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Article: [Preliminary evaluation of immunogenicity and protective effect of multicomponent recombinant protein vaccine EPRHP014 against tuberculosis].

Cao, B / Fan, X T / Wang, R H / Luan, X L / Qian, C Y / Yu, J J / Liu, H C / Li, M C / Li, G L / Zhao, X Q / Yuan, X Q / Wan, K L

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2023 Volume 44, Issue 10, Page(s) 1653–1660

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Mice ; BCG Vaccine ; Granulocyte-Macrophage Colony-Stimulating Factor ; Interleukin-10 ; Interleukin-4 ; Interleukin-6 ; Tuberculosis/prevention & control ; Antigens, Bacterial ; Tuberculosis Vaccines ; Mycobacterium tuberculosis ; Interleukin-12 ; Recombinant Proteins ; Epitopes ; Bacterial Proteins
Chemical Substances	BCG Vaccine ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; Interleukin-6 ; Antigens, Bacterial ; Tuberculosis Vaccines ; Interleukin-12 (187348-17-0) ; Recombinant Proteins ; Epitopes ; Bacterial Proteins
Language	Chinese
Publishing date	2023-10-24
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20230217-00088
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Article ; Online: The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits.

Akgül, G / Abebe, D / Yuan, X Q / Auville, K / McBain, C J

Scientific reports

2019 Volume 9, Issue 1, Page(s) 5435

Abstract: In the hippocampal CA1, caudal ganglionic eminence (CGE)-derived interneurons are recruited by activation of glutamatergic synapses comprising GluA2-containing calcium-impermeable AMPARs and exert inhibitory regulation of the local microcircuit. However, ...

Abstract	In the hippocampal CA1, caudal ganglionic eminence (CGE)-derived interneurons are recruited by activation of glutamatergic synapses comprising GluA2-containing calcium-impermeable AMPARs and exert inhibitory regulation of the local microcircuit. However, the role played by AMPARs in maturation of the developing circuit is unknown. We demonstrate that elimination of the GluA2 subunit (GluA2 KO) of AMPARs in CGE-derived interneurons, reduces spontaneous EPSC frequency coupled to a reduction in dendritic glutamatergic synapse density. Removal of GluA1&2&3 subunits (GluA1-3 KO) in CGE-derived interneurons, almost completely eliminated sEPSCs without further reducing synapse density, but increased dendritic branching. Moreover, in GluA1-3 KOs, the number of interneurons invading the hippocampus increased in the early postnatal period but converged with WT numbers later due to increased apoptosis. However, the CCK-containing subgroup increased in number, whereas the VIP-containing subgroup decreased. Both feedforward and feedback inhibitory input onto pyramidal neurons was decreased in GluA1-3 KO. These combined anatomical, synaptic and circuit alterations, were accompanied with a wide range of behavioural abnormalities in GluA1-3 KO mice compared to GluA2 KO and WT. Thus, AMPAR subunits differentially contribute to numerous aspects of the development and maturation of CGE-derived interneurons and hippocampal circuitry that are essential for normal behaviour.
MeSH term(s)	Animals ; GABAergic Neurons/cytology ; GABAergic Neurons/metabolism ; Ganglia/cytology ; Ganglia/metabolism ; Glutamates/metabolism ; Hippocampus/cytology ; Hippocampus/metabolism ; Hippocampus/physiology ; Interneurons/cytology ; Interneurons/metabolism ; Mice ; Receptors, AMPA/physiology ; Synapses/metabolism ; Synapses/physiology
Chemical Substances	Glutamates ; Receptors, AMPA
Language	English
Publishing date	2019-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-41920-9
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Article: [Analysis on drug sensitivity spectrum of 167 multidrug-resistant

Chen, R / Li, M C / Zhao, L L / Zhao, X Q / Liu, H C / Liu, Z G / Lu, Y / Deng, Y L / Chen, Z X / Wan, K L / Yuan, X Q

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2020 Volume 41, Issue 5, Page(s) 764–769

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Antitubercular Agents ; China ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Tuberculosis, Multidrug-Resistant
Chemical Substances	Antitubercular Agents
Language	Chinese
Publishing date	2020-05-23
Publishing country	China
Document type	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20191121-00823
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Article ; Online: Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells.

