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  1. Book ; Online ; E-Book: Vaccine efficacy evaluation

    Yuan, Lijuan

    the gnotobiotic pig model

    (Pocket Guides to Biomedical Sciences)

    2022  

    Author's details Lijuan Yuan
    Series title Pocket Guides to Biomedical Sciences
    Keywords Vaccines ; Vaccines/Research
    Subject code 615.3/72
    Language English
    Size 1 online resource (207 pages)
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-327782-9 ; 1-003-27782-9 ; 1-000-56601-3 ; 9781032234748 ; 978-1-00-327782-8 ; 978-1-003-27782-8 ; 978-1-000-56601-7 ; 1032234741
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: EFL teacher-student interaction, teacher immediacy, and Students' academic engagement in the Chinese higher learning context.

    Yuan, Lingjie

    Acta psychologica

    2024  Volume 244, Page(s) 104185

    Abstract: The present study was conducted with the aim of determining the role of mediators of teacher-student rapport in the relationship between the teachers' immediacy and academic engagement in EFL contexts. The participants of this correlational study were ... ...

    Abstract The present study was conducted with the aim of determining the role of mediators of teacher-student rapport in the relationship between the teachers' immediacy and academic engagement in EFL contexts. The participants of this correlational study were 285 students of Xinxiang which is an important central city in northern Henan province, China. They (195 females and 90 males) were selected as a convenient sampling. To collect the data, Teacher-Student Rapport Questionnaire (Wilson et al., 2010), Teachers' Immediacy Questionnaire (Gorham, 1988), and Learners' Academic Engagement (Kember & Leung, 2009) were employed. The collected data were analyzed using the Structural Equation Modeling (SEM) method. The results showed that the research model is confirmed in terms of significance and fit indicators, and the variable of teachers' immediacy indirectly affects academic engagement through teacher-student rapport (p < .05). The research findings presented robust evidence supporting a robust and positive correlation between teachers' verbal immediacy and students' engagement. This implies that when educators exhibit clear and expressive communication, it contributes significantly to fostering active involvement and participation among students. Expanding on this insight, the study suggests that the impact of teachers' nonverbal immediacy should not be overlooked. Indeed, nonverbal cues from educators can hold considerable influence in shaping the dynamics of the teacher-student relationship. Furthermore, it is proposed that nonverbal immediacy plays a pivotal role in influencing academic engagement. In essence, both verbal and nonverbal aspects of immediacy contribute synergistically to creating a conducive learning environment, enhancing the teacher-student connection, and ultimately promoting students' academic engagement.
    MeSH term(s) Female ; Male ; Humans ; Students ; Asian People ; China ; Communication ; Cues
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1480049-4
    ISSN 1873-6297 ; 0001-6918
    ISSN (online) 1873-6297
    ISSN 0001-6918
    DOI 10.1016/j.actpsy.2024.104185
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  3. Article ; Online: A dynamic culture system that models the intricacy of the mammary gland.

    Yuan, Lei

    Nature reviews. Molecular cell biology

    2024  Volume 25, Issue 4, Page(s) 248

    MeSH term(s) Humans ; Mammary Glands, Human
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-024-00704-4
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  4. Article: Enhancing Chinese EFL Students' Grit: The Impact of Teacher Stroke and Teacher-Student Rapport.

    Yuan, Lingjie

    Frontiers in psychology

    2022  Volume 12, Page(s) 823280

    Abstract: Due to the important role that students' grit plays in the effectiveness of their success in the educational system in which they are engaged, the current study scrutinized whether some factors regarding teachers such as their stroke and rapport can ... ...

    Abstract Due to the important role that students' grit plays in the effectiveness of their success in the educational system in which they are engaged, the current study scrutinized whether some factors regarding teachers such as their stroke and rapport can affect the learners' grit in one hand and on the other hand whether these factors can predict the learners' grit or not. To this end, a group of 316 Chinese university English as a Foreign Language (EFL) learners from more than 30 cities from nine provinces of China were asked to fill out the three scales, namely, teacher stroke, student rapport, and students' grit questionnaires. The foremost findings of the study, gained through running regression, indicate that there are positive relations between these variables as they affect learners' grit and also both variables were the predictors of grit, while teacher stroke was a better predictor, uniquely clarifying 45.5% of the grit's variance and teacher-student rapport similarly showed to be a predictor of grit, distinctively clarifying 4.6% of its variance. Accordingly, based on these findings, it can be concluded that both of these factors, as instances of positive teacher interpersonal behaviors, develop learners' grit in language learning. In addition, this study can provide further implications and recommendations for language teaching team members in academic circumstances.
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.823280
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  5. Article ; Online: Diabetic striatopathy: a case report.

