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Article ; Online: Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

Yuanyuan Liu / Kaihua Rao / Zhengfeng Li / Chunhua Huang

Immunity, Inflammation and Disease, Vol 11, Iss 8, Pp n/a-n/a (2023)

2023

Abstract: Abstract The incidence rate of insomnia is increasing, but the mechanism of it remains unclear. Warming Yang Strategy (WY) is a kind of Traditional Chinese Medicine, and it is proved to be effective in treating insomnia patients. The insomnia animal was ... ...

Abstract	Abstract The incidence rate of insomnia is increasing, but the mechanism of it remains unclear. Warming Yang Strategy (WY) is a kind of Traditional Chinese Medicine, and it is proved to be effective in treating insomnia patients. The insomnia animal was established with chlorophenylalanine (PCPA). Morris water maze and open field test were performed to evaluate the influence of WY on the neurological recovery of insomnia rats. TUNEL staining and flow cytometry were used to measure apoptosis level. WY promoted the neurological recovery in the insomnia rats through Morris water maze and open field test evaluation. The increase of γ‐aminobutyric acid, dopamine, 5‐hydroxytryptamine, and norepinephrine caused by WY was suppressed by siSIRT4. The decrease of apoptosis and inflammation factors expression induced by WY was promoted by siRNA‐SIRT4 (siSIRT4). WY improve neurological recovery in the insomnia rats through SIRT4 by inhibiting inflammation and apoptosis. This research might provide a novel insight for the prevention and treatment of insomnia through targeting SIRT4.
Keywords	chlorophenylalanine ; insomnia ; SIRT4 ; Traditional Chinese Medicine ; Warming Yang Strategy ; Immunologic diseases. Allergy ; RC581-607
Subject code	610
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on the Extraction Method of Microplastic System in Textile Wastewater

Jiachen Li / Yuanyuan Liu / Yingxi Gao / Xin Li / Yan Gong

Polymers, Vol 15, Iss 1394, p

2023 Volume 1394

Abstract: Microplastic pollution has become a global environmental problem. Textile microplastics are an important component of microplastic pollution, but little is known about their contamination in the industrial environment. The lack of standardized methods ... ...

Abstract	Microplastic pollution has become a global environmental problem. Textile microplastics are an important component of microplastic pollution, but little is known about their contamination in the industrial environment. The lack of standardized methods for detecting and quantifying textile microplastics is a major obstacle to determining the risks they pose to the natural environment. This study systematically examines the pretreatment options for the extraction of microplastics from printing and dyeing wastewater. The effectiveness of potassium hydroxide, nitric acid–hydrogen peroxide mixed solution, hydrogen peroxide, and Fenton’s reagent for the removal of organic matter from textile wastewater is compared. Three textile microplastics, polyethylene terephthalate, polyamide, and polyurethane, are studied. The effects of the digestion treatment on the physicochemical properties of textile microplastics are characterized. The separation efficiency of sodium chloride, zinc chloride, sodium bromide, sodium iodide, and sodium chloride-sodium iodide mixed solution on the textile microplastics is tested. The results showed that Fenton’s reagent achieved a 78% removal rate of organic matter from printing and dyeing wastewater. Meanwhile, it has less of an effect on the physicochemical properties of textile microplastics after digestion and is the best reagent for digestion. The zinc chloride solution achieved a 90% recovery for separating textile microplastics with good reproducibility. It does not affect the subsequent characterization analysis after separation and is the best solution for density separation.
Keywords	microplastics ; printing and dyeing wastewater ; digestion ; density separation ; detection and analysis ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation of Energy Harvesting Capabilities of Metglas 2605SA1

Yuanyuan Liu / Benjamin Ducharne / Gaël Sebald / Kanjuro Makihara / Mickaël Lallart

Applied Sciences, Vol 13, Iss 3477, p

2023 Volume 3477

Abstract: In the framework of electromechanical energy conversion devices for vibrational energy harvesting, magnetostrictive materials are an attractive alternative solution to the brittleness of piezoelectric materials. Electromagnetic systems have low voltage ... ...

