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Article ; Online: Efficacy and safety of macitentan for pulmonary hypertension: A meta-analysis.

Du, Dan / Yuan, Ya-Dong

2023 Volume 17, Issue 11, Page(s) 1117–1129

Abstract: Introduction: Our purpose of this study is to evaluate the effect and safety of macitentan in the treatment of pulmonary hypertension (PH).: Methods: We retrieved the safety and efficacy of macitentan treatment for PH using PubMed, the Cochrane ... ...

Abstract	Introduction: Our purpose of this study is to evaluate the effect and safety of macitentan in the treatment of pulmonary hypertension (PH). Methods: We retrieved the safety and efficacy of macitentan treatment for PH using PubMed, the Cochrane Library, EMBASE databases and clinicaltrials.gov. The Cochrane Risk of Bias Tool was used for literature screening and quality assessment. Data analysis was conducted using RevMan 5.4.1 and Stata/SE 15.1 software. Results are presented as standardization mean differences (SMDs) and odds ratio (OR). Results: Meta-analysis of seven randomized controlled trial (RCT) studies and four non-RCT studies with 2769 patients was included, involving 723 in the macitentan group and 599 in the placebo group. The results of the study showed that macitentan had effectively decreased pulmonary vascular resistance (PVR) (SMD = -0.53, 95% CI: -0.77--0.29, p < 0.05), cardiac index (CI) (SMD = 0.60, 95% CI: 0.37-0.83, p < 0.05) and N-terminal pro-brain natriuretic peptide (NT-proBNP) (SMD = -0.22, 95% CI: -0.40--0.03, p < 0.05). Furthermore, macitentan also significantly reduced PVR (SMD = -0.58, 95% CI: -0.80--0.35, p < 0.05), 6-min walk distance (6WMD) (SMD = 0.33, 95% CI: 0.15-0.50, p < 0.05), CI (SMD = 0.48, 95% CI: 0.28-0.69, p < 0.05), mean pulmonary arterial pressure (mPAP) (SMD = -0.43, 95% CI: -0.64--0.23, p < 0.05) and NT-proBNP (SMD = -0.55, 95% CI: -1.07--0.03, p < 0.05) between baseline and follow-up. The adverse reactions to macitentan were mild, with headache, anaemia and bronchitis. Other efficacy and safety outcomes did not reach statistical differences. Conclusion: Macitentan therapy for PH is effective and safe. The effectiveness on PVR, mPAP, mean right atrial pressure (mRAP), mortality and other indicators still needs to be further confirmed.
MeSH term(s)	Humans ; Hypertension, Pulmonary ; Sulfonamides/adverse effects ; Pyrimidines/adverse effects ; Vascular Resistance
Chemical Substances	macitentan (Z9K9Y9WMVL) ; Sulfonamides ; Pyrimidines
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13621
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insight into Multiphase Interlayer Molecular Packing and Stepwise Phase Transition in 4-(Phenylazo)benzoate Anion-Intercalated Layered Zinc Hydroxide.

Zhang, Jing-Ru / Mo, Yi / Fang, Wei / Yuan, Ya-Xian / Yao, Jian-Lin / Wu, Ji Hong

Inorganic chemistry

2024 Volume 63, Issue 8, Page(s) 3692–3701

Abstract: The properties of layered intercalation hybrids are closely related to interlayer molecular packing. To develop functional intercalation hybrids, it is essential to gain deep insights into interlayer molecular packing. This work reports a new ... ...

Abstract	The properties of layered intercalation hybrids are closely related to interlayer molecular packing. To develop functional intercalation hybrids, it is essential to gain deep insights into interlayer molecular packing. This work reports a new comprehensive insight into the controllable multiphase interlayer molecular packing in 4-(phenylazo)benzoate anion-intercalated layered zinc hydroxide (LZH-4-PAB intercalation hybrids). The new insight breaks up the general understanding that the interlayer molecular packing of anions is usually single-phase, lacking diversity and controllability. Furthermore, it uncovers an interesting stepwise rather than the generally expected continuous phase transition of the interlayer molecular packing. The intercalated 4-PAB anions initially organize into the horizontal monolayer packing (θ = 0°, Phase I), which stepwise transforms to the tilted interdigitated antiparallel bilayer packing (θ ≈ 50°, Phase II) along with an increased intercalation loading and eventually to the vertical interdigitated antiparallel bilayer packing (θ = 90°, Phase III). The LZH-4-PAB hybrids exhibited a greatly enhanced interlayer molecular packing-dependent UV-vis absorption. This study provides helpful guidance for developing property-tailored intercalation hybrids. It may attract new interest in more layered intercalation hybrids. New and rich intercalation chemistry might be discovered in more functional intercalation hybrids beyond the 4-PAB anion-intercalated layered zinc hydroxide.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c03650
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Article ; Online: Study on green closed-loop regeneration of waste lithium iron phosphate based on oxalic acid system.

