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  1. Article ; Online: Evaluation of the Diagnostic Algorithms for Serodiagnosis of Syphilis.

    Evren, Kübra / Berkem, Rukiye / Yücel, Mihriban

    Japanese journal of infectious diseases

    2021  Volume 75, Issue 1, Page(s) 70–75

    Abstract: We analyzed the performance parameters of the traditional and reverse algorithms to determine which is more convenient for serodiagnosis of syphilis. In total, 4,789 serum samples were obtained from a cross-sectional study. Venereal Disease Research ... ...

    Abstract We analyzed the performance parameters of the traditional and reverse algorithms to determine which is more convenient for serodiagnosis of syphilis. In total, 4,789 serum samples were obtained from a cross-sectional study. Venereal Disease Research Laboratory (VDRL), Treponema pallidum hemagglutination assay (TPHA), and chemiluminescent microparticle immunoassay (CMIA) tests were performed on each serum sample. In case of discordance between results, TPHA was applied as a second treponemal test. Overall, 207 patients were serodiagnosed with syphilis. Among the 4,789 samples tested, 125 (2.6%) and 206 (4.3%) were positive using the traditional and reverse algorithms, respectively. The missed diagnosis rate of the traditional algorithm was 42.5%. The reverse algorithm had a higher sensitivity than that of the traditional algorithm. The sensitivity levels of the traditional and reverse algorithms were 57.49% and 99.85% respectively. The false positivity rate of the reverse algorithm was 0.02%.
    MeSH term(s) Algorithms ; Antibodies, Bacterial ; Cross-Sectional Studies ; Humans ; Sensitivity and Specificity ; Syphilis/diagnosis ; Syphilis Serodiagnosis ; Treponema pallidum
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2021-06-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1478383-6
    ISSN 1884-2836 ; 1344-6304
    ISSN (online) 1884-2836
    ISSN 1344-6304
    DOI 10.7883/yoken.JJID.2021.164
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  2. Article: Pozitif Sinyal Veren Kan Kültürü Şişelerinde EUCAST Doğrudan Hızlı Antimikrobiyal Duyarlılık Testi Yönteminin Değerlendirilmesi.

    Erdoğan, Gizem / Karakoç, Ayşe Esra / Yücel, Mihriban / Yağcı, Serap

    Mikrobiyoloji bulteni

    2021  Volume 55, Issue 4, Page(s) 626–634

    Abstract: Early reporting of the antibiotic susceptibility testing (AST) results is essential for the survival of sepsis patients. In 2019, European Committee on Antimicrobial Susceptibility Testing (EUCAST) published a proposal to detect antimicrobial ... ...