Abstract	In the framework of electromechanical energy conversion devices for vibrational energy harvesting, magnetostrictive materials are an attractive alternative solution to the brittleness of piezoelectric materials. Electromagnetic systems have low voltage output at a low frequency while magnetostrictive materials are suitable for a larger frequency bandwidth. In this work, a special experimental emphasis is placed on Fe 80 Si 9 B 11 (also known as Metglas 2605SA1) alloy. The ultimate energy conversion abilities are investigated by performing experimental Ericsson cycles as well as through theoretical predictions using a dedicated model for the magnetic curves at the material scale. Typical output magnetic energy densities ranged between 0.1 and 1 mJ/cm 3 /cycle under moderate stress (<100 MPa) and magnetic excitation (up to 4 kA/m). Apart from its energy conversion abilities, Metglas 2605SA1 also features attractive characteristics for realistic applications in microgenerators, such as a low price, which is an important advantage for the mass production and cost-effectiveness of the harvester. Furthermore, its soft magnetic property reduces the need for high magnetic fields and yields a well-adapted solution from a system point of view. It is therefore shown that this material is a suitable conversion material according to the available stress and magnetic excitation magnitudes, in addition to economic considerations.
Keywords	energy harvesting ; magnetostrictive ; Metglas 2605SA1 ; Ericsson cycle ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Grain-refining mechanism in hypereutectic Al-20Si alloy with minor Sr - Sc - La and ultrasonic vibration treatment

Jiping Lei / Bowen Lei / Kai Zhang / Guanlin Liu / Yuanyuan Liu

Heliyon, Vol 9, Iss 9, Pp e19272- (2023)

2023

Abstract: The grain-refining mechanism with minor Sr - Sc - La and ultrasonic vibration treatment (UVT) in the hypereutectic Al-20Si alloy were studied. The results demonstrated that the microstructure of the hypereutectic Al-20Si alloy could be refined ... ...

Abstract	The grain-refining mechanism with minor Sr - Sc - La and ultrasonic vibration treatment (UVT) in the hypereutectic Al-20Si alloy were studied. The results demonstrated that the microstructure of the hypereutectic Al-20Si alloy could be refined significantly, further improve its mechanical properties. The desirable refinement of the microstructure was achieved using 0.2% Sr, 0.15% Sc, and 0.3% La under UVT, achieving the highest grain circularity coefficient, hardness, elongation, and area reduction. The tensile strength was the largest with the addition of 0.2% La. The findings of this study provide theoretical and experimental guidelines for the fabrication of structural materials for application in automotive, aerospace, and deep-sea equipment.
Keywords	Grain-refining mechanism ; Hypereutectic Al-20Si ; Ultrasonic vibration treatment ; Eutectic Si ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	669
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Significance of EZH2 in Acute Myeloid Leukemia

Weiyun Jiao / Yuanyuan Liu / Yangyi Bao

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: In this paper, we have focused on the investigation of the expression level of the enhancer of zeste homolog 2 (EZH2) gene in bone marrow mononuclear cells of acute myeloid leukemia (AML) patients and analyze the relationship between EZH2 gene expression ...

Abstract	In this paper, we have focused on the investigation of the expression level of the enhancer of zeste homolog 2 (EZH2) gene in bone marrow mononuclear cells of acute myeloid leukemia (AML) patients and analyze the relationship between EZH2 gene expression and EMI. The expression of EZH2mRNA in bone marrow mononuclear cells of 26 patients with incipient AML was detected by qRT-PCR, and the relationship between EZH2mRNA expression and clinical characteristics was analyzed. EZH2 mRNA expression was increased in 26 AML patients. EZH2 gene expression in male patients was significantly higher than that in female patients. The expression of EZH2 in the group with extramedullary infiltration (EMI) was significantly higher than that in the group without EMI. The patients were divided into different groups according to the chromosomal karyotype and prognosis. Statistical analysis showed that the expression level of the medium-risk group was significantly higher than that of the low-risk group, while there was no statistical difference in other groups (P>0.05). The expression of EZH2 gene in AML patients was closely related to EMI, and the expression of EZH2 in AML cells was closely related to cell migration ability. EZH2 is expected to be one of the indicators of disease recurrence.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Humic Lake Exhibits Higher Microbial Functional Gene Diversity and Weaker Gene Interaction Efficiency than a Common Alkaline Lake

Dan He / Yuanyuan Liu / Qinglong Wu / Yuyang Peng / Lijuan Ren

Biology, Vol 11, Iss 1448, p

2022 Volume 1448

Abstract: Humic lakes (HLs) are special water bodies (high organic matter content, low pH, and low transparency) that are important sources of major greenhouse gases. The knowledge about microbial functional potentials and the interactions among different genes in ...