Chai, Xiaolong / Yu, Xiaohua / Shen, Qingfeng / Li, Xingbin / Lin, Yan / Cai, Weisong / Yuan, Ya

Waste management (New York, N.Y.)

2024 Volume 181, Page(s) 168–175

Abstract: The recovery of valuable metals from used lithium batteries is essential from an environmental and resource management standpoint. However, the most widely used acid leaching method causes significant ecological harm. Here, we proposed a method of ... ...

Abstract	The recovery of valuable metals from used lithium batteries is essential from an environmental and resource management standpoint. However, the most widely used acid leaching method causes significant ecological harm. Here, we proposed a method of recovering Li and Fe selectively from used lithium iron phosphate batteries by using low-concentration organic acid and completing the closed-loop regeneration. Low-concentration oxalic acid is used to carry out PO
MeSH term(s)	Oxalic Acid/chemistry ; Phosphates/chemistry ; Lithium/chemistry ; Recycling/methods ; Iron/chemistry ; Electric Power Supplies ; Ferric Compounds
Chemical Substances	Oxalic Acid (9E7R5L6H31) ; Phosphates ; Lithium (9FN79X2M3F) ; Iron (E1UOL152H7) ; ferric phosphate (N6BAA189V1) ; Ferric Compounds
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2024.03.037
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Article ; Online: Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review.

Yuan, Ya-Chen / Li, Ying / Pan, Yun / Gao, Bo

Oncology letters

2023 Volume 26, Issue 3, Page(s) 368

Abstract: Primary malignant melanoma (MM) of the external ear accounts for a low proportion of cases of cutaneous MM, and its incidence in non-white women is very low. The stomach is a rare metastatic site for MM. Gastric metastasis of MM of the external ear is ... ...

Abstract	Primary malignant melanoma (MM) of the external ear accounts for a low proportion of cases of cutaneous MM, and its incidence in non-white women is very low. The stomach is a rare metastatic site for MM. Gastric metastasis of MM of the external ear is extremely rare, and the associated gene alterations and mechanisms are poorly understood. The present report describes the case of a 58-year-old Asian woman who had a mass on the left auricle for 5 years and was diagnosed with nodular MM with the BRAF V600E mutation after surgical resection. Postoperative metastases to the stomach and descending duodenum appeared 1 year after resection. After 11 months of BRAF-targeted therapy and immunotherapy, the patient developed drug resistance and died from systemic metastases to the brain, lungs, liver, left adrenal gland and peritoneum. Genetic testing revealed additional aberrations in MYB, p16, MYC and PTEN. The clinical characteristics of MM of the external ear and gastric metastatic MM were also summarized through a retrospective literature review. Immunohistochemical staining is critical in the diagnosis of gastric metastasis from MM of the external ear. This disease often requires a multidisciplinary treatment approach, including surgery, targeted therapy and immunotherapy. The present study provides some genetic information about this rare disease and discusses appropriate treatment strategies. The findings of the present study suggests that the surgical margin size, tumor histological type and number of genetic aberrations may be closely associated with metastasis potential, therapeutic efficacy and patient outcome.
Language	English
Publishing date	2023-07-13
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.13954
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Article ; Online: Comments on Surgeon-Patient Sex Concordance and Postoperative Outcomes.

Liao, Yuan-Ya / Wei, James Cheng-Chung / Shu, Hsin-Yi

JAMA surgery

2022 Volume 157, Issue 7, Page(s) 639

MeSH term(s)	Humans ; Postoperative Complications/epidemiology ; Postoperative Period ; Retrospective Studies ; Surgeons
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2022.0296
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Article ; Online: Thrombin injection under B-flow and ultrasound guidance: A safe and effective treatment of pseudoaneurysms.

Li, Lu / Deng, Hongyan / Yuan, Ya / Ye, Xinhua

Vascular

2022 Volume 32, Issue 1, Page(s) 147–153

Abstract: Purpose: To evaluate the method of thrombin injection under B-flow and ultrasound guidance (BUGTI) for the treatment of pseudoaneurysms.: Materials and methods: Twenty-one patients suffering from pseudoaneurysm (PSA) were retrospectively reviewed at ... ...