    Title translation Evaluation of EUCAST Direct Rapid Antimicrobial Susceptibility Test Method in Blood Culture Bottles with Positive Signal.
    Abstract Early reporting of the antibiotic susceptibility testing (AST) results is essential for the survival of sepsis patients. In 2019, European Committee on Antimicrobial Susceptibility Testing (EUCAST) published a proposal to detect antimicrobial susceptibility from positive blood culture bottles with a rapid antimicrobial susceptibility test (RAST) method in a maximum of eight hours. In this study, it was aimed to evaluate the EUCAST RAST method in blood culture bottles that resulted with positive signal in BacT/ALERT (bioMérieux, France) blood culture system and that showed gram-negative bacteria with single morphology with Gram stain. The study was conducted prospectively between April 2019 and November 2019. Ninety blood culture bottles that we detected single gram negative bacteria morphology by Gram stain were tested according to the EUCAST RAST method, The isolates obtained from the blood culture bottles were studied with the EUCAST disk diffusion method and the Vitek 2 Compact (bioMerieux, France) automated system. The results obtained with RAST were compared with the results of these methods. The turn around time of the RAST method was recorded. Categorical agreement of the RAST method with conventional methods and the very major error rates were determined. Of the 14 isolates not yet covered by the EUCAST HADT method, 12 were determined to be other Enterobacterales members and two as other non-fermentatives. Two isolates were detected with the same morphological characteristics in Gram stain of the blood culture bottle and the same antibiotic susceptibility profile, but with different identification results. These sixteen isolates were excluded from the study. In this study the susceptibility of 74 isolates were determined according to the EUCAST breakpoint tables, of which 31 were Klebsiella pneumoniae, 35 were Escherichia coli, four were Acinetobacter baumannii and four were Pseudomonas aeruginosa. According to the evaluation periods of EUCAST RAST; the susceptibility profile was reported for nine (12%) of E.coli at four hours, eight (11%) at six hours, 18 (24%) at eight hours; three (4%) of K.pneumoniae at four hours, 16 (21%) at six hours, 12 (16%) at eight hours; three of P.aeruginosa (4%) at six hours, one (1%) at eight hours; two of A.baumannii (2%) at six hours and two (2%) at eight hours. The categorical aggrement of the RAST method was 91.8% with the automated system and 96.8% with the disc diffusion method. Very major errors of RAST method compared to the automated system were detected for piperacillin-tazobactam (17.7%), ceftazidime (11.6%) and meropenem (5.6%); and when compared to the disc diffusion method, for cefotaxime (5.7%) and meropenem (6.7%). Our results have shown that EUCAST RAST method can practicaly be performed in routine laboratories to report early results with a low cost. Because of the very major errors it is necessary to confirm the results with the standard methods.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Blood Culture ; Gram-Negative Bacteria ; Humans ; Microbial Sensitivity Tests ; Piperacillin, Tazobactam Drug Combination
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Piperacillin, Tazobactam Drug Combination (157044-21-8)
    Language Turkish
    Publishing date 2021-10-19
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
    DOI 10.5578/mb.20219713
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  3. Article: Wickerhamomyces anomalus (Candida pelliculosa)’un Etken Olduğu Periton Diyalizi İlişkili Bir Peritonit Olgusu.

    Evren, Kübra / Akçay, Eda / Yücel, Mihriban / Bal, Ayşe Zeynep / Erdinç, Fatma Şebnem / Dinç, Bedia / Kalkancı, Ayşe

    Mikrobiyoloji bulteni

    2021  Volume 55, Issue 4, Page(s) 665–672

    Abstract: Fungal peritonitis is less commonly seen than bacterial peritonitis in patients undergoing peritoneal dialysis (PD), but it is a serious complication with high morbidity and mortality. It often results in catheter loss and modifying therapy from PD to ... ...

