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  1. Book ; Online: NKT Cells in Cancer Immunotherapy

    Webb, Tonya J. / Dellabona, Paolo / Yuan, Weiming / Meyer, Everett

    2020  

    Keywords Medicine ; Immunology ; iNKT ; CD1d ; dendritic cells ; α-GalCer ; cancer ; immunotherapy
    Size 1 electronic resource (178 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231147
    ISBN 9782889639335 ; 2889639339
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: NKT Cells in Cancer Immunotherapy, 2nd Edition

    Webb, Tonya J. / Dellabona, Paolo / Yuan, Weiming / Meyer, Everett

    2020  

    Keywords Medicine ; Immunology ; iNKT ; CD1d ; dendritic cells ; α-GalCer ; cancer ; immunotherapy
    Size 1 electronic resource (178 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230665
    ISBN 9782889661534 ; 2889661539
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Three-component reductive conjugate addition/aldol tandem reaction enabled by nickel/photoredox dual catalysis.

    Zhao, Hongping / Yuan, Weiming

    Chemical science

    2023  Volume 14, Issue 6, Page(s) 1485–1490

    Abstract: A three-component reductive cross-coupling of aryl halides, aldehydes, and alkenes by nickel/photoredox dual catalysis is disclosed. The key to success for this tandem transformation is to identify α-silylamine as a unique organic reductant, which ... ...

    Abstract A three-component reductive cross-coupling of aryl halides, aldehydes, and alkenes by nickel/photoredox dual catalysis is disclosed. The key to success for this tandem transformation is to identify α-silylamine as a unique organic reductant, which releases silylium ions instead of protons to prevent unwanted protonation processes, and meanwhile serves as Lewis acid to activate aldehydes
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc06303d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: α-Tertiary Primary Amine Synthesis via Photocatalytic C(sp

    Zhao, Hongping / Hu, Yuanyuan / Zheng, Songlin / Yuan, Weiming

    Organic letters

    2023  Volume 25, Issue 36, Page(s) 6699–6704

    Abstract: Facile access to sterically hindered α-tertiary primary amines via photocatalytic radical coupling of native C( ... ...

    Abstract Facile access to sterically hindered α-tertiary primary amines via photocatalytic radical coupling of native C(sp
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: N-Cyanation of Primary and Secondary Amines with Cyanobenzio-doxolone (CBX) Reagent.

    Chen, Zimin / Yuan, Weiming

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 60, Page(s) 14836–14840

    Abstract: An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides ... ...

    Abstract An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules.
    MeSH term(s) Amines ; Catalysis ; Indicators and Reagents
    Chemical Substances Amines ; Indicators and Reagents
    Language English
    Publishing date 2021-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202102354
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article: Nickel-Catalyzed Three-Component Alkylacylation of Alkenes Enabled by a Photoactive Electron Donor–Acceptor Complex

    Xi, Xiaoxiang / Chen, Yukun / Yuan, Weiming

    Organic letters. 2022 May 23, v. 24, no. 22

    2022  

    Abstract: An electron donor–acceptor complex-enabled, nickel-catalyzed three-component net-reductive 1,2-alkylacylation of alkenes is developed. This conjunctive reductive acyl cross-coupling process obviates the use of an exogenous photocatalyst and a ... ...

    Abstract An electron donor–acceptor complex-enabled, nickel-catalyzed three-component net-reductive 1,2-alkylacylation of alkenes is developed. This conjunctive reductive acyl cross-coupling process obviates the use of an exogenous photocatalyst and a stoichiometric metal-based reductant, affording various synthetically useful 1,3-dicarbonyl compounds in good yields with a broad substrate scope and excellent functional group tolerance. Both alkyl and acyl electrophiles are derived from the highly abundant and readily accessible carboxylic acids, making the catalytic 1,2-dicarbofunctionalization more synthetically general and sustainable.
    Keywords Lewis acids ; alkenes ; cross-coupling reactions ; photocatalysts ; reducing agents ; stoichiometry
    Language English
    Dates of publication 2022-0523
    Size p. 3938-3943.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c01237
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Remote and Proximal Hydroaminoalkylation of Alkenes Enabled by Photoredox/Nickel Dual Catalysis.

