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  1. Article ; Online: Innovations in online classes introduced during the COVID-19 pandemic and their educational outcomes in Japan.

    Yamamoto, Kyoko / Akiyoshi, Kumiko / Kondo, Hidekazu / Akioka, Hidefumi / Teshima, Yasushi / Yufu, Kunio / Takahashi, Naohiko / Nakagawa, Mikiko

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 894

    Abstract: Background: The novel coronavirus disease (COVID-19) pandemic emerged in Japan in February 2020, forcing the adoption of online education by university medical schools across Japan. The advantages and disadvantages of online education have been studied ... ...

    Abstract Background: The novel coronavirus disease (COVID-19) pandemic emerged in Japan in February 2020, forcing the adoption of online education by university medical schools across Japan. The advantages and disadvantages of online education have been studied in Japan; however, the educational outcome of online classes conducted during the COVID-19 pandemic has not been completely evaluated. In this study, we examined the relationship between lecture format (e.g., face-to-face or online) and performance of third-year university students in their organ-specific cardiovascular course examination.
    Methods: This retrospective, nonclinical, and noninterventional comparative educational study included 550 third-year medical students who took a cardiovascular course between April 2018 and May 2022. Cardiovascular coursework was conducted in-person in 2018 and 2019, online in 2020 and 2021, and again in-person in 2022. The course comprised 62 lecture and 2 problem-based learning (PBL) sessions. A quiz was set up in advance on Moodle based on all lectures conducted in 2021 and 2022. A written examination was administered at the end of the course to evaluate the knowledge of students. The student online course evaluation questionnaires were administered in 2020 and 2021. Examination scores and proportion of failures in each year were compared.
    Results: The mean examination scores were significantly higher in 2021 and 2022 than in 2018, 2019, and 2020 (p < 0.05). Univariate and multivariate analyses adjusted for the class type, online quiz, and PBL revealed that only online quiz was significantly associated with better examination results (p < 0.05). A student course evaluation survey indicated that the online format did not interfere with the students' learning and was beneficial.
    Conclusions: The introduction of online classes into medical education due to the COVID-19 pandemic was as effective as face-to-face classes owing to learning management system and other innovations, such as online quizzes. Online education may confer more benefits when provided in a combination with face-to-face learning after COVID-19 pandemic.
    MeSH term(s) Humans ; Pandemics ; Japan/epidemiology ; Retrospective Studies ; COVID-19/epidemiology ; Surveys and Questionnaires ; Students, Medical
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04874-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interatrial conduction time is associated with left atrial low voltage area and predicts the recurrence after single atrial fibrillation ablation.

    Hirota, Kei / Fukui, Akira / Yamaguchi, Takanori / Takahashi, Masaki / Kondo, Hidekazu / Akioka, Hidefumi / Shinohara, Tetsuji / Yufu, Kunio / Node, Koichi / Takahashi, Naohiko

    Journal of arrhythmia

    2023  Volume 39, Issue 2, Page(s) 142–148

    Abstract: Background: Interatrial conduction time (IACT) prolongs in fibrotic left atrium. We tested the hypothesis that IACT is related to left atrial low voltage area (LVA) and predicts the recurrence after single atrial fibrillation (AF) ablation.: Methods: ...

    Abstract Background: Interatrial conduction time (IACT) prolongs in fibrotic left atrium. We tested the hypothesis that IACT is related to left atrial low voltage area (LVA) and predicts the recurrence after single atrial fibrillation (AF) ablation.
    Methods: One hundred sixty-four consecutive AF patients (79 non-paroxysmal) who underwent initial ablation in our institute were analyzed. IACT and LVA were defined as interval from the onset of P-wave to the basal left atrial appendage (P-LAA) activation, and area with bipolar electrogram < 0.5 mV covering over 5% of the total left atrial surface area during sinus rhythm, respectively. Pulmonary vein antrum isolation, non-PV foci ablation, and atrial tachycardia (AT) ablation were performed without substrate modification.
    Results: LVA was frequently identified in patients with prolonged P-LAA ≥ 84 ms (
    Conclusions: Our results suggested that prolonged IACT as measured by P-LAA was associated with LVA and predicts AT/AF recurrence after single AF ablation.
    Language English
    Publishing date 2023-01-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact of the COVID-19 Pandemic on the Long-Term Prognosis of Acute Myocardial Infarction in Japan.