Abstract	Purpose: To evaluate the method of thrombin injection under B-flow and ultrasound guidance (BUGTI) for the treatment of pseudoaneurysms. Materials and methods: Twenty-one patients suffering from pseudoaneurysm (PSA) were retrospectively reviewed at the First Affiliated Hospital of Nanjing Medical University in Nanjing, China, from January 2018 to August 2019. The patients were treated using an ultrasound-guided injection of thrombin (500 IU/mL) combined with B-mode blood flow imaging (B-flow). The information on the PSA, including the size of the arterial rupture and sac, flow rate, thrombin dose, and treatment outcome, was recorded during the procedure. Follow-up evaluation was performed at 1, 3, and 6 months after the treatment. Pearson's correlation analysis was performed among the characteristics of PSA and the dose of thrombin. Result: The age of patients ranged from 34 to 80 years and averaged 62.8 years. The maximum cross-sectional area of PSA ranged from 208 to 1148 mm Conclusion: Thrombin injection under B-flow and ultrasound guidance is a rapid and effective treatment for PSA. Additionally, the sac size could be used to estimate the dose of thrombin.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Thrombin/adverse effects ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/drug therapy ; Retrospective Studies ; Ultrasonography, Interventional/adverse effects ; Femoral Artery/diagnostic imaging ; Treatment Outcome ; Hemostatics/pharmacology ; Hemostatics/therapeutic use ; Injections, Intra-Arterial ; Iatrogenic Disease
Chemical Substances	Thrombin (EC 3.4.21.5) ; Hemostatics
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381221124708
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Article ; Online: Screening for mitochondrial 12S rRNA C1494T mutation in 655 patients with non-syndromic hearing loss: An observational study.

Gao, Zhen / Yuan, Ya-Sheng

Medicine

2020 Volume 99, Issue 13, Page(s) e19373

Abstract: Mutations in mitochondrial DNA, especially in 12S rRNA gene, are the most important causes for hearing loss. In particular, the A1555G and C1494T mutations have been found to be associated with both aminoglycoside-induced and non-syndromic hearing loss ... ...

Abstract	Mutations in mitochondrial DNA, especially in 12S rRNA gene, are the most important causes for hearing loss. In particular, the A1555G and C1494T mutations have been found to be associated with both aminoglycoside-induced and non-syndromic hearing loss in many families worldwide. To determine the frequency of C1494T mutation in deaf patients, in the current study, we screened this mutation in 655 patients with non-syndromic hearing loss and 300 control subjects. After PCR amplification of mitochondrial 12S rRNA gene and direct sequence analysis, we found that there were 2 patients carrying the C1494T mutation; however, this mutation was not detected in 300 healthy subjects. Further genetic counseling suggested that only 1 patient had an obvious family history of hearing impairment. Clinical evaluation showed that 3 of 10 matrilineal relatives suffered from hearing loss, with different age at onset of hearing loss. Molecular analysis revealed the presence of homoplasmic 12S rRNA C1494T and ND5 T12338C mutations, together with a set of polymorphisms belonging to human mitochondrial haplogroup F2. Interestingly, T12338C mutation resulted in the replacement of the first amino acid, a translation-initiating methionine with a threonine, shortening 2 amino acids of ND5 polypeptide. Moreover, this mutation is located in 2 nucleotides adjacent to the 3' end of the mt-tRNALeu(CUN) gene. Therefore, this mutation may alter ND5 mRNA metabolism and the processing of RNA precursors. Thus, the combination of T12338C and C1494T mutations may contribute to deafness expression in this family. Taken together, our data suggested that the C1494T mutation was the molecular basis for hearing loss, screening for the mitochondrial DNA pathogenic mutations was recommended for early detection, prevention, and diagnosis of mitochondrial deafness.
MeSH term(s)	Adult ; Age of Onset ; China ; DNA, Mitochondrial/genetics ; Female ; Genetic Predisposition to Disease ; Hearing Loss/genetics ; Humans ; Male ; Middle Aged ; RNA, Ribosomal/genetics ; Young Adult
Chemical Substances	DNA, Mitochondrial ; RNA, Ribosomal ; RNA, ribosomal, 12S
Language	English
Publishing date	2020-03-26
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000019373
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Article ; Online: Long-Wavelength Illumination-Induced Photocurrent Enhancement of a ZnPc Photocathodic Material for Bioanalytical Applications

Deng, Han-Mei / Zheng, Meiling / Yuan, Ya-Li / Yuan, Ruo / Chai, Ya-Qin

Analytical Chemistry. 2023 Nov. 01, v. 95, no. 45 p.16625-16630

2023

Abstract: Herein, a novel photocathodic nanocomposite poly{4,8-bis[5-(2-ethylhexyl)-thiophen-2-yl] benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)-carbonyl]thieno[3,4-b]thiophene-4,6-diyl}/phthalocyanine zinc (PTB7-Th/ZnPc) with high ... ...