    Guan, Yi / Yuan, Lu / Yuan, Lei

    Neurocase

    2024  , Page(s) 1–2

    Abstract: Diabetic striatopathy, a rare condition also known as hyperglycemic nonketotic hemichorea, is characterized by chorea or hemiballismus and distinctive basal ganglia abnormalities visible on neuroimaging. We present the case of an 86-year-old woman with ... ...

    Abstract Diabetic striatopathy, a rare condition also known as hyperglycemic nonketotic hemichorea, is characterized by chorea or hemiballismus and distinctive basal ganglia abnormalities visible on neuroimaging. We present the case of an 86-year-old woman with diabetic striatopathy exhibiting hemichorea. She had a history of poorly controlled type 2 diabetes and presented with involuntary movements of her left limb along with facial expressions suggestive of chorea. Laboratory tests confirmed hyperglycemia, with an elevated hemoglobin A1c level. Neuroimaging revealed T1-hyperintensity in the right basal ganglia. The patient was diagnosed with diabetic striatopathy and responded well to intensive insulin therapy with a rapid resolution of symptoms.
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1302651-3
    ISSN 1465-3656 ; 1355-4794
    ISSN (online) 1465-3656
    ISSN 1355-4794
    DOI 10.1080/13554794.2024.2317788
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  6. Thesis ; Online: Transcriptional regulation and chromatin reorganization in mechanically induced cellular reprogramming and rejuvenation

    Yuan, Luezhen

    2023  

    Abstract: This doctoral thesis explores the remarkable domain of mechanobiology, transcriptional regulation, and its relevance in regenerative medicine. Cells are known to be plastic, capable of transitioning between different states based on their ... ...

    Abstract This doctoral thesis explores the remarkable domain of mechanobiology, transcriptional regulation, and its relevance in regenerative medicine. Cells are known to be plastic, capable of transitioning between different states based on their microenvironment. Mechanical cues, in particular, have emerged as a potent trigger for cell-state transitions, such as reprogramming and differentiation, offering exciting prospects for regenerative medicine. However, the molecular mechanisms underlying these mechanically induced transitions remained poorly understood. The first chapter discusses recent work on exploring the role of mechanical environment and nucleus mechanisms in transcriptional regulation in various cell state transitions. The second chapter unveils the power of laterally confined growth of fibroblasts in inducing dedifferentiation programs. The molecular mechanisms underlying mechanically induced cell-state transitions are illuminated, with a focus on the critical role of the somatic transcription factor, Lef1. Lef1 has been implicated in various cellular contexts, but its central role in mechanically induced fibroblast dedifferentiation emerges as a key finding. Network optimization methods applied to time-lapse RNA-seq data identify Lef1-dependent signaling as potential regulators of these transitions, shedding light on Lef1's interaction with downstream reprogramming factors. Moreover, it identifies Smad4 and Atf2 as potential critical activators of Lef1, establishing an important mechanotransduction pathway for fibroblast dedifferentiation. Building on this foundation, the thesis dives into the rejuvenation of fibroblasts - a key focus for functional tissue regeneration. Traditional methods of cellular rejuvenation can be limited, often necessitating complete reprogramming and carrying risks like genomic mutations and low efficiency. However, the mechanically induced partially reprogrammed spheroids offer an innovative solution. When embedded in 3D collagen matrices with optimized stiffness, these ...
    Keywords Mechanobiology ; Stem cell ; Aging ; Reprogramming ; Rejuvenation ; Transcriptional regulation ; Bioinformatics ; Microscopy ; Imaging ; Image analysis ; info:eu-repo/classification/ddc/570 ; Life sciences
    Subject code 571
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: [Mechanism study of the protective effects of selective cyclooxygenase-2 enzyme inhibitors on the liver of rats with type 2 diabetes mellitus combined with nonalcoholic steatohepatitis via Rho/ROCK pathway].

    Yuan, L / Tian, F

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2022  Volume 30, Issue 1, Page(s) 74–80

    Abstract: Objective: ...

    Abstract Objective:
    Language Chinese
    Publishing date 2022-02-14
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20200507-00234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Posterior chamber implantation of iris-claw intraocular lenses in a child with bilateral dislocated spherophakia].

    Yuan, L / Bao, Y Z

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2022  Volume 58, Issue 5, Page(s) 371–372

    Abstract: A 6-year-old boy with blurred vision for 18 months was diagnosed as bilateral spherophakia and ectopia lentis. He received lensectomy and implantation of an iris-claw intraocular lens in the posterior chamber in both eyes. Good visual results were ... ...