    Sato, Hiroki / Yonezu, Keisuke / Saito, Shotaro / Abe, Ichitaro / Tawara, Katsunori / Akioka, Hidefumi / Shinohara, Tetsuji / Teshima, Yasushi / Yufu, Kunio / Abe, Ryuzo / Takahashi, Naohiko

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51905

    Abstract: Background During the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a global reduction in hospitalizations for acute myocardial infarction (AMI) was observed. Generally, patients experienced increased severity of AMI with delays in ... ...

    Abstract Background During the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a global reduction in hospitalizations for acute myocardial infarction (AMI) was observed. Generally, patients experienced increased severity of AMI with delays in time from symptom onset to treatment during the pandemic. However, the impact of the COVID-19 pandemic on in-hospital mortality among patients with AMI remains unclear. This study aimed to compare the long-term prognosis of patients with AMI during the COVID-19 pandemic to that observed in the pre-pandemic period and to evaluate the influence of the COVID-19 pandemic on the prognosis of patients with AMI. Methods We reviewed the data of patients admitted to our hospital for AMI treatment between April 1, 2018, and March 31, 2021. The time from admission to major adverse cardiac events (MACE), as well as the time from admission to all-cause death, were examined between the pandemic period (April 1, 2020, to March 31, 2021) and the pre-pandemic period (April 1, 2018, to March 31, 2020). Results Eighty patients were included in the study, and those admitted during the pandemic exhibited a higher likelihood of advanced age, lower levels of LDL-cholesterol, and a reduced prevalence of hypertension. The 2.5-year MACE-free survival and overall survival rates between the patients during the pre-pandemic and pandemic periods were not significantly different. Conclusion The long-term prognosis of patients with AMI during the COVID-19 pandemic remains unclear. In this study, we reported that the 2.5-year MACE-free survival and overall survival rates of the patients with AMI admitted during the COVID-19 pandemic were not significantly different from those during the pre-pandemic period. The impact of the COVID-19 pandemic on the prognosis of patients with AMI appears to vary according to the study population.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quality of epicardial adipose tissue predicts major adverse cerebral and cardiovascular events following transcatheter aortic valve implantation.

    Sato, Takaaki / Yufu, Kunio / Yamasaki, Hirochika / Harada, Taisuke / Yamauchi, Shuichiro / Ishii, Yumi / Fukuda, Tomoko / Kawashima, Takayuki / Shuto, Takashi / Akioka, Hidefumi / Shinohara, Tetsuji / Teshima, Yasushi / Wada, Tomoyuki / Miyamoto, Shinji / Takahashi, Naohiko

    Heart and vessels

    2024  

    Abstract: Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation ...

    Abstract Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation determined using computed tomography (CT) imaging, can detect the histologically-assessed remodeled EAT. We tested the hypothesis that quality of EAT would predict major adverse cerebral and cardiovascular events (MACCE) following transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS). A total of 125 consecutive severe AS patients who underwent TAVI were enrolled (39 male, mean 85.4 ± 4.0 years). Using CT imaging before TAVI, we measured the average CT fat attenuation of EAT (EAT attenuation) and investigated the association with MACCE. During the mean follow up period of 567 ± 371 days, 21 cases of MACCE were observed. Patients with MACCE had greater levels of EAT attenuation compared to those without (- 74 ± 3.7 Hounsfield Units (HU) vs - 77 ± 5.5 HU, p = 0.010). Based on the ROC curves, the high EAT attenuation was defined as > - 74.3 HU. According to this cut-off index, 44 patients were classified into the high EAT attenuation group (28 female, mean age 87 ± 3.6 years), whereas 81 patients were classified into the low EAT attenuation group (13 female, 85 ± 4.1 years). Kaplan-Meier survival curve demonstrated that the patients in the high EAT attenuation group showed greater prevalence of MACCE (log-rank 6.64, p = 0.010). Cox proportional hazards regression analysis revealed that EAT attenuation and Logistic EuroSCORE were independently associated with the incidence of MACCE. Our results suggest that quality of EAT, assessed by EAT attenuation detected by CT imaging, can predict the cerebral and cardiovascular events after TAVI in patients with AS.
    Language English
    Publishing date 2024-03-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-024-02374-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fragmented QRS as a risk marker for the occurrence of ventricular fibrillation in patients with variant angina.

    Shinohara, Tetsuji / Yonezu, Keisuke / Hirota, Kei / Kondo, Hidekazu / Fukui, Akira / Akioka, Hidefumi / Teshima, Yasushi / Yufu, Kunio / Nakagawa, Mikiko / Takahashi, Naohiko

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

    2022  Volume 27, Issue 3, Page(s) e12937

    Abstract: Background: Variant angina (VA) is caused by reversible coronary artery spasm, which is characterized by chest pain with ST-segment elevations on standard 12-lead electrocardiogram (ECG) at rest. Ventricular fibrillation (VF) is often caused by VA ... ...

