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  1. Article ; Online: Comparison of DJ stented, external stented and stent-less procedures for pediatric pyeloplasty: A network meta-analysis.

    Liu, Xu / Huang, Chuiguo / Guo, Yin / Yue, Yiwei / Hong, Jiawen

    International journal of surgery (London, England)

    2019  Volume 68, Page(s) 126–133

    Abstract: Objective: To assess the efficacy and safety of double J (DJ) stented, external stented and stent-less procedures in pediatric pyeloplasty by adopting a network meta-analysis (NMA).: Material and methods: Electronic databases including PubMed, ... ...

    Abstract Objective: To assess the efficacy and safety of double J (DJ) stented, external stented and stent-less procedures in pediatric pyeloplasty by adopting a network meta-analysis (NMA).
    Material and methods: Electronic databases including PubMed, Cochrane Library, Web of science and Embase database were retrieved. The trials that compared double J (DJ) stented, external stented or stent-less procedures in pediatric pyeloplasty were identified. A network meta-analysis was conducted with the software of STATA 14.0. Probability-based ranking results were performed to identify the best treatment, and publication bias was analyzed by funnel plots.
    Results: 15 studies with 1731 participants were enrolled in the analysis, including 4 randomized controlled trials (RCT) and 11 retrospective studies. The NMA results revealed that no significant differences were detected in the outcomes of operative time, operative success, hospital stay, improvement of renal functions, overall complications and redo pyeloplasty. DJ stented and external stented procedures were associated with more postoperative pain than that of stent-less procedures [DJ stented: OR = 4.47, 95%CI(1.05,19.08); external stented: OR = 5.83, 95%CI(0.09,1.43)]. DJ stented procedure had a lower rate of urine leakage than those of external stented procedure [OR = 0.18, 95%CI (0.04, 0.76)] and stent-less procedure [OR = 0.07, 95%CI=(0.01, 0.34)]. No significant difference was observed in other types of complications such as urinary tract infection (UTI), stent migration, recurrent ureteropelvic junction obstruction (UPJO) and fever. The probabilities of ranking results indicated that the DJ stented procedure was the best treatment in the outcomes of hospital stay, operative success, improvement of renal functions, and the complication of urine leakage. Stent-less procedure showed its advantages in the outcomes of operative time, flank pain and UTI. External stented procedure had the lowest rate of overall complications and redo pyeloplasty.
    Conclusions: There were no obvious differences in operative time, operative success, hospital stay, improvement of renal functions, overall complications between external stented, DJ stented and stent-less procedures for pediatric pyeloplasty. When considering the ranking results, the DJ stented procedure seemed to be more beneficial for pediatric pyeloplasty than the other methods. However, with the limitation of our study, additional high-quality studies are needed for further evaluation.
    MeSH term(s) Child ; Humans ; Kidney Pelvis/surgery ; Length of Stay ; Network Meta-Analysis ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Stents ; Ureteral Obstruction/surgery ; Urologic Surgical Procedures/methods
    Language English
    Publishing date 2019-07-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2019.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 24 h Rest/Activity Rhythms in Older Adults with Memory Impairment: Associations with Cognitive Performance and Depressive Symptomatology.

    Antonsdottir, Inga M / Low, Dominique V / Chen, Diefei / Rabinowitz, Jill A / Yue, Yiwei / Urbanek, Jacek / Wu, Mark N / Zeitzer, Jamie M / Rosenberg, Paul B / Friedman, Leah F / Sheikh, Javaid I / Yesavage, Jerome A / Zipunnikov, Vadim / Spira, Adam P

    Advanced biology

    2023  Volume 7, Issue 11, Page(s) e2300138

    Abstract: Little is known about links of circadian rhythm alterations with neuropsychiatric symptoms and cognition in memory impaired older adults. Associations of actigraphic rest/activity rhythms (RAR) with depressive symptoms and cognition are examined using ... ...

    Abstract Little is known about links of circadian rhythm alterations with neuropsychiatric symptoms and cognition in memory impaired older adults. Associations of actigraphic rest/activity rhythms (RAR) with depressive symptoms and cognition are examined using function-on-scalar regression (FOSR). Forty-four older adults with memory impairment (mean: 76.84 ± 8.15 years; 40.9% female) completed 6.37 ± 0.93 days of actigraphy, the Beck depression inventory-II (BDI-II), mini-mental state examination (MMSE) and consortium to establish a registry for Alzheimer's disease (CERAD) delayed word recall. FOSR models with BDI-II, MMSE, or CERAD as individual predictors adjusted for demographics (Models A1-A3) and all three predictors and demographics (Model B). In Model B, higher BDI-II scores are associated with greater activity from 12:00-11:50 a.m., 2:10-5:50 p.m., 8:40-9:40 p.m., 11:20-12:00 a.m., higher CERAD scores with greater activity from 9:20-10:00 p.m., and higher MMSE scores with greater activity from 5:50-10:50 a.m. and 12:40-5:00 p.m. Greater depressive symptomatology is associated with greater activity in midafternoon, evening, and overnight into midday; better delayed recall with greater late evening activity; and higher global cognitive performance with greater morning and afternoon activity (Model B). Time-of-day specific RAR alterations may affect mood and cognitive performance in this population.
    MeSH term(s) Humans ; Female ; Male ; Aged ; Neuropsychological Tests ; Cognition ; Circadian Rhythm ; Alzheimer Disease ; Memory Disorders/diagnosis
    Language English
    Publishing date 2023-07-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202300138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Generation of induced pluripotent stem cell line (ZZUi0014-A) from a patient with spinocerebellar ataxia type 3.

