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  1. Article ; Online: Antibody evasion properties of SARS-CoV-2 Omicron sublineages.

    Iketani, Sho / Liu, Lihong / Guo, Yicheng / Liu, Liyuan / Chan, Jasper F-W / Huang, Yiming / Wang, Maple / Luo, Yang / Yu, Jian / Chu, Hin / Chik, Kenn K-H / Yuen, Terrence T-T / Yin, Michael T / Sobieszczyk, Magdalena E / Huang, Yaoxing / Yuen, Kwok-Yung / Wang, Harris H / Sheng, Zizhang / Ho, David D

    Nature

    2022  Volume 604, Issue 7906, Page(s) 553–556

    Abstract: The identification of the Omicron (B.1.1.529.1 or BA.1) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Botswana in November ... ...

    Abstract The identification of the Omicron (B.1.1.529.1 or BA.1) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Botswana in November 2021
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; sotrovimab (1MTK0BPN8V) ; bebtelovimab (8YL4SYR6CU)
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04594-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

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  2. Article ; Online: Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations.

    Chu, Hin / Yuen, Terrence T T / Chik, Kenn K H / Yuan, Shuofeng / Shuai, Huiping / Zou, Zijiao / Wang, Yixin / Zhu, Zheng / Yang, Dong / Poon, Vincent K M / Chan, Chris C S / Zhou, Jie / Yin, Feifei / Kok, Kin-Hang / Yuen, Kwok-Yung / Chan, Jasper F W

    ACS infectious diseases

    2020  Volume 6, Issue 7, Page(s) 1745–1758

    Abstract: Zika virus (ZIKV) is an emerging flavivirus that may be associated with congenital anomalies in infected fetuses and severe neurological and genital tract complications in infected adults. Currently, antiviral treatments to revert these ZIKV-induced ... ...

    Abstract Zika virus (ZIKV) is an emerging flavivirus that may be associated with congenital anomalies in infected fetuses and severe neurological and genital tract complications in infected adults. Currently, antiviral treatments to revert these ZIKV-induced complications are lacking. ZIKV infection has recently been suggested to upregulate the host unfolded protein response, which may contribute to the congenital neurological anomalies. As an extension from these findings, we thoroughly investigated the ZIKV-induced unfolded protein response using a combination of the neuronal cell line, induced pluripotent stem cell-derived human neuronal stem and progenitor cells, and an interferon receptor-deficient A129 mouse model. Our results revealed a critical contribution of the inositol-requiring enzyme-1 (IRE1) arm of the unfolded protein response to ZIKV-induced neurological and testicular complications. Importantly, the inhibition of the IRE1 signaling pathway activation with KIRA6 (kinase-inhibiting RNAse attenuator 6), a selective small molecule IRE1 inhibitor that promotes cell survival, potently reverted the ZIKV-induced perturbations of the key gene expressions associated with neurogenesis and spermatogenesis
    MeSH term(s) Humans ; Imidazoles ; Inositol ; Naphthalenes ; Neurogenesis ; Protein-Serine-Threonine Kinases ; Pyrazines ; Spermatogenesis ; Zika Virus ; Zika Virus Infection/drug therapy
    Chemical Substances Imidazoles ; KIRA6 ; Naphthalenes ; Pyrazines ; Inositol (4L6452S749) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.9b00526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2.

    Liu, Lihong / Iketani, Sho / Guo, Yicheng / Chan, Jasper F-W / Wang, Maple / Liu, Liyuan / Luo, Yang / Chu, Hin / Huang, Yiming / Nair, Manoj S / Yu, Jian / Chik, Kenn K-H / Yuen, Terrence T-T / Yoon, Chaemin / To, Kelvin K-W / Chen, Honglin / Yin, Michael T / Sobieszczyk, Magdalena E / Huang, Yaoxing /
    Wang, Harris H / Sheng, Zizhang / Yuen, Kwok-Yung / Ho, David D

    Nature

    2021  Volume 602, Issue 7898, Page(s) 676–681

    Abstract: The B.1.1.529/Omicron variant of SARS-CoV-2 was only recently detected in southern Africa, but its subsequent spread has been extensive, both regionally and ... ...

    Abstract The B.1.1.529/Omicron variant of SARS-CoV-2 was only recently detected in southern Africa, but its subsequent spread has been extensive, both regionally and globally
    MeSH term(s) Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Cell Line ; Convalescence ; Evolution, Molecular ; Humans ; Immune Evasion/immunology ; Immune Sera/immunology ; Inhibitory Concentration 50 ; Models, Molecular ; Mutation ; Neutralization Tests ; SARS-CoV-2/chemistry ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Immune Sera ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-04388-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

    Qiao, Wei / Lau, Hui En / Xie, Huizhi / Poon, Vincent K.M. / Chan, Chris C.S. / Chu, Hin / Yuan, Shuofeng / Yuen, Terrence T.T. / Chik, Kenn K.H. / Tsang, Jessica O.L. / Chan, Chris C.Y. / Cai, Jian-Piao / Luo, Cuiting / Yuen, Kwok-Yong / Cheung, Kenneth M.C. / Chan, Jasper F.W. / Yeung, Kelvin W.K.

    bioRxiv

    Abstract: Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though ...

    Abstract Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterized the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. The bone loss progressively worsens from the acute phase to the post-recovery phase. Mechanistically, the bone loss was associated with SARS-CoV-2-induced cytokine dysregulation which upregulates osteoclastic differentiation of monocyte-macrophage lineage. The pro-inflammatory cytokines further trigger a second wave of cytokine storm in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings in this established hamster model suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.
    Keywords covid19
    Language English
    Publishing date 2021-10-09
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.10.08.463665
    Database COVID19

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