    Abstract A 6-year-old boy with blurred vision for 18 months was diagnosed as bilateral spherophakia and ectopia lentis. He received lensectomy and implantation of an iris-claw intraocular lens in the posterior chamber in both eyes. Good visual results were achieved, and there were no complications during the two-year follow-up.
    MeSH term(s) Child ; Ectopia Lentis/surgery ; Follow-Up Studies ; Humans ; Lens Implantation, Intraocular ; Lens, Crystalline ; Lenses, Intraocular ; Male ; Postoperative Complications ; Retrospective Studies ; Visual Acuity
    Language Chinese
    Publishing date 2022-05-01
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20210902-00405
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  9. Article ; Online: Analysis of ginseng in the treatment of Interstitial Cystitis/Bladder Pain Syndrome based on network pharmacology.

    Wang, L / Yuan, L

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 13, Page(s) 4709–4720

    Abstract: Objective: The network pharmacology is adopted in the paper to elaborate the active components, targets, and pathways of ginseng in the treatment of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).: Materials and methods: The active components ... ...

    Abstract Objective: The network pharmacology is adopted in the paper to elaborate the active components, targets, and pathways of ginseng in the treatment of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Materials and methods: The active components and potential targets of ginseng were obtained through the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). The OMIM, Disgenet, and Genecards databases for IC/BPS targets, and the STRING11.0 database were used for the protein-protein interaction (PPI) network. Meanwhile, the latter covers R language was used for the target of ginseng for IC/BPS, Bioconductor bioinformatics software for GO and KEGG functional enrichment analysis of key target genes, and the Cytoscape 3.8.2 software for constructing the "component-target" network and the "component-target-pathway" network map.
    Results: The results are categorized into three camps: components, targets, and pathways. As for components, 22 active components of ginseng that perform biological activities in the cell membrane, cytoplasm, and nucleus were observed, among which kaempferol, girinimbin, suchilacton, arachidonate, and gomisin B are the main active ones. 650 targets were found, mainly represented by PTGS2, PTGS1, AR, SLC6A4, and CHRM2, 134 of which (especially AKT1, TNF, VEGFA, TP53, EGFR, STAT3, IL-1β, ESR1, and JUN) contribute to the treatment of IC/BPS. Moreover, the pathways that serve as major contributors are the PI3K-Akt signaling pathway, the HIF-1 signaling pathway, the STAT3 signaling pathway, the MAPK signaling pathway, the NF-κB signaling pathway, and the apoptosis-related pathway.
    Conclusions: Ginseng can exert anti-inflammatory, anti-oxidative stress and anti-apoptotic effects on IC/BPS thanks to its multi-component, multi-target and multi-way functions.
    MeSH term(s) Cystitis, Interstitial/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Molecular Docking Simulation ; Network Pharmacology ; Panax ; Phosphatidylinositol 3-Kinases ; Serotonin Plasma Membrane Transport Proteins
    Chemical Substances Drugs, Chinese Herbal ; SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2022-07-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202207_29196
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  10. Article: What keeps historical theme park visitors coming? Research based on expectation confirmation theory.

    Yuan, Li / Marzuki, Azizan

    Frontiers in psychology

    2024  Volume 15, Page(s) 1293638

    Abstract: Culture is one of the most important factors in attracting tourists and influencing the tourist experience. In China, "theme park" is a new field of tourism research, an excellent theme park can not only drive the development of a city's tourism industry, ...

    Abstract Culture is one of the most important factors in attracting tourists and influencing the tourist experience. In China, "theme park" is a new field of tourism research, an excellent theme park can not only drive the development of a city's tourism industry, but also help it better publicize its history and culture. The article takes Kaifeng, China as the background, and selects the Song Dynasty historical and cultural theme park, which was established based on the traditional ink painting Qingming Riverside Drawing, as an example, to study the factors affecting tourists' travel experience in historical and cultural theme parks, and based on which it explores the reasons for the formation of tourists' satisfaction and post-trip behavioral intentions, to provide references and suggestions for the development of cultural theme parks from the point of view of travel experience. Based on the expectation confirmation theory, this essay introduces five constructs, namely, expectation (tourism motivation), performance (service quality), confirmation (tourism experience), satisfaction, and post-trip behavior intention, to construct a model of the factors influencing tourists' satisfaction by tourism experience in historical theme parks and analyze the intrinsic correlation among the factors within the model. It is found that tourists' tourism experience is mainly affected by tourism motivation and service quality, satisfaction and post-trip behavior intention are jointly determined by the above three. According to the research results, this study believes that tourism motivation, service quality, and tourism experience should be the focus of attention of the current tourist destinations, therefore, focusing on tourists' motivation to optimize the quality of service, helping tourists to enhance the sense of tourism experience, and improving based on the above focuses is of great significance to promote the development of historical and cultural theme parks.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1293638
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