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  1. Article ; Online: Re-Induction of Avelumab for Patients with Metastatic Merkel Cell Carcinoma.

    Hiroyuki, Goto / Yuichi, Yoshida

    Indian journal of dermatology

    2022  Volume 68, Issue 2, Page(s) 234

    Language English
    Publishing date 2022-06-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_870_22
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  2. Article ; Online: Safety and efficacy of glecaprevir and pibrentasvir in north Tohoku Japanese patients with genotype 1/2 hepatitis C virus infection

    Akio Miyasaka / Yuichi Yoshida / Akihiko Murakami / Takao Hoshino / Kei Sawara / Hiroshi Numao / Yasuhiro Takikawa

    Health Science Reports, Vol 5, Iss 1, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Background and aims To assess the efficacy and safety of treatment with glecaprevir/pibrentasvir in Japanese patients with genotype (GT) 1/2 hepatitis C virus (HCV) infection in a real‐world clinical setting. Methods A total of 230 patients from ...

    Abstract Abstract Background and aims To assess the efficacy and safety of treatment with glecaprevir/pibrentasvir in Japanese patients with genotype (GT) 1/2 hepatitis C virus (HCV) infection in a real‐world clinical setting. Methods A total of 230 patients from 12 centers in northern Tohoku Japan with chronic hepatitis (CH) or compensated liver cirrhosis (LC) and GT1/2 HCV infection were treated with glecaprevir/pibrentasvir and followed up for 12 weeks after treatment completion. Those patients were evaluated by dividing them into the following three groups: CH GT1/2 HCV‐infected, direct‐acting antiviral agents (DAA)‐naive patients received 8 weeks of treatment (8‐week initial treatment group), compensated LC GT1/2 HCV‐infected, DAA‐naive patients received 12 weeks of treatment (12‐week initial treatment group), and GT1/2 HCV‐infected patients with previous failed DAA treatment were assigned to 12‐week treatment (12‐week re‐treatment group). Results The overall sustained virologic response (SVR) rate in the modified intention‐to‐treat population was 99% (222/225). The SVR rate in 8‐week initial treatment group, 12‐week initial treatment group, and 12‐week re‐treatment group were 99% (118/119), 98% (104/106), and 97% (56/58), respectively. SVR rates based on chronic kidney disease (CKD) stage were 99% in stage 1/2, 96% in stage 3, and 100% in stage 4/5 patients. SVR rate among the three treatment groups was not influenced by CKD stage. Furthermore, all 18 patients (six in the 8‐week initial treatment group, 12 in 12‐week initial treatment group) who underwent hemodialysis attained SVR. Serious treatment‐associated adverse events (grade ≥ 3) occurred in 12 patients (5.2%). Five patients (2.2%) discontinued treatment because of adverse events; however, three of these patients achieved SVR. Conclusion Primary treatment and re‐treatment with glecaprevir/pibrentasvir are effective and safe for patients without decompensated LC and GT1/2 HCV infection in a real‐world clinical setting. Furthermore, the SVR rate was not ...
    Keywords antiviral agent ; chronic kidney disease ; hepatitis C virus ; sustained virologic response ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cycle and flow trusses in directed networks

    Taro Takaguchi / Yuichi Yoshida

    Royal Society Open Science, Vol 3, Iss

    2016  Volume 11

    Abstract: When we represent real-world systems as networks, the directions of links often convey valuable information. Finding module structures that respect link directions is one of the most important tasks for analysing directed networks. Although many notions ... ...

    Abstract When we represent real-world systems as networks, the directions of links often convey valuable information. Finding module structures that respect link directions is one of the most important tasks for analysing directed networks. Although many notions of a directed module have been proposed, no consensus has been reached. This lack of consensus results partly because there might exist distinct types of modules in a single directed network, whereas most previous studies focused on an independent criterion for modules. To address this issue, we propose a generic notion of the so-called truss structures in directed networks. Our definition of truss is able to extract two distinct types of trusses, named the cycle truss and the flow truss, from a unified framework. By applying the method for finding trusses to empirical networks obtained from a wide range of research fields, we find that most real networks contain both cycle and flow trusses. In addition, the abundance of (and the overlap between) the two types of trusses may be useful to characterize module structures in a wide variety of empirical networks. Our findings shed light on the importance of simultaneously considering different types of modules in directed networks.
    Keywords complex networks ; module structure ; directed networks ; data analysis ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Development of a New Index to Distinguish Hepatic Encephalopathy through Automated Quantification of Globus Pallidal Signal Intensity Using MRI

    Yasuyuki Tamai / Motoh Iwasa / Yuichi Yoshida / Jun Nomoto / Takahiro Kato / Hiroe Asuke / Akiko Eguchi / Yoshiyuki Takei / Hayato Nakagawa

    Diagnostics, Vol 12, Iss 1584, p

    2022  Volume 1584

    Abstract: Hyperintensities within the bilateral globus pallidus on T1-weighted magnetic resonance images were present in some liver cirrhosis patients with hepatic encephalopathy. The symptoms of covert hepatic encephalopathy are similar to those of mild dementia. ...