    Title translation A case of Peritonitis Caused by Wickerhamomyces anomalus (Candida pelliculosa) Related to Peritoneal Dialysis.
    Abstract Fungal peritonitis is less commonly seen than bacterial peritonitis in patients undergoing peritoneal dialysis (PD), but it is a serious complication with high morbidity and mortality. It often results in catheter loss and modifying therapy from PD to hemodialysis. The causative organisms are often Candida species. In this report, a PD-associated peritonitis caused by Wickerhamomyces anomalus (Candida pelliculosa), a rare fungal infection agent with increasing clinical importance by causing different clinical pictures was presented. An outpatient peritoneal fluid culture was sent from a 48-yearold male patient, who had been undergoing continuous peritoneal dialysis (CAPD) for 9 years, due to abdominal pain and blur in peritoneal fluid during dialysis. The patient admitted to the emergency department four days later due to the persistence of his complaints. A sample of peritoneal fluid was taken in the emergency department and sent to the laboratory for microbiological analysis. In the direct microscopical examination of the peritoneal fluid; cell number was determined as 210/mm3, and no microorganisms were seen in the Gram and methylene blue staining. The patient was admitted to the nephrology service with a pre-diagnosis of PD-associated peritonitis. Enterobacter aerogenes was grown in the peritoneal fluid culture which was sent from the dialysis outpatient clinic four days ago. The peritoneal fluid sample sent from the emergency department was inoculated on 5% sheep blood , EMB and chocolate agars and no growth was detected. As the patient's complaints and peritoneal fluid leukocyte count continued to increase, peritoneal fluid cultures were repeated and recurrent growth of yeast was detected in cultures. The yeast was identified as Candida pelliculosa by matrix assisted laser desorption ionization time-of-flight mass spectrofotometry (MALDI-TOF) VITEK®MS (bioMerieux, France). The species identification was confirmed by sequencing the target ITS gene regions on the rRNA and the isolate was identified as 100% Wickerhamomyces anomalus (sexual reproduction form of Candida pelliculosa, teleomorph). The reference microdilution method was performed according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI) in order to test the antifungal susceptibility. After 24 hour incubation, the minimal inhibitory concentrations (MIC) were determined as 0.03 μg/ml for amphotericin B, 0.125 μg/ml for caspofungin 0.125 μg/ml for voriconazole, 0.03 μg/ ml for itraconazole and 4 μg/ml for fluconazole. Fluconazole and anidulafungin were started for the treatment of fungal peritonitis. The patient's peritoneal dialysis catheter was removed and hemodialysis was applied to the patient. Clinical and laboratory symptoms regressed with antifungal therapy and the patient's anidulafungin treatment was discontinued for 14 days after the catheter removal. In conclusion, in patients undergoing CAPD, as in our case, fungal pathogens should also be considered although it is rare, when there is no laboratory and clinical improvement, and the response to treatment is not complete in PD-associated peritonitis to prevent delays in diagnosis and treatment.
    MeSH term(s) Animals ; Antifungal Agents/therapeutic use ; Candida ; Humans ; Male ; Peritoneal Dialysis/adverse effects ; Peritonitis/diagnosis ; Peritonitis/drug therapy ; Peritonitis/etiology ; Saccharomycetales ; Sheep
    Chemical Substances Antifungal Agents
    Language Turkish
    Publishing date 2021-10-19
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
    DOI 10.5578/mb.20219718
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  4. Article ; Online: Pneumococcal carriage in children with COVID-19.

    Aykac, Kubra / Ozsurekci, Yasemin / Cura Yayla, Burcu Ceylan / Evren, Kubra / Lacinel Gurlevik, Sibel / Oygar, Pembe Derin / Yucel, Mihriban / Karakoc, Ayse Esra / Alp, Alpaslan / Cengiz, Ali Bulent / Ceyhan, Mehmet

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 6, Page(s) 1628–1634

    Abstract: ... ...

    Abstract Background
    MeSH term(s) COVID-19/complications ; COVID-19/microbiology ; Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Humans ; Nasopharynx/microbiology ; Pandemics ; Pneumococcal Infections/epidemiology ; Retrospective Studies ; Streptococcus pneumoniae ; Turkey
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1849516
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    Zs.A 6967: Show issues Location:
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  5. Article ; Online: Comparison of non-invasive tests with invasive tests in the diagnosis of celiac disease.

    Gülseren, Yasemin Derya / Adiloğlu, Ali Kudret / Yücel, Mihriban / Dağ, Zuhal / Eyerci, Nilnur / Berkem, Rukiye / Filik, Levent / Çaydere, Muzaffer

    Journal of clinical laboratory analysis

    2018  Volume 33, Issue 3, Page(s) e22722

    Abstract: Background/aims: Today, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to ... ...

