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Article ; Online: A web-based system to determine risk of investment in international rail construction projects.

Yuan, Ting

2023 Volume 13, Issue 1, Page(s) 8125

Abstract: Manual evaluation of investment risk make results and solutions are not timely. The objective of the study is to explore intelligent risk data collecting and risk early warning of international rail construction. First, this study has identified risk ... ...

Abstract	Manual evaluation of investment risk make results and solutions are not timely. The objective of the study is to explore intelligent risk data collecting and risk early warning of international rail construction. First, this study has identified risk variables by content mining. Second, risk thresholds are calculated by the quantile method based on data from 2010 to A.D. 2019. Third, this study has developed risk early warning system by the gray system theory model, the matter-element extension method and the entropy weight method. Fourth, the risk early warning system is verified using Nigeria coastal railway project in Abuja. This study found that: (1) the framework of the developed risk warning system contains a software and hardware infrastructure layer, a data collection layer, an application support layer, and an application layer. (2) 37 investment risk variables are recognized; (3) 12 risk variables thresholds intervals are not equally divided between 0 and 1, the others are evenly distributed; (4) based on the application of Nigeria coastal railway project in Abuja, the system verification results are consistent with real situations, which is shown that risk early warning system is reasonable and feasible. These findings offer a good reference for intelligent risk management.
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34358-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sample multiplexing for increasing throughput for quantification of estrogens in serum by LC-MS/MS.

Yuan, Tengfei

Analytical and bioanalytical chemistry

2022

Abstract: Estrogens are involved in many physiological processes in vivo. The accurate and rapid quantification of estrogens is required for the diagnosis and prognosis of estrogen-related diseases. To achieve high-volume assays, we developed and validated a ... ...

Abstract	Estrogens are involved in many physiological processes in vivo. The accurate and rapid quantification of estrogens is required for the diagnosis and prognosis of estrogen-related diseases. To achieve high-volume assays, we developed and validated a sample-multiplexing liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of serum estrogens including estrone (E1), estradiol (E2), and estriol (E3). A total of 100 μL serum samples were extracted using ethyl acetate. After derivatization with either dansyl chloride or pyridine-3-sulfonyl chloride, derivatized samples were combined. Then we performed the second liquid-liquid extraction using hexane to purify the mixture. Finally, the reconstitution solutions were injected into LC-MS/MS. In addition, the proposed LC-MS/MS method was validated according to FDA and CLSI guidelines. Within a single run (7 min), this sample-multiplexing LC-MS/MS method could simultaneously analyze E1, E2, and E3 in 2 serum samples. Meanwhile, the method demonstrated satisfactory analytical characteristics including accuracy (87.7-110.3%), linearity (2-1000 pg/mL, R
Language	English
Publishing date	2022-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-022-04423-7
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Article ; Online: Sample multiplexing for increasing throughput for quantification of estrogens in serum by LC–MS/MS

Yuan, Tengfei

Anal Bioanal Chem. 2023 Jan., v. 415, no. 3 p.439-445

2023

Abstract	Estrogens are involved in many physiological processes in vivo. The accurate and rapid quantification of estrogens is required for the diagnosis and prognosis of estrogen-related diseases. To achieve high-volume assays, we developed and validated a sample-multiplexing liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the quantification of serum estrogens including estrone (E1), estradiol (E2), and estriol (E3). A total of 100 μL serum samples were extracted using ethyl acetate. After derivatization with either dansyl chloride or pyridine-3-sulfonyl chloride, derivatized samples were combined. Then we performed the second liquid–liquid extraction using hexane to purify the mixture. Finally, the reconstitution solutions were injected into LC–MS/MS. In addition, the proposed LC–MS/MS method was validated according to FDA and CLSI guidelines. Within a single run (7 min), this sample-multiplexing LC–MS/MS method could simultaneously analyze E1, E2, and E3 in 2 serum samples. Meanwhile, the method demonstrated satisfactory analytical characteristics including accuracy (87.7–110.3%), linearity (2–1000 pg/mL, R² > 0.99), precision (intra-assay CV, 1.7–8.7%; inter-assay CV, 1.9–9.4%), and negligible interference and carry-over effect as well as acceptable matrix effect. In conclusion, this sample-multiplexing LC–MS/MS method has achieved a doubled-throughput assay for simultaneous quantification of E1, E2, and E3 without compromising analytical characteristics.
Keywords	blood serum ; chlorides ; derivatization ; estradiol ; estriol ; estrone ; ethyl acetate ; hexane ; liquid chromatography ; liquid-liquid extraction ; prognosis ; tandem mass spectrometry
Language	English
Dates of publication	2023-01
Size	p. 439-445.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ISSN	1618-2642
DOI	10.1007/s00216-022-04423-7
Database	NAL-Catalogue (AGRICOLA)

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Thesis ; Online: Prescriptive Maintenance and Operation with Deep Reinforcement Learning

Yuan, Tian

2023

Keywords	info:eu-repo/classification/ddc/000 ; info:eu-repo/classification/ddc/620 ; Generalities ; science ; Engineering & allied operations
Language	English
Publisher	ETH Zurich
Publishing country	ch
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How 2D Nanoflakes Improve Transport in Mixed Matrix Membranes: Insights from a Simple Lattice Model and Dynamic Mean Field Theory.

