical applications. However, a comprehensive understanding of the mechanistic aspects of endocytosis and the impact of particle ... ...

Abstract	The cellular endocytosis of nanoparticles (NPs) is a fundamental biological process with significant potential in biomedical applications. However, a comprehensive understanding of the mechanistic aspects of endocytosis and the impact of particle properties on this process remains elusive. In this study, we investigated the membrane-wrapping behavior of soft NPs (SNPs) with varying rigidities using theoretical calculations. Our findings reveal that the membrane-wrapping process of SNPs involves a complex energy change including the possible existence of an energy barrier; moreover, it is found that the location and height of this barrier strongly depend on the mechanistic properties of the NPs and membranes. Additionally, by considering force balance in the membrane-wrapping process, we calculated the speed at which NP is internalized by the membrane, showing a nonmonotonic dependence on particle rigidity and/or wrapping degree. These phenomena can be attributed to competition between different energy components associated with NP-membrane binding, membrane tension, and deformations occurring during SNP-membrane interaction processes. Our results contribute to a deeper understanding of cellular-level endocytosis mechanisms and offer potential applications for soft NPs in biomedicine.
MeSH term(s)	Cell Membrane/chemistry ; Nanoparticles/chemistry ; Membranes ; Endocytosis ; Physical Phenomena
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c07177
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A coupling model based on spatial characteristics and evolution of terrestrial ecosystem carbon storage: a case study of Hanzhong.

Yuan, Bing / Hou, Kang / Li, Yaxin / Sun, Pengcheng

Environmental science and pollution research international

2024

Abstract: Ecosystem carbon storage (ECS) is a critical consideration in reducing the impact of global warming and tackling environmental challenges, positioning it at the forefront of contemporary research. Due to the significant differences in the influence of ... ...

Abstract	Ecosystem carbon storage (ECS) is a critical consideration in reducing the impact of global warming and tackling environmental challenges, positioning it at the forefront of contemporary research. Due to the significant differences in the influence of land usage patterns on ECS in various policy contexts and China's commitment to attaining a carbon-neutral status, a model simulating different scenarios is needed to analyze the spatiotemporal characteristics and evolutionary process of carbon storage in terrestrial ecosystems accurately. To address this challenge, this study established a coupling model of "Geographical analysis -Evolution analysis -Predicting (GEP)" for assessing ecosystem ECS and analyzing its spatial characteristics and evolutionary patterns and projecting the spatial distribution of ECS under various developmental scenarios, which analyzed variations in ECS across different levels of magnitude and delineated the changing areas across a range of varying scenarios in the future additionally. The outcomes suggested that the ECS decreased by 1.17 × 10
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-33441-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chinese Medicine, Which Targets Body's Response State, Is An Effective Way to Treat Epidemic Infectious Diseases

Yuan, Bing

Chin. j. integr. med

Abstract	In the fight against epidemic infectious diseases in the past 2,000 years, Chinese medicine (CM) has gradually developed a complete response system including diagnosis and treatment. The focal point of CM in the treatment of infectious diseases is the personalized response state to pathogen, which is a treatment method consistent with the personalized concept of precision medicine. Compared with the methods of directly killing or inactivating pathogens, which are used in modern medicine, CM is an effective treatment modality that has a wider range of points of action in the human body. The remarkable effects achieved while treating SARS in 2003 and the current coronavirus disease 2019 (COVID-19) pneumonia and the history of the effective responses to epidemics in the past 2,000 years have fully demonstrated the effectiveness of CM in treating infectious diseases. This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods, which will reacquaint the world with CM. The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #846799
Database	COVID19

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Article ; Online: Transcatheter arterial embolization with N-butyl cyanoacrylate for postoperative hemorrhage treatment following pancreatoduodenectomy.

Zhang, Jin Long / Yuan, Bing / Zhang, Heng / Wang, Mao Qiang

Emergency radiology

2024 Volume 31, Issue 2, Page(s) 179–185

Abstract: Purpose: Postoperative hemorrhage (PPH) is a severe complication of pancreatoduodenectomy (PD) with a mortality rate of 5-20.2% and mortality due to hemorrhage of 11-58%. Transcatheter arterial embolization (TAE) has been widely recommended for PPH, ... ...