Chittajallu, R / Wester, J C / Craig, M T / Barksdale, E / Yuan, X Q / Akgül, G / Fang, C / Collins, D / Hunt, S / Pelkey, K A / McBain, C J

Nature communications

2017 Volume 8, Issue 1, Page(s) 152

Abstract: Appropriate integration of GABAergic interneurons into nascent cortical circuits is critical for ensuring normal information processing within the brain. Network and cognitive deficits associated with neurological disorders, such as schizophrenia, that ... ...

Abstract	Appropriate integration of GABAergic interneurons into nascent cortical circuits is critical for ensuring normal information processing within the brain. Network and cognitive deficits associated with neurological disorders, such as schizophrenia, that result from NMDA receptor-hypofunction have been mainly attributed to dysfunction of parvalbumin-expressing interneurons that paradoxically express low levels of synaptic NMDA receptors. Here, we reveal that throughout postnatal development, thalamic, and entorhinal cortical inputs onto hippocampal neurogliaform cells are characterized by a large NMDA receptor-mediated component. This NMDA receptor-signaling is prerequisite for developmental programs ultimately responsible for the appropriate long-range AMPAR-mediated recruitment of neurogliaform cells. In contrast, AMPAR-mediated input at local Schaffer-collateral synapses on neurogliaform cells remains normal following NMDA receptor-ablation. These afferent specific deficits potentially impact neurogliaform cell mediated inhibition within the hippocampus and our findings reveal circuit loci implicating this relatively understudied interneuron subtype in the etiology of neurodevelopmental disorders characterized by NMDA receptor-hypofunction.Proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. Here the authors show that during early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for their appropriate integration into the hippocampal circuitry.
MeSH term(s)	Animals ; CA3 Region, Hippocampal/growth & development ; CA3 Region, Hippocampal/metabolism ; Dendrites/metabolism ; Entorhinal Cortex/metabolism ; GABAergic Neurons/metabolism ; Hippocampus/growth & development ; Hippocampus/metabolism ; Interneurons/metabolism ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neuroglia/metabolism ; Neuronal Plasticity/genetics ; Neurons, Afferent/metabolism ; Parvalbumins/metabolism ; Patch-Clamp Techniques ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism ; Thalamus/metabolism
Chemical Substances	Gprin1 protein, mouse ; Nerve Tissue Proteins ; Parvalbumins ; Receptors, AMPA ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2017--28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/s41467-017-00218-y
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Article ; Online: The Association between Distal Findings and Proximal Colorectal Neoplasia: A Systematic Review and Meta-Analysis.

Huang, Jason L W / Wang, Y H / Jiang, Johnny Y / Yu, C P / Wu, Y L / Chen, P / Yuan, X Q / Wang, Harry H X / Wong, Martin C S

The American journal of gastroenterology

2017 Volume 112, Issue 8, Page(s) 1234–1245

Abstract: Objectives: Whether screening participants with distal hyperplastic polyps (HPs) detected by flexible sigmoidoscopy (FS) should be followed by subsequent colonoscopy is controversial. We evaluated the association between distal HPs and proximal ... ...

Abstract	Objectives: Whether screening participants with distal hyperplastic polyps (HPs) detected by flexible sigmoidoscopy (FS) should be followed by subsequent colonoscopy is controversial. We evaluated the association between distal HPs and proximal neoplasia (PN)/advanced proximal neoplasia (APN) in asymptomatic, average-risk patients. Methods: We searched Ovid Medline, EMBASE, and the Cochrane Library from inception to 30 June 2016 and included all screening studies that examined the relationship between different distal findings and PN/APN. Data were independently extracted by two reviewers with disagreements resolved by a third reviewer. We pooled absolute risks and odds ratios (ORs) with a random effects meta-analysis. Seven subgroup analyses were performed according to study characteristics. Heterogeneity was characterized with the I Results: We analyzed 28 studies (104,961 subjects). When compared with normal distal findings, distal HP was not associated with PN (OR=1.16, 95% confidence interval (CI)=0.89-1.51, P=0.14, I Conclusions: Distal HP is not associated with PN/APN in asymptomatic screening population when compared with normal distal findings. Hence, the presence of distal HP alone detected by FS does not automatically indicate colonoscopy referral for all screening participants, as other risk factors of PN/APN should be considered.
MeSH term(s)	Colon/pathology ; Colonic Neoplasms/pathology ; Colonic Polyps/pathology ; Colonoscopy ; Colorectal Neoplasms/pathology ; Humans ; Rectum/pathology
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.1038/ajg.2017.130
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Article: Influence of the extent of enzymatic hydrolysis on the functional properties of protein hydrolysate from grass carp (Ctenopharyngodon idella) skin

