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Article ; Online: Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.

Yuan, Xinrui / Jiang, Hua / Fu, Denggang / Rech, Jason C / Robida, Aaron / Rajanayake, Krishani / Yuan, Hebao / He, Miao / Wen, Bo / Sun, Duxin / Liu, Chen / Chinnaswamy, Krishnapriya / Stuckey, Jeanne A / Paczesny, Sophie / Yang, Chao-Yie

ACS pharmacology & translational science

2023 Volume 6, Issue 9, Page(s) 1275–1287

Abstract: Hematopoietic cell transplantation (HCT) is a proven and potentially curable therapy for hematological malignancies and inherited hematological disease. The main risk of HCT is the development of graft versus host disease (GVHD) acquired in up to 50% of ... ...

Abstract	Hematopoietic cell transplantation (HCT) is a proven and potentially curable therapy for hematological malignancies and inherited hematological disease. The main risk of HCT is the development of graft versus host disease (GVHD) acquired in up to 50% of patients. Upregulation of soluble ST2 (sST2) is a key clinical biomarker for GVHD prognosis and was shown to be a potential therapeutic target for GVHD. Agents targeting sST2 to reduce the sST2 level after HCT have the potential to mitigate GVHD progression. Here, we report
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.3c00122
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Article ; Online: Corrigendum to "A steamed broccoli sprout diet preparation that reduces colitis via the gut microbiota" [J Nutr Biochem 2023;112:109215].

Zhang, Tao / Holman, Johanna / McKinstry, Delaney / Trindade, Bruno C / Eaton, Kathryn A / Castrejon, Jonny Mendoza / Ho, Sharon / Wells, Emily / Yuan, Hebao / Wen, Bo / Sun, Duxin / Chen, Grace Y / Li, Yanyan

The Journal of nutritional biochemistry

2023 Volume 117, Page(s) 109340

Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2023.109340
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Article: Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety.

Gao, Wei / Hu, Hongxiang / Dai, Lipeng / He, Miao / Yuan, Hebao / Zhang, Huixia / Liao, Jinhui / Wen, Bo / Li, Yan / Palmisano, Maria / Traore, Mohamed Dit Mady / Zhou, Simon / Sun, Duxin

Acta pharmaceutica Sinica. B

2022 Volume 12, Issue 5, Page(s) 2462–2478

Abstract: Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However, the current drug optimization may overlook the ... ...

Abstract	Drug optimization, which improves drug potency/specificity by structure‒activity relationship (SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However, the current drug optimization may overlook the structure‒tissue exposure/selectivity-relationship (STR) in disease-targeted tissues
Language	English
Publishing date	2022-02-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2022.02.015
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Article ; Online: Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel in combination with α-PD1 induces tumor remission of breast cancer in mice.

Song, Yudong / Bugada, Luke / Li, Ruiting / Hu, Hongxiang / Zhang, Luchen / Li, Chengyi / Yuan, Hebao / Rajanayake, Krishani Kumari / Truchan, Nathan A / Wen, Fei / Gao, Wei / Sun, Duxin

Science translational medicine

2022 Volume 14, Issue 643, Page(s) eabl3649

Abstract: Immunomodulators that remodel the tumor immunosuppressive microenvironment have been combined with anti-programmed death 1 (α-PD1) or anti-programmed death ligand 1 (α-PDL1) immunotherapy but have shown limited success in clinical trials. However, ... ...

Abstract	Immunomodulators that remodel the tumor immunosuppressive microenvironment have been combined with anti-programmed death 1 (α-PD1) or anti-programmed death ligand 1 (α-PDL1) immunotherapy but have shown limited success in clinical trials. However, therapeutic strategies to modulate the immunosuppressive microenvironment of lymph nodes have been largely overlooked. Here, we designed an albumin nanoparticle, Nano-PI, containing the immunomodulators PI3Kγ inhibitor (IPI-549) and paclitaxel (PTX). We treated two breast cancer mouse models with Nano-PI in combination with α-PD1, which remodeled the tumor microenvironment in both lymph nodes and tumors. This combination achieved long-term tumor remission in mouse models and eliminated lung metastases. PTX combined with IPI-549 enabled the formation of a stable nanoparticle and enhanced the repolarization of M2 to M1 macrophages. Nano-PI not only enhanced the delivery of both immunomodulators to lymph nodes and tumors but also improved the drug accumulation in the macrophages of these two tissues. Immune cell profiling revealed that the combination of Nano-PI with α-PD1 remodeled the immune microenvironment by polarizing M2 to M1 macrophages, increasing CD4
MeSH term(s)	Albumins/therapeutic use ; Animals ; Breast Neoplasms/drug therapy ; CD8-Positive T-Lymphocytes ; Cell Line, Tumor ; Female ; Humans ; Mice ; Nanoparticles ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Tumor Microenvironment
Chemical Substances	Albumins ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abl3649
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Zs.A 6941: Show issues