    Abstract Background/aims: Today, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria.
    Methods: Thirty-nine patients (aged 17-66) with symptoms of CD were included. Serum samples were tested for total IgA, tTG-IgA (antitissue transglutaminase), tTG-IgG, DGP-IgA (antideamidated gliadin peptide), DGP-IgG, and EMA (endomysial antibodies). HLA-DQ typing was studied with PCR-SSP (sequence-specific primers) method. Biopsy samples were evaluated according to Marsh scoring.
    Results: In CD patients, 71.4% (15/21) of the patients were diagnosed without biopsy according to the EPSGHAN criteria but when ESPGHAN's IgA tTG threshold value for children was taken into consideration (>200 IU/mL), the sensitivity decreased to 81%. Celiac disease diagnosed and control groups were compared in terms of HLA tissue types. DQ2.5 homozygous or DQ2.5/DQ2.2 was significantly higher in CD group, and DQ2- or DQ8-negative HLA tissue type was significantly higher in control group.
    Conclusion: When serological tests, HLA typing, and clinical symptoms are all in favor of CD, biopsy may not be performed in selected adult CD patients.
    MeSH term(s) Adolescent ; Adult ; Aged ; Autoantibodies/blood ; Biopsy ; Celiac Disease/diagnosis ; Celiac Disease/immunology ; Celiac Disease/pathology ; Female ; Histocompatibility Testing ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Serologic Tests ; Young Adult
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2018-11-21
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.22722
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  6. Article ; Online: Evaluation of Invasive and Noninvasive Methods for the Diagnosis of Helicobacter Pylori Infection

    Cosgun, Yasemin / Yildirim, Abdullah / Yucel, Mihriban / Karakoc, Ayse Esra / Koca, Gokhan / Gonultas, Alpaslan / Gursoy, Gul / Ustun, Huseyin / Korkmaz, Meliha

    Asian Pacific journal of cancer prevention : APJCP

    2016  Volume 17, Issue 12, Page(s) 5265–5272

    Language English
    Publishing date 2016--01
    Publishing country Thailand
    Document type Journal Article
    ISSN 2476-762X
    ISSN (online) 2476-762X
    DOI 10.22034/APJCP.2016.17.12.5265
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  7. Article: A pilot study to evaluate the adhesion of oral microorganisms to temporary soft lining materials.

    Bal, Bilge T / Yavuzyilmaz, Hüsnü / Yücel, Mihriban

    Journal of oral science

    2008  Volume 50, Issue 1, Page(s) 1–8

    Abstract: The aim of the study was to compare the adhesion of oral microorganisms to different types of soft liner and acrylic resin surfaces. Three different soft lining materials were applied to cavities formed on the fitting surfaces of prostheses in 17 ... ...

    Abstract The aim of the study was to compare the adhesion of oral microorganisms to different types of soft liner and acrylic resin surfaces. Three different soft lining materials were applied to cavities formed on the fitting surfaces of prostheses in 17 patients. On days 1, 7 and 14, the specimens were taken out and immediately processed for bacteriological evaluation. The numbers of adhering microorganisms were calculated and the specimens were compared among each other and also with a control group (acrylic resin). Data were analyzed by two-way ANOVA and least squares differences at a significance level of P < 0.05. Among the four materials tested the total number of oral microorganisms adhering to Softliner material was the greatest after each of the time periods tested. Higher numbers of oral bacteria and Candida were shown to adhere to soft lining materials than to acrylic resin. Microbial coverage increased continuously with time and the differences between days 1 and 14 were statistically significant (P < 0.05). Temporary soft lining materials are not resistant to adhesion and possible surface damage caused by oral bacteria, and therefore their use should be limited to short-term periods.
    MeSH term(s) Acrylic Resins/chemistry ; Aged ; Bacterial Adhesion/physiology ; Candida/physiology ; Dental Materials/chemistry ; Denture Liners/microbiology ; Denture, Complete ; Dimethylpolysiloxanes/chemistry ; Humans ; Materials Testing ; Methacrylates/chemistry ; Methylmethacrylates/chemistry ; Microscopy, Electron, Scanning ; Middle Aged ; Mouth/microbiology ; Pilot Projects ; Polymethyl Methacrylate/chemistry ; Silicone Elastomers/chemistry ; Silicones/chemistry ; Siloxanes/chemistry ; Surface Properties ; Time Factors
    Chemical Substances Acrylic Resins ; Dental Materials ; Dimethylpolysiloxanes ; Methacrylates ; Methylmethacrylates ; Silicone Elastomers ; Silicones ; Siloxanes ; Ufi gel ; Vertex Soft ; Coe-Soft denture lining material (113979-46-7) ; baysilon (63148-62-9) ; poly(ethylmethacrylate) (9003-42-3) ; Polymethyl Methacrylate (9011-14-7)
    Language English
    Publishing date 2008-01-31
    Publishing country Japan
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1434462-2
    ISSN 1343-4934
    ISSN 1343-4934
    DOI 10.2334/josnusd.50.1
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    Zs.A 189: Show issues Location:
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  8. Article: A grubu beta-hemolitik streptokoklarda eritromisin direnç oranlarinin ve direnc fenotipinin araştirilmasi.