    Wang, Yanlin / Sun, Huifang / Wang, Zhuoya / Yue, Yiwei / Zhang, Rui / Yang, Jing / Liu, Yutao / Liu, Han / Zhang, Qi / Zhang, Shoutao / Zhang, Jin / Xu, Yuming / Shi, Changhe

    Stem cell research

    2019  Volume 41, Page(s) 101564

    Abstract: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant disorder that is caused by the abnormal amplification of cytosine-adenine-guanine (CAG) trinucleotide repeats in the ATXN3 gene. The main feature of SCA3 is progressive ataxia. Currently, no ... ...

    Abstract Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant disorder that is caused by the abnormal amplification of cytosine-adenine-guanine (CAG) trinucleotide repeats in the ATXN3 gene. The main feature of SCA3 is progressive ataxia. Currently, no effective treatment exists for this condition. For this study, we obtained dermal fibroblasts from a patient. The fibroblasts were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC. Our approach offers a resource for further research into SCA3 mechanism in an attempt to facilitate the development and screening of pharmaceutical and gene therapy.
    MeSH term(s) Ataxin-3/genetics ; Ataxin-3/metabolism ; Cell Line ; Cellular Reprogramming Techniques ; Dermis/metabolism ; Dermis/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Amplification ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Machado-Joseph Disease/genetics ; Machado-Joseph Disease/metabolism ; Machado-Joseph Disease/pathology ; Repressor Proteins/genetics ; Repressor Proteins/metabolism
    Chemical Substances Repressor Proteins ; ATXN3 protein, human (EC 3.4.19.12) ; Ataxin-3 (EC 3.4.19.12)
    Language English
    Publishing date 2019-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2019.101564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DNAJC12 mutation is rare in Chinese Han population with Parkinson's disease.

    Fan, Yu / Yang, Zhi-Hua / Li, Fang / Hu, Xin-Chao / Yue, Yi-Wei / Yang, Jing / Liu, Yu-Tao / Liu, Han / Wang, Yan-Lin / Shi, Chang-He / Xu, Yu-Ming

    Neurobiology of aging

    2018  Volume 68, Page(s) 159.e1–159.e2

    Abstract: Recently, mutations of DNAJC12 gene were reported to be associated with early-onset parkinsonism, progressive neurodevelopmental delay, and dystonia in several unrelated pedigrees. This study aimed to evaluate DNAJC12 coding mutations in sporadic Chinese ...

    Abstract Recently, mutations of DNAJC12 gene were reported to be associated with early-onset parkinsonism, progressive neurodevelopmental delay, and dystonia in several unrelated pedigrees. This study aimed to evaluate DNAJC12 coding mutations in sporadic Chinese Han patients with Parkinson's disease (PD) and test whether an age-of-onset effect exists. Seven hundred two Chinese Han sporadic PD patients, including 181 early-onset PD and 521 late-onset PD, and 728 healthy controls were recruited. No documented disease-causing mutation of DNAJC12 was identified, but we found 7 single-nucleotide polymorphisms. Allele frequencies did not differ between all the PD patients and controls or between any 2 subgroups for all these single-nucleotide polymorphisms. Our study suggests that DNAJC12 mutation is not a risk factor of PD in Chinese Han population, and no age-of-onset effect was verified.
    MeSH term(s) Adult ; Age of Onset ; Asian Continental Ancestry Group/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Parkinson Disease/genetics ; Polymorphism, Single Nucleotide ; Repressor Proteins/genetics ; Risk Factors
    Chemical Substances DNAJC12 protein, human ; Repressor Proteins
    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2018.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Amyloid-β25-35 Upregulates Endogenous Neuroprotectant Neuroglobin via NFκB Activation in vitro.

    Liu, Ning / Yu, Zhanyang / Xun, Yu / Shu, Pan / Yue, Yiwei / Yuan, Shishan / Jiang, Yinghua / Huang, Zixuan / Yang, Xiaoping / Feng, Xing / Xiang, Shuanglin / Wang, Xiaoying

    Journal of Alzheimer's disease : JAD

    2018  Volume 64, Issue 4, Page(s) 1163–1174

    Abstract: Neuroglobin (Ngb) has been reported to be increased in early and moderately advanced Alzheimer's disease (AD) stages but declined in the severe stage. However, its regulatory mechanisms and pathophysiological roles in the disease remain to be defined. In ...

