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Article ; Online: Scalable spin Seebeck thermoelectric generation using Fe-oxide nanoparticle assembled film on flexible substrate.

Kurokawa, Yuichiro / Tahara, Yusuke / Hamada, Yuki / Fujimoto, Masahiro / Yuasa, Hiromi

2022 Volume 12, Issue 1, Page(s) 16605

Abstract: We fabricated ... ...

Abstract	We fabricated Fe
Language	English
Publishing date	2022-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21200-9
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Article ; Online: Ultra-wide-band millimeter-wave generator using spin torque oscillator with strong interlayer exchange couplings.

Kurokawa, Yuichiro / Yamada, Keisuke / Taniguchi, Tomohiro / Horiike, Shu / Tanaka, Terumitsu / Yuasa, Hiromi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 10849

Abstract: Recent increased development interest in millimeter-wave oscillator devices has necessitated realization of small oscillators with high frequency, wide frequency tunability, and room-temperature operation. Spin-torque oscillators (STOs) are fascinating ... ...

Abstract	Recent increased development interest in millimeter-wave oscillator devices has necessitated realization of small oscillators with high frequency, wide frequency tunability, and room-temperature operation. Spin-torque oscillators (STOs) are fascinating candidates for such applications because of their nanometer size and suitability for room-temperature operation. However, their oscillation frequency and tunable range are limited to the order of 100 MHz-10 GHz. Here, we propose use of bilinear (J
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-15014-y
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Book ; Online: Large anomalous Nernst effect in non-crystalline Gd-Fe ferrimagnetic alloy films for flexible thermoelectric applications

Kurokawa, Yuichiro / Fujimoto, Masahiro / Hamada, Yuki / Yuasa, Hiromi

2021

Abstract: The anomalous Nernst effect (ANE), a heat-charge conversion mechanism based on a magnetic metal, has been extensively studied for application in thin thermoelectric devices. The low magnetization and fabrication at room temperature are important for ... ...

Abstract	The anomalous Nernst effect (ANE), a heat-charge conversion mechanism based on a magnetic metal, has been extensively studied for application in thin thermoelectric devices. The low magnetization and fabrication at room temperature are important for flexible ANE thermoelectric devices on plastic substrates. Therefore, we investigated the ANE in ferrimagnetic GdxFe100-x films with low magnetization in this study by systematically varying the Gd composition x. Although the Gd33Fe67 film with a Gd composition close to magnetic compensation composition exhibited very low magnetization, an ANE coefficient \|S_ANE\| of 2.13 uV/K was obtained, which is close to the highest value reported thus far. Finally, we demonstrated the ANE in a Gd33Fe67 film deposited on a flexible sheet. A sufficient ANE voltage was obtained while maintaining the flexibility of the sample, indicating the potential application of this material in thermoelectric devices exploiting the ANE of Gd-Fe films. Comment: 25 pages, 8 figures
Keywords	Condensed Matter - Materials Science
Subject code	530
Publishing date	2021-07-12
Publishing country	us
Document type	Book ; Online
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Article ; Online: Influence of dose reduction of vincristine in R-CHOP on outcomes of diffuse large B cell lymphoma.

Utsu, Yoshikazu / Takaishi, Koji / Inagaki, Shunichirou / Arai, Hironori / Yuasa, Hiromi / Masuda, Shinichi / Matsuura, Yasuhiro / Aotsuka, Nobuyuki / Wakita, Hisashi

Annals of hematology

2015 Volume 95, Issue 1, Page(s) 41–47

Abstract: Dose intensity (DI) of chemotherapy affects prognosis of diffuse large B cell lymphoma (DLBCL). Myelotoxicity is the major dose-limiting toxicity (DLT) of most cytotoxic agents for hematological malignancies, whereas DLT of vincristine (VCR) is mainly ... ...