    Abstract Background: Variant angina (VA) is caused by reversible coronary artery spasm, which is characterized by chest pain with ST-segment elevations on standard 12-lead electrocardiogram (ECG) at rest. Ventricular fibrillation (VF) is often caused by VA attack, but the risk stratification is not well understood. The purpose of this study was to evaluate the impact of fragmented QRS (fQRS) on VF occurrence in VA patients.
    Methods: Ninety-four patients who showed ST elevation on 12-lead ECGs with total or nearly total occlusion in response to coronary spasm provocation test were enrolled. Among them, 16 patients had documented VF before hospital admission (n = 12) or experienced VF during provocation test (n = 4) (VF occurrence group). The fQRS was defined as the presence of spikes within the QRS complex of two or more consecutive leads.
    Results: The prevalence of fQRS was more often observed in the VF occurrence group than in the non-VF occurrence group (63% [10/16] vs. 27% [21/78], p = 0.009). Univariate analyses revealed that age, history of syncope, QTc, and the presence of fQRS were associated with VF occurrence (p = 0.004, 0.005, 0.029, and 0.008, respectively). Furthermore, upon multivariate analyses using those risk factors, age, QTc, and fQRS predicted VF occurrence independently (p = 0.007, 0.041, and 0.014, respectively).
    Conclusions: The present study demonstrated that fQRS in VA patients is a risk factor for VF. The fQRS may be a useful factor for the risk stratification of VF occurrence in VA patients.
    MeSH term(s) Arrhythmias, Cardiac/complications ; Electrocardiography/adverse effects ; Humans ; Risk Factors ; Spasm/complications ; Syncope/complications ; Ventricular Fibrillation/complications ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/epidemiology
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325530-7
    ISSN 1542-474X ; 1082-720X
    ISSN (online) 1542-474X
    ISSN 1082-720X
    DOI 10.1111/anec.12937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Usefulness of Prehospital 12-Lead Electrocardiography System in ST-Segment Elevation Myocardial Infarction Patients in Oita - Comparison Between Urban and Rural Areas, Weekday Daytime and Weekday Nighttime/Holidays.

    Yufu, Kunio / Shimomura, Tsuyoshi / Kawano, Kyoko / Sato, Hiroki / Yonezu, Keisuke / Saito, Shotaro / Kondo, Hidekazu / Fukui, Akira / Akioka, Hidefumi / Shinohara, Tetsuji / Teshima, Yasushi / Abe, Ryuzo / Takahashi, Naohiko

    Circulation journal : official journal of the Japanese Circulation Society

    2023  

    Abstract: Background: We have reported that a prehospital 12-lead electrocardiography system (P-ECG) contributed to transport of suspected acute coronary syndrome (ACS) patients to appropriate institutes and in this study, we compared its usefulness between urban ...

    Abstract Background: We have reported that a prehospital 12-lead electrocardiography system (P-ECG) contributed to transport of suspected acute coronary syndrome (ACS) patients to appropriate institutes and in this study, we compared its usefulness between urban and rural areas, and between weekday daytime and weekday nighttime/holiday.Methods and Results: Consecutive STEMI patients who underwent successful primary percutaneous coronary intervention after using P-ECG were assigned to the P-ECG group (n=123; 29 female, 70±13 years), and comparable STEMI patients without using P-ECG were assigned to the conventional group (n=117; 33 females, mean age 70±13 years). There was no significant difference in door-to-reperfusion times between the rural and urban cases (70±32 vs. 69±29 min, P=0.73). Door-to-reperfusion times in the urban P-ECG group were shorter than those in the urban conventional group for weekday nighttime/holiday (65±21 vs. 83±32 min, P=0.0005). However, there was no significance different between groups for weekday daytime. First medical contact to reperfusion time (90±22 vs. 105±37 min, P=0.0091) in the urban P-ECG group were significantly shorter than in the urban conventional groups for weekday nighttime/holiday, but were not significantly different between the groups for weekday daytime.
    Conclusions: P-ECG is useful even in urban areas, especially for patients who develop STEMI during weekday nighttime or while on a holiday.
    Language English
    Publishing date 2023-08-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-23-0365
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  7. Article ; Online: Multiple accessory pathways coexisting with a persistent left superior vena cava: a case report.