    Abstract Neuroglobin (Ngb) has been reported to be increased in early and moderately advanced Alzheimer's disease (AD) stages but declined in the severe stage. However, its regulatory mechanisms and pathophysiological roles in the disease remain to be defined. In this study, we found that Ngb expression was significantly upregulated by low dose Aβ25-35, the neurotoxic fragment of Aβ1 - 40 and Aβ1 - 42, but was not further increased by a higher dose of Aβ25-35. Mutation analysis and supershift assay demonstrated that transcription factor Nuclear Factor κB (NFκB), κB2 and κB3 sites located in mouse Ngb promoter region were involved in dynamic regulation of Ngb expression in response to different doses of Aβ25-35 stimulation. In addition, we found that suppression of endogenous Ngb expression exacerbated Aβ25-35-induced neuronal cell death and mitochondrial dysfunction. Our results indicate that endogenous Ngb expression may be upregulated by low dose Aβ25-35, which is responsible for protecting against Aβ25-35-mediated neurotoxicity. These experimental findings suggest that upregulation of endogenous Ngb expression might be an effective intervention approach for AD.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Amyloid beta-Peptides/pharmacology ; Animals ; Cells, Cultured ; Cerebral Cortex/cytology ; Dose-Response Relationship, Drug ; Electron Transport Complex III/genetics ; Electron Transport Complex III/metabolism ; Electrophoretic Mobility Shift Assay ; Embryo, Mammalian ; Membrane Potential, Mitochondrial/drug effects ; Membrane Potential, Mitochondrial/genetics ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Neuroblastoma/pathology ; Neuroglobin/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Peptide Fragments/pharmacology ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Statistics, Nonparametric ; Transfection ; Up-Regulation/drug effects
    Chemical Substances Amyloid beta-Peptides ; NF-kappa B ; Neuroglobin ; Peptide Fragments ; RNA, Messenger ; RNA, Small Interfering ; amyloid beta-protein (25-35) ; Adenosine Triphosphate (8L70Q75FXE) ; Electron Transport Complex III (EC 7.1.1.8)
    Language English
    Publishing date 2018-07-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-180163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agents in the management of paediatric monosymptomatic nocturnal enuresis: a network meta-analysis.

    Song, Pan / Huang, Chuiguo / Wang, Yan / Wang, Qingwei / Zhu, Wen / Yue, Yiwei / Wang, Wancong / Feng, Jinjin / He, Xiangfei / Cui, Lingang / Wan, Tingxiang / Wen, Jianguo

    BJU international

    2018  Volume 123, Issue 3, Page(s) 388–400

    Abstract: Objective: To assess the efficacy of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agent (AA) therapy in the management of paediatric monosymptomatic nocturnal enuresis (MNE) using a network meta-analysis.: ... ...

    Abstract Objective: To assess the efficacy of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agent (AA) therapy in the management of paediatric monosymptomatic nocturnal enuresis (MNE) using a network meta-analysis.
    Materials and methods: We searched the electronic databases PubMed, Cochrane Library, EMBASE and Web of Science from inception to 1 March 2018. Randomized controlled trials (RCTs) that compared desmopressin, alarm, desmopressin plus alarm, and desmopressin plus AAs were identified. The network meta-analysis was conducted with software R 3.3.2 and STATA 14.0.
    Results: Eighteen RCTs with a total of 1 649 participants were included. The meta-analysis results showed that complete response (CR) and success rates with desmopressin plus AAs were higher than with desmopressin or alarm monotherapy. Success rates for desmopressin plus alarm therapy were higher than for alarm monotherapy. No obvious difference was observed between desmopressin plus AAs and desmopressin plus alarm therapy with regard to CR rate and success rate. The relapse rate with alarm monotherapy was much lower than with desmopressin monotherapy. Adverse events seemed to be infrequently and tolerable for all treatments. The ranking probability results were as follows: desmopressin plus AA ranked first for the outcomes of CR and success, desmopressin plus alarm therapy ranked first for mean number of wet nights per week, and alarm therapy had the lowest relapse rate.
    Conclusions: The network meta-analysis showed that desmopressin had similar efficacy to alarm therapy but a higher relapse rate. Desmopressin plus AA therapy was associated with better efficacy than and a similar relapse rate to desmopressin monotherapy. Desmopressin plus alarm therapy was similar to both desmopressin and alarm monotherapy in efficacy. All treatments, including desmopressin plus AAwere associated with tolerable adverse events; however, additional high-quality studies are needed for further evaluation of these treatments.
    MeSH term(s) Antidiuretic Agents/therapeutic use ; Child ; Cholinergic Antagonists/therapeutic use ; Clinical Alarms ; Deamino Arginine Vasopressin/therapeutic use ; Humans ; Network Meta-Analysis ; Nocturnal Enuresis/drug therapy ; Nocturnal Enuresis/physiopathology ; Randomized Controlled Trials as Topic ; Recurrence ; Treatment Outcome
    Chemical Substances Antidiuretic Agents ; Cholinergic Antagonists ; Deamino Arginine Vasopressin (ENR1LLB0FP)
    Language English
    Publishing date 2018-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.14539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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