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Article ; Online: Impact of NQO1 dysregulation in CNS disorders.

Yuhan, Li / Khaleghi Ghadiri, Maryam / Gorji, Ali

2024 Volume 22, Issue 1, Page(s) 4

Abstract: NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous ... ...

Abstract	NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous system (CNS). Impairment of the NQO1 activity in the CNS can result in abnormal neurotransmitter release and clearance, increased oxidative stress, and aggravated cellular injury/death. Furthermore, it can cause disturbances in neural circuit function and synaptic neurotransmission. The abnormalities of NQO1 enzyme activity have been linked to the pathophysiological mechanisms of multiple neurological disorders, including Parkinson's disease, Alzheimer's disease, epilepsy, multiple sclerosis, cerebrovascular disease, traumatic brain injury, and brain malignancy. NQO1 contributes to various dimensions of tumorigenesis and treatment response in various brain tumors. The precise mechanisms through which abnormalities in NQO1 function contribute to these neurological disorders continue to be a subject of ongoing research. Building upon the existing knowledge, the present study reviews current investigations describing the role of NQO1 dysregulations in various neurological disorders. This study emphasizes the potential of NQO1 as a biomarker in diagnostic and prognostic approaches, as well as its suitability as a target for drug development strategies in neurological disorders.
MeSH term(s)	Humans ; Alzheimer Disease ; Brain Neoplasms ; Carcinogenesis ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Neurons/pathology ; Oxidative Stress ; Brain Diseases/metabolism
Chemical Substances	NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; NQO1 protein, human (EC 1.6.5.2)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04802-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Direct Tax Burden, Financing Constraints, and Innovation-Based Output

Yu Lu / Yaqi Zhao / Yuhan Li / Yuhe Cao

Sustainability, Vol 15, Iss 21, p

2023 Volume 15275

Abstract: Tax and fee reductions serve as pivotal instruments in the deepening of structural reforms on the supply side and constitute a significant element of China’s proactive fiscal policy. Although China’s tax regime encompasses both direct and indirect tax ... ...

Abstract	Tax and fee reductions serve as pivotal instruments in the deepening of structural reforms on the supply side and constitute a significant element of China’s proactive fiscal policy. Although China’s tax regime encompasses both direct and indirect tax burdens, the direct tax burden directly impacts the operational costs of firms and remains non-transferable. As such, it holds significant influence over corporate growth trajectories. A decrease in the direct tax burden alleviates financing constraints for firms, subsequently reducing their exposure to business risks. Focusing on the innovative output capabilities of firms, this study analyzes A-share-listed companies on the Shanghai and Shenzhen stock exchanges from 2010 to 2021. It aims to ascertain the influence of direct tax burden reductions on innovation output within the tax and fee reduction framework. The findings indicate that lessening the direct tax burden ameliorates financing constraints, thereby enhancing a firm’s innovative output capabilities. A deeper analysis reveals that non-state-owned enterprises benefit more significantly from this dynamic than their state-owned counterparts, underscoring the potential for targeted tax and fee reduction policies to bolster enterprise innovation. Furthermore, the government should recognize enterprise differentiation and drive broader economic growth through tailored strategies. Notably, the positive impact of mitigating financing constraints on innovation is more pronounced in firms with suboptimal corporate governance structures. While this mechanism notably influences non-invention patent applications, its effect on invention patent applications is comparatively muted. Post-outbreak, the interplay between tax burdens and innovative outputs has intensified, becoming more pronounced than in pre-outbreak times.
Keywords	tax and fee reduction ; direct tax burden ; enterprise innovation output ; financing constraints ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	336
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tax Burden and Corporate Investment Efficiency

Yu Lu / Rui Liu / Yuhe Cao / Yuhan Li

Sustainability, Vol 15, Iss 1747, p

2023 Volume 1747

Abstract: Using A-share listed companies in Shanghai and Shenzhen from 2015 to 2021 as the research sample, a fixed-effects model was used to examine the effect of the reduction of corporate tax burden on investment efficiency under the tax reduction policy, as ... ...

Abstract	Using A-share listed companies in Shanghai and Shenzhen from 2015 to 2021 as the research sample, a fixed-effects model was used to examine the effect of the reduction of corporate tax burden on investment efficiency under the tax reduction policy, as well as the role of tax avoidance and financing constraints in the mechanism. The results of the study show that the reduction of tax burden can effectively improve the efficiency of corporate investment, and this positive effect is reflected in the alleviation of corporate under-investment and discouragement of over-investment. The paper also analyses the mechanism through which tax burden affects the efficiency of corporate investment, and finds that tax reduction can discourage inefficient investment by reducing corporate tax avoidance and alleviating corporate financing constraints. In further analysis, it is found that the effect of tax cuts on investment efficiency is more significant in the sample of non-state enterprises, low corporate governance and low marketisation. The findings of the study support the positive significance of the current tax reduction policy. We provide a reference of tax reduction benefits to curb tax avoidance behavior, and provide a basis for relevant policy departments to further accelerate the implementation of tax reduction policies.
Keywords	tax burden ; degree of tax avoidance ; financing constraints ; efficiency of investment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	336
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Spatio-Temporal Evolution of Regional Settlements under the Background of Rapid Urbanization

Dongling Ma / Yuhan Li / Qingji Huang / Baoze Liu

Sustainability, Vol 15, Iss 7368, p

A Case Study in Sishui County, China

2023 Volume 7368

Abstract: China’s urbanization has achieved rapid development in the past 20 years, with towns expanding in size and the population increasing, while rural society has also undergone dramatic changes. An in-depth study on the evolution process of rural settlements ...