Wasswa, J / Tang, J / Gu, X.H / Yuan, X.Q

Food chemistry. 2007, v. 104, issue 4

2007

Abstract: Protein hydrolysates from grass carp skin were obtained by enzymatic hydrolysis using Alcalase. Hydrolysis was performed using the pH-stat method. The hydrolysis reaction was terminated by heating the mixture to 95 °C for 15 min. At 5.02%, 10.4%, and 14 ... ...

Abstract	Protein hydrolysates from grass carp skin were obtained by enzymatic hydrolysis using Alcalase. Hydrolysis was performed using the pH-stat method. The hydrolysis reaction was terminated by heating the mixture to 95 °C for 15 min. At 5.02%, 10.4%, and 14.9% degree of hydrolysis (DH), the hydrolysates were analyzed for functional properties. The protein hydrolysates had desirable essential amino acid profiles. Results demonstrated that the hydrolysates had better oil holding and emulsifying capacity at low DH. The water holding capacity increased with increased levels of hydrolysis. Enzymatic modification was responsible for the changes in protein functionality. These results suggest that grass carp fish skin hydrolysates could find potential use as functional food ingredients as emulsifiers and binder agents.
Keywords	enzymatic hydrolysis ; functional properties ; protein hydrolysates ; Ctenopharyngodon idella ; fish waste ; skin ; emulsifying properties ; water holding capacity ; enzymatic treatment ; proximate composition ; emulsifying ; color ; amino acid composition
Language	English
Size	p. 1698-1704.
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2007.03.044
Database	NAL-Catalogue (AGRICOLA)

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Article: Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.

Yuan, X Q / Wade, C E

Journal of neurotrauma

1993 Volume 10, Issue 3, Page(s) 307–313

Abstract: To determine the influence of brain trauma on blood acid-base and lactate-pyruvate responses to hemorrhage, and the effect of lactated Ringer's solution on these responses, 30 anesthetized rats were assigned to four groups: hemorrhage (n = 7), hemorrhage ...

Abstract	To determine the influence of brain trauma on blood acid-base and lactate-pyruvate responses to hemorrhage, and the effect of lactated Ringer's solution on these responses, 30 anesthetized rats were assigned to four groups: hemorrhage (n = 7), hemorrhage following fluid percussion brain trauma (trauma-hemorrhage group) (n = 7), hemorrhage treated with lactated Ringer's solution (hemorrhage-resuscitation group) (n = 8), and hemorrhage following brain trauma treated with lactated Ringer's solution (trauma-hemorrhage-resuscitation group) (n = 8). The hemorrhage group showed no significant changes in pH, HCO3, and base excess after hemorrhage. Base excess and pH were significantly reduced after the hemorrhage in the trauma-hemorrhage group but were raised after resuscitation in the hemorrhage-resuscitation group. Acid-base values showed no difference between the trauma-hemorrhage-resuscitation and hemorrhage groups. The trauma-hemorrhage-resuscitation group also had a significantly higher base excess than the trauma-hemorrhage group. Lactate rose significantly after hemorrhage in the hemorrhage group and was even higher in the trauma-hemorrhage group, but there were no differences between the hemorrhage versus hemorrhage-resuscitation or trauma-hemorrhage-resuscitation groups. Both brain trauma and lactated Ringer's solution increased pyruvate with marked reduction in the ratio of lactate to pyruvate. These data indicate that brain trauma precipitates blood lactate accumulation and metabolic acidosis after hemorrhage, and infusion of lactated Ringer's solution can relieve these disturbances.
MeSH term(s)	Acidosis, Lactic/drug therapy ; Acidosis, Lactic/etiology ; Animals ; Blood Glucose/analysis ; Brain Injuries/blood ; Brain Injuries/complications ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/etiology ; Gases/blood ; Hydrogen-Ion Concentration ; Isotonic Solutions/therapeutic use ; Lactates/blood ; Lactic Acid ; Male ; Pyruvates/blood ; Pyruvic Acid ; Rats ; Rats, Sprague-Dawley ; Resuscitation ; Shock, Hemorrhagic/complications ; Shock, Hemorrhagic/drug therapy
Chemical Substances	Blood Glucose ; Gases ; Isotonic Solutions ; Lactates ; Pyruvates ; Lactic Acid (33X04XA5AT) ; Ringer's lactate (8022-63-7) ; Pyruvic Acid (8558G7RUTR)
Language	English
Publishing date	1993
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.1993.10.307
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Article: Traumatic brain injury attenuates the effectiveness of lactated Ringer's solution resuscitation of hemorrhagic shock in rats.

