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  1. Article ; Online: Perceived Sustainable Urbanization Based on Geographically Hierarchical Data Structures in Nanjing, China

    Keyu Zhai / Xing Gao / Yuerong Zhang / Meiling Wu

    Sustainability, Vol 11, Iss 8, p

    2019  Volume 2289

    Abstract: Concentrating on geographically hierarchical data structures and using large-scale satisfaction survey data in Nanjing, this study employs Bayesian spatial multilevel model (MLM) to evaluate Nanjing’s perceived sustainable urbanization. In this study, we ...

    Abstract Concentrating on geographically hierarchical data structures and using large-scale satisfaction survey data in Nanjing, this study employs Bayesian spatial multilevel model (MLM) to evaluate Nanjing’s perceived sustainable urbanization. In this study, we consider the geographically hierarchical data structures and the city’s individual perceptions of sustainable urbanization to explore the effect of environment and self-rated health on perceived sustainable urbanization, controlling for individual sociodemographic attributes and household. Through clarifying the spatial dependence and heterogeneity, this paper provides a flexible framework for assessing sustainable urbanization and dealing with the geographical hierarchical data. In particular, by drawing on existing studies, our questionnaire is more representative of the overall characteristics of Nanjing’s population than census data, which can be helpful for understanding whether urbanization is sustainable from individual perspective and further for correcting practices. Based on a survey of 10,077 questionnaires, this paper finds the geographically hierarchical data structures have significantly influenced the evaluation of sustainable urbanization, and the Bayesian spatial MLM is an effective tool for evaluating China’s sustainable urbanization. In particular, this paper takes spatial effects into consideration and compares the geographically hierarchical data. Results show that spatial patterns significantly influence the assessment of sustainable urbanization, and perceived pollution, age, education level, and income are the four key factors influencing individual perceived sustainable urbanization.
    Keywords sustainable urbanization ; sustainability evaluation ; geographically hierarchical data ; sustainable cities ; urban development ; spatial statistics ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Association between Urban Public Transport Infrastructure and Social Equity and Spatial Accessibility within the Urban Environment

    Neil Cuthill / Mengqiu Cao / Yuqi Liu / Xing Gao / Yuerong Zhang

    Sustainability, Vol 11, Iss 5, p

    An Investigation of Tramlink in London

    2019  Volume 1229

    Abstract: The pursuit of sustainability has been at the forefront of contemporary planning initiatives. However, most recent research has focused on the environmental and economic aspects of developing sustainable urban environment, whilst largely neglecting the ... ...

    Abstract The pursuit of sustainability has been at the forefront of contemporary planning initiatives. However, most recent research has focused on the environmental and economic aspects of developing sustainable urban environment, whilst largely neglecting the social aspects. Contemporary political thinking in the UK often disregards the potential of the urban infrastructure to improve social equity. The aim of this study was to analyse the impact of transport infrastructure on a variety of social measures, in an empirical and ideologically unbiased fashion, using both quantitative and qualitative methods. We selected “Tramlink„ as a case study: a light-rail system in the London Borough of Croydon which began operation in 2000. We used quantitative methods, including advanced spatial statistics, to produce a more detailed analysis of social equity than has been previously published. This acknowledges that determining localised issues can produce more informed and effective policy interventions. Our results demonstrate that the physical properties of transport infrastructure and the non-physical attributes of society, in combination, help to create opportunities for individuals to succeed. We also find that in order to reduce the negative effects of austerity, public money could be more effectively spent if diverted to areas that are most in need which can be highlighted through localised investigations.
    Keywords transport infrastructure investment ; urban transport ; social equity ; spatial accessibility ; geographically weighted regression ; urban environment ; light railway (Tramlink) ; London ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 380
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Glycolysis drives STING signaling to facilitate dendritic cell antitumor function

    Zhilin Hu / Xiaoyan Yu / Rui Ding / Ben Liu / Chuanjia Gu / Xiu-Wu Pan / Qiaoqiao Han / Yuerong Zhang / Jie Wan / Xin-Gang Cui / Jiayuan Sun / Qiang Zou

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 7

    Abstract: Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that ... ...

    Abstract Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity. Mechanistically, glycolysis augmented ATP production to boost STING activation and STING-dependent DC antitumor functions. Moreover, DC-intrinsic STING activation accelerated HIF-1α–mediated glycolysis and established a positive feedback loop. Importantly, glycolysis facilitated STING-dependent DC activity in tissue samples from patients with non–small cell lung cancer. Our results provide mechanistic insight into how the crosstalk of glycolytic metabolism and STING signaling enhances DC antitumor activity and can be harnessed to improve cancer therapies.
    Keywords Immunology ; Metabolism ; Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Significant reduction of antibiotic consumption and patients' costs after an action plan in China, 2010-2014.

    Lidao Bao / Rui Peng / Yi Wang / Ruilian Ma / Xianhua Ren / Wenbin Meng / Fusheng Sun / Junxia Fang / Ping Chen / Yang Wang / Qiuhong Chen / Jian Cai / Jian Jin / Jinhui Guo / Shucheng Yang / Xiaomei Mo / Enjing Zhang / Yuerong Zhang / Zhaoxin Lu /
    Binbin Chen / Xiujuan Yue / Meijun Zhu / Yingying Wang / Xinchao Li / Yuan Bian / Shaoshan Kong / Wenfei Pan / Qian Ding / Jun Cao / Rupin Liu / Nan Chen / Xuelian Huang / Agula B / Haijun Lyu

    PLoS ONE, Vol 10, Iss 3, p e

    2015  Volume 0118868

    Abstract: On July 1, 2011, the Chinese government launched a national Action Plan for antibiotic stewardship targeting antibiotic misuse in public hospitals. The aim of this study was to evaluate the impacts of the Action Plan in terms of frequency and intensity ... ...

    Abstract On July 1, 2011, the Chinese government launched a national Action Plan for antibiotic stewardship targeting antibiotic misuse in public hospitals. The aim of this study was to evaluate the impacts of the Action Plan in terms of frequency and intensity of antibiotic utilization and patients costs in public general hospitals.Administrative pharmacy data from July 2010 to June 2014 were sampled from 65 public general hospitals and divided into three segments: (1) July 2010 to June 2011 as the preparation period; (2) July 2011 to June 2012 as the intervention period; and (3) July 2012 to June 2014 as the assessment period. The outcome measures included (1) antibiotic prescribing rates; (2) intensity of antibiotic consumption; (3) patients costs; and (4) duration of peri-operative antibiotic treatment in clean surgeries of thyroidectomy, breast, hernia, and orthopedic procedures. Longitudinal and cross-sectional analyses were conducted.Longitudinal analyses showed significant trend changes in the frequency and intensity of antibiotic consumption, the patients' costs on antibiotics, and the duration of antibiotic treatment received by surgical patients undergoing the 4 clean procedures during the intervention period. Cross-sectional analyses showed that the antibiotic prescribing rates were reduced to 35.3% and 12.9% in inpatient and outpatient settings, that the intensity of antibiotic consumption was reduced to 35.9 DDD/100 bed-days, that patients' costs on antibiotics were reduced significantly, and that the duration of peri-operative antibiotic treatment received by surgical patients undergoing the 4 types of clean procedures decreased to less than 24 hour during the assessment period.The Action Plan, as a combination of managerial and professional strategies, was effective in reducing the frequency and intensity of antibiotic consumption, patients' costs on antibiotics, and the duration of peri-operative antibiotic treatment in the 4 clean surgeries.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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