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  1. Article: Integrating UPLC-Q-Orbitrap MS with serum pharmacochemistry network and experimental verification to explore the pharmacological mechanisms of

    Gao, Hejun / Yuan, Ziyi / Liang, Haoxuan / Liu, Youtan

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1261772

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1261772
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  2. Article ; Online: Impact of physicochemical properties on biological effects of lipid nanoparticles: Are they completely safe.

    Yuan, Ziyi / Yan, Ruyu / Fu, Zuyi / Wu, Tao / Ren, Chaoxiu

    The Science of the total environment

    2024  Volume 927, Page(s) 172240

    Abstract: Lipid nanoparticles (LNPs) are promising materials and human-use approved excipients, with manifold applications in biomedicine. Researchers have tended to focus on improving the pharmacological efficiency and organ targeting of LNPs, while paid ... ...

    Abstract Lipid nanoparticles (LNPs) are promising materials and human-use approved excipients, with manifold applications in biomedicine. Researchers have tended to focus on improving the pharmacological efficiency and organ targeting of LNPs, while paid relatively less attention to the negative aspects created by their specific physicochemical properties. Here, we discuss the impacts of LNPs' physicochemical properties (size, surface hydrophobicity, surface charge, surface modification and lipid composition) on the adsorption-transportation-distribution-clearance processes and bio-nano interactions. In addition, since there is a lack of review emphasizing on toxicological profiles of LNPs, this review outlined immunogenicity, inflammation, hemolytic toxicity, cytotoxicity and genotoxicity induced by LNPs and the underlying mechanisms, with the aim to understand the properties that underlie the biological effects of these materials. This provides a basic strategy that increased efficacy of medical application with minimized side-effects can be achieved by modulating the physicochemical properties of LNPs. Therefore, addressing the effects of physicochemical properties on toxicity induced by LNPs is critical for understanding their environmental and health risks and will help clear the way for LNPs-based drugs to eventually fulfill their promise as a highly effective therapeutic agents for diverse diseases in clinic.
    MeSH term(s) Nanoparticles/toxicity ; Humans ; Lipids/chemistry ; Liposomes
    Chemical Substances Lipids ; Lipid Nanoparticles ; Liposomes
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172240
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Synergistic tuning mixed matrix membranes by Ag+-doping in UiO-66-NH2/polymers of intrinsic microporosity for remarkable CO2/N2 separation

    Lin, Zhihong / Yuan, Ziyi / Wang, Kaifang / He, Xuezhong

    Journal of Membrane Science. 2023 Sept., v. 681 p.121775-

    2023  

    Abstract: Novel mixed matrix membranes (MMMs) with superior CO₂/N₂ separation properties are of great importance for post-combustion CO₂ capture from flue gas. Metal-organic frameworks (MOFs) as one of the most attractive porous fillers for MMMs fabrication, are ... ...

    Abstract Novel mixed matrix membranes (MMMs) with superior CO₂/N₂ separation properties are of great importance for post-combustion CO₂ capture from flue gas. Metal-organic frameworks (MOFs) as one of the most attractive porous fillers for MMMs fabrication, are considered to provide a solid molecular sieving mechanism for enhancing CO₂/N₂ selectivity. However, it causes the reduction in gas permeability and limits its further industrialization. Herein, we proposed a new strategy for filler functionalization by doping silver ions (Ag⁺) into UiO-66-NH₂ nanoparticles through the double-solvent method and used for the preparation of advanced MMMs. The double-solvent method is benefits for the enrichment of Ag⁺ in the hydrophilic pores of UiO-66-NH₂. As a result, the prepared novel MMMs called Ag⁺@UiO@PIM-1 with the polymers of intrinsic microporosity (PIMs) as polymer matrix, show outstanding CO₂ permeability. According to the mixed gases (CO₂/N₂ = 10:90) permeation experiments under 25 °C and 2 bar, the membrane with 30%Ag⁺@10%UiO loading achieves more than 65% increase in CO₂/N₂ selectivity (∼30) and 120% in CO₂ permeability (>15,000 Barrer) compared to the pristine PIM-1 membrane. By optimizing the Ag⁺ doping amount and Ag⁺@UiO loading content, the separation performance exceeds the 2019 CO₂/N₂ upper bound. To figure out the separation mechanism, the pore texture properties and CO₂ affinity of the functional filler (Ag⁺@UiO) together with the membrane structure were characterized by XPS, PXRD, SEM, gas sorption, etc. The synergistic mechanisms by combing CO₂ facilitated transport and molecular sieving from pore regulation were identified to enable advanced CO₂/N₂ membrane separation.
    Keywords carbon dioxide ; flue gas ; hydrophilicity ; industrialization ; nanoparticles ; permeability ; polymers ; silver ; sorption ; texture ; Mixed matrix membranes ; MOFs ; Gas separation ; Synergistic mechanism ; Pore regulation ; CO2 facilitated transport
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2023.121775
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    In stock of ZB MED Bonn / Germany

    Z 78/706: Show issues

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  4. Article ; Online: Fluorescence-based method for fast quantification of active aluminums in natural and treated water.