Abstract	Herein, a novel photocathodic nanocomposite poly{4,8-bis[5-(2-ethylhexyl)-thiophen-2-yl] benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)-carbonyl]thieno[3,4-b]thiophene-4,6-diyl}/phthalocyanine zinc (PTB7-Th/ZnPc) with high photoelectric conversion efficiency under long-wavelength illumination was prepared to construct an ultrasensitive biosensor for the detection of microRNA-21 (miRNA-21), accompanied by a prominent anti-interference capability toward reductive substances. Impressively, the new heterojunction PTB7-Th/ZnPc nanocomposite could not only generate a strong cathodic photocurrent to improve the detection sensitivity under long-wavelength illumination (660 nm) but also effectively avoid the high damage of biological activity caused by short-wavelength light stimulation. Accordingly, by coupling with rolling circle amplification (RCA)-triggered DNA amplification to form functional biquencher nanospheres, a PEC biosensor was fabricated to realize the ultrasensitive analysis of miRNA-21 in the concentration range of 0.1 fM to 10 nM with a detection limit as low as 32 aM. This strategy provided a novel long-wavelength illumination-induced photocurrent enhancement photoactive material for a sensitive and low-damage anti-interference bioassay and early clinical disease diagnosis.
Keywords	DNA ; analytical chemistry ; bioactive properties ; bioassays ; biosensors ; detection limit ; disease diagnosis ; electric current ; lighting ; nanocomposites ; nanospheres ; zinc
Language	English
Dates of publication	2023-1101
Size	p. 16625-16630.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c02971
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: On Underdamped Nesterov's Acceleration

Chen, Shuo / Shi, Bin / Yuan, Ya-xiang

2023

Abstract: The high-resolution differential equation framework has been proven to be tailor-made for Nesterov's accelerated gradient descent method~(\texttt{NAG}) and its proximal correspondence -- the class of faster iterative shrinkage thresholding algorithms ( ... ...

Abstract	The high-resolution differential equation framework has been proven to be tailor-made for Nesterov's accelerated gradient descent method~(\texttt{NAG}) and its proximal correspondence -- the class of faster iterative shrinkage thresholding algorithms (FISTA). However, the systems of theories is not still complete, since the underdamped case ($r < 2$) has not been included. In this paper, based on the high-resolution differential equation framework, we construct the new Lyapunov functions for the underdamped case, which is motivated by the power of the time $t^{\gamma}$ or the iteration $k^{\gamma}$ in the mixed term. When the momentum parameter $r$ is $2$, the new Lyapunov functions are identical to the previous ones. These new proofs do not only include the convergence rate of the objective value previously obtained according to the low-resolution differential equation framework but also characterize the convergence rate of the minimal gradient norm square. All the convergence rates obtained for the underdamped case are continuously dependent on the parameter $r$. In addition, it is observed that the high-resolution differential equation approximately simulates the convergence behavior of~\texttt{NAG} for the critical case $r=-1$, while the low-resolution differential equation degenerates to the conservative Newton's equation. The high-resolution differential equation framework also theoretically characterizes the convergence rates, which are consistent with that obtained for the underdamped case with $r=-1$. Comment: 21 pages, 4 figures, 2 tables
Keywords	Mathematics - Optimization and Control ; Computer Science - Machine Learning ; Mathematics - Numerical Analysis
Subject code	518
Publishing date	2023-04-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Linear convergence of Nesterov-1983 with the strong convexity

Li, Bowen / Shi, Bin / Yuan, Ya-xiang

2023

Abstract: For modern gradient-based optimization, a developmental landmark is Nesterov's accelerated gradient descent method, which is proposed in [Nesterov, 1983], so shorten as Nesterov-1983. Afterward, one of the important progresses is its proximal ... ...

Abstract	For modern gradient-based optimization, a developmental landmark is Nesterov's accelerated gradient descent method, which is proposed in [Nesterov, 1983], so shorten as Nesterov-1983. Afterward, one of the important progresses is its proximal generalization, named the fast iterative shrinkage-thresholding algorithm (FISTA), which is widely used in image science and engineering. However, it is unknown whether both Nesterov-1983 and FISTA converge linearly on the strongly convex function, which has been listed as the open problem in the comprehensive review [Chambolle and Pock, 2016, Appendix B]. In this paper, we answer this question by the use of the high-resolution differential equation framework. Along with the phase-space representation previously adopted, the key difference here in constructing the Lyapunov function is that the coefficient of the kinetic energy varies with the iteration. Furthermore, we point out that the linear convergence of both the two algorithms above has no dependence on the parameter $r$ on the strongly convex function. Meanwhile, it is also obtained that the proximal subgradient norm converges linearly. Comment: 17 pages, 3 figures
Keywords	Mathematics - Optimization and Control ; Computer Science - Machine Learning ; Mathematics - Numerical Analysis ; Statistics - Machine Learning
Subject code	510
Publishing date	2023-06-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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