Abstract	Dose intensity (DI) of chemotherapy affects prognosis of diffuse large B cell lymphoma (DLBCL). Myelotoxicity is the major dose-limiting toxicity (DLT) of most cytotoxic agents for hematological malignancies, whereas DLT of vincristine (VCR) is mainly neurological toxicity. Although VCR is a key drug and its combination with other cytotoxic agents needs consideration, studies focused on relative DI (RDI) of VCR have not been done before. We retrospectively analyzed 86 cases of DLBCL that received six or more cycles of cyclophosphamide (CPM), doxorubicin (DXR), VCR, prednisolone, and rituximab [R-CHOP] and calculated RDI of each cytotoxic agent to analyze its influence on treatment outcome. The median RDI of CPM, doxorubicin, and VCR was 80.0, 81.7, and 78.4 %, respectively (p = 0.002). The average RDI (ARDI) of these three agents was 80.0 %. The overall survival was significantly worse in the low ARDI (<85 %) than in the high ARDI (>85 %) group (2-year survival rate 67.2 vs 93.4 %, p = 0.011). The survival rate with low RDI VCR (<85 %) was lower than that with high RDI VCR (>85 %), even when the remaining two agents had high ARDI (2-year survival rate 74.3 vs 95.8 %, p = 0.047). In conclusion, VCR dose tended to be reduced compared with CPM and DXR in R-CHOP. Lower ARDI of cytotoxic agents and lower RDI of VCR could lead to poor prognosis in the treatment of DLBCL with R-CHOP. We thought these observations should be confirmed in a prospective study.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Male ; Middle Aged ; Prednisone/administration & dosage ; Retrospective Studies ; Survival Rate/trends ; Treatment Outcome ; Vincristine/administration & dosage
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; R-CHOP protocol ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2015-10-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-015-2514-9
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Article: Skin capacitance in normal and atopic infants, and effects of moisturizers on atopic skin.

Matsumoto, Tomoaki / Yuasa, Hiromi / Kai, Rie / Ueda, Hiromi / Ogura, Shunko / Honda, Yoshiko

The Journal of dermatology

2007 Volume 34, Issue 7, Page(s) 447–450

Abstract: Skin capacitance depends on the water content of the stratum corneum, and moisturizers have beneficial effects in atopic dermatitis. This study was performed to determine the skin capacitance in normal and atopic infants, and to evaluate the effects of ... ...

Abstract	Skin capacitance depends on the water content of the stratum corneum, and moisturizers have beneficial effects in atopic dermatitis. This study was performed to determine the skin capacitance in normal and atopic infants, and to evaluate the effects of different moisturizers on infantile atopic skin. The skin capacitance in 186 normal infants and 37 atopic infants was measured with a Moisture Checker. Measurements were also made for atopic infants after an application of pure petrolatum or an oil-in-water cream containing a humectant. Age-related decreases in skin capacitance were observed at the majority of dermal sites in normal infants. The skin capacitance was significantly lower in atopic infants compared with normal infants at all body sites. Pure petrolatum and oil-in-water creams containing humectants significantly augmented the capacitance from 2% to 7%. The reference values for skin capacitance may be helpful for delineating normal from atopic skin. Certain moisturizers can increase skin hydration.
MeSH term(s)	Administration, Topical ; Analysis of Variance ; Child, Preschool ; Dermatitis, Atopic/physiopathology ; Electric Capacitance ; Emollients/pharmacology ; Female ; Humans ; Infant ; Male ; Petrolatum/pharmacology ; Reference Values ; Skin/drug effects ; Skin/physiopathology ; Skin Physiological Phenomena/drug effects
Chemical Substances	Emollients ; Petrolatum (8009-03-8)
Language	English
Publishing date	2007-07
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/j.1346-8138.2007.00308.x
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Article: Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression.

Yuasa, Hiromi / Oike, Yuichi / Iwama, Atsushi / Nishikata, Ichiro / Sugiyama, Daisuke / Perkins, Archibald / Mucenski, Michael L / Suda, Toshio / Morishita, Kazuhiro

The EMBO journal

2005 Volume 24, Issue 11, Page(s) 1976–1987

Abstract: The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in hematopoietic stem cells (HSCs) in embryos and adult bone marrows, suggesting ... ...