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Article ; Online: Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity.

Hu, Hongxiang / Mady Traore, Mohamed Dit / Li, Ruiting / Yuan, Hebao / He, Miao / Wen, Bo / Gao, Wei / Jonsson, Colleen B / Fitzpatrick, Elizabeth A / Sun, Duxin

Journal of medicinal chemistry

2022 Volume 65, Issue 18, Page(s) 12044–12054

Abstract: COVID-19 patients with severe symptoms still lack antiviral treatment options. Although remdesivir is the only FDA-approved drug for those patients, its efficacy is limited by premature hydrolysis to nucleoside (NUC), low accumulation in the disease- ... ...

Abstract	COVID-19 patients with severe symptoms still lack antiviral treatment options. Although remdesivir is the only FDA-approved drug for those patients, its efficacy is limited by premature hydrolysis to nucleoside (NUC), low accumulation in the disease-targeted tissue (lungs), and low antiviral potency. In this study, we synthesized a new series of remdesivir analogues by modifying the ProTide moiety. In comparison with remdesivir, the lead compound MMT5-14 showed 2- to 7-fold higher antiviral activity in four variants of SARS-CoV-2. By reducing premature hydrolysis in hamsters, MMT5-14 increased the prodrug concentration by 200- to 300-fold in the plasma and lungs but also enhanced lung accumulation of the active metabolite triphosphate nucleosides (NTP) by 5-fold. Compared to remdesivir, MMT5-14 also increased the intracellular uptake and activation in lung epithelial cells by 4- to 25-fold. These data suggest that MMT5-14 could be a potential antiviral drug to treat COVID-19 patients with severe symptoms.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Alanine/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Humans ; Lung ; Nucleosides ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Nucleosides ; Prodrugs ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c00758
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Article ; Online: A steamed broccoli sprout diet preparation that reduces colitis via the gut microbiota.

Zhang, Tao / Holman, Johanna / McKinstry, Delaney / Trindade, Bruno C / Eaton, Kathryn A / Mendoza-Castrejon, Jonny / Ho, Sharon / Wells, Emily / Yuan, Hebao / Wen, Bo / Sun, Duxin / Chen, Grace Y / Li, Yanyan

The Journal of nutritional biochemistry

2022 Volume 112, Page(s) 109215

Abstract: Sulforaphane is a bioactive metabolite with anti-inflammatory activity and is derived from the glucosinolate glucoraphanin, which is highly abundant in broccoli sprouts. However, due to its inherent instability its use as a therapeutic against ... ...

Abstract	Sulforaphane is a bioactive metabolite with anti-inflammatory activity and is derived from the glucosinolate glucoraphanin, which is highly abundant in broccoli sprouts. However, due to its inherent instability its use as a therapeutic against inflammatory diseases has been limited. There are few studies to investigate a whole food approach to increase sulforaphane levels with therapeutic effect and reduce inflammation. In the current study, using a mouse model of inflammatory bowel disease, we investigated the ability of steamed broccoli sprouts to ameliorate colitis and the role of the gut microbiota in mediating any effects. We observed that despite inactivation of the plant myrosinase enzyme responsible for the generation of sulforaphane via steaming, measurable levels of sulforaphane were detectable in the colon tissue and feces of mice after ingestion of steamed broccoli sprouts. In addition, this preparation of broccoli sprouts was also capable of reducing chemically-induced colitis. This protective effect was dependent on the presence of an intact microbiota, highlighting an important role for the gut microbiota in the metabolism of cruciferous vegetables to generate bioactive metabolites and promote their anti-inflammatory effects.
MeSH term(s)	Gastrointestinal Microbiome ; Isothiocyanates/pharmacology ; Diet ; Brassica/metabolism ; Colitis/chemically induced ; Colitis/prevention & control ; Glucosinolates
Chemical Substances	sulforaphane (GA49J4310U) ; Isothiocyanates ; Glucosinolates
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.109215
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Article ; Online: Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.