Yuan, Tianmu / Sarkisov, Lev

ACS applied materials & interfaces

2024 Volume 16, Issue 6, Page(s) 8184–8195

Abstract: Mixed matrix membranes (MMMs), incorporating graphene and graphene oxide structural fragments, have emerged as promising materials for challenging gas separation processes. What remains unclear is the actual molecular mechanism responsible for the ... ...

Abstract	Mixed matrix membranes (MMMs), incorporating graphene and graphene oxide structural fragments, have emerged as promising materials for challenging gas separation processes. What remains unclear is the actual molecular mechanism responsible for the enhanced permeability and perm-selectivity of these materials. With the fully atomistic models still unable to handle the required time and length scales, here, we employ a simple qualitative model based on the lattice representation of the physical system and dynamic mean field theory. We demonstrate that the performance enhancement results from the flux-regularization impact of the 2D nanoflakes and that this effect sensitively depends on the orientation of the nanoflakes and the properties of the interface between the nanoflakes and the polymer.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c00661
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Article: Neutrophil extracellular traps in adult diseases and neonatal bacterial infectious diseases: A review.

Li, Ziheng / Yuan, Tianming

Heliyon

2023 Volume 10, Issue 1, Page(s) e23559

Abstract: Neutrophils, the most abundant type of white blood cells, are pivotal in fighting bacterial infections due to their immunological and anti-infection capabilities. In recent years, scientists have discovered a novel mechanism known as neutrophil ... ...

Abstract	Neutrophils, the most abundant type of white blood cells, are pivotal in fighting bacterial infections due to their immunological and anti-infection capabilities. In recent years, scientists have discovered a novel mechanism known as neutrophil extracellular traps, which are fibrous networks primarily released by neutrophils that combat bacterial infections. There is a growing interest in studying NETs and their role in human infectious diseases, particularly in neonates susceptible to bacterial infections. NETs and their components have been found in various samples from neonatal-infected patients, providing a new route for early diagnosis of neonatal infectious diseases. This paper aims to summarize the studies on NETs in adult diseases and mainly discuss NETs in neonatal sepsis, necrotizing enterocolitis, and purulent meningitis, to provide scientific evidence for early monitoring, diagnosis, and treatment of neonatal infections.
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23559
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Article ; Online: The effects of precipitation change on urban meadows in different design models and substrates.

Jiang, Yarong / Yuan, Tao

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20592

Abstract: Climate change, such as temperature and precipitation changes, is becoming increasingly obvious, and in this context, planting designs need to urgently consider future climate change in advance. A field experiment was conducted in Beijing, China, where ... ...

Abstract	Climate change, such as temperature and precipitation changes, is becoming increasingly obvious, and in this context, planting designs need to urgently consider future climate change in advance. A field experiment was conducted in Beijing, China, where the future precipitation is predicted to increase, and extra irrigation was used to simulate the future precipitation increase. The species richness of sown meadows, including spontaneous plants and sown plants, and the adaptive strategies of the communities were recorded under different types of design models and substrates. The results showed that precipitation increased the diversity of sown plants and resource-demanding spontaneous plants but had no significant effect on the dry matter content of the entire community of species. Moreover, the interactions among precipitation and substrate, especially the design models, were significant. Of the models, the three-layer model had the highest species richness and least invasive plants. In addition, increased precipitation significantly changed the functional strategy of the plant community away from ruderals and towards competitor-stress tolerant species. This study provides guidance for the design and management of naturalistic plant communities under climate change.
MeSH term(s)	Grassland ; Rain ; Plants ; China ; Climate Change ; Ecosystem
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44974-y
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Article ; Online: Glycan-Lectin interactions between platelets and tumor cells drive hematogenous metastasis.

Shu, Longqiang / Lin, Shanyi / Zhou, Shumin / Yuan, Ting

Platelets

2024 Volume 35, Issue 1, Page(s) 2315037

Abstract: Glycosylation is a ubiquitous cellular or microenvironment-specific post-translational modification that occurs on the surface of normal cells and tumor cells. Tumor cell-associated glycosylation is involved in hematogenous metastasis. A wide variety of ... ...

Abstract	Glycosylation is a ubiquitous cellular or microenvironment-specific post-translational modification that occurs on the surface of normal cells and tumor cells. Tumor cell-associated glycosylation is involved in hematogenous metastasis. A wide variety of tumors undergo aberrant glycosylation to interact with platelets. As platelets have many opportunities to engage circulating tumor cells, they represent an important avenue into understanding the role glycosylation plays in tumor metastasis. Platelet involvement in tumor metastasis is evidenced by observations that platelets protect tumor cells from damaging shear forces and immune system attack, aid metastasis through the endothelium at specific sites, and facilitate tumor survival and colonization. During platelet-tumor-cell interactions, many opportunities for glycan-ligand binding emerge. This review integrates the latest information about glycans, their ligands, and how they mediate platelet-tumor interactions. We also discuss adaptive changes that tumors undergo upon glycan-lectin binding and the impact glycans have on targeted therapeutic strategies for treating tumors in clinical settings.
MeSH term(s)	Humans ; Lectins/metabolism ; Neoplasms/pathology ; Polysaccharides/metabolism ; Blood Platelets/metabolism ; Glycosylation ; Neoplasm Metastasis/pathology ; Tumor Microenvironment
Chemical Substances	Lectins ; Polysaccharides
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1034283-7
ISSN	1369-1635 ; 0953-7104
ISSN (online)	1369-1635
ISSN	0953-7104
DOI	10.1080/09537104.2024.2315037
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Article ; Online: The causal relationship between atopic dermatitis and brain cancer: A bidirectional Mendelian randomization study.