    Uemura, Tetsuya / Kondo, Hidekazu / Shinohara, Tetsuji / Takahashi, Masaki / Akamine, Koshiro / Ogawa, Naoko / Hirota, Kei / Fukui, Akira / Akioka, Hidefumi / Yufu, Kunio / Takahashi, Naohiko

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 111

    Abstract: Background: Wolff-Parkinson-White syndrome is characterized by a short PR interval (delta-wave), long QRS complex, and the appearance of paroxysmal supraventricular tachycardia. Patients with Wolff-Parkinson-White syndrome usually have one accessory ... ...

    Abstract Background: Wolff-Parkinson-White syndrome is characterized by a short PR interval (delta-wave), long QRS complex, and the appearance of paroxysmal supraventricular tachycardia. Patients with Wolff-Parkinson-White syndrome usually have one accessory pathway, whereas cases with multiple accessory pathways are rare. Persistent left superior vena cava is a vascular anomaly in which the vein drains into the right atrium through the coronary sinus at the junction of the left internal jugular and subclavian veins due to abnormal development of the left cardinal vein. The simultaneous presence of multiple accessory pathways and persistent left superior vena cava has not been reported before.
    Case presentation: A 56-year-old Japanese man with a 5-year history of palpitations was referred for radiofrequency catheter ablation due to increased frequency of tachycardia episodes in the previous 2 months. Persistent left superior vena cava was confirmed by transthoracic echocardiography and computed tomography. An electrophysiological study revealed that the accessory pathways were located in the left lateral wall, anterolateral wall, and posteroseptal region. They were completely ablated with radiofrequency energy application.
    Conclusions: We reported an extremely rare case of a patient with multiple accessory pathways and persistent left superior vena cava. Our case may suggest a potential embryological relationship between the multiple accessory pathways and persistent left superior vena cava.
    MeSH term(s) Male ; Humans ; Middle Aged ; Wolff-Parkinson-White Syndrome/complications ; Wolff-Parkinson-White Syndrome/surgery ; Persistent Left Superior Vena Cava/complications ; Vena Cava, Superior/diagnostic imaging ; Vena Cava, Superior/abnormalities ; Electrocardiography ; Echocardiography/adverse effects
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03865-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Empagliflozin Suppresses the Differentiation/Maturation of Human Epicardial Preadipocytes and Improves Paracrine Secretome Profile.

    Takano, Masayuki / Kondo, Hidekazu / Harada, Taisuke / Takahashi, Masaki / Ishii, Yumi / Yamasaki, Hirochika / Shan, Tong / Akiyoshi, Kumiko / Shuto, Takashi / Teshima, Yasushi / Wada, Tomoyuki / Yufu, Kunio / Sako, Hidenori / Anai, Hirofumi / Miyamoto, Shinji / Takahashi, Naohiko

    JACC. Basic to translational science

    2023  Volume 8, Issue 9, Page(s) 1081–1097

    Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce epicardial adipose tissue (EAT) in humans, enhancing cardioprotective effects on heart failure and atrial fibrillation. We investigated the direct effect of the SGLT2 inhibitor empagliflozin on ... ...

    Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce epicardial adipose tissue (EAT) in humans, enhancing cardioprotective effects on heart failure and atrial fibrillation. We investigated the direct effect of the SGLT2 inhibitor empagliflozin on human primary epicardial adipocytes and preadipocytes. SGLT2 is primarily expressed in human preadipocytes in the EAT. The expression levels of SGLT2 significantly diminished when the preadipocytes were terminally differentiated. Adipogenesis of preadipocytes was attenuated by empagliflozin treatment without affecting cell proliferation. The messenger RNA levels and secreted protein levels of interleukin 6 and monocyte chemoattractant protein 1 were significantly decreased in empagliflozin-treated adipocytes. Coculture of human induced pluripotent stem cell-derived atrial cardiomyocytes and adipocytes pretreated with or without empagliflozin revealed that empagliflozin significantly suppressed reactive oxygen species.
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.05.007
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  9. Article ; Online: R-R' interval in the left bundle branch block predicts long-term outcomes after cardiac resynchronization therapy by estimating greater mechanical dyssynchrony and viable myocardium.

