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Article ; Online: Face Detection Algorithm Based on Double-Channel CNN with Occlusion Perceptron

Yueying Li

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: Aiming at the problem of low accuracy of face detection under complex occlusion conditions, a double-channel occlusion perceptron neural network model was proposed. The area occlusion judgment unit is designed and integrated into the VGG16 network to ... ...

Abstract	Aiming at the problem of low accuracy of face detection under complex occlusion conditions, a double-channel occlusion perceptron neural network model was proposed. The area occlusion judgment unit is designed and integrated into the VGG16 network to form an occlusion perceptron neural network. Thereupon, the features of unoccluded regions and less occluded regions in facial images are extracted by the perceptual neural network. Transfer learning algorithm is utilized to pretrain parameters of the convolution layer to reduce the overfitting problem caused by insufficient training data samples. Face features of the whole face were extracted by optimizing the residual network, and then the face features of the occluding perceptron neural network and the residual network were weighted and fused. Experiments were carried out on two open data sets, AR and MAFA. The results demonstrate that the detection accuracy of this method is higher than that of other methods, and the detection speed is faster.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improved Population Intelligence Algorithm and BP Neural Network for Network Security Posture Prediction

Yueying Li / Feng Wu

International Journal of Distributed Sensor Networks, Vol

2023 Volume 2023

Abstract: To address the problems of low prediction accuracy and slow convergence of the network security posture prediction model, a population intelligence optimization algorithm is proposed to improve the network security posture prediction model of the BP ... ...

Abstract	To address the problems of low prediction accuracy and slow convergence of the network security posture prediction model, a population intelligence optimization algorithm is proposed to improve the network security posture prediction model of the BP neural network. First, the adaptive adjustment of the two parameters with the increase of iterations is achieved by improving the inertia weights and learning factors in the particle swarm optimization (PSO) algorithm so that the PSO has a large search range and high speed at the initial stage and a strong and stable convergence capability at the later stage. Secondly, to address the problem that PSO is prone to fall into a local optimum, the genetic operator is embedded into the operation process of the particle swarm algorithm, and the excellent global optimization performance of the genetic algorithm is used to open up the spatial vision of the particle population, revive the stagnant particles, accelerate the update amplitude of the algorithm, and achieve the purpose of improving the premature problem. Finally, the improved algorithm is combined with the BP neural network to optimize the BP neural network and applied to the network security posture assessment. The experimental comparison of different optimization algorithms is applied, and the results show that the network security posture prediction method of this model has the smallest error, the highest accuracy, and the fastest convergence, and can effectively predict future changes in network security posture.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatoid adenocarcinoma in ureter with next-generation sequencing

Mengxin Lu / Yueying Li / Dongliang Hu / Jingtian Yu / Hang Zheng / Tongzu Liu

BMC Medical Genomics, Vol 17, Iss 1, Pp 1-

A case report and literature review

2024 Volume 7

Abstract: Abstract Background Hepatoid adenocarcinoma (HAC) is rare in the urinary system, with only 7 reported cases in upper urinary tract. This report aimed to explore the genetic characteristics of ureteral HAC for first time, and to describe the treatment ... ...

Abstract	Abstract Background Hepatoid adenocarcinoma (HAC) is rare in the urinary system, with only 7 reported cases in upper urinary tract. This report aimed to explore the genetic characteristics of ureteral HAC for first time, and to describe the treatment prognosis of ureteral HAC. Case presentation We present a rare case of ureteral HAC in a 53-year-old female, showing elevated serum levels of AFP and CEA, prolonged chronic irritation may be an important cause of her ureteral HAC. Radical nephroureterectomy was performed, the serum levels of AFP and CEA decreased significantly, and metastasis in lymph nodes was found at 9 months after surgery, she had no related symptoms after 18 months postoperatively without adjuvant chemotherapy. Three driver somatic mutations in cancer were identified by NGS testing, including: TP53D281H, KMT2DL1211Ifs2, KMT2DT1843Nfs5, demonstrating that ureteral HAC has the similar mutational features to upper tract urothelial carcinoma. Homologous-recombination deficiency (HRD) was positive in this tumor with no mutations in HRD-related genes, which was possibly induced by the copy number deletion of SETD2 gene. Conclusions We report a rare case of ureteral HAC with elevated serum levels of AFP and CEA. NGS testing demonstrated that ureteral HAC has the similar mutational features to upper tract urothelial carcinoma, which is an important guide for the diagnosis and treatment of ureteral HAC.
Keywords	Ureter ; Hepatoid adenocarcinoma ; Chronic irritation ; TP53 mutation ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Land-Use Layout of the Rail Station Area Based on the Difference in Noise Sensitivity to Rail Transit, Taking a Suburb of Tokyo as an Example

