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  1. Article: A comprehensive genomic analysis provides insights on the high environmental adaptability of

    Zhao, Yang / Wei, Hua-Mei / Yuan, Jia-Li / Xu, Lian / Sun, Ji-Quan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1177951

    Abstract: ... ...

    Abstract Acinetobacter
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1177951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Palladium-catalyzed asymmetric [4+2] annulation of vinyl benzoxazinanones with pyrazolone 4,5-diones to access spirobenzoxazine frameworks.

    Chen, Ben-Hong / Liu, Shuai-Jiang / Zhao, Qian / Hou, Qiumeng / Yuan, Jia-Li / Zhan, Gu / Yang, Qian-Qian / Huang, Wei

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 9, Page(s) 1233–1236

    Abstract: Herein, a palladium-catalyzed general synthetic strategy to access an attractive and decorated set of chiral spiro derivatives of benzoxazine compounds is unveiled utilizing vinyl benzoxazinanones reacted with pyrazolone 4,5-diones, which extends the ... ...

    Abstract Herein, a palladium-catalyzed general synthetic strategy to access an attractive and decorated set of chiral spiro derivatives of benzoxazine compounds is unveiled utilizing vinyl benzoxazinanones reacted with pyrazolone 4,5-diones, which extends the application of vinyl benzoxazinanones with ketones. This asymmetric catalytic [4+2] cycloaddition reaction demonstrates a broad substrate scope with functional group tolerance in yields of up to 76% and up to 96% ee. A facile scale-up and straightforward conversion to diversely substituted products verify the synthetic utility of this method.
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc06621a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bioinformatics analysis of endophytic bacteria related to berberine in the Chinese medicinal plant

    Liu, Tian-Hao / Zhang, Xiao-Mei / Tian, Shou-Zheng / Chen, Li-Guo / Yuan, Jia-Li

    3 Biotech

    2020  Volume 10, Issue 3, Page(s) 96

    Abstract: Endophytic microorganisms absorb nutrients and prevent pathogen damage, supporting healthy plant growth. However, the relationship between endophytic bacteria and berberine synthesis in the medicinal ... ...

    Abstract Endophytic microorganisms absorb nutrients and prevent pathogen damage, supporting healthy plant growth. However, the relationship between endophytic bacteria and berberine synthesis in the medicinal plant
    Language English
    Publishing date 2020-02-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-020-2084-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: EZH2 as an Epigenetic Regulator of Cardiovascular Development and Diseases.

    Yuan, Jia-Li / Yin, Cheng-Ye / Li, Ying-Ze / Song, Shuai / Fang, Guo-Jian / Wang, Qun-Shan

    Journal of cardiovascular pharmacology

    2021  Volume 78, Issue 2, Page(s) 192–201

    Abstract: Abstract: Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3). Many noncoding RNAs or signaling ... ...

    Abstract Abstract: Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3). Many noncoding RNAs or signaling pathways are involved in EZH2 functional alterations. This new epigenetic regulation of target genes is able to silence downstream gene expression and modify physiological and pathological processes in heart development, cardiomyocyte regeneration, and cardiovascular diseases, such as hypertrophy, ischemic heart diseases, atherosclerosis, and cardiac fibrosis. Targeting the function of EZH2 could be a potential therapeutic approach for cardiovascular diseases.
    MeSH term(s) Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/physiopathology ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental ; Heart/growth & development ; Heart/physiopathology ; Humans ; Morphogenesis ; Myocardium/metabolism ; Myocardium/pathology ; Signal Transduction
    Chemical Substances EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1471: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Bioinformatics analysis of endophytic bacteria related to berberine in the Chinese medicinal plant Coptis teeta Wall

    Liu, Tian-hao / Zhang, Xiao-mei / Tian, Shou-zheng / Chen, Li-guo / Yuan, Jia-li

    3 Biotech. 2020 Mar., v. 10, no. 3

    2020  

    Abstract: Endophytic microorganisms absorb nutrients and prevent pathogen damage, supporting healthy plant growth. However, the relationship between endophytic bacteria and berberine synthesis in the medicinal plant Coptis teeta Wall. remains unclear. Herein, we ... ...

    Abstract Endophytic microorganisms absorb nutrients and prevent pathogen damage, supporting healthy plant growth. However, the relationship between endophytic bacteria and berberine synthesis in the medicinal plant Coptis teeta Wall. remains unclear. Herein, we explored the community composition of endophytic bacteria related to berberine in roots, stems, and leaves of wild-type and cultivated C. teeta. Endophytic bacterial communities were analyzed by 16S rRNA sequencing, and berberine content in roots was analyzed by high-performance liquid chromatography. Proteobacteria, Actinobacteria, and Bacteroidetes were the major phyla, and Mycobacterium, Salmonella, Nocardioides, Burkholderia-Paraburkholderia, and Rhizobium were the dominant genera in root, stem, and leaf tissues. Root berberine content was positively correlated with total N, total P, total K, and available K in rhizosphere soil. In addition, root berberine content was positively correlated with Microbacterium and norank_f_7B-8, whereas soil total K was positively correlated with Microbacterium and Burkholderia-Paraburkholderia in roots. Our results demonstrated a clear correlation between dominant endophytic bacteria and berberine synthesis in C. teeta. The findings are useful for the promotion of berberine production in C. teeta via manipulation of endophytic bacteria.
    Keywords Bacteroidetes ; Coptis ; Microbacterium ; Mycobacterium ; Nocardioides ; Rhizobium ; Salmonella ; bacteria ; bacterial communities ; berberine ; bioinformatics ; community structure ; endophytes ; high performance liquid chromatography ; leaves ; medicinal plants ; nutrients ; pathogens ; plant growth ; potassium ; rhizosphere ; ribosomal RNA ; roots ; sequence analysis ; soil ; stems ; tissues ; total nitrogen ; total phosphorus
    Language English
    Dates of publication 2020-03
    Size p. 96.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-020-2084-y
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.