Yuan, X Q / Wade, C E

Surgery, gynecology & obstetrics

1992 Volume 174, Issue 4, Page(s) 305–312

Abstract: Traumatic brain injury suppresses spontaneous cardiovascular compensation for hemorrhage, prompting us to examine the possibility that trauma to the brain modifies hemodynamic response to therapy in hemorrhage. Thirty rats that were anesthetized were ... ...

Abstract	Traumatic brain injury suppresses spontaneous cardiovascular compensation for hemorrhage, prompting us to examine the possibility that trauma to the brain modifies hemodynamic response to therapy in hemorrhage. Thirty rats that were anesthetized were randomly assigned to four groups--hemorrhagic shock (H), hemorrhagic shock after brain trauma (TH), hemorrhagic shock treated with lactated Ringer's (LR) solution (HR), and hemorrhagic shock after brain trauma treated with LR (THR). After hemorrhage, group TH had significantly lower mean arterial pressure (MAP), cardiac index (CI) and stroke volume index (SVI) than group H. Throughout the postresuscitative period, group HR had significantly higher MAP, CI, SVI and central venous pressure than group H. At 50 and 70 minutes after the start of hemorrhage, group THR showed significantly lower MAP, CI and SVI than group HR. This difference in hemodynamics is not because of transcapillary refill effect, because brain trauma did not cause changes in hematocrit and plasma protein levels. As heart rate, preload and afterload were not significantly different between groups THR and HR, the attenuation of fluid resuscitation can be attributed mainly to a depressed cardiac function. Furthermore, neither brain trauma nor fluid replacement altered the content of water in the brain in hemorrhaged rats. These data indicate that brain trauma not only suppresses spontaneous hemodynamic recovery from hemorrhage, but also impedes the efficacy of LR resuscitation. The results of the current study suggested that a more aggressive fluid replacement may be needed to treat hemorrhagic shock in individuals with brain injury.
MeSH term(s)	Animals ; Blood Proteins/metabolism ; Body Water/physiology ; Brain Injuries/complications ; Brain Injuries/physiopathology ; Fluid Therapy ; Hematocrit ; Hemodynamics/physiology ; Isotonic Solutions/therapeutic use ; Male ; Rats ; Rats, Inbred Strains ; Resuscitation/methods ; Shock, Hemorrhagic/physiopathology ; Shock, Hemorrhagic/therapy
Chemical Substances	Blood Proteins ; Isotonic Solutions ; Ringer's lactate (8022-63-7)
Language	English
Publishing date	1992-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	5099-4
ISSN	0039-6087
ISSN	0039-6087
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Article: Neuroendocrine abnormalities in patients with traumatic brain injury.

Yuan, X Q / Wade, C E

Frontiers in neuroendocrinology

1991 Volume 12, Issue 3, Page(s) 209–230

Abstract: This article provides an overview of hypothalamic and pituitary alterations in brain trauma, including the incidence of hypothalamic-pituitary damage, injury mechanisms, features of the hypothalamic-pituitary defects, and major hypothalamic-pituitary ... ...