    Kodama, Nozomi / Nakagawa, Mikiko / Ishii, Yumi / Yufu, Kunio / Yamauchi, Syuichiro / Yamamoto, Ena / Miyoshi, Miho / Abe, Ichitaro / Kondo, Hidekazu / Fukui, Akira / Satoh, Hideki / Akiyoshi, Kumiko / Fukuda, Tomoko / Shinohara, Tetsuji / Teshima, Yasushi / Takahashi, Naohiko

    Heart rhythm

    2023  Volume 21, Issue 4, Page(s) 436–444

    Abstract: Background: Typical left bundle branch block (LBBB) shows 2 peaks of the R wave, which reflect activation reaching the interventricular septum (R) and posterolateral wall (R') sequentially.: Objective: The purpose of this study was to investigate the ...

    Abstract Background: Typical left bundle branch block (LBBB) shows 2 peaks of the R wave, which reflect activation reaching the interventricular septum (R) and posterolateral wall (R') sequentially.
    Objective: The purpose of this study was to investigate the relationship among R-R' interval (RR'), mechanical dyssynchrony, extent of viable myocardium, and long-term outcomes in cardiac resynchronization therapy (CRT) candidates.
    Methods: The study enrolled 49 patients (34 men; mean age: 69 ± 11 years) with LBBB who received CRT. The LBBB definition used requires the presence of mid-QRS notching in leads V
    Results: RR' predicted volumetric response better than QRSd (area under the curve 0.73 vs 0.67, respectively). The long RR' group (≥48 ms) revealed more frequent eyeball dyssynchrony and significantly greater radial (SL) and circumferential dyssynchrony (AP and SL) and %viable segment than the short RR' group. In multivariate regression analysis, only RR' ≥48 ms was independently associated with higher event-free survival rates following CRT (hazard ratio 0.21; P = .014).
    Conclusion: These findings suggest that RR' in complete LBBB was associated with mechanical dyssynchrony, extent of viable myocardium, and long-term outcomes following CRT.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/therapy ; Cardiac Resynchronization Therapy/methods ; Treatment Outcome ; Arrhythmias, Cardiac/therapy ; Electrocardiography/methods ; Myocardium
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.12.014
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  10. Article ; Online: Vagal response is involved in the occurrence of ventricular fibrillation in patients with early repolarization syndrome.

    Fukuda, Tomoko / Shinohara, Tetsuji / Yonezu, Keisuke / Mitarai, Kazuki / Hirota, Kei / Kondo, Hidekazu / Fukui, Akira / Akioka, Hidefumi / Teshima, Yasushi / Yufu, Kunio / Nakagawa, Mikiko / Takahashi, Naohiko

    Heart rhythm

    2023  Volume 20, Issue 6, Page(s) 879–885

    Abstract: Background: Patients with early repolarization syndrome (ERS) and Brugada syndrome (BruS) have comparable clinical symptoms. In both conditions, ventricular fibrillation (VF) is experienced often near midnight or in the early morning hours when the ... ...

    Abstract Background: Patients with early repolarization syndrome (ERS) and Brugada syndrome (BruS) have comparable clinical symptoms. In both conditions, ventricular fibrillation (VF) is experienced often near midnight or in the early morning hours when the parasympathetic tone is augmented. However, differences between ERS and BruS regarding the risk of VF occurrence have recently been reported. The role of vagal activity remains especially unclear.
    Objective: The goal of this study was to determine the relationship between VF occurrence and autonomic nervous activity in patients with ERS and BruS.
    Methods: We enrolled 50 patients with ERS (n = 16) and BruS (n = 34) who received an implantable cardioverter-defibrillator. Of these, 20 patients (5 ERS and 15 BruS) experienced VF recurrence (recurrent VF group). We investigated baroreflex sensitivity (BaReS) with the phenylephrine method and heart rate variability using Holter electrocardiography in all patients to estimate autonomic nervous function.
    Results: In both patients with ERS and BruS, there was no significant difference in heart rate variability between the recurrent VF and nonrecurrent VF groups. However, in patients with ERS, BaReS was significantly higher in the recurrent VF group than in the nonrecurrent VF group (P = .03); this difference was not evident in patients with BruS. High BaReS was independently associated with VF recurrence in patients with ERS according to Cox proportional hazards regression analyses (hazard ratio 1.52; 95% confidence interval 1.031-3.061; P = .032).
    Conclusion: Our findings suggest that in patients with ERS, an exaggerated vagal response, as represented by increased BaReS indices, may be involved in the risk of VF occurrence.
    MeSH term(s) Humans ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/etiology ; Electrocardiography/methods ; Arrhythmias, Cardiac ; Brugada Syndrome/complications ; Brugada Syndrome/diagnosis ; Electrocardiography, Ambulatory
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.02.029
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