Zhijunjie Zhai / Minfeng Yao / Yueying Li

Sustainability, Vol 14, Iss 7553, p

2022 Volume 7553

Abstract: Rail transit has been deemed a sustainable means of transportation, but its agglomeration effect and the noise therefrom create conflict. Generally, such conflict can be solved by designing the architecture and facilities of rail transit using noise- ... ...

Abstract	Rail transit has been deemed a sustainable means of transportation, but its agglomeration effect and the noise therefrom create conflict. Generally, such conflict can be solved by designing the architecture and facilities of rail transit using noise-reduction methods. However, relevant studies have pointed out the limitations of such methods from the perspective of enforceability and social justice. Specifically, extensive monitoring of noise is difficult, and the cost of noise reduction is mostly borne by the surrounding residents. Thus, another question has been raised: Can we apply a land-use layout that takes into account the difference in sensitivity to rail noise of different types of land so as to weaken the negative impact of rail noise? In this paper, we adopted various methods of the characteristic price method, progressive multivariate regression analysis method and noise simulation method, and adopted the suburban rail transit system in Japan as the research object to analyze the impact of rail noise on the price of residential land within 200 m of the rail line. Additionally, we investigated the impact of the accessibility to the station site on the price of commercial and residential land within 800 m of the rail line. We also established the evaluation model on this basis. Lastly, we conducted a further discussion on the evaluation model by studying the re-development project of Tokyo’s Futako Tamagawa Station. The major conclusions in this paper are the following: rail noise is negatively related to the price of residential land within 200 m of the rail line; the price of commercial land within 800 m of the station site is negatively related to the station’s accessibility; and the price of residential land is unrelated to the station’s accessibility. According to the results of the analysis of Tokyo’s Futako Tamagawa Station, designing and arranging commercial land that is insensitive to rail noise in the area surrounding the rail line and using commercial buildings as a shield for the ...
Keywords	noise sensitivity ; land use ; station accessibility ; land price ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Social Benefits Evaluation of Rural Micro-Landscapes in Southeastern Coastal Towns of China—The Case of Jinjiang, Fujian

Lan Shen / Yueying Li / Siren Lan / Minfeng Yao

Sustainability, Vol 14, Iss 13, p

2022 Volume 8036

Abstract: Faced with the current situation of the decay and alienation of traditional public space and the broken and disorderly spatial structure caused by the rapid urbanization of the Chinese countryside, rural micro-landscape creation has become an effective ... ...

Abstract	Faced with the current situation of the decay and alienation of traditional public space and the broken and disorderly spatial structure caused by the rapid urbanization of the Chinese countryside, rural micro-landscape creation has become an effective way to improve human living environments. However, it is currently difficult for rural micro-landscape construction to achieve the sustainable development of social benefits due to the lack of scientific design guidelines. Evaluating the social benefits of completed projects and identifying the important influencing factors are key to realizing the evidence-based design of rural micro-landscapes. To this end, this study deduces the mechanism of social benefit generation based on the psychological process of spatial perception and establishes a structural equation model containing compound influence pathways to measure the social benefits of micro-landscapes. The evaluation model consists of four latent variables, “physical element characteristics”, “perceptual quality”, “cognitive experience”, and “activity behavior”, and 35 observed variables. The researchers selected 18 micro-landscape areas in Jinjiang City, Fujian Province, China, as the survey sample and analyzed the influence of the potential variables and the explanatory power of the observed variables through a quantitative analysis of objective environmental elements and perception data from 102 respondents. The results showed that “perceptual quality” and “cognitive experience” had the greatest direct effect on social benefits, and, based on the progressive influence relationships among the dimensions, “physical element characteristics” dominated the total social benefits through direct and indirect means. Compared with single-function green space, comfortable and diverse artificial facilities encourage residents to enter and use micro-landscapes and contribute to their social benefits. The purpose of this paper is to explore the ideal form of rural micro-landscape creation and provide a theoretical ...
Keywords	rural micro-landscape ; social benefits ; PLS-SEM ; evaluation model ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bsu polymerase-mediated fluorescence coding for rapid and sensitive detection of 8-oxo-7,8-dihydroguanine in telomeres of cancer cells.