Abstract	This article provides an overview of hypothalamic and pituitary alterations in brain trauma, including the incidence of hypothalamic-pituitary damage, injury mechanisms, features of the hypothalamic-pituitary defects, and major hypothalamic-pituitary disturbances in brain trauma. While hypothalamic-pituitary lesions have been commonly described at postmortem examination, only a limited number of clinical cases of traumatic hypothalamic-pituitary dysfunction have been reported, probably because head injury of sufficient severity to cause hypothalamic and pituitary damage usually leads to early death. With the improvement in rescue measures, an increasing number of severely head-injured patients with hypothalamic-pituitary dysfunction will survive to be seen by clinicians. Patterns of endocrine abnormalities following brain trauma vary depending on whether the injury site is in the hypothalamus, the anterior or posterior pituitary, or the upper or lower portion of the pituitary stalk. Injury predominantly to the hypothalamus can produce dissociated ACTH-cortisol levels with no response to insulin-induced hypoglycemia and a limited or failed metopirone test, hypothyroxinemia with a preserved thyroid-stimulating hormone response to thyrotropin-releasing hormone, low gonadotropin levels with a normal response to gonadotropin-releasing hormone, a variable growth hormone (GH) level with a paradoxical rise in GH after glucose loading, hyperprolactinemia, the syndrome of inappropriate ADH secretion (SIADH), temporary or permanent diabetes insipidus (DI), disturbed glucose metabolism, and loss of body temperature control. Severe damage to the lower pituitary stalk or anterior lobe can cause low basal levels of all anterior pituitary hormones and eliminate responses to their releasing factors. Only a few cases showed typical features of hypothalamic or pituitary dysfunction. Most severe injuries are sufficient to damage both structures and produce a mixed endocrine picture. Increased intracranial pressure, which releases vasopressin by altering normal hypothalamic anatomy, may represent a unique type of stress to neuroendocrine systems and may contribute to adrenal secretion by a mechanism that requires intact brainstem function. Endocrine function should be monitored in brain-injured patients with basilar skull fractures and protracted posttraumatic amnesia, and patients with SIADH or DI should be closely monitored for other endocrine abnormalities.
MeSH term(s)	Brain Injuries/complications ; Brain Injuries/physiopathology ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Hypothalamus/injuries ; Hypothalamus/physiopathology ; Neurosecretory Systems/physiopathology ; Pituitary Gland/injuries ; Pituitary Gland/physiopathology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology
Language	English
Publishing date	1991
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	390985-2
ISSN	1095-6808 ; 0091-3022 ; 0532-7466
ISSN (online)	1095-6808
ISSN	0091-3022 ; 0532-7466
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Zs.A 3423: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Influences of traumatic brain injury on the outcomes of delayed and repeated hemorrhages.

Yuan, X Q / Wade, C E

Circulatory shock

1991 Volume 35, Issue 4, Page(s) 231–236

Abstract: Effects of traumatic brain injury (fluid percussion) on outcomes of hemorrhage, either delayed (70.5 min after the injury) or repeated (0.5 min after injury, then followed by a delayed hemorrhage), were examined in 4 groups of 10 anesthetized rats. ... ...

Abstract	Effects of traumatic brain injury (fluid percussion) on outcomes of hemorrhage, either delayed (70.5 min after the injury) or repeated (0.5 min after injury, then followed by a delayed hemorrhage), were examined in 4 groups of 10 anesthetized rats. Comparisons were made for delayed hemorrhage following sham injury (A1) vs. injury (A2) and for repeated hemorrhage following sham injury (B1) vs. injury (B2). No significant differences were observed in MAP, Cl, HR, SVI, SVRI, and CVP between groups A1 and A2. Hemodynamic recovery was significantly better in B1 than B2 at 70 min after the initial hemorrhage. The respective values of MAP and Cl for the groups B1 and B2 at 70 min were 65 +/- 3 vs. 56 +/- 4 mmHg and 220 +/- 15 vs. 182 +/- 15 ml/min/kg. Brain trauma did not affect survival rate (90 vs. 100%) following delayed hemorrhage, but significantly worsened the outcome of repeated hemorrhage. The 130 min survival rates for groups B1 and B2 were 50% and 10% (P = 0.08), respectively; their survival curves were significantly different (P = 0.02). Our data indicate that brain trauma has greater impact on responses to immediate hemorrhage than delayed hemorrhage, suggesting that traumatic brain injury may have a time-dependent effect on the response to hemorrhage.
MeSH term(s)	Animals ; Brain Injuries/complications ; Hemorrhage/etiology ; Hemorrhage/therapy ; Male ; Rats ; Rats, Inbred Strains ; Shock, Traumatic/complications ; Survival Rate
Language	English
Publishing date	1991-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	192087-x
ISSN	0092-6213
ISSN	0092-6213
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