    Yuan, Zi-Yi / Li, Tian-Yu / Zhang, Jian-Feng / Wang, Xiao-Mao

    Journal of hazardous materials

    2022  Volume 433, Page(s) 128815

    Abstract: Fast quantitative determination of active aluminum ( ... ...

    Abstract Fast quantitative determination of active aluminum (Al
    MeSH term(s) Aluminum/chemistry ; Hydrogen-Ion Concentration ; Magnesium ; Water/chemistry ; Water Pollutants, Chemical/chemistry
    Chemical Substances Water Pollutants, Chemical ; Water (059QF0KO0R) ; Aluminum (CPD4NFA903) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-03-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128815
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  5. Article: Partial Replacement of Fishmeal with Poultry By-Product Meal in Diets for Coho Salmon (

    Yu, Hairui / Li, Min / Yu, Leyong / Ma, Xuejun / Wang, Shuliang / Yuan, Ziyi / Li, Lingyao

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 17

    Abstract: The present study evaluated the effects of partially substituting fish meal (FM) with poultry by-product meal (PBPM) on the growth, muscle composition, and tissue biochemical parameters of coho salmon ( ...

    Abstract The present study evaluated the effects of partially substituting fish meal (FM) with poultry by-product meal (PBPM) on the growth, muscle composition, and tissue biochemical parameters of coho salmon (
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13172789
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  6. Article: Dietary L-Lysine Requirement of Coho Salmon (

    Yu, Leyong / Yu, Hairui / Yuan, Ziyi / Zhang, Jiayi / Li, Lingyao / Ma, Chengyu / Kong, Weiguang

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 23

    Abstract: The suitable dietary L-lysine concentration for coho salmon ( ...

    Abstract The suitable dietary L-lysine concentration for coho salmon (
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13233670
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  7. Article: Fluorescence-based method for fast quantification of active aluminums in natural and treated water

    Yuan, Zi-yi / Li, Tian-yu / Zhang, Jian-feng / Wang, Xiao-mao

    Journal of hazardous materials. 2022 July 05, v. 433

    2022  

    Abstract: Fast quantitative determination of active aluminum (Alₐ) in natural and treated water is extremely desirable. The fluorescence method based on complexation by 8-hydroxyquinoline (8-HQ) is highly promising, but the measurement could be severely interfered ...

    Abstract Fast quantitative determination of active aluminum (Alₐ) in natural and treated water is extremely desirable. The fluorescence method based on complexation by 8-hydroxyquinoline (8-HQ) is highly promising, but the measurement could be severely interfered by hardness ions and natural organic matter (NOM). This study was devoted to refining the 8-HQ complexation–fluorescence method for measurement of Alₐ by eliminating the interferences. Results showed that magnesium ions at a typical concentration in natural water could have a substantial positive interference, due to the formation of Mg–8-HQ complexes which have fluorescence regions similar to Al–8-HQ. NOM, represented by fulvic acid (FA), could not interfere the aluminum measurement considerably. It was primarily because 8-HQ has much stronger complexing ability than NOM with aluminum. Theoretical calculations showed that reducing the buffering pH (from 7.5) to 6.5 or using a masking ligand such as edetate (EDTA) could effectively alleviate the interference mainly caused by magnesium. Experimental results confirmed the theoretical predictions. Refined procedures were suggested for more accurate while fast determination of Alₐ in natural or treated water. The refined method has a quantification limit of ~4 μg/L, a linear range of measurement up to 700 μg/L, and a relative standard deviation of ~0.8%.
    Keywords 8-hydroxyquinoline ; aluminum ; crossover interference ; fluorescence ; fulvic acids ; hardness ; ligands ; magnesium ; pH ; quantitative analysis ; standard deviation
    Language English
    Dates of publication 2022-0705
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128815
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  8. Article ; Online: Clinical Features and Treatment of Congenital Pyriform Sinus Fistula: Analysis of 12 Cases.

    Zhang, Shurou / Yuan, Ziyi / Xia, Zhigang / Chen, Huanqi / Zhang, Ziheng / Chen, Mengjiao / Ye, Fan

    Ear, nose, & throat journal

    2022  Volume 103, Issue 5, Page(s) 319–323

    Abstract: Background: Congenital pyriform sinus fistula (CPSF) is a rare congenital disease derived from the remnants of the third or fourth branchial cleft.: Objectives: To investigate the imaging characteristics, clinical manifestations, surgical methods, ... ...

