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  1. Article ; Online: Novel Strategies for Gene Therapy-Recent Advances in the Use of Exosomes for Disease Treatment.

    Yuan, Ling-Qing

    Current pharmaceutical design

    2020  Volume 25, Issue 42, Page(s) 4463

    MeSH term(s) Bone and Bones/metabolism ; Drug Carriers ; Exosomes ; Fibrosis/therapy ; Genetic Therapy/trends ; Humans ; Inflammation ; Musculoskeletal Diseases ; Parkinson Disease/drug therapy ; Sepsis/therapy
    Chemical Substances Drug Carriers
    Language English
    Publishing date 2020-01-14
    Publishing country United Arab Emirates
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282542191230114518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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  2. Article: Editorial: The Role of Exosomes in Metabolic and Endocrine Disease.

    Guo, Bei / Yuan, Ling-Qing

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 859650

    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.859650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Identification and validation of a novel cuproptosis-related lncRNA signature for prognosis and immunotherapy of head and neck squamous cell carcinoma.

    Xu, Qiu-Shuang / Shen, Zheng-Zhong / Yuan, Ling-Qing

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 968590

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent and heterogeneous malignancy with a dismal overall survival rate. Nevertheless, the effective biomarkers remain ambiguous and merit further investigation. Cuproptosis is a novel defined ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent and heterogeneous malignancy with a dismal overall survival rate. Nevertheless, the effective biomarkers remain ambiguous and merit further investigation. Cuproptosis is a novel defined pathway of programmed cell death that contributes to the progression of cancers. Meanwhile, long non-coding RNAs (lncRNAs) play a crucial role in the biological process of tumors. Nevertheless, the prognostic value of cuproptosis-related lncRNAs in HNSCC is still obscure. This study aimed to develop a new cuproptosis-related lncRNAs (CRLs) signature to estimate survival and tumor immunity in patients with HNSCC. Herein, 620 cuproptosis-related lncRNAs were identified from The Cancer Genome Atlas database through the co-expression method. To construct a risk model and validate the accuracy of the results, the samples were divided into two cohorts randomly and equally. Subsequently, a prognostic model based on five CRLs was constructed by the Cox regression analysis with the least absolute shrinkage and selection operator (LASSO) algorithm. In addition, the prognostic potential of the five-CRL signature was verified
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.968590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The effects of circulating non-sex hormones in cardiovascular disease.

    Shan, Su-Kang / Yan, Tong / Yuan, Ling-Qing

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 1065155

    MeSH term(s) Humans ; Cardiovascular Diseases ; Thyroxine ; Triiodothyronine
    Chemical Substances Thyroxine (Q51BO43MG4) ; Triiodothyronine (06LU7C9H1V)
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1065155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association of osteoporotic fractures of femoral neck and femoral neck geometric parameters in native Chinese women.

    Li, Lin / Shen, Yi / Tan, Li-Hua / Zhang, Hong / Dai, Ru-Chun / Yuan, Ling-Qing / Sheng, Zhi-Feng / Wu, Xi-Yu

    BMC musculoskeletal disorders

    2024  Volume 25, Issue 1, Page(s) 349

    Abstract: Background: Although it is generally believed that the femoral neck fracture is related to the femoral neck geometric parameters (FNGPs), the association between the risk of osteoporotic fracture of the femoral neck and FNGPs in native Chinese women is ... ...

    Abstract Background: Although it is generally believed that the femoral neck fracture is related to the femoral neck geometric parameters (FNGPs), the association between the risk of osteoporotic fracture of the femoral neck and FNGPs in native Chinese women is still unclear.
    Methods: A total of 374 female patients (mean age 70.2 ± 9.32 years) with osteoporotic fracture of the femoral neck, and 374 non-fracture control groups were completely matched with the case group according to the age ratio of 1:1. Using DXA bone densitometer to measured eight FNGPs: the outer diameter (OD), cross-sectional area (CSA), cortical thickness (CT), endocortical diameter (ED), buckling ratio (BR), section modulus (SM), cross-sectional moment of inertia (CSMI), and compressive strength index (CSI) at the narrowest point of the femoral neck.
    Results: Compared with the control group, the average values of OD (2.9%), ED (4.5%), and BR (26.1%) in the patient group significantly increased (p = 0.015 to < 0.001), while CSA (‒15.3%), CT (‒18.2%), SM (‒10.3%), CSMI (‒6.4%), and CSI (‒10.8%) significantly decreased (all p < 0.001). The prevalence of osteoporosis in the lumbar spine, femoral neck, and total hip was, respectively, 82%, 81%, and 65% in fracture patients. Cox proportional hazard model analysis showed that in the age adjusted model, the fracture hazard ratio (HR) of CSA, CT, BR, SM, and CSI significantly increased (HRs = 1.60‒8.33; 95% CI = 1.08‒16.6; all p < 0.001). In the model adjusted for age and femoral neck BMD, HRs of CT (HRs = 3.90‒8.03; 95% CI = 2.45‒15.1; all p < 0.001) and BR (HRs = 1.62‒2.60; 95% CI = 1.20‒5.44; all p < 0.001) were still significantly increased.
    Conclusion: These results suggest that the majority of osteoporotic fractures of the femoral neck of native Chinese women occur in patients with osteoporosis. CT thinning or BR increase of FNGPs may be independent predictors of fragility fracture of femoral neck in native Chinese women unrelated to BMD.
    MeSH term(s) Humans ; Female ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/diagnostic imaging ; Femoral Neck Fractures/diagnostic imaging ; Femoral Neck Fractures/epidemiology ; Femoral Neck Fractures/ethnology ; Aged ; Femur Neck/diagnostic imaging ; Middle Aged ; China/epidemiology ; Bone Density ; Absorptiometry, Photon ; Aged, 80 and over ; Case-Control Studies ; Asian People ; Risk Factors ; East Asian People
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07483-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of follicle-stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition.

