Article ; Online: Antibiotic-Loaded Ultrahigh Molecular Weight Polyethylenes.
2024 Volume 24, Issue 4, Page(s) e2300389
Abstract: The occurrence of periprosthetic joint infections (PJI) after total joint replacement constitutes a great burden for the patients and the healthcare system. Antibiotic-loaded polymethylmethacrylate (PMMA) bone cement is often used in temporary spacers ... ...
Abstract | The occurrence of periprosthetic joint infections (PJI) after total joint replacement constitutes a great burden for the patients and the healthcare system. Antibiotic-loaded polymethylmethacrylate (PMMA) bone cement is often used in temporary spacers during antibiotic treatment. PMMA is not a load-bearing solution and needs to be replaced by a functional implant. Elution from the ultrahigh molecular weight polyethylene (UHMWPE) bearing surface for drug delivery can combine functionality with the release of clinically relevant doses of antibiotics. In this study, the feasibility of incorporating a range of antibiotics into UHMWPE is investigated. Drug stability is assessed by thermo-gravimetric analysis and nuclear magnetic resonance spectroscopy. Drug-loaded UHMWPEs are prepared by compression molding, using eight antibiotics at different loading. The predicted intra-articular concentrations of drugs eluted from UHMWPE are above minimum inhibitory concentration for at least 3 weeks against Staphylococci, which are the major causative bacteria for PJI. The antibacterial efficacy is confirmed for samples covering 2% of a representative knee implant in vitro over 72 h, showing that a small fraction of the implant surface loaded with antibiotics may be sufficient against Staphylococci. |
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MeSH term(s) | Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Polymethyl Methacrylate/chemistry ; Molecular Weight ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/microbiology ; Polyethylenes/pharmacology ; Bone Cements/pharmacology |
Chemical Substances | Anti-Bacterial Agents ; ultra-high molecular weight polyethylene ; Polymethyl Methacrylate (9011-14-7) ; Polyethylenes ; Bone Cements |
Language | English |
Publishing date | 2024-01-07 |
Publishing country | Germany |
Document type | Journal Article |
ZDB-ID | 2039130-4 |
ISSN | 1616-5195 ; 1616-5187 |
ISSN (online) | 1616-5195 |
ISSN | 1616-5187 |
DOI | 10.1002/mabi.202300389 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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