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  1. AU="Yucel, Kamile"
  2. AU=Kumar Arun
  3. AU="Zou, Bin"
  4. AU="Krass, Stefan"
  5. AU="Patrick Connerton"
  6. AU="Lai, Jiaying"
  7. AU=Kalra Mannudeep K AU=Kalra Mannudeep K
  8. AU=Wright Zachary AU=Wright Zachary
  9. AU="Brakensiek, Stefan"
  10. AU="Akilov, Oleg"
  11. AU="Pavlish, April"
  12. AU="Kim, Joonhee"
  13. AU="Napp, Adriane"
  14. AU="Alchin, David Rhys"
  15. AU="Chenxiang Xi"
  16. AU="Alatawi, Mohammed Naif"
  17. AU="Jacquemet, Elise"
  18. AU="Cappelleri, Joseph C"
  19. AU="Frank, Samuel A"
  20. AU="Srensen, Henrik Toft"
  21. AU="Matteo Tosato"

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  1. Artikel ; Online: Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients.

    Yucel, Kamile / Fuat Gurbuz, Ali

    Hormone molecular biology and clinical investigation

    2022  

    Abstract: Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is ... ...

    Abstract Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature.
    Methods: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study.
    Results: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA.
    Conclusions: The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2022-07-18
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2536635-X
    ISSN 1868-1891 ; 1868-1883
    ISSN (online) 1868-1891
    ISSN 1868-1883
    DOI 10.1515/hmbci-2022-0024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Hypoxia induced factor-1α levels in patients undergoing adenoidectomy.

    Yucel, Kamile / Aydin, Isa / Erdem, Said Sami

    Scandinavian journal of clinical and laboratory investigation

    2020  Band 81, Heft 1, Seite(n) 34–38

    Abstract: Among  the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study ... ...

    Abstract Among  the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL,
    Mesh-Begriff(e) Adenoidectomy ; Adenoids/pathology ; Adenoids/surgery ; Child ; Female ; Hemoglobins/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Nasopharynx/pathology ; ROC Curve
    Chemische Substanzen HIF1A protein, human ; Hemoglobins ; Hypoxia-Inducible Factor 1, alpha Subunit
    Sprache Englisch
    Erscheinungsdatum 2020-11-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2020.1849786
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Comparison of Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Methods in the Measurement of Serum Androstenedione Levels.

    Yucel, Kamile / Abusoglu, Sedat / Unlu, Ali

    Clinical laboratory

    2018  Band 64, Heft 1, Seite(n) 69–75

    Abstract: Background: Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. In this study, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed according to CLSI rules. ...

    Abstract Background: Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. In this study, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed according to CLSI rules. The developed method was compared with two immunoassay methods, the enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA).
    Methods: After liquid-liquid extraction, a Shimadzu Prominence LC unit coupled to an ABSCIEX API 3200 mass spectrometer with atmospheric pressure chemical ionization was used to quantify serum androstenedione levels. Serum androstenedione results taken from tandem mass spectrometry were compared with the immunoassays.
    Results: The androstenedione assay was linear up to 50 ng/mL. Lower limit of quantitation and lower limit of detection were 0.195 ng/mL and 0.097 ng/mL, respectively. This method was not affected by matrix effect and other steroid hormone interferences. In this study, the obtained recovery was 69 - 99%, carryover value was determined as 0.026 ng/mL. According to the results of an interference study, androstenedione bias % did not exceed the limit of allowable bias % and 88.7% recovery was acquired for androstenedione. In the LC-MS/MS and ELISA comparison study, the slope value was found as 18.412, intercept -22.87, and r2 value as 0.1033. In the LC-MS/MS and RIA comparison study, slope value was found as 1.085, intercept 0.4541, and r2 value as 0.3712. In the RIA and ELISA comparison study, slope value was found as 9.57, intercept -15.5, and r2 value as 0.19.
    Conclusions: The LC-MS/MS provides agreement with the results of radioimmunoassay but not with ELISA. This method offers better selectivity compared to immunoassay systems.
    Mesh-Begriff(e) Androstenedione/blood ; Calibration ; Chromatography, Liquid/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Immunoassay/methods ; Male ; Radioimmunoassay/methods ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
    Chemische Substanzen Androstenedione (409J2J96VR)
    Sprache Englisch
    Erscheinungsdatum 2018-03-02
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2017.170612
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ud II Zs.170: Hefte anzeigen Standort:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 25: Hefte anzeigen

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  4. Artikel ; Online: Homocysteine levels in patients with masked hypertension.

    Yücel, Kamile / Bekçi, Taha Tahir / Taner, Alparslan / Kayrak, Mehmet / Korucu, Emine Nedime / Unlü, Ali

    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology

    2014  Band 14, Heft 4, Seite(n) 357–362

    Abstract: Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the ... ...

    Abstract Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension.
    Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis.
    Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with MHT. Patients with high blood pressure showed higher homocysteine levels when compared to MHT (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036).
    Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with MHT, homocysteine levels may not have any significant effect upon high blood pressure levels.
    Mesh-Begriff(e) Biomarkers/blood ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Case-Control Studies ; Cholesterol/blood ; Cross-Sectional Studies ; Female ; Homocysteine/blood ; Humans ; Male ; Masked Hypertension/blood ; Masked Hypertension/diagnosis ; Middle Aged
    Chemische Substanzen Biomarkers ; Homocysteine (0LVT1QZ0BA) ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2014-06
    Erscheinungsland Turkey
    Dokumenttyp Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2278670-3
    ISSN 1308-0032 ; 1302-8723
    ISSN (online) 1308-0032
    ISSN 1302-8723
    DOI 10.5152/akd.2014.4689
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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