    Kaya, Esma Gündüz / Yücel, Mihriban / Karakoç, A Esra

    Mikrobiyoloji bulteni

    2006  Volume 40, Issue 3, Page(s) 161–168

    Abstract: Although penicillin resistance has not been determined in group A beta haemolytic streptococci (GABHS) yet, resistance to erythromycin and other macrolids is being reported frequently in the last years. In this study we investigated erythromycin ... ...

    Title translation Investigation of erythromycin resistance and resistance phenotypes in group A beta hemolytic streptococci.
    Abstract Although penicillin resistance has not been determined in group A beta haemolytic streptococci (GABHS) yet, resistance to erythromycin and other macrolids is being reported frequently in the last years. In this study we investigated erythromycin resistance by using agar dilution method in 282 GABHS strains which were isolated from throat cultures that had been evaluated in the Ministry of Health, Ankara Training and Research Hospital's, Microbiology Laboratory. We also determined resistance phenotypes of resistant strains by double disc synergy method using erythromycin and clindamycin discs. Twelve of 282 strains (4.3%) were found resistant to erythromycin; five (41.7%) of which were M phenotype, four (33.3%) of which were constitutive type MLSB phenotype and three (25%) of which were inducible type MLSB phenotype. Investigation of resistance to macrolides that are alternatives to penicillin therapy in GABHS, is very important for the determination of the therapy and also to provide epidemiological data.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Clindamycin/pharmacology ; Drug Resistance, Bacterial ; Erythromycin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Pharynx/microbiology ; Phenotype ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/drug effects
    Chemical Substances Anti-Bacterial Agents ; Clindamycin (3U02EL437C) ; Erythromycin (63937KV33D)
    Language Turkish
    Publishing date 2006-07
    Publishing country Turkey
    Document type English Abstract ; Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
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  9. Article: Prevalence of Helicobacter pylori in symptomatic patients and detection of clarithromycin resistance using melting curve analysis.

    Kaya, Ayse Demet / Oztürk, C Elif / Akcan, Yusuf / Behçet, Mustafa / Karakoç, A Esra / Yücel, Mihriban / Mısırlıoglu, Müge / Tuncer, Serdar

    Current therapeutic research, clinical and experimental

    2014  Volume 68, Issue 3, Page(s) 151–160

    Abstract: Unlabelled: Abstract.: Background: Clarithromycin is often a component of combination therapies for Helicobacter pylori eradication; however, increases in resistance rates have decreased the success of the treatment.: Objective: This study was ... ...