Xin, Yu / Yuan, Tao / Wang, Jun

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

2024 Volume 30, Issue 4, Page(s) e13715

Abstract: Background: Atopic dermatitis ranks among the prevalent skin disorders. Research has indicated a potential association with brain cancer. Yet, establishing a direct causal relationship between atopic dermatitis and brain cancer continues to be ... ...

Abstract	Background: Atopic dermatitis ranks among the prevalent skin disorders. Research has indicated a potential association with brain cancer. Yet, establishing a direct causal relationship between atopic dermatitis and brain cancer continues to be challenging. Materials and methods: We extracted single nucleotide polymorphisms (SNPs) significantly associated with atopic dermatitis (sample size = 382 254) at a genome-wide level from a large Finnish Genome-Wide Association Study (GWAS) dataset (n cases = 15 208, n controls = 367 046). Summary data for 372 622 cases of brain cancer (n cases = 606, n controls = 372 016) were obtained via the IEU Open GWAS database. We employed the Inverse Variance Weighted (IVW) method as our primary analytical approach for Mendelian Randomization (MR) analysis. Additionally, heterogeneity was measured using Cochran's Q value, and horizontal pleiotropy was evaluated using MR-Egger 、Mendelian Randomization Pleiotropy RESidual Sum and Outlier and leave-one-out analyses. Results: The risk of brain cancer increases with the presence of atopic dermatitis, as evidenced by the odds ratios (ORs) and 95% confidence intervals (CIs),(OR = 1.0005; 95% CI = 1.0001, 1.0009; p = 0.0096). However, when conducting the analysis in reverse, no significant link was observed. Conclusion: The findings from our study indicate a causative link between atopic dermatitis and brain cancer, highlighting the importance of conducting broader clinical investigations into their potential association going forward.
MeSH term(s)	Humans ; Dermatitis, Atopic/genetics ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide ; Brain Neoplasms/genetics ; Genome-Wide Association Study ; Genetic Predisposition to Disease/genetics ; Finland/epidemiology ; Risk Factors
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1229160-2
ISSN	1600-0846 ; 0909-752X ; 1397-1344
ISSN (online)	1600-0846
ISSN	0909-752X ; 1397-1344
DOI	10.1111/srt.13715
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Article ; Online: Modified technique of Hepatojejunostomy for biliary tract reconstruction after resection of tumors affecting the perihilar region: a case series.

Kuang, Yi / Ji, Ran / Yuan, Tao / Liu, Menggang

BMC surgery

2024 Volume 24, Issue 1, Page(s) 102

Abstract: Backgrounds: Radical resection is the most effective treatment for perihilar tumors. Biliary tract reconstruction after resection is one of the key steps in this surgery. Mucosa-to-mucosa cholangiojejunostomy is traditionally performed, in which the ... ...

Abstract	Backgrounds: Radical resection is the most effective treatment for perihilar tumors. Biliary tract reconstruction after resection is one of the key steps in this surgery. Mucosa-to-mucosa cholangiojejunostomy is traditionally performed, in which the bile ducts at the resection margin are separately anastomosed to the jejunum. However, this approach is associated with long operative time and high risk of postoperative complications. The present study presents a modified technique of hepatojejunostomy and its outcomes. Methods: The data of patients who underwent hepatojejunostomy using the modified technique at the Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China, from January 2016 to December 2021, were retrospectively analyzed. Results: A total of 13 patients with perihilar tumors underwent R0 resection and bilioenteric reconstruction using the modified hepatojejunostomy technique during the study period. During the operation, the alignment of the bile duct stumps was improved, the posterior wall of the anastomosis was reinforced, internal stents were placed in the smaller bile ducts, external stents were placed in the larger bile ducts, and hepatojejunostomy was performed using 4 - 0 prolene. No serious postoperative complications, such as death or bile leakage, occurred during the hospitalization. Furthermore, there were no cases of biliary stricture or cholangitis after the six-month follow-up period. Conclusion: The modified hepatojejunostomy technique is a safe and effective technique of biliary reconstruction after the resection of perihilar tumors. This can be easily performed for difficult cases with multiple bile ducts that require reconstruction after resection.
MeSH term(s)	Humans ; Retrospective Studies ; Bile Ducts/surgery ; Anastomosis, Surgical/methods ; Hepatectomy/methods ; Postoperative Complications/etiology ; Neoplasms ; Bile Duct Neoplasms/surgery
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-024-02393-4
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