Abstract	Humic lakes (HLs) are special water bodies (high organic matter content, low pH, and low transparency) that are important sources of major greenhouse gases. The knowledge about microbial functional potentials and the interactions among different genes in HL water has been scarcely understood. In this study, we used 16S rRNA gene sequencing and the GeoChip 5.0 to investigate microbial community compositions and functional gene structures in an HL and a reference weakly alkaline lake (RAL). The HL microbial communities showed distinct compositions and functional gene structures than those in the RAL. The functional gene diversity was significantly higher in the HL than in the RAL. Specifically, higher gene relative intensities in carbon and nitrogen fixations, the degradation of various types of carbon, methane oxidation and methanogenesis, ammonification, denitrification, and assimilatory N reduction were observed in the HL samples. By contrast, the metabolic potentials of microorganisms involved in dissimilatory N reduction, phosphorus degradation, and sulfur oxidation were weaker in the HL than in the RAL. Despite higher functional gene diversity, the interaction efficiency among genes (reflected by network geodesic distance and clustering coefficient) might be reduced in the HL. Different functional microbes may develop less interdependent relationships in acquiring nutrients given the high resource availability in the HL. Overall, the enhanced microbial metabolic potentials and less efficient functional interactions might have great consequences on nutrient cycling and greenhouse gas emissions in the HL ecosystem.
Keywords	humic lake ; microbial community ; functional gene ; nutrient cycling ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality risks from a spectrum of causes associated with sand and dust storms in China

Can Zhang / Meilin Yan / Hang Du / Jie Ban / Chen Chen / Yuanyuan Liu / Tiantian Li

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively. We ... ...

Abstract	Abstract Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively. We analyzed 1,495,724 deaths and 2024 SDS events from 1 February to 31 May (2013–2018) in 214 Chinese counties. The excess mortality risks associated with SDS were 7.49% (95% CI: 3.12–12.05%), 5.40% (1.25–9.73%), 4.05% (0.41–7.83%), 3.45% (0.34–6.66%), 3.37% (0.28–6.55%), 3.33% (0.07–6.70%), 8.90% (4.96–12.98%), 12.51% (6.31–19.08%), and 11.55% (5.55–17.89%) for ischemic stroke, intracerebral hemorrhagic stroke, hypertensive heart disease, myocardial infarction, acute myocardial infarction, acute ischemic heart disease, respiratory disease, chronic lower respiratory disease, and chronic obstructive pulmonary disease (COPD), respectively. SDS had significantly added effects on ischemic stroke, chronic lower respiratory disease, and COPD mortality. Our results suggest the need to implement public health policy against SDS.
Keywords	Science ; Q
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response of Sea Water Exchange Processes to Monsoons in Jiaozhou Bay, China

Zhenhuan Tian / Jinghao Shi / Yuanyuan Liu / Wei Wang / Chunhua Liu / Fangfang Li / Yanqin Shao

Sustainability, Vol 15, Iss 21, p

2023 Volume 15198

Abstract: The self-purification capacity of semi-closed bays is closely related to the exchange process of open sea water. In recent years, with the enhancement of human development activities, environmental problems such as eutrophication, weak hydrodynamics, and ...

Abstract	The self-purification capacity of semi-closed bays is closely related to the exchange process of open sea water. In recent years, with the enhancement of human development activities, environmental problems such as eutrophication, weak hydrodynamics, and poor water exchange capacity have appeared in the bays. In this paper, the water exchange time and flow field in Jiaozhou Bay (JZB) were investigated using the environmental fluid dynamics code with a coupled dye module. Specifically, Jiaozhou Bay was divided into seven zones to explore the effect mechanism of a monsoon on the water exchange process. A detailed analysis was performed on the current water exchange status in the highly polluted northeastern region of the bay and its influence on the surrounding areas. Based on the definition of the average residence time and considering the effect of the tracer release moment, the distribution of the water exchange time in the bay under three circumstances was obtained. Results showed that the timing of the tracer release exerted minimal influence on the average residence time. The water exchange process was influenced by a combination of astronomical and meteorological factors. The overall exchange capacity of the bay was strongest under the impact of a winter monsoon and tides, followed by a summer monsoon and tides, and the weakest exchange occurred under the influence of tides alone. Moreover, both summer and winter monsoons greatly facilitated water exchange in the heavily polluted northeastern region. However, pollutants from this region had a significant impact on surrounding areas during a summer monsoon. Changes in the structure and intensity of residual flow fields were the primary causes of exchange rate discrepancies.
Keywords	Jiaozhou Bay ; Eulerian dispersion model ; water exchange ; average residence time ; exchange rate discrepancies ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ESRGAN-DP