    Yin, Wen / Zhang, Si-Qi / Pang, Wen-Lin / Chen, Xiao-Jiao / Wen, Jing / Hou, Jiong / Wang, Cui / Song, Li-Yun / Qiu, Zhen-Ming / Liang, Peng-Tao / Yuan, Jia-Li / Yang, Zhong-Shan / Bian, Yao

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2022  Volume 15, Page(s) 2563–2581

    Abstract: Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the ...

    Abstract Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated.
    Patients and methods: In the present study, we established an animal model of T2DM using a high‑fat diet (HFD) with intraperitoneal injection streptozotocin injection.
    Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the pro-inflammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the
    Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
    Language English
    Publishing date 2022-08-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S375572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Astragaloside trigger autophagy: Implication a potential therapeutic strategy for pulmonary fibrosis.

    Yu, Jing-Ze / Wen, Jing / Ying, Yi / Yin, Wen / Zhang, Si-Qi / Pang, Wen-Ling / Wang, Cui / Bian, Yao / Yuan, Jia-Li / Yan, Jin-Yuan / Yang, Zhong-Shan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 154, Page(s) 113603

    Abstract: Pulmonary fibrosis is an abnormal wound-healing response to repeated alveolar injury, characterized by continuous inflammation and abnormal collagen deposition. Its treatment is problematic. Astragaloside (AST) is an active component of Astragalus ... ...

    Abstract Pulmonary fibrosis is an abnormal wound-healing response to repeated alveolar injury, characterized by continuous inflammation and abnormal collagen deposition. Its treatment is problematic. Astragaloside (AST) is an active component of Astragalus membranaceus with anti-inflammatory and anti-tumor properties. Although the underlying mechanisms are unknown, AST is also used to treat fibrotic diseases. This study aimed to investigate the mechanisms of action of AST in pulmonary fibrosis treatment. We found that AST significantly improved restrictive ventilatory impairment, compliance, total lung capacity, and functional residual capacity. In mice with pulmonary fibrosis, extracellular matrix deposition in the pulmonary parenchyma and intemperate inflammation were reversed. This therapeutic effect can be attributed to autophagy, activating the genes for autophagy flux and autophagic vacuoles. Impaired autophagy increased susceptibility to pulmonary fibrosis by exacerbating collagen deposition in vitro and in vivo. Using a combination of molecular docking and network pharmacology, the Ras/Raf/MEK/ERK signaling pathway was identified as a possible candidate for the pharmacologic target of AST. Functional dephosphorylation of MEK and ERK inhibited the Ras/Raf/MEK/ERK signaling pathway, which converges at the rapamycin switch to initiate autophagy. Inhibitors of Ras and MEK regulated autophagy. These findings suggest that AST might treat pulmonary fibrosis by modulating the Ras/Raf/MEK/ERK signaling pathway mediated by depression.
    MeSH term(s) Mice ; Animals ; Pulmonary Fibrosis/drug therapy ; Molecular Docking Simulation ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Autophagy ; Inflammation ; Collagen/metabolism
    Chemical Substances Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-09-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Left Atrial Appendage Closure for Primary and Secondary Stroke Prevention in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Pilot Study.

    Mo, Bin-Feng / Zhang, Rui / Yuan, Jia-Li / Sun, Jian / Zhang, Peng-Pai / Li, Wei / Chen, Mu / Cai, Xing-Xing / Yu, Yi-Chi / Wang, Qun-Shan / Li, Yi-Gang

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 719755

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.719755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Curcumin and Curcumol Inhibit NF-

    Li, Ning / Liu, Tian-Hao / Yu, Jing-Ze / Li, Chen-Xi / Liu, Yang / Wu, Yue-Ying / Yang, Zhong-Shan / Yuan, Jia-Li

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 3035125

    Abstract: E-Zhu ( ...

    Abstract E-Zhu (
    Language English
    Publishing date 2019-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/3035125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats.

    Liu, Tian-Hao / Zhang, Xiao-Mei / Han, Ni-Ping / Liu, Yang / Wu, Yue-Ying / Li, Xiao-Ya / Yang, Zhong-Shan / Yuan, Jia-Li

    Evidence-based complementary and alternative medicine : eCAM

    2018  Volume 2018, Page(s) 4821821

    Abstract: Flora and mucosal immunity are considered to be the barrier, which is associated with multiple respiratory diseases, including recurrent respiratory tract infection (RRTI). Fei-Xi-Tiao-Zhi-Fang (FTF) is a traditional Chinese herbal formula used in the ... ...

    Abstract Flora and mucosal immunity are considered to be the barrier, which is associated with multiple respiratory diseases, including recurrent respiratory tract infection (RRTI). Fei-Xi-Tiao-Zhi-Fang (FTF) is a traditional Chinese herbal formula used in the treatment of RRTI. However, the mechanism is little known. This study aims to identify the function of FTF in flora and mucosal immune secretory immunoglobulin A (sIgA) in the model of RRTI rats. The samples of intestine and lung were collected to detect sIgA, short chain fatty acids (SCFAS), and flora with enzyme-linked immunosorbent assay (ELISA), gas chromatography, and 16S rDNA sequencing. The body weight and viscera index were increased dynamically in RRTI rats after the administration of FTF. Furthermore, the types and proportions of aboriginal flora were significantly changed in the model group, whereas the altered flora was rescued in the FTF administration group.
    Language English
    Publishing date 2018-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2018/4821821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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