Yuan, Xinrui / Jiang, Hua / Fu, Denggang / Robida, Aaron / Rajanayake, Krishani / Yuan, Hebao / Wen, Bo / Sun, Duxin / Watch, Brennan T / Chinnaswamy, Krishnapriya / Stuckey, Jeanne A / Paczesny, Sophie / Rech, Jason C / Yang, Chao-Yie

Bioorganic & medicinal chemistry

2022 Volume 71, Page(s) 116942

Abstract: An elevated plasma level of soluble ST2 (sST2) is a risk biomarker for graft-versus-host disease (GVHD) and death in patients receiving hematopoietic cell transplantation (HCT). sST2 functions as a trap for IL-33 and amplifies the pro-inflammatory type 1 ...

Abstract	An elevated plasma level of soluble ST2 (sST2) is a risk biomarker for graft-versus-host disease (GVHD) and death in patients receiving hematopoietic cell transplantation (HCT). sST2 functions as a trap for IL-33 and amplifies the pro-inflammatory type 1 and 17 response while suppressing the tolerogenic type 2 and regulatory T cells activation during GVHD development. We previously identified small-molecule ST2 inhibitors particularly iST2-1 that reduces plasma sST2 levels and improved survival in two animal models. Here, we reported the structure-activity relationship of the furanylmethylpyrrolidine-based ST2 inhibitors based on iST2-1. Based on the biochemical AlphaLISA assay, we improved the activity of iST2-1 by 6-fold (∼6 μM in IC
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/metabolism ; Furans ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/metabolism ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Interleukin-33/metabolism ; Pyrrolidines/pharmacology ; Structure-Activity Relationship
Chemical Substances	Furans ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Pyrrolidines
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2022.116942
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Article ; Online: Albumin Nanoparticle of Paclitaxel (Abraxane) Decreases while Taxol Increases Breast Cancer Stem Cells in Treatment of Triple Negative Breast Cancer.

Yuan, Hebao / Guo, Hongwei / Luan, Xin / He, Miao / Li, Feng / Burnett, Joseph / Truchan, Nathan / Sun, Duxin

Molecular pharmaceutics

2020 Volume 17, Issue 7, Page(s) 2275–2286

Abstract: Triple-negative breast cancer (TNBC) has a high rate of metastasis, which is associated with breast cancer stem-like cells (CSCs). Although Taxol (micelle formulation of paclitaxel) is the first line chemotherapy to treat TNBC, it increases CSCs in ... ...

Abstract	Triple-negative breast cancer (TNBC) has a high rate of metastasis, which is associated with breast cancer stem-like cells (CSCs). Although Taxol (micelle formulation of paclitaxel) is the first line chemotherapy to treat TNBC, it increases CSCs in residual tumors. Abraxane, albumin nanoparticle of paclitaxel, showed lower plasma concentration compared to Taxol in both human and animal models, but it is not clear why Abraxane showed superior efficacy to Taxol in treatment of metastatic breast cancer in humans. In this study, we intend to investigate if Abraxane eliminates CSCs for its better efficacy. The results showed that Abraxane showed similar cytotoxicity in SUM149 cells in comparison with Taxol. Although Abraxane showed 3- to 5-fold lower blood drug concentration compared to Taxol, it achieved similar tumor drug concentration and 10-fold higher tumor/plasma ratio in SUM149 xenograft NOD/SCID mouse model. In addition, Abraxane and Taxol showed similar efficacy to shrink the tumor size in orthotopic breast cancer NOD/SCID mouse model. However, Abraxane decreased breast CSCs frequency by 3- to 9-fold, while Taxol increased breast CSCs frequency in an orthotopic breast cancer NOD/SCID mouse model. Furthermore, Abraxane increased 3- to 15-fold intracellular uptake in both ALDH+ CSCs and differentiated ALDH- cells in comparison with Taxol, which provides a mechanism for Abraxane's superior efficacy to eliminate CSCs in comparison with Taxol. Our data suggest albumin nanoparticle Abraxane may have a broad implication to enhance drug's efficacy by eliminating breast cancer stem cells for treatment of metastatic diseases.
MeSH term(s)	Albumin-Bound Paclitaxel/administration & dosage ; Albumin-Bound Paclitaxel/chemistry ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Disease Models, Animal ; Drug Delivery Systems/methods ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Nanoparticles/chemistry ; Neoplastic Stem Cells/drug effects ; Treatment Outcome ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Chemical Substances	Albumin-Bound Paclitaxel ; Antineoplastic Agents
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.9b01221
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Article ; Online: Germline stem cells: stems of the next generation.