    Abstract Background: Congenital pyriform sinus fistula (CPSF) is a rare congenital disease derived from the remnants of the third or fourth branchial cleft.
    Objectives: To investigate the imaging characteristics, clinical manifestations, surgical methods, complications, and personalized treatment of CPSF.
    Material and methods: The clinical data of 12 CPSF patients admitted to the Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Wenzhou Medical University from March 2016 to May 2021 were retrospectively analyzed. Cryogenic plasma radiofrequency ablation, carbon dioxide laser resection, and external cervical excision were selected based on the individual condition, and postoperative complications and efficacy were evaluated.
    Results: There were 6 men and 6 women. Neck abscess or thyroiditis was considered at the initial diagnosis. In 11 of the cases, the CPSF was on the left side, whereas in the rest one case, it was on the right. A pyriform fossa fistula was observed during hypopharyngeal iodine angiography. Eight patients were treated with endoscopic piriform fossa fistula laser resection, two with cryogenic plasma radiofrequency ablation, and the rest with external cervical fistula resection. There was no evidence of postoperative hoarseness, pharyngeal fistula, dysphagia, and other complications.
    Conclusion and significance: CPSF is less common in adults than in children. For patients with recurrent neck abscesses, CPSF should be highly suspected, timely angiography should be performed as soon as possible, and care should be taken to avoid missed diagnoses. The primary method for piriform fossa fistula removal is surgical treatment. Finally, tailoring treatment regimens to the patient's condition can significantly improve curative efficacy.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Abscess/surgery ; Fistula/surgery ; Fistula/congenital ; Laser Therapy/methods ; Lasers, Gas/therapeutic use ; Pharyngeal Diseases/surgery ; Postoperative Complications/etiology ; Pyriform Sinus/abnormalities ; Pyriform Sinus/diagnostic imaging ; Retrospective Studies ; Treatment Outcome ; Child, Preschool
    Language English
    Publishing date 2022-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613221117004
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthesis of primary propargylic alcohols from terminal alkynes using rongalite as the C1 unit.

    Wang, Miao / Jiang, Shan / Lu, Xin-Xin / Zhang, Kun / Yuan, Zi-Yi / Xu, Rui-Li / Zhao, Bang-Tun / Wu, An-Xin

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 29, Page(s) 5949–5952

    Abstract: Here, an efficient leaving group-activated methylene alcohol strategy for the preparation of primary propargyl alcohols from terminal alkynes by employing the bulk industrial product rongalite as the C1 unit has been described. The reaction avoids the ... ...

    Abstract Here, an efficient leaving group-activated methylene alcohol strategy for the preparation of primary propargyl alcohols from terminal alkynes by employing the bulk industrial product rongalite as the C1 unit has been described. The reaction avoids the low-temperature reaction conditions and inconvenient lithium reagents required for the classical method of preparing primary propargylic alcohols. Preliminary mechanistic studies showed that the reaction may not proceed
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00902e
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  10. Article: Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study.

    Zhou, Tingfeng / Chen, Mengjiao / Yuan, Ziyi / Xia, Zhigang / Zhang, Shurou / Zhang, Ziheng / Chen, Huanqi / Lin, Renyu

    Frontiers in neurology

    2023  Volume 14, Page(s) 1111255

    Abstract: Background: Observational studies suggest that inflammatory markers may increase the risk of idiopathic sudden sensorineural hearing loss (ISSHL). However, the causal relationship between the two has not been established. We sought to assess the ... ...

    Abstract Background: Observational studies suggest that inflammatory markers may increase the risk of idiopathic sudden sensorineural hearing loss (ISSHL). However, the causal relationship between the two has not been established. We sought to assess the possible causal effect between several genetically predicted inflammatory markers and ISSHL by Mendelian random (MR) analysis.
    Methods: We extracted single nucleotide polymorphisms (SNPs) associated with C-reactive protein (CRP), Tumor necrosis factor-α (TNF-α), and fibrinogen from abstract data from the European Individual Large genome-wide association studies (GWAS). Genetic data for ISSHL were obtained from the FinnGen study (
    Results: In the random-effects IVW approach, there was a significant causal relationship between genetic susceptibility to CRP levels and ISSHL (OR = 1.23, 95% CI = 1.02-1.49,
    Conclusion: This Mendelian randomization study provides causal evidence that CRP is a risk factor for ISSHL, while TNF-α and fibrinogen do not increase the risk for ISSHL Introduction.
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1111255
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