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  1. Article ; Online: A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy.

    Li, Jun / Zong, Qingyu / Zhao, Zhongyi / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 21, Page(s) 3142–3145

    Abstract: In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug ... ...

    Abstract In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH
    MeSH term(s) Prodrugs/pharmacology ; Reactive Oxygen Species ; Drug Liberation ; Nanoparticles ; Drug Delivery Systems ; Doxorubicin/pharmacology ; Cell Line, Tumor
    Chemical Substances Prodrugs ; Reactive Oxygen Species ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00052d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A highly sensitive ratiometric fluorescence immunoassay based on bioorthogonal nanozymes.

    Liu, Xiajian / Wang, Nianhua / Hou, Yixuan / Dong, He / Liang, Wenhua / Li, Xinchun / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 29, Page(s) 3978–3981

    Abstract: We designed a novel ratiometric fluorescence immunoassay based on bioorthogonal nanozymes for carcinoembryonic antigen detection. The analytical performance of our designed immunoassay showed a wide linear range, a low detection limit, good ... ...

    Abstract We designed a novel ratiometric fluorescence immunoassay based on bioorthogonal nanozymes for carcinoembryonic antigen detection. The analytical performance of our designed immunoassay showed a wide linear range, a low detection limit, good reproducibility, selectivity and stability. Thus, bioorthogonal nanozymes hold great potential applications in clinical diagnoses.
    MeSH term(s) Carcinoembryonic Antigen ; Reproducibility of Results ; Immunoassay
    Chemical Substances Carcinoembryonic Antigen
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00731j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: AIEgens Cross-linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity-Mediated Click Reaction.

    Dong, Yansong / Liu, Ye / Tu, Yalan / Yuan, Youyong / Wang, Jun

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 52, Page(s) e202310975

    Abstract: Activatable dual-modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual-modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal ... ...

    Abstract Activatable dual-modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual-modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation-induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near-infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity-mediated click reaction. Tumor acidity-responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) and AIEgens containing azide groups (termed AATs) can be covalently cross-linked in response to tumor acidity, which leads to a simultaneous enhancement in NIRF intensity (≈12.4-fold) and r
    MeSH term(s) Mice ; Animals ; Neoplasms ; Molecular Probes ; Magnetic Resonance Imaging/methods ; Molecular Imaging ; Magnetic Iron Oxide Nanoparticles ; Nanoparticles ; Optical Imaging/methods
    Chemical Substances Molecular Probes
    Language English
    Publishing date 2023-11-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202310975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy.

    Zong, Qingyu / Xiao, Xuan / Li, Jisi / Yuan, Youyong

    Biomaterials science

    2022  Volume 10, Issue 15, Page(s) 4228–4234

    Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a ... ...

    Abstract The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a reactive oxygen species (ROS)-sensitive polyprodrug (TS
    MeSH term(s) Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Liberation ; Humans ; Nanoparticles ; Neoplasms/drug therapy ; Polymers/metabolism ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Reactive Oxygen Species/metabolism
    Chemical Substances Polymers ; Prodrugs ; Reactive Oxygen Species ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00647b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy

    Zong, Qingyu / Xiao, Xuan / Li, Jisi / Yuan, Youyong

    Biomaterials science. 2022 July 26, v. 10, no. 15

    2022  

    Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a ... ...

    Abstract The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a reactive oxygen species (ROS)-sensitive polyprodrug (TSCA/DOX) with cascade amplification of triggering agents and drug activation by incorporating both an ROS signal amplifier (TACA) and a drug activation amplifier (SIPDOX) into a delivery system. Endogenous ROS as a triggering mechanism kicked off the initial circulation phase to increase intracellular ROS signals. Subsequently, the enhanced ROS initiated the second degradation step, allowing the polyprodrug SIPDOX to fracture spontaneously in a domino-like fashion, resulting in self-accelerated drug activation in tumor tissue. Therefore, the polyprodrug created in this study with cascade amplification of drug activation holds great promise for effective cancer treatment.
    Keywords biocompatible materials ; cancer therapy ; drugs ; neoplasms ; polymers ; reactive oxygen species
    Language English
    Dates of publication 2022-0726
    Size p. 4228-4234.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00647b
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Tumor-acidity and bioorthogonal chemistry-mediated construction and deconstruction of drug depots for ferroptosis under normoxia and hypoxia.