    Abstract Hyperintensities within the bilateral globus pallidus on T1-weighted magnetic resonance images were present in some liver cirrhosis patients with hepatic encephalopathy. The symptoms of covert hepatic encephalopathy are similar to those of mild dementia. We aimed to develop a new diagnostic index in which to distinguish hepatic encephalopathy from dementia. The globus pallidus signal hyperintensity was quantified using three-dimensional images. In addition, the new index value distribution was evaluated in a cohort of dementia patients. Signal intensity of globus pallidus significantly increased in liver cirrhosis patients with hepatic encephalopathy compared to those without hepatic encephalopathy ( p < 0.05), healthy subjects ( p < 0.05) or dementia patients ( p < 0.001). Only 12.5% of liver cirrhosis patients without hepatic encephalopathy and 2% of dementia patients exceeded the new index cut-off value of 0.994, which predicts hepatic encephalopathy. One dementia patient in our evaluation had a history of liver cancer treatment and was assumed to have concomitant hepatic encephalopathy. The automatic assessment of signal intensity in globus pallidus is useful for distinguishing liver cirrhosis patients with hepatic encephalopathy from healthy subjects and liver cirrhosis patients without hepatic encephalopathy. Our image analyses exclude possible cases of hepatic encephalopathy from patients with neurocognitive impairment, including dementia.
    Keywords globus pallidus ; MRI ; hepatic encephalopathy ; liver cirrhosis ; dementia ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Detection of Lung Cancer Cells in Solutions Using a Terahertz Chemical Microscope

    Yuichi Yoshida / Xue Ding / Kohei Iwatsuki / Katsuya Taniizumi / Hirofumi Inoue / Jin Wang / Kenji Sakai / Toshihiko Kiwa

    Sensors, Vol 21, Iss 7631, p

    2021  Volume 7631

    Abstract: Cancer genome analysis has recently attracted attention for personalized cancer treatment. In this treatment, evaluation of the ratio of cancer cells in a specimen tissue is essential for the precise analysis of the genome. Conventionally, the evaluation ...

    Abstract Cancer genome analysis has recently attracted attention for personalized cancer treatment. In this treatment, evaluation of the ratio of cancer cells in a specimen tissue is essential for the precise analysis of the genome. Conventionally, the evaluation takes at least two days and depends on the skill of the pathologist. In our group, a terahertz chemical microscope (TCM) was developed to easily and quickly measure the number of cancer cells in a solution. In this study, an antibody was immobilized on a sensing plate using an avidin-biotin reaction to immobilize it for high density and to improve antibody alignment. In addition, as the detected terahertz signals vary depending on the sensitivity of the sensing plate, the sensitivity was evaluated using pH measurement. The result of the cancer cell detection was corrected using the result of pH measurement. These results indicate that a TCM is expected to be an excellent candidate for liquid biopsies in cancer diagnosis.
    Keywords terahertz ; cancer genomic medicine ; cancer cells ; Chemical technology ; TP1-1185
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A folded‐blister pill pack causes ileal perforation

    Yukihiro Otaka / Naoko Yukawa / Yuichi Yoshida / Jun'ichi Tamura / Takaaki Tsutsui

    Clinical Case Reports, Vol 7, Iss 11, Pp 2254-

    2019  Volume 2255

    Abstract: Abstract Ileal perforation by an accidental ingestion of a blister pill pack is rare. A detailed history of the present illness is the initial key to proceed appropriate investigations. Computed tomography is the gold standard for diagnosis of the ... ...

    Abstract Abstract Ileal perforation by an accidental ingestion of a blister pill pack is rare. A detailed history of the present illness is the initial key to proceed appropriate investigations. Computed tomography is the gold standard for diagnosis of the disease.
    Keywords blister pack ; computed tomography ; ileal perforation ; ingestion ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma

    Machiko Kai / Hayato Hikita / Maesaka Kazuki / Yuki Tahata / Kazuma Shinkai / Akira Doi / Kazuyoshi Ohkawa / Masanori Miyazaki / Hisashi Ishida / Kengo Matsumoto / Yasutoshi Nozaki / Takayuki Yakushijin / Ryotaro Sakamori / Akira Kaneko / Sadaharu Iio / Takatoshi Nawa / Naruyasu Kakita / Naoki Morishita / Naoki Hiramatsu /
    Takeo Usui / Kazuho Imanaka / Yoshinori Doi / Mitsuru Sakakibara / Yuichi Yoshida / Tsugiko Oze / Takahiro Kodama / Tomohide Tatsumi / Tetsuo Takehara

    PLoS ONE, Vol 19, Iss

    A multicenter prospective observational study

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: An iterative approach for the global estimation of sentence similarity.