Li, Panyue / Wang, Zi-Yue / Yueying Li / Liu, Ling-Zhi / Qiu, Jian-Ge / Zhang, Chun-Yang

Talanta

2022 Volume 243, Page(s) 123340

Abstract: Guanine is the most susceptible to oxidation among all the DNA bases, and 8-oxo-7,8-dihydroguanine (OG) is one of main oxidation products that can occur in any part of chromosomal DNA. OG in the telomere sequence is associated with telomere shortening, ... ...

Abstract	Guanine is the most susceptible to oxidation among all the DNA bases, and 8-oxo-7,8-dihydroguanine (OG) is one of main oxidation products that can occur in any part of chromosomal DNA. OG in the telomere sequence is associated with telomere shortening, cell aging, and dysfunction, and it may induce cancers. The accurate detection of OG in telomeres is important to early clinical diagnosis and molecular research. Herein, we develop a simple and rapid method to sensitively measure 8-oxo-7,8-dihydroguanine (OG) in telomeres of cancer cells by using Bsu polymerase-mediated fluorescence coding. This method is very simple without the requirement for any nucleic acid amplification or specific restriction enzyme recognition reaction, and Bsu polymerase can selectively incorporate Cy5-dATP into the opposite site of OG, endowing this method with good specificity. Moreover, the introduction of single-molecule detection significantly improves the sensitivity. This method can detect OG within 70 min with a limit of detection (LOD) of 2.45 × 10
MeSH term(s)	DNA Damage ; Fluorescence ; Guanine/analogs & derivatives ; HeLa Cells ; Humans ; Hydrogen Peroxide ; Neoplasms/diagnosis ; Neoplasms/genetics ; Oxidation-Reduction ; Telomere/genetics
Chemical Substances	8-hydroxyguanine (5614-64-2) ; Guanine (5Z93L87A1R) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2022-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2022.123340
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential expression of ACE2 in the respiratory tracts and its relationship to COVID-19 pathogenesis

Chunxiu Yang / Yueying Li / Shu-Yuan Xiao

EBioMedicine, Vol 60, Iss , Pp 103004- (2020)

2020

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decrease of CD38 expression is linked to increase of solitary plasmacytoma pathological grade

Yueying Li / Jianchun Guo / Chunxiu Yang / Jian Xu / Pei Meng / Shu-Yuan Xiao

Frontiers in Bioscience-Landmark, Vol 27, Iss 1, p

a single institution experience from China

2022 Volume 021

Abstract: Introduction: Solitary plasmacytoma (SP) is a rare plasma cell disorder characterized by localized neoplastic proliferation of monoclonal plasma cell. Due to its rarity, further understanding of the spectrum of its clinicopathologic features is needed. ... ...

Abstract	Introduction: Solitary plasmacytoma (SP) is a rare plasma cell disorder characterized by localized neoplastic proliferation of monoclonal plasma cell. Due to its rarity, further understanding of the spectrum of its clinicopathologic features is needed. Methods: A retrospective analysis of cases from a single institution was conducted. Clinical characteristics of the patients were collected; histopathological and semi-quantitative immunohistochemical analyses were performed. Results: Thirteen cases were identified from our pathology archives, including 4 cases of solitary plasmacytoma of bone (SPB) (30.8%) and 9 extraosseous plasmacytoma (EP) (69.2%). The mean age of EP is a decade older than SPB. There is no gender disparity. The most common sites involved are the vertebrae and nasopharynx. Histologically, the tumors can be classified into two grades based on degree of differentiation. Immunohistochemically the tumor cells express CD38, CD138, MUM-1, and exhibit light chain restriction. Ki-67 proliferation index is 30%. In situ hybridization for Epstein-Barr virus-encoded small RNAs (EBER) is negative in six cases tested. Semi-quantitative immunohistochemical analysis showed decreased integrated optical density (IOD) of CD38 in neoplastic cells. IgH gene rearrangement was identified in two cases. Conclusion: SP is a rare plasmacytoid neoplasm that occurs more frequently in older patients. Diagnosis requires a systematic clinical approach combined with the pathological characteristics of plasmacytoid morphology, immunophenotype and light chain restriction. There are more cases of EP than SPB in our series, which is in contrast to that reported in literature. Results from this study suggest that CD38 is a potential immunohistochemical marker associated with prognosis of SP. Further studies with more cases and longer term follow-up may provide more definitive information on risk of progression from SP to multiple myeloma (MM).
Keywords	plasmacytoma ; solitary ; extraosseous ; immunohistochemistry ; cd38 ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	IMR Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extracellular protein kinase A and G are potential biomarkers of some inflammation-associated disorders