Abstract	The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in hematopoietic stem cells (HSCs) in embryos and adult bone marrows, suggesting a physiological role of Evi1 in HSCs. We therefore investigate the role and authentic target genes of Evi1 in hematopoiesis using Evi1-/- mice, which die at embryonic day 10.5. HSCs in Evi1-/- embryos are markedly decreased in numbers in vivo with defective self-renewing proliferation and repopulating capacity. Notably, expression rate of GATA-2 mRNA, which is essential for proliferation of definitive HSCs, is profoundly reduced in HSCs of Evi1-/- embryos. Restoration of the Evi1 or GATA-2 expression in Evi1-/- HSCs could prevent the failure of in vitro maintenance and proliferation of HSC through upregulation of GATA-2 expression. An analysis of the GATA-2 promoter region revealed that Evi1 directly binds to GATA-2 promoter as an enhancer. Our results reveal that GATA-2 is presumably one of critical targets for Evi1 and that transcription factors regulate the HSC pool hierarchically.
MeSH term(s)	Angiopoietin-1/biosynthesis ; Angiopoietin-1/genetics ; Angiopoietin-2/biosynthesis ; Angiopoietin-2/genetics ; Animals ; Blood Vessels/embryology ; Bone Marrow/metabolism ; Cell Division ; Cells, Cultured/cytology ; Cells, Cultured/metabolism ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/physiology ; GATA2 Transcription Factor ; Gene Expression Regulation, Developmental ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Hematopoietic System/embryology ; Humans ; MDS1 and EVI1 Complex Locus Protein ; Mice ; Mice, Knockout ; Neovascularization, Physiologic/genetics ; Neovascularization, Physiologic/physiology ; Promoter Regions, Genetic ; Proto-Oncogenes/genetics ; Proto-Oncogenes/physiology ; RNA, Messenger/biosynthesis ; Receptor, TIE-2/biosynthesis ; Receptor, TIE-2/genetics ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Transcription Factors/physiology ; Transcription, Genetic ; Yolk Sac/blood supply
Chemical Substances	Angiopoietin-1 ; Angiopoietin-2 ; DNA-Binding Proteins ; GATA2 Transcription Factor ; GATA2 protein, human ; Gata2 protein, mouse ; MDS1 and EVI1 Complex Locus Protein ; MECOM protein, human ; Mecom protein, mouse ; RNA, Messenger ; Transcription Factors ; Receptor, TIE-2 (EC 2.7.10.1)
Language	English
Publishing date	2005-05-12
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/sj.emboj.7600679
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis.

Suenobu, Souichi / Takakura, Nobuyuki / Inada, Tomohisa / Yamada, Yoshihiro / Yuasa, Hiromi / Zhang, Xiu-Qin / Sakano, Seiji / Oike, Yuichi / Suda, Toshio

Biochemical and biophysical research communications

2002 Volume 293, Issue 3, Page(s) 1124–1131

Abstract: Erythropoiesis is regulated not only by erythropoietin but also by microenvironments which are composed of transmembrane molecules. We have previously shown that a receptor tyrosine kinase EphB4 is predominantly expressed on human erythroid progenitors ... ...