Yuan, Hebao / Yamashita, Yukiko M

Current opinion in cell biology

2010 Volume 22, Issue 6, Page(s) 730–736

Abstract: Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell ... ...

Abstract	Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highly proliferative, owing to organismal requirement to produce large number of differentiated cells. While many somatic stem cells are multipotent, with multiple differentiation pathways, GSCs are unipotent. For these relatively simple characteristics (e.g. constant proliferation and unipotency), GSCs have served as ideal model systems for the study of adult stem cell behavior, leading to many important discoveries. Here, we summarize recent progress in GSC biology, with an emphasis on evolutionarily conserved mechanisms.
MeSH term(s)	Aging/physiology ; Animals ; Cell Dedifferentiation/physiology ; Cell Differentiation/physiology ; Germ Cells/cytology ; Germ Cells/physiology ; Signal Transduction/physiology ; Stem Cell Niche ; Stem Cells/cytology ; Stem Cells/physiology
Language	English
Publishing date	2010-09-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2010.08.013
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Article: Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation

Luan, Xin / Yuan, Hebao / Song, Yudong / Hu, Hongxiang / Wen, Bo / He, Miao / Zhang, Huixia / Li, Yan / Li, Feng / Shu, Pan / Burnett, Joseph P / Truchan, Nathan / Palmisano, Maria / Pai, Manjunath P / Zhou, Simon / Gao, Wei / Sun, Duxin

Biomaterials. 2021 Aug., v. 275

2021

Abstract: Anticancer nanomedicines are designed to improve anticancer efficacy by increasing drug accumulation in tumors through enhanced permeability retention (EPR) effect, and to reduce toxicity by decreasing drug accumulation in normal organs through long ... ...

Abstract	Anticancer nanomedicines are designed to improve anticancer efficacy by increasing drug accumulation in tumors through enhanced permeability retention (EPR) effect, and to reduce toxicity by decreasing drug accumulation in normal organs through long systemic circulation. However, the inconsistent efficacy/safety of nanomedicines in cancer patients versus preclinical cancer models have provoked debate for nanomedicine design criteria. In this study, we investigate nanomedicine design criteria in three types of preclinical cancer models using five clinically used nanomedicines, which identifies the factors for better clinical translations of their observed clinical efficacy/safety compared to free drug or clinical micelle formulation. When those nanomedicines were compared with drug solution or clinical micelle formulation in breast tumors, long and short-circulating nanomedicines did not enhance tumor accumulation by EPR effect in transgenic spontaneous breast cancer model regardless of their size or composition, although they improved tumor accumulations in subcutaneous and orthotopic breast cancer models. However, when tumors were compared to normal breast tissue, nanomedicines, drug solution and clinical micelle formulation showed enhanced tumor accumulation regardless of the breast cancer models. In addition, long-circulating nanomedicines did not further increase tumor accumulation in transgenic mouse spontaneous breast cancer nor universally decrease drug accumulations in normal organs; they decreased or increased accumulation in different organs, potentially changing the clinical efficacy/safety. In contrast, short-circulating nanomedicines decreased blood concentration and altered drug distribution in normal organs, which are correlated with their clinical efficacy/safety. A reappraisal of current nanomedicine design criteria is needed to ensure consistent clinical translation for improvement of their clinical efficacy/safety in cancer patients.
Keywords	biocompatible materials ; blood ; breast neoplasms ; breasts ; drugs ; mice ; micelles ; nanomedicine ; permeability ; toxicity
Language	English
Dates of publication	2021-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.120910
Database	NAL-Catalogue (AGRICOLA)

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