    Abstract Unlabelled: Abstract.
    Background: Clarithromycin is often a component of combination therapies for Helicobacter pylori eradication; however, increases in resistance rates have decreased the success of the treatment.
    Objective: This study was designed to determine the prevalence of H pylori infection in symptomatic patients and to detect clarithromycin resistance rates using melting curve analysis.
    Methods: Patients scheduled for upper endoscopy at the Endoscopy Unit of the Department of Gastroenterology, Duzce University, Medical Faculty Hospital, Konuralp/Duzce, Turkey, were assessed for enrollment in the study. Two pairs of gastric biopsy specimens (antrum and corpus) were obtained from each study patient. Histopathologic examination, rapid urease test, culture, and polymerase chain reaction (PCR) of the specimens were used to identify H pylori infection. Clarithromycin resistance was detected using melting curve analysis.
    Results: Seventy-five patients (41 women, 34 men; mean [SD]age, 42.6 [14.5] years [range, 17-70 years]) were included in the study. Using histopathology and rapid urease test, H pylori was detected in 40 (53.3%) of the 75 specimens. H pylori was detected using PCR in 40 (53.3%) specimens and by culture in 10 (13.3%) specimens. The specificity and sensitivity of PCR and culture were interpreted by comparing them with the results of histopathologic examination and urease tests. The specificity and sensitivity of PCR were 68.6% and 72.5%, respectively, and the specificity and sensitivity of culture were 97.1% and 22.5%, respectively. Of the 40 isolates, 21 (52.5%) were susceptible to clarithromycin, 12 (30.0%) were resistant, and a mixed susceptibility pattern was detected in 7 (17.5%) specimens. H pylori isolates from 19 (79.2%) of the 24 patients who had formerly used clarithromycin showed clarithromycin resistance.
    Conclusions: The prevalence of H pylori infection was 53.3% for the symptomatic patients in this study, and 47.5% of the isolates showed clarithromycin resistance using melting curve analysis. The PCR-based system used in this study was accurate for the detection of H pylori infection as well as clarithromycin susceptibility testing directly in biopsy specimens.
    Language English
    Publishing date 2014-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2007.06.001
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  10. Article ; Online: Does Helicobacter pylori exist in vocal fold pathologies and in the interarytenoid region?

    Islam, Ahmet / Oguz, Haldun / Yucel, Mihriban / Koca, Gökhan / Gonultas, Mehmet A / Arslan, Necmi / Demirci, Münir

    Dysphagia

    2013  Volume 28, Issue 3, Page(s) 382–387

    Abstract: The aim of this study was to investigate the existence of Helicobacter pylori (HP) in patients with benign and malignant vocal fold pathologies. This was a prospective clinical study conducted at a tertiary-care academic medical center. Fifty consecutive ...

    Abstract The aim of this study was to investigate the existence of Helicobacter pylori (HP) in patients with benign and malignant vocal fold pathologies. This was a prospective clinical study conducted at a tertiary-care academic medical center. Fifty consecutive patients who had undergone microlaryngoscopy between August 2007 and July 2009 were included in the study. The patients with a reflux symptom index (RSI) above 12 and a reflux finding score (RFS) above 6 were accepted as having laryngopharyngeal reflux. Patients with urea breath test (UBT), HP-IgG, and HP cytotoxin-associated gene A (CagA)-IgG positivity were diagnosed as HP positive. During laryngoscopy, two surgical specimens were obtained, one from the primary vocal fold pathology and one from the interarytenoid region. The interarytenoid biopsy specimen was used for HP culture and PCR. The specimen from the vocal fold pathology was used to investigate the presence of HP. RSI was positive in 23 (46%) patients. The RFS positivity was 56%. The presence of HP was confirmed by UBT in 35 (70%), HP-IgG in 37 (74%), and HP CagA-IgG in 38 (76%) patients. There was no difference between RFS-positive and RFS-negative patients in terms of HP-IgG and UBT. None of the interarytenoid or vocal fold specimens showed the presence of HP. HP was not found in the histological specimens of vocal fold pathologies and the interarytenoid region. The presence of HP in the gastric mucosa does not have an effect on the RFS and RSI.
    MeSH term(s) Adult ; Aged ; Antibodies, Bacterial/blood ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Breath Tests ; Female ; Helicobacter pylori/genetics ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Humans ; Laryngopharyngeal Reflux/complications ; Laryngopharyngeal Reflux/diagnosis ; Laryngopharyngeal Reflux/microbiology ; Laryngoscopy ; Larynx/microbiology ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Young Adult
    Chemical Substances Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Proteins ; cagA protein, Helicobacter pylori
    Language English
    Publishing date 2013-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-012-9444-7
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