    Zhou, Jielian / Wang, Kewei / Jiang, Maolin / Li, Jisi / Yuan, Youyong

    Acta biomaterialia

    2022  Volume 142, Page(s) 253–263

    Abstract: Mounting evidence shows that tumor hypoxia stress promotes tumor invasion and metastasis and induces therapeutic resistance. Oxygen-independent Fenton reaction, which refers to the iron-catalyzed conversion of endogenous hydrogen peroxide ( ... ...

    Abstract Mounting evidence shows that tumor hypoxia stress promotes tumor invasion and metastasis and induces therapeutic resistance. Oxygen-independent Fenton reaction, which refers to the iron-catalyzed conversion of endogenous hydrogen peroxide (H
    MeSH term(s) Cell Line, Tumor ; Ferroptosis ; Humans ; Hydrogen Peroxide/chemistry ; Hypoxia ; Neoplasms/drug therapy ; Oxygen ; Pharmaceutical Preparations ; Tumor Microenvironment
    Chemical Substances Pharmaceutical Preparations ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.01.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Self-amplified chain-shattering cinnamaldehyde-based poly(thioacetal) boosts cancer chemo-immunotherapy.

    Zong, Qingyu / Li, Jisi / Xiao, Xuan / Du, Xiaojiao / Yuan, Youyong

    Acta biomaterialia

    2022  Volume 154, Page(s) 97–107

    Abstract: The selective activation of stimuli-responsive polymers in the tumor microenvironment is a great concern to achieve intelligent cancer therapy, but most of them show inadequate response due to insufficient endogenous triggering agents. Herein, we ... ...

    Abstract The selective activation of stimuli-responsive polymers in the tumor microenvironment is a great concern to achieve intelligent cancer therapy, but most of them show inadequate response due to insufficient endogenous triggering agents. Herein, we rationally designed a reactive oxygen species (ROS)-responsive cinnamaldehyde (CA)-based poly(thioacetal), consisting of ROS-responsive thioacetal (TA) and ROS-generating agent CA, with self-amplified chain-shattering polymer degradation. The mechanism of self-amplified chain-shattering is that endogenous ROS as a triggering agent facilitates chain cleavage of TA with the release of CA, which in turn produces more ROS through mitochondrial dysfunction, resulting in an exponential polymer degradation cascade. The polymer can be further modified with anticancer drug doxorubicin (DOX) for cooperative amplification of oxidative stress and immunogenic cell death (ICD) of tumor cells, thereby boosting the effect of chemo-immunotherapy. The self-amplified chain-shattering polymer designed in this work holds great promise in developing stimuli-responsive polymers for efficient drug delivery. STATEMENT OF SIGNIFICANCE: This study presented an approach to utilize self-amplified chain-shattering cinnamaldehyde-based poly (thioacetal) as a drug delivery system to restrain tumor growth and boost chemo-immunotherapy. The endogenous ROS as a triggering agent initiates the chain cleavage with the release of CA, which in turn produces ROS through mitochondria dysfunction, resulting in an exponential polymer degradation cascade and rapid drug release.
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.09.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bioorthogonal chemistry and illumination controlled programmed size-changeable nanomedicine for synergistic photodynamic and hypoxia-activated therapy.

    Jiang, Maolin / Liu, Ye / Dong, Yansong / Wang, Kewei / Yuan, Youyong

    Biomaterials

    2022  Volume 284, Page(s) 121480

    Abstract: Photodynamic therapy (PDT) can aggravate the hypoxia aggravation and be further utilized for the activation of hypoxia-activated prodrug (HAP). Ideally, photosensitizers (PSs) are mainly administrated to tumor vasculatures adjacent to regions with high ... ...