    Tomoyuki Kajiwara / Danushka Bollegala / Yuichi Yoshida / Ken-Ichi Kawarabayashi

    PLoS ONE, Vol 12, Iss 9, p e

    2017  Volume 0180885

    Abstract: Measuring the similarity between two sentences is often difficult due to their small lexical overlap. Instead of focusing on the sets of features in two given sentences between which we must measure similarity, we propose a sentence similarity method ... ...

    Abstract Measuring the similarity between two sentences is often difficult due to their small lexical overlap. Instead of focusing on the sets of features in two given sentences between which we must measure similarity, we propose a sentence similarity method that considers two types of constraints that must be satisfied by all pairs of sentences in a given corpus. Namely, (a) if two sentences share many features in common, then it is likely that the remaining features in each sentence are also related, and (b) if two sentences contain many related features, then those two sentences are themselves similar. The two constraints are utilized in an iterative bootstrapping procedure that simultaneously updates both word and sentence similarity scores. Experimental results on SemEval 2015 Task 2 dataset show that the proposed iterative approach for measuring sentence semantic similarity is significantly better than the non-iterative counterparts.
    Keywords Medicine ; R ; Science ; Q
    Subject code 401
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Poroma with sebaceous differentiation

    Takamichi Ito / Yuichi Yoshida / Masutaka Furue / Osamu Yamamoto

    Indian Journal of Dermatology, Vol 60, Iss 1, Pp 85-

    Dermoscopy for the diagnosis of skin tumor with sebaceous differentiation

    2015  Volume 87

    Abstract: Although divergent adnexal differentiations are occasionally seen in poroma, poroma with sebaceous differentiation is extremely rare. We present here the second case of dermoscopy on poroma with sebaceous differentiation. A 38-year-old Japanese female ... ...

    Abstract Although divergent adnexal differentiations are occasionally seen in poroma, poroma with sebaceous differentiation is extremely rare. We present here the second case of dermoscopy on poroma with sebaceous differentiation. A 38-year-old Japanese female presented with a 2-year history of a slow-growing nodule on her left forearm. Dermoscopically, fine hairpin-like vessels, beige lobular structures were seen in the nodule. Many small yellow dots were scattered between beige lobular structures, giving orange-beige in color as a whole. On the basis of histopathologic findings, a diagnosis of poroma with sebaceous differentiation was made. Some sebaceous tumors are known to exhibit yellowish structures on dermoscopy. Tumors with sebaceous differentiation, as well as conventional sebaceous tumors, can show yellow structures on dermoscopy.
    Keywords Dermoscopy ; poroma ; sebaceous differentiation ; skin tumor ; yellow ; Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Poroma with sebaceous differentiation

    Takamichi Ito / Yuichi Yoshida / Masutaka Furue / Osamu Yamamoto

    Indian Journal of Dermatology, Vol 60, Iss 1, Pp 85-

    Dermoscopy for the diagnosis of skin tumor with sebaceous differentiation

    2015  Volume 87

    Abstract: Although divergent adnexal differentiations are occasionally seen in poroma, poroma with sebaceous differentiation is extremely rare. We present here the second case of dermoscopy on poroma with sebaceous differentiation. A 38-year-old Japanese female ... ...

    Abstract Although divergent adnexal differentiations are occasionally seen in poroma, poroma with sebaceous differentiation is extremely rare. We present here the second case of dermoscopy on poroma with sebaceous differentiation. A 38-year-old Japanese female presented with a 2-year history of a slow-growing nodule on her left forearm. Dermoscopically, fine hairpin-like vessels, beige lobular structures were seen in the nodule. Many small yellow dots were scattered between beige lobular structures, giving orange-beige in color as a whole. On the basis of histopathologic findings, a diagnosis of poroma with sebaceous differentiation was made. Some sebaceous tumors are known to exhibit yellowish structures on dermoscopy. Tumors with sebaceous differentiation, as well as conventional sebaceous tumors, can show yellow structures on dermoscopy.
    Keywords Dermoscopy ; poroma ; sebaceous differentiation ; skin tumor ; yellow ; Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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