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  1. Article ; Online: Clinical Efficacy of Bisphosphonates in Treating Osteoporosis in Diabetes Patients: A Meta-Analysis.

    Yang, Yuan-Xun / Jin, Yan

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2024  

    Abstract: The aim of the study was to explore the clinical efficacy of bisphosphonates in patients with osteoporosis in diabetes patients by meta-analysis. Six databases were systematically searched from inception to January 30,2023. Studies evaluating the ... ...

    Abstract The aim of the study was to explore the clinical efficacy of bisphosphonates in patients with osteoporosis in diabetes patients by meta-analysis. Six databases were systematically searched from inception to January 30,2023. Studies evaluating the treatment of diabetic osteoporosis with bisphosphonates were included. Key outcome measures, such as bone mineral density (BMD), bone metabolism markers, pain improvement, and safety assessments, were extracted and analyzed. STATA MP V17.0 was used to calculate the combined effect size. After searching Chinese and English databases, 15 studies met the inclusion criteria of this study. The results of the meta-analysis showed that the BMD of patients with osteoporosis in diabetes increased significantly after bisphosphonate treatment, and the lumbar BMD increased by 0.08 g/cm² (95% CI: 0.05-0.11). Femoral neck BMD increased by 0.06 g/cm² (95% CI: 0.01-0.11); Ward's triangle BMD increased 0.07 g/cm² (95% CI: 0.04-0.09); and trochanter BMD increased by 0.06 g/cm² (95% CI: 0.04-0.08). In addition, bone alkaline phosphatase increased 1.95 μg/l (95% CI: 1.18-2.72), while serum tartrate-resistant acid phosphatase-5b decreased 1.28 U/l (95% CI: -1.81-0.75). Moreover, improvements in pain were statistically significant. The effects of bisphosphonates on osteocalcin (MD: -0.07; 95% CI: -1.12-1.25), serum calcium (MD: 0.01; 95% CI: -0.03-0.04), serum phosphorus (MD: 0.04; 95% CI: -0.03-0.10) and medication safety (OR: 1.75; 95% CI: 1.29-2.37) were not statistically significant. Bisphosphonates have a significant positive effect on bone mineral density and bone metabolism in patients with osteoporosis in diabetes and have good safety.
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-2295-9335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 681: Show issues Location:
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  2. Article ; Online: Intramural haematoma of the ascending aorta-pragmatic management over evidence-based decisions?

    Nienaber, Christoph A / Yuan, Xun

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 63, Issue 5

    MeSH term(s) Humans ; Aorta, Thoracic/surgery ; Endovascular Aneurysm Repair ; Aortic Dissection ; Aorta/diagnostic imaging ; Aorta/surgery ; Hematoma/diagnostic imaging ; Hematoma/surgery
    Language English
    Publishing date 2023-05-09
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2303: Show issues Location:
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  3. Article ; Online: Plasma suspected to be contaminated causes fear in China.

    Yuan, Xun

    Lancet (London, England)

    2019  Volume 393, Issue 10173, Page(s) 732

    Language English
    Publishing date 2019-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30408-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [No title information]

    Yang, Yuan-Xun / Jin, Yan

    Hormone and Metabolic Research

    2024  

    Abstract: The aim of the study was to explore the clinical efficacy of bisphosphonates in patients with osteoporosis in diabetes patients by meta-analysis. Six databases were systematically searched from inception to January ...