Yan Wu / Jun Ye / Chunhui Zhao / Ji Pang / Yueying Li / Xinyue Lin

European Journal of Inflammation, Vol

2022 Volume 20

Abstract: Introduction Protein kinase A (PKA) and protein kinase G (PKG) are the main downstream effectors of second messengers cAMP and cGMP, which play important roles in physiological and pathological processes. Recently, there are two findings: one is PKA ... ...

Abstract	Introduction Protein kinase A (PKA) and protein kinase G (PKG) are the main downstream effectors of second messengers cAMP and cGMP, which play important roles in physiological and pathological processes. Recently, there are two findings: one is PKA catalytic subunits α (PKACα) and PKG II can be secreted, the other is that the two secretory protein kinases are associated with the progression of tumors. Previous data also demonstrate that the two kinases, as signal cascades, involved in inflammation-associated disorders. However, it remains unclear whether the secreted PKACα or PKG II could serve as diagnostic biomarkers for inflammation-associated disorders. Methods The serum from suffered coronary disease, diabetes, rheumatoid arthritis, and schizophrenia were collected. The serum PKACα and PKG II were detected by ELISA. All the patients were consent informed. Results Our results showed that the serum PKACα and PKG II had obvious changes in coronary disease, rheumatoid arthritis, schizophrenia patients. However, the trends was opposite, especially in rheumatoid arthritis. Conclusions Serum PKACα and PKG II could serve as potentially diagnostic biomarkers for some inflammation-associated disorders, such as coronary disease, rheumatoid arthritis, and schizophrenia.
Keywords	Medicine ; R
Subject code	571
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolomics analysis reveal the molecular responses of high CO2 concentration improve resistance to Pb stress of Oryza sativa L. seedlings

Lanlan Wang / Yuxi Yao / Jiayu Wang / Jinghui Cui / Xuhao Wang / Xuemei Li / Yueying Li / Lianju Ma

Ecotoxicology and Environmental Safety, Vol 251, Iss , Pp 114515- (2023)

2023

Abstract: Rice seedlings were exposed to two CO2 concentrations (400 ± 20 and 800 ± 20 μmol mol−1) and three PbNO3 concentrations (0, 50 and 100 µmol L−1) for 10 days to explore the regulatory mechanisms of elevated CO2 for Pb stress resistance. Electrical ... ...

Abstract	Rice seedlings were exposed to two CO2 concentrations (400 ± 20 and 800 ± 20 μmol mol−1) and three PbNO3 concentrations (0, 50 and 100 µmol L−1) for 10 days to explore the regulatory mechanisms of elevated CO2 for Pb stress resistance. Electrical conductivity, MDA content, SOD, POD, CAT activities and metabolomics changes were studied. Results showed that: Pb stress damaged cell membrane system, electrical conductivity and MDA content increased 49.34 % and 73.27 %, respectively, and some antioxidant enzymes activities increased. Sugar, polyol, amino acid metabolism and fatty acid β-oxidation were all enhanced to improve osmotic adjustments, maintain cell membrane stability, supply energy, nitrogen assimilates and antioxidant capacity; Under composite treatments, cell membrane damage was reduced, activities of protective enzymes increased compared with only Pb stress, POD activity increased the most (49.14 %) under severe Pb composite treatment. High CO2 caused the enhance of cells antioxidant capacity, TCA cycle intermediate products contents and fatty acid desaturation under mild Pb stress. Many sugars, polyols and amino acids contents were increased as osmotic regulatory substances by high CO2 under severe Pb stress; Secondary metabolites played an important role under Pb stress and composite treatments. The object of this study is to provide a possible molecular mechanism of rice response to Pb stress under high CO2 in the future.
Keywords	Pb stress ; Elevated CO2 concentration ; Metabolomics ; Antioxidant enzymes ; Electrical conductivity ; MDA content ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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