Jie Song / Huawei Yi / Wenqian Xu / Xiaohui Li / Bo Li / Yuanyuan Liu

Heliyon, Vol 9, Iss 4, Pp e15134- (2023)

Enhanced super-resolution generative adversarial network with adaptive dual perceptual loss

2023

Abstract: The proposal of perceptual loss solves the over-smoothing problem of images caused by pixel-wise loss and improves the visual quality of the images, but it also inevitably produces a large number of artifacts and distortions in images. The reason for ... ...

Abstract	The proposal of perceptual loss solves the over-smoothing problem of images caused by pixel-wise loss and improves the visual quality of the images, but it also inevitably produces a large number of artifacts and distortions in images. The reason for this phenomenon is that the perceptual features only rely on a single pre-trained visual geometry group (VGG) network, which results in the features of the image being unable to be fully extracted, thus limiting the reasoning ability of the model. To fundamentally reduce the generation of artifacts and distortions, this paper proposes the Dual Perceptual Loss (DP Loss). First, we improve the perceptual feature extraction method so that it no longer only extracts single-type VGG features. In addition, a residual network (ResNet) feature that has a complementary relationship with the VGG feature can also be extracted. Then, we propose a dynamic weighting method to eliminate the magnitude difference between perceptual losses. Finally, to obtain the excellent effect of image reconstruction, enhanced super-resolution generative adversarial network (ESRGAN) with strong learning capability is used in this paper to adapt the complexity of DP Loss. The abundant experimental studies and evaluations are conducted on benchmark datasets. Results are encouraging and better than those previously reported on these datasets. The code is available at https://github.com/Sunny6-6-6/ESRGAN-DP.
Keywords	Super resolution ; Perceptual loss ; Residual network ; Visual geometry group ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	006
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accurate Detection Algorithm of Citrus Psyllid Using the YOLOv5s-BC Model

Shilei Lyu / Zunbai Ke / Zhen Li / Jiaxing Xie / Xu Zhou / Yuanyuan Liu

Agronomy, Vol 13, Iss 896, p

2023 Volume 896

Abstract: Citrus psyllid is the main vector of Huanglongbing, and as such, it is responsible for huge economic losses across the citrus industry. The small size of this pest, difficulties in data acquisition, and the lack of target detection algorithms suitable ... ...

Abstract	Citrus psyllid is the main vector of Huanglongbing, and as such, it is responsible for huge economic losses across the citrus industry. The small size of this pest, difficulties in data acquisition, and the lack of target detection algorithms suitable for complex occlusion environments inhibit detection of the pest. The present paper describes the construction of a standard sample database of citrus psyllid in multi-focal lengths and out-of-focus states in the natural environment. By integrating the attention mechanism and optimizing the key module of BottleneckCSP, YOLOv5s-BC, we have created an accurate detection algorithm for small targets. Based on YOLOv5s, our algorithm incorporates an SE-Net channel attention module into the Backbone network and improves the detection of small targets by guiding the algorithm to the channel characteristics of small-target information. At the same time, the BottleneckCSP module in the neck network is improved, and extraction of multiple features of recognition targets is improved by the addition of a normalization layer and SiLU activation function. Experimental results based on a standard sample database show the recognition accuracy (intersection over union (IoU) = 0.5) of the YOLOv5s-BC algorithm for citrus psyllid to be 93.43%, 2.41% higher than that of traditional YOLOv5s. The accuracy and recall rates are also increased by 1.31% and 4.22%, respectively. These results confirm that the YOLOv5s-BC algorithm has good generalization ability in the natural context of citrus orchards, and it offers a new approach for the control of citrus psyllid.
Keywords	citrus psyllid ; small-target group ; YOLOv5s-BC ; SE-Net ; BottleneckCSP ; Agriculture ; S
Subject code	006
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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