Abstract	Erythropoiesis is regulated not only by erythropoietin but also by microenvironments which are composed of transmembrane molecules. We have previously shown that a receptor tyrosine kinase EphB4 is predominantly expressed on human erythroid progenitors in bone marrow. EphB4 is expressed in approximately 45% of hematopoietic progenitor cells, which are CD34-positive and c-Kit-positive in human umbilical cord blood (hUCB). The transmembrane ligand for EphB4 or ephrin-B2 is expressed on bone marrow stromal cells and arterial endothelial cells. When such EphB4-positive hematopoietic progenitor cells were co-cultured with stromal cells which express ephrin-B2, they were immediately detached from stromal cells and differentiated to mature erythroid cells. At that time, expression of EphB4 immediately down-regulated. In contrast, on ephrin-B2 non-expressing stromal cells, they remained EphB4-positive cells and the generated number of mature erythroid cells was less than that on ephrin-B2 expressing stromal cells. Additionally, ephrin-B2 expression on endothelial cells up-regulated under hypoxic condition. Taken together, we propose that one of the molecular cues that regulate erythropoiesis is ephrin-B2 on stromal cells.
MeSH term(s)	Cell Division ; Cell Line ; Cells, Cultured ; Coculture Techniques ; Ephrin-B2 ; Erythropoiesis ; Hematopoietic Stem Cells/physiology ; Humans ; Ligands ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; RNA, Messenger/biosynthesis ; Stromal Cells/physiology
Chemical Substances	Ephrin-B2 ; Ligands ; Membrane Proteins ; RNA, Messenger
Language	English
Publishing date	2002-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/S0006-291X(02)00330-3
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Article: Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood.

Yuasa, Hiromi / Takakura, Nobuyuki / Shimomura, Taizou / Suenobu, Souichi / Yamada, Taketo / Nagayama, Hitomi / Oike, Yuichi / Suda, Toshio

Biochemical and biophysical research communications

2002 Volume 298, Issue 5, Page(s) 731–737

Abstract: To investigate the behavior of hematopoietic stem cells (HSCs) in cord blood (CB), we analyzed the expression and function of TIE2, a tyrosine kinase receptor. A subpopulation of Lineage (Lin)(-/low)CD34(+) cells in CB expressed TIE2 (18.8%). Assays for ... ...

Abstract	To investigate the behavior of hematopoietic stem cells (HSCs) in cord blood (CB), we analyzed the expression and function of TIE2, a tyrosine kinase receptor. A subpopulation of Lineage (Lin)(-/low)CD34(+) cells in CB expressed TIE2 (18.8%). Assays for long-term culture-initiating cells (LTC-IC) and cobble-stone formation revealed that Lin(-/low)CD34(+)TIE2(+) cells showed to have a capacity of primitive hematopoietic precursor cells in vitro. When Lin(-/low)CD34(+)TIE2(+) cells were cultured on the stromal cells, they transmigrated under the stromal layers and kept an immature character for a few weeks. By contrast, Lin(-/low)CD34(+)TIE2(-) cells differentiated immediately within a few weeks. Finally, we confirmed that 1x10(4)Lin(-/low)CD34(+)TIE2(+) cells were engrafted in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice, while 1x10(4)Lin(-/low)CD34(+)TIE2(-) cells were not. Taken together, we conclude that TIE2 is a marker of HSCs in CB. A ligand for TIE2, Ang-1 promoted the adhesion of sorted primary Lin(-/low)CD34(+)TIE2(+) cells to fibronectin (FN), and this adhesion may play a critical role in keeping HSCs in an immature status under the stromal cells.
MeSH term(s)	Angiogenesis Inducing Agents/metabolism ; Angiopoietin-1 ; Animals ; Antigens, CD34/blood ; Biomarkers ; Cell Adhesion ; Cells, Cultured ; Female ; Fetal Blood/cytology ; Fetal Blood/enzymology ; Fetal Blood/immunology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/classification ; Hematopoietic Stem Cells/enzymology ; Hematopoietic Stem Cells/immunology ; Humans ; In Vitro Techniques ; Infant, Newborn ; Ligands ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Pregnancy ; Receptor Protein-Tyrosine Kinases/blood ; Receptor, TIE-2 ; Transplantation, Heterologous
Chemical Substances	ANGPT1 protein, human ; Angiogenesis Inducing Agents ; Angiopoietin-1 ; Angpt1 protein, mouse ; Antigens, CD34 ; Biomarkers ; Ligands ; Membrane Glycoproteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, TIE-2 (EC 2.7.10.1)
Language	English
Publishing date	2002-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/s0006-291x(02)02524-x
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