    Abstract Photodynamic therapy (PDT) can aggravate the hypoxia aggravation and be further utilized for the activation of hypoxia-activated prodrug (HAP). Ideally, photosensitizers (PSs) are mainly administrated to tumor vasculatures adjacent to regions with high oxygen to effectively generate reactive oxygen species (ROS) effectively and further aggravate tumor hypoxia, while the HAP is delivered to the inner tumor as far as possible for efficient activation. However, a delivery system capable of transporting PSs and HAP to the desired region respectively for the optimum effect is urgently needed. Here, we developed a bioorthogonal click chemistry and illumination controlled programmed size-changeable nanomedicine for synergistic photodynamic and hypoxia-activated therapy. It utilized tumor acidity responsive bioorthogonal click reaction for crosslinking nanoparticles to construct a drug depot with tumor vasculatures adjacent region retention for PDT in normoxia. Under laser illumination, cleavage of the ROS-responsive thioketal (TK) crosslinker to release small sized poly(amidoamine) (PAMAM) dendrimer conjugated with HAP for enhanced tumor penetration into the hypoxic region. Therefore, this strategy could differentially deliver PSs and HAP in desired spatial distribution, eventually achieving the enhanced synergistic enhancement in the combined PDT and hypoxia-activated therapy.
    MeSH term(s) Cell Line, Tumor ; Humans ; Hypoxia/drug therapy ; Lighting ; Nanomedicine ; Nanoparticles/therapeutic use ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Prodrugs/therapeutic use ; Reactive Oxygen Species
    Chemical Substances Photosensitizing Agents ; Prodrugs ; Reactive Oxygen Species
    Language English
    Publishing date 2022-04-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Nanoparticle-mediated blockade of CXCL12/CXCR4 signaling enhances glioblastoma immunotherapy: Monitoring early responses with MRI radiomics.

    Wei, Ruili / Li, Jiamin / Lin, Wanxian / Pang, Xinrui / Yang, Huikang / Lai, Shengsheng / Wei, Xinhua / Jiang, Xinqing / Yuan, Youyong / Yang, Ruimeng

    Acta biomaterialia

    2024  Volume 177, Page(s) 414–430

    Abstract: The limited therapeutic efficacy of checkpoint blockade immunotherapy against glioblastoma is closely related to the blood-brain barrier (BBB) and tumor immunosuppressive microenvironment, where the latter is driven primarily by tumor-associated myeloid ... ...

    Abstract The limited therapeutic efficacy of checkpoint blockade immunotherapy against glioblastoma is closely related to the blood-brain barrier (BBB) and tumor immunosuppressive microenvironment, where the latter is driven primarily by tumor-associated myeloid cells (TAMCs). Targeting the C-X-C motif chemokine ligand-12/C-X-C motif chemokine receptor-4 (CXCL12/CXCR4) signaling orchestrates the recruitment of TAMCs and has emerged as a promising approach for alleviating immunosuppression. Herein, we developed an iRGD ligand-modified polymeric nanoplatform for the co-delivery of CXCR4 antagonist AMD3100 and the small-molecule immune checkpoint inhibitor BMS-1. The iRGD peptide facilitated superior BBB crossing and tumor-targeting abilities both in vitro and in vivo. In mice bearing orthotopic GL261-Luc tumor, co-administration of AMD3100 and BMS-1 significantly inhibited tumor proliferation without adverse effects. A reprogramming of immunosuppression upon CXCL12/CXCR4 signaling blockade was observed, characterized by the reduction of TAMCs and regulatory T cells, and an increased proportion of CD8
    MeSH term(s) Animals ; Mice ; B7-H1 Antigen ; Glioblastoma/diagnostic imaging ; Glioblastoma/drug therapy ; Programmed Cell Death 1 Receptor/therapeutic use ; Ligands ; Radiomics ; Immunotherapy ; Nanoparticles/therapeutic use ; Tumor Microenvironment ; Cell Line, Tumor ; Cyclams ; Benzylamines
    Chemical Substances plerixafor (S915P5499N) ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Ligands ; Cyclams ; Benzylamines
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A helical oncolytic polypeptide with potent membranolytic activity for cancer therapy.

    Hu, Xue / Li, Jie / Zhang, Yuhao / Xiong, Menghua / Zhang, Houbing / Yuan, Youyong

    Biomaterials science

    2023  Volume 11, Issue 4, Page(s) 1451–1458

    Abstract: Oncolytic peptides (OLPs) with membranolytic activity show great potential to combat multidrug-resistant cancer cells. Herein, we report a cationic helical oncolytic polypeptide (OLPP) with potent membranolytic activity for cancer therapy. The OLPP was ... ...

    Abstract Oncolytic peptides (OLPs) with membranolytic activity show great potential to combat multidrug-resistant cancer cells. Herein, we report a cationic helical oncolytic polypeptide (OLPP) with potent membranolytic activity for cancer therapy. The OLPP was synthesized by ring-opening polymerization of
    MeSH term(s) Animals ; Mice ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Peptides ; Neoplasms/therapy ; Necrosis ; Oncolytic Virotherapy ; Cell Line, Tumor
    Chemical Substances Peptides
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm01892f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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