    Abstract The aim of the study was to explore the clinical efficacy of bisphosphonates in patients with osteoporosis in diabetes patients by meta-analysis. Six databases were systematically searched from inception to January 30,2023. Studies evaluating the treatment of diabetic osteoporosis with bisphosphonates were included. Key outcome measures, such as bone mineral density (BMD), bone metabolism markers, pain improvement, and safety assessments, were extracted and analyzed. STATA MP V17.0 was used to calculate the combined effect size. After searching Chinese and English databases, 15 studies met the inclusion criteria of this study. The results of the meta-analysis showed that the BMD of patients with osteoporosis in diabetes increased significantly after bisphosphonate treatment, and the lumbar BMD increased by 0.08 g/cm² (95% CI: 0.05–0.11). Femoral neck BMD increased by 0.06 g/cm² (95% CI: 0.01–0.11); Ward’s triangle BMD increased 0.07 g/cm² (95% CI: 0.04–0.09); and trochanter BMD increased by 0.06 g/cm² (95% CI: 0.04–0.08). In addition, bone alkaline phosphatase increased 1.95 μg/l (95% CI: 1.18–2.72), while serum tartrate-resistant acid phosphatase-5b decreased 1.28 U/l (95% CI: –1.81–0.75). Moreover, improvements in pain were statistically significant. The effects of bisphosphonates on osteocalcin (MD: –0.07; 95% CI: –1.12–1.25), serum calcium (MD: 0.01; 95% CI: –0.03–0.04), serum phosphorus (MD: 0.04; 95% CI: –0.03–0.10) and medication safety (OR: 1.75; 95% CI: 1.29–2.37) were not statistically significant. Bisphosphonates have a significant positive effect on bone mineral density and bone metabolism in patients with osteoporosis in diabetes and have good safety.
    Keywords bone mineral density ; bisphosphonates ; osteoporosis ; bone metabolism
    Language English
    Publishing date 2024-04-26
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-2295-9335
    Database Thieme publisher's database

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  5. Article ; Online: How Iran's worsening economy contributes to Afghans' deteriorating mental health.

    Yuan, Xun

    The lancet. Psychiatry

    2018  Volume 6, Issue 1, Page(s) 17–18

    Language English
    Publishing date 2018-12-19
    Publishing country England
    Document type Journal Article
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(18)30481-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: China's vaccine production scare.

    Yuan, Xun

    Lancet (London, England)

    2018  Volume 392, Issue 10145, Page(s) 371

    MeSH term(s) China ; Counterfeit Drugs/adverse effects ; Diphtheria-Tetanus-Pertussis Vaccine/adverse effects ; Drug Industry/legislation & jurisprudence ; Humans ; Rabies Vaccines/adverse effects ; Vaccines/adverse effects
    Chemical Substances Counterfeit Drugs ; Diphtheria-Tetanus-Pertussis Vaccine ; Rabies Vaccines ; Vaccines
    Language English
    Publishing date 2018-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)31725-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Concern over reported number of measles cases in Yemen.

    Yuan, Xun

    Lancet (London, England)

    2018  Volume 391, Issue 10133, Page(s) 1886

    MeSH term(s) Adolescent ; Armed Conflicts ; Child ; Child, Preschool ; Humans ; Immunization Programs/organization & administration ; Infant ; Infant, Newborn ; Measles/epidemiology ; Measles/prevention & control ; Yemen/epidemiology
    Language English
    Publishing date 2018-05-10
    Publishing country England
    Document type News
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)31063-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Demystifying the Weekend Effect: What We Can Do to Avoid Deadly Weekends.

    Yuan, Xun / Nienaber, Christoph A

    JACC. Asia

    2022  Volume 2, Issue 3, Page(s) 382–384

    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2021.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Taming Hypertension to Prevent Aortic Dissection: Universal Recognition of a "New Normal" Blood Pressure?

    Nienaber, Christoph A / Yuan, Xun

    Circulation

    2022  Volume 145, Issue 9, Page(s) 645–647

    MeSH term(s) Aneurysm, Dissecting/physiopathology ; Aneurysm, Dissecting/prevention & control ; Blood Pressure ; Humans ; Hypertension/physiopathology
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.058133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Commentary: The X and Y of zero gender gap in outcomes of aortic dissection.

    Nienaber, Christoph A / Yuan, Xun

    The Journal of thoracic and cardiovascular surgery

    2022  Volume 167, Issue 1, Page(s) 86–88

    MeSH term(s) Humans ; Sex Factors ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/surgery ; Aortic Aneurysm, Thoracic
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2022.02.045
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