Abstract	Purpose: Postoperative hemorrhage (PPH) is a severe complication of pancreatoduodenectomy (PD) with a mortality rate of 5-20.2% and mortality due to hemorrhage of 11-58%. Transcatheter arterial embolization (TAE) has been widely recommended for PPH, however, TAE with N-butyl cyanoacrylate (NBCA) for PPH treatment has been reported rarely. Therefore, this study aimed to evaluate the safety and efficacy of TAE with NBCA for PPH treatment following PD. Methods: This retrospective study included 14 male patients (mean age, 60.93 ± 10.97 years) with postoperative hemorrhage following PD treated with TAE using NBCA as the main embolic agent from October 2019 to February 2022. The clinical data, technical and success rate, and complications were analyzed. Results: Among the 14 patients who underwent TAE, the technical and clinical success rates were 100 and 85.71%, respectively. Angiography revealed contrast extravasation in 12 cases and a pseudoaneurysm in 3 cases. One patient developed a serious infection and died 2 days after the TAE. Conclusion: TAE with NBCA for PPH treatment following PD, especially for massive hemorrhage caused by a pancreatic fistula, biliary fistula, or inflammatory corrosion, can result in rapid and effective hemostasis with high safety.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Enbucrilate/therapeutic use ; Pancreaticoduodenectomy/adverse effects ; Retrospective Studies ; Treatment Outcome ; Embolization, Therapeutic/adverse effects ; Postoperative Hemorrhage/therapy ; Postoperative Hemorrhage/drug therapy
Chemical Substances	Enbucrilate (F8CEP82QNP)
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1425144-9
ISSN	1438-1435 ; 1070-3004
ISSN (online)	1438-1435
ISSN	1070-3004
DOI	10.1007/s10140-024-02211-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulatory mechanisms underlying yeast chemical stress response and development of robust strains for bioproduction.

Yuan, Bing / Wang, Wei-Bin / Wang, Ya-Ting / Zhao, Xin-Qing

Current opinion in biotechnology

2024 Volume 86, Page(s) 103072

Abstract: Yeast is widely studied in producing biofuels and biochemicals using renewable biomass. Among various yeasts, Saccharomyces cerevisiae has been particularly recognized as an important yeast cell factory. However, economic bioproduction using S. ... ...

Abstract	Yeast is widely studied in producing biofuels and biochemicals using renewable biomass. Among various yeasts, Saccharomyces cerevisiae has been particularly recognized as an important yeast cell factory. However, economic bioproduction using S. cerevisiae is challenged by harsh environments during fermentation, among which inhibitory chemicals in the culture media or toxic products are common experiences. Understanding the stress-responsive mechanisms is conducive to developing robust yeast strains. Here, we review recent progress in mechanisms underlying yeast stress response, including regulation of cell wall integrity, membrane transport, antioxidative system, and gene transcription. We highlight epigenetic regulation of stress response and summarize manipulation of yeast stress tolerance for improved bioproduction. Prospects in the application of machine learning to improve production efficiency are also discussed.
MeSH term(s)	Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Epigenesis, Genetic ; Ethanol/metabolism ; Fermentation ; Biofuels
Chemical Substances	Ethanol (3K9958V90M) ; Biofuels
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1052045-4
ISSN	1879-0429 ; 0958-1669
ISSN (online)	1879-0429
ISSN	0958-1669
DOI	10.1016/j.copbio.2024.103072
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Article ; Online: Multi-timescale changes of water temperature due to the Three Gorges Reservoir and climate change in the Yangtze River, China

Xiao, Zijun / Sun, Jian / Lin, Binliang / Yuan, Bing

Ecological Indicators. 2023 Apr., v. 148 p.110129-

2023

Abstract: The water temperature in the Yangtze River has been found altering over the last decades. Although these alterations are expected to occur over multiple timescales and with multiple factors, including both reservoir operation and climate change, few ... ...

Abstract	The water temperature in the Yangtze River has been found altering over the last decades. Although these alterations are expected to occur over multiple timescales and with multiple factors, including both reservoir operation and climate change, few efforts have been made to quantify the alterations and conduct attribution analysis on multiple timescales. It hinders the deep understanding of the thermal regime in the Yangtze River and how it responses to the driving forces. Here, a multiresolution analysis based on the maximal overlap discrete wavelet analysis is applied to quantify the multi-timescale alterations of the water temperature, and to distinguish the impacts caused by reservoirs and climate change. The results indicate that the water temperature displays a significant upward trend in past three decades, which is mostly driven by the climate change. Reservoir operation has reduced the intra-annual variability of the water temperature, especially for the short-term and annual scales, resulting in a smoother and flatter water temperature process. The correlation between the water and air temperature is also investigated on multiple timescales based on the wavelet cross-correlation coefficients. It is found that the correlation between the air and water temperature in the natural state shows an overall increasing trend with the increasing timescale and peaks on annual scale. Due to the reservoir operation, the correlation on the moderate scales (1-4 months) has been notably weakened. While for the longer scales, the correlation between air and water temperature remains high, although their phases difference on some scales may be extended by months due to the reservoir operation.
Keywords	air ; air temperature ; climate change ; water temperature ; wavelet ; China ; Yangtze River ; River water temperature ; The Three Gorges Reservoir ; MODWT ; MRA
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2023.110129
Database	NAL-Catalogue (AGRICOLA)

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