    Zheng, Songlin / Wang, Wenlong / Yuan, Weiming

    Journal of the American Chemical Society

    2022  Volume 144, Issue 39, Page(s) 17776–17782

    Abstract: A mild and site-selective hydroaminoalkylation of activated and unactivated alkenes via dual photoredox/Ni catalysis is developed. This dual catalytic strategy enables exclusive access to α-selective products, which is complementary to previously ... ...

    Abstract A mild and site-selective hydroaminoalkylation of activated and unactivated alkenes via dual photoredox/Ni catalysis is developed. This dual catalytic strategy enables exclusive access to α-selective products, which is complementary to previously reported photocatalytic hydroaminoalkylation of activated alkenes that provides the β-selective products. The chain-walking of a Ni-H intermediate toward a carbonyl allows for the hydroaminoalkylation of unactivated alkenes at remote
    MeSH term(s) Alkenes/chemistry ; Amines/chemistry ; Amino Acids ; Catalysis ; Nickel/chemistry
    Chemical Substances Alkenes ; Amines ; Amino Acids ; Nickel (7OV03QG267)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c08039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Nickel-Catalyzed Three-Component Alkylacylation of Alkenes Enabled by a Photoactive Electron Donor-Acceptor Complex.

    Xi, Xiaoxiang / Chen, Yukun / Yuan, Weiming

    Organic letters

    2022  Volume 24, Issue 22, Page(s) 3938–3943

    Abstract: An electron donor-acceptor complex-enabled, nickel-catalyzed three-component net-reductive 1,2-alkylacylation of alkenes is developed. This conjunctive reductive acyl cross-coupling process obviates the use of an exogenous photocatalyst and a ... ...

    Abstract An electron donor-acceptor complex-enabled, nickel-catalyzed three-component net-reductive 1,2-alkylacylation of alkenes is developed. This conjunctive reductive acyl cross-coupling process obviates the use of an exogenous photocatalyst and a stoichiometric metal-based reductant, affording various synthetically useful 1,3-dicarbonyl compounds in good yields with a broad substrate scope and excellent functional group tolerance. Both alkyl and acyl electrophiles are derived from the highly abundant and readily accessible carboxylic acids, making the catalytic 1,2-dicarbofunctionalization more synthetically general and sustainable.
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mathematical modeling of interaction between innate and adaptive immune responses in COVID-19 and implications for viral pathogenesis.

    Du, Sean Quan / Yuan, Weiming

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1615–1628

    Abstract: We have applied mathematical modeling to investigate the infections of the ongoing coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 virus. We first validated our model using the well-studied influenza viruses and then compared the ... ...

    Abstract We have applied mathematical modeling to investigate the infections of the ongoing coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 virus. We first validated our model using the well-studied influenza viruses and then compared the pathogenesis processes between the two viruses. The interaction between host innate and adaptive immune responses was found to be a potential cause for the higher severity and mortality in COVID-19 patients. Specifically, the timing mismatch between the two immune responses has a major impact on disease progression. The adaptive immune response of the COVID-19 patients is more likely to come before the peak of viral load, while the opposite is true for influenza patients. This difference in timing causes delayed depletion of vulnerable epithelial cells in the lungs in COVID-19 patients while enhancing viral clearance in influenza patients. Stronger adaptive immunity in COVID-19 patients can potentially lead to longer recovery time and more severe secondary complications. Based on our analysis, delaying the onset of adaptive immune responses during the early phase of infections may be a potential treatment option for high-risk COVID-19 patients. Suppressing the adaptive immune response temporarily and avoiding its interference with the innate immune response may allow the innate immunity to more efficiently clear the virus.
    MeSH term(s) Adaptive Immunity ; Algorithms ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/etiology ; Disease Susceptibility ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Influenza, Human/immunology ; Models, Theoretical ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Nickel/Photoredox Dual-Catalyzed Regiodivergent Aminoalkylation of Unactivated Alkyl Halides.

    Wang, Wenlong / Yan, Xueyuan / Ye, Fu / Zheng, Songlin / Huang, Genping / Yuan, Weiming

    Journal of the American Chemical Society

    2023  Volume 145, Issue 42, Page(s) 23385–23394

    Abstract: A mild and regiodivergent aminoalkylation of unactivated alkyl halides is disclosed via a dual photoredox/nickel catalysis. Bipyridyl-type ligands without ... ...

    Abstract A mild and regiodivergent aminoalkylation of unactivated alkyl halides is disclosed via a dual photoredox/nickel catalysis. Bipyridyl-type ligands without an
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c09705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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