    Li, Lin / Pi, Yin-Zhen / Zhang, Hong / Dai, Ru-Chun / Yuan, Ling-Qing / Sheng, Zhi-Feng / Wu, Xi-Yu

    Journal of clinical laboratory analysis

    2023  Volume 37, Issue 9-10, Page(s) e24899

    Abstract: Background: Elevated follicle-stimulating hormone (FSH) is associated with an increased risk of postmenopausal osteoporosis. This study investigated the association of serum FSH with bone turnover markers (BTMs) and bone mineral density (BMD) in healthy ...

    Abstract Background: Elevated follicle-stimulating hormone (FSH) is associated with an increased risk of postmenopausal osteoporosis. This study investigated the association of serum FSH with bone turnover markers (BTMs) and bone mineral density (BMD) in healthy women undergoing menopausal transition.
    Methods: A total of 487 healthy women (age 35-65 years, 50 ± 8.5 years) were enrolled in this study. Serum FSH, BTMs, and BMD at lumbar spine and total hip were measured in these subjects.
    Results: Follicle-stimulating hormone was positively correlated with various BTMs (r = 0.339-0.583, all p < 0.001) and negatively correlated with lumbar spine and total hip BMD (r = -0.629 and -0.514, all p < 0.001). After adjusting for age and body mass index, the partial correlation coefficients of FSH with BTMs and BMD remained significant. Estimating from the regression equation, for every 10 IU/L increase in serum FSH, BTMs increased by 0.38-3.6 units, and BMD decreased by 0.03-0.05 g/cm
    Conclusions: This study suggests that serum FSH levels are an independent risk factor for BTMs and BMD in menopause-transitioning women, particularly for serum BAP and lumbar spine BMD.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Middle Aged ; Biomarkers ; Bone Density ; Bone Remodeling ; Collagen Type I ; East Asian People ; Follicle Stimulating Hormone ; Lumbar Vertebrae ; Menopause
    Chemical Substances Biomarkers ; Collagen Type I ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2471: Show issues Location:
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  7. Article ; Online: Complex Relationship Between Proton Pump Inhibitor Use and Bone Health.

    Zhu, Ting / Yuan, Ling-Qing

    The American journal of gastroenterology

    2017  Volume 112, Issue 4, Page(s) 651

    MeSH term(s) Gastroesophageal Reflux ; Humans ; Proton Pump Inhibitors
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2017-04-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2017.24
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    Ui V Zs.36: Show issues Location:
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  8. Article ; Online: Adipose exosomal noncoding RNAs: Roles and mechanisms in metabolic diseases.

    Wu, Yan-Lin / Lin, Zheng-Jun / Li, Chang-Chun / Lin, Xiao / Shan, Su-Kang / Guo, Bei / Zheng, Ming-Hui / Wang, Yi / Li, Fuxingzi / Yuan, Ling-Qing

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2024  , Page(s) e13740

    Abstract: Exosomes are extracellular vesicles, measuring 40-160 nm in diameter, that are released by many cell types and tissues, including adipose tissue. Exosomes are critical mediators of intercellular communication and their contents are complex and diverse. ... ...

    Abstract Exosomes are extracellular vesicles, measuring 40-160 nm in diameter, that are released by many cell types and tissues, including adipose tissue. Exosomes are critical mediators of intercellular communication and their contents are complex and diverse. In recent years, accumulating evidence has proved that multiple adipose tissue-derived exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play pivotal roles in the pathogenesis of diverse metabolic diseases, such as obesity. In this narrative review, we focus on the adipose tissue-derived exosomal ncRNAs, especially exosomal miRNAs, and their dysregulation in multiple types of metabolic diseases. A deeper understanding of the role of adipose tissue-derived exosomal ncRNAs may help provide new diagnostic and treatment methods for metabolic diseases.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13740
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  9. Article ; Online: Osteoporosis Overtreatment-A Clinical Problem That Needs to Be Discussed.

    Xu, Feng / Yuan, Ling-Qing

    JAMA internal medicine

    2016  Volume 176, Issue 7, Page(s) 1033–1034

    Language English
    Publishing date 2016-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2016.2731
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  10. Article ; Online: Obstructive sleep apnoea and bone health.

    Zhong, Jia-Yu / Yuan, Ling-Qing

    The European respiratory journal

    2016  Volume 48, Issue 4, Page(s) 1248–1249

    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00870-2016
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    Zs.MO 292: Show issues

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