Abstract	China’s urbanization has achieved rapid development in the past 20 years, with towns expanding in size and the population increasing, while rural society has also undergone dramatic changes. An in-depth study on the evolution process of rural settlements in the context of rapid urbanization is beneficial to the rational planning of villages and the promotion of green and sustainable urban development. Located in East China, Sishui County is in the transition area between three types of landforms: hills, plains, and mountains. The spatial distribution of rural settlements in the urbanization process shows obvious regional differences. To our best knowledge, research on the spatio-temporal evolution of regional settlements in Sishui County is rare. In this study, we chose Sishui County as the study area, utilized Landsat5 (TM) and Landsat8 (OLI) satellite data as remote sensing data sources, and applied Geographic Information System (GIS) spatial analysis methods, central place theory, and core–periphery theory to explore the evolution process for the pattern, scale, and structure of rural settlements in this region from 2000 to 2021 and to investigate the influencing factors. The results show that: (1) in terms of the evolution of the rural settlement pattern, its distribution shows a gradual increase in the degree of dispersion, which indicates an overall development trend in the region of Sishui County in recent years and that the trend is gradually increasing; (2) in terms of scale evolution, the degree and speed of expansion in rural settlements of Sishui County have gradually decreased, and the scale grade has gradually increased; (3) in terms of structural evolution, the hierarchy system in rural settlements of Sishui County is constantly being improved and optimized from a simple to a complex core–periphery structure. These results will provide data support for the rational planning of villages and sustainable, high-quality urban development. They will also help local governments take appropriate measures ...
Keywords	rapid urbanization ; central place theory ; core–periphery theory ; sustainable development ; Sishui County ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum

Mengqiu Wu / Yuhan Li / Chengyu Ma

Frontiers in Public Health, Vol

Patients' choice preferences for specialist outpatient online consultations: a discrete choice experiment

2023 Volume 11

Keywords	internet hospitals ; specialist outpatient online consultations (SOOC) ; preference ; discrete choice experiment ; logit regression ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The modification of pomegranate polyphenol with ultrasound improves mechanical, antioxidant, and antibacterial properties of tuna skin collagen-chitosan film

Wenjuan Qu / Ting Xiong / Bo Wang / Yuhan Li / Xinxin Zhang

Ultrasonics Sonochemistry, Vol 85, Iss , Pp 105992- (2022)

2022

Abstract: To produce an edible film with high mechanical and physicochemical properties, Tuna skin collagen-chitosan (TSC-CTS) composite films were prepared by incorporating ultrasound (UT) and pomegranate polyphenols including gallic acid (GA), tannic acid (TA), ... ...

Abstract	To produce an edible film with high mechanical and physicochemical properties, Tuna skin collagen-chitosan (TSC-CTS) composite films were prepared by incorporating ultrasound (UT) and pomegranate polyphenols including gallic acid (GA), tannic acid (TA), and ellagic acid (EA), respectively. The tensile strength and the DPPH scavenging activity of the GA-UT-TSC-CTS film (ultrasound frequency of 28 ± 0.5 kHz, power of 100 W/L, sweep frequency cycle of 100 ms, duty ratio of 77% and time of 10 min; GA concentration of 1.0 g/L and reaction time of 10 min) were increased by 47.03% and 24.16 folds, respectively compared to the control (TSC-CTS film). Meanwhile, light transmittance and water vapor permeability of the GA-UT-TSC-CTS film were decreased by 29.26% and 15.70%, respectively. These positive modification results were attributed to the altered structure during the film formation process, which were verified by Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), X-ray diffraction (XRD), and thermogravimetry results. Moreover, the GA-UT-TSC-CTS film possessed moderate thermal stability and color indexes and improved antibacterial activity. The antibacterial effect of the film against Bacillus subtilis was the highest, followed by Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus. Overall, the combination modification of gallic acid and ultrasound was an efficient modification method to improve the mechanical, antioxidant, and antibacterial properties of edible TSC-CTS films.
Keywords	Edible film ; Ultrasound ; Pomegranate polyphenol ; Modification ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: International media coverage of the Bolivian jaguar trade

Yuhan Li / Melissa Arias / Amy Hinsley / Eleanor Jane Milner‐Gulland

People and Nature, Vol 4, Iss 1, Pp 115-

2022 Volume 126

Abstract: Abstract The trade in jaguar body parts is viewed as an alarming threat to the jaguar, and there is the assumption that Chinese demand is driving the trade. However, there has been little analysis of the discourses around the trade both with respect to ... ...

Abstract	Abstract The trade in jaguar body parts is viewed as an alarming threat to the jaguar, and there is the assumption that Chinese demand is driving the trade. However, there has been little analysis of the discourses around the trade both with respect to the Chinese public, internationally and in source countries. We analysed 298 media articles in Chinese, English and Spanish languages from 2010 to 2019, to understand the disparities in reporting of this jaguar trade and what impact they would have for jaguar conservation. Temporal analysis showed that this trade did not receive global media attention until 2018, despite having taken place for a couple of years. Only four (teeth, skin, head and claws) out of the 15 body parts reported to have been traded had evidence of trade based on seizures. Jaguars were viewed positively, while the experiences of local people who suffer losses from coexisting with jaguars were rarely captured. The claim that the trade was Chinese driven was strongly and positively associated with whether seizure and arrest evidence was presented in an article, though articles held different views on if Chinese companies were involved. English‐ and Spanish‐language articles stated that traditional Chinese medicine was the main use of the jaguar body parts and were more likely to mention that this trade was Chinese driven while journalistic investigations and narratives from within China were missing. This research highlights the evidence gap with respect to media coverage of the jaguar trade, and stresses the need to collaborate with stakeholders whose voices are less prominent in the articles analysed, such as Chinese communities and local people who live around jaguars. A free Plain Language Summary can be found within the Supporting Information of this article.
Keywords	Bolivia ; illegal wildlife trade ; Jaguar ; media content analysis ; Panthera onca ; Human ecology. Anthropogeography ; GF1-900 ; Ecology ; QH540-549.5
Subject code	950
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ki-67 labeling index and Knosp classification of pituitary adenomas.

Yuhan, Li / Zhiqun, Wu / Jihui, Tian / Renlong, Pan

British journal of neurosurgery

2021 Volume 38, Issue 2, Page(s) 393–397

Abstract: The classification of pituitary tumors is frequently updated to optimize guidance for clinical treatment based on current knowledge. To date, the World Health Organization conducts periodic expert review consensus meetings and publishes the results. ... ...

Abstract	The classification of pituitary tumors is frequently updated to optimize guidance for clinical treatment based on current knowledge. To date, the World Health Organization conducts periodic expert review consensus meetings and publishes the results. These include recommendations for the behavior of more aggressive, high Ki-67 index (>3%)pituitary. A high Knosp grade (>3) is associated with a high risk of recurrence. We report an inverse relationship between the Ki-67 labeling index and Knosp grade for functional pituitary adenomas and nonfunctional pituitary adenoma (Spearman correlation coefficient in functional pituitary adenomas
MeSH term(s)	Humans ; Ki-67 Antigen ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/pathology ; Adenoma/pathology
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2021.1884186
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Article ; Online: Carbon-Dot-Based Thin Film with Responses toward Mechanical Stimulation and Acidic/Basic Vapors

Xiaoyu Zhang / Hongqiang Xu / Yuhan Li / Yang Xu

ACS Omega, Vol 5, Iss 21, Pp 12144-

2020 Volume 12147

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study of the Relationship between ICU Patient Recovery and TCM Treatment in Acute Phase

Zhiqun Wu / Xue Wang / Renlong Pan / Xiufu Huang / Yuhan Li

Evidence-Based Complementary and Alternative Medicine, Vol

A Retrospective Study Based on Python Data Mining Technology

2021 Volume 2021

Abstract: Background. Data was mined with the help of an artificial intelligence system based on Python, data was collected, and a database was established using a Python crawler, and the relationship between the outcome of neurosurgery ICU patients and treatment ... ...

Abstract	Background. Data was mined with the help of an artificial intelligence system based on Python, data was collected, and a database was established using a Python crawler, and the relationship between the outcome of neurosurgery ICU patients and treatment using traditional Chinese medicine was ascertained through data management and statistical processing. Method. The source data cases (n = 2237) were selected. By following the experimental design, data (n = 739) were obtained through artificial intelligence processing, including n = 480 in the group with traditional Chinese medicine treatment and n = 259 in the group without traditional Chinese medicine treatment. An evaluation was carried out using characteristics of patents’ ICU stays and summated rating scales. Results. There were statistical differences in 5 evaluation items (P<0.05), and other comparison items also showed data with results favoring the outcomes in the intervention group using traditional Chinese medicine. Discussion. Traditional Chinese medicine as an alternative medical protocol effectively alleviates the stress and treatment fatigue brought about by modern medicine. Artificial intelligence data mining is a favorable medium to quantify this. Python will play a greater role in future clinical research because of its own characteristics.
Keywords	Other systems of medicine ; RZ201-999
Subject code	020
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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