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Article ; Online: NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers

Yujie Zhou / Songyan Yu / Wenyong Zhang

International Journal of Molecular Sciences, Vol 24, Iss 14511, p

2023 Volume 14511

Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated ... ...

Abstract	Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.
Keywords	NOD-like receptor ; gastrointestinal inflammatory diseases ; esophageal cancer ; gastric cancer ; colorectal cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and vascular lesion characteristics of the patients with takayasu arteritis manifested firstly as acute myocardial infarction at onset

Ruifang Liu / Fangxing Xu / Yujie Zhou / Dongmei Shi / Tongku Liu

Heliyon, Vol 9, Iss 2, Pp e13099- (2023)

2023

Abstract: Objective: To explore clinical and vascular lesion characteristics of the patients with Takayasu arteritis (TA) manifested firstly as acute myocardial infarction (AMI) at onset and to improve the diagnostic rate of TA. Methods: The clinical and ... ...

Abstract	Objective: To explore clinical and vascular lesion characteristics of the patients with Takayasu arteritis (TA) manifested firstly as acute myocardial infarction (AMI) at onset and to improve the diagnostic rate of TA. Methods: The clinical and angiographic data of six patients with TA manifested firstly as AMI at onset were retrospectively analyzed. Results: Of six patients (16–25 years old), 83.33% (five cases) was female, three patients had a history of hypertension and three patients did not have any medical history. One patient had intermittent effort chest tightness. On admission patients all presented with chest pain, dyspnea, hypotension, cardiogenic shock, abnormal electrocardiogram, and elevated cardiac troponin I. The vessel involvement was left coronary main trunk 83.33%, left anterior descending artery 33.33% and left circumflex branch 16.67%, right coronary artery 66.67%, subclavian artery 83.33%, and renal artery 50%. Five patients received the emergency PCI. One patient died of heart failure. During follow-up 3 patients received again PCI treatment. Conclusion: Clinical and vascular lesion characteristics of those patients were no discomfort before admission, and the suddenly typical manifestation of AMI. Severe stenosis or occlusion occurred in main coronary artery ostia and peripheral large artery. For the TA patients with hemodynamic instability the effectiveness of emergency PCI is positive.
Keywords	Takayasu arteritis ; Acute myocardial infarction ; Artery vessel lesions ; characteristic ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610 ; 616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of biochar prepared at different pyrolysis temperatures on microbially driven conversion and retention of nitrogen during composting

Haihou Wang / Tianyun Shao / Yujie Zhou / Xiaohua Long / Zed Rengel

Heliyon, Vol 9, Iss 3, Pp e13698- (2023)

2023

Abstract: Aerobic composting is one of the most economical ways to produce organic fertilizer from agricultural wastes. In this research, we independently developed a simple composting simulation reactor. The effects of biochar pyrolysised at different pyrolysis ... ...

Abstract	Aerobic composting is one of the most economical ways to produce organic fertilizer from agricultural wastes. In this research, we independently developed a simple composting simulation reactor. The effects of biochar pyrolysised at different pyrolysis temperatures (B1-450 °C; B2-550 °C; and B3-650 °C) on nitrogen conversion (Total nitrogen (TN), ammonium nitrogen (NH4+-N), nitrate nitrogen (NO3−-N), cumulative amount of ammonia (CEA) and nitrous oxide (CEN) emission, nitrogen loss rate (NLR), etc.) and functional microbial community (cbbL, cbbM and nifH) structure in the composting system were studied. Results showed that the addition of biochar significantly improved the efficiency of composting, increased the NO3−-N concentration and reduced the NLR (%) in the composting system (B3 (31.4 ± 2.73)<B2=B1 (41.7 ± 3.29)<B0 (54.5 ± 3.34), p ≤ 0.05), while the loss rate of nitrogen positively correlated with compost pH. Denitrifying bacterial genera such as Pseudomonas, Alcaligenes, Paracoccus, Bacillus, Citrobacter, Mesorhizobium, Thiobacillus and Rhodococcus in this study was an important reason for nitrogen loss during composting, and the abundance of autotrophic microorganisms (such as Sulfuritalea, Hydrogenophaga, Thiobacillus, Thiomonas and Candidatus_Thioglobus) in treatments with biochar (B1, B2 and B3) were higher than that in B0. Besides, the community structure in the treatments B2 and B3 was similar at the end of composting and clearly distinguished from that in B1. Moreover, the five functions predicted by OTUs in this study with the highest proportions were chemoheterotrophy, nitrate reduction, fermentation, aerobic chemoheterotrophy and nitrogen respiration. The study provided a theoretical basis for the application of biochar to improve the compost-related processes.<br />
Keywords	Agricultural residues ; Biochar ; Nitrogen conversion ; Nitrate nitrogen ; Nitrogen loss rate ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	660
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LncRNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated low PROS1 expression is an onco-immunological biomarker in low-grade gliomas

Yujie Zhou / Dongdong Xiao / Xiaobing Jiang

Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-

a pan-cancer analysis with experimental verification

2022 Volume 25

Abstract: Abstract Background Glioma is the most common cancer in the central nervous system, and low grade gliomas are notorious for many types of tumors and heterogeneity. PROS1 not only plays an important role in the blood coagulation system, and recent studies ...

Abstract	Abstract Background Glioma is the most common cancer in the central nervous system, and low grade gliomas are notorious for many types of tumors and heterogeneity. PROS1 not only plays an important role in the blood coagulation system, and recent studies have found that it was correlated with the development of tumors, especially related to tumor immune infiltration. However, the study of underlying role and mechanism of PROS1 in gliomas, especially in low-grade gliomas, is almost absent. Methods We integrated the information of patients with LGG in The Cancer Genome Atlas (TCGA) cohort and Chinese Glioma Genome Atlas (CGGA) cohort. Then, we systematically demonstrated the differences and prognostic prognosis value of PROS1 based on multi-omics analyses. In addition, Cell counting kit-8 (CCK-8) assay, colony formation assay, 5-Ethynyl-2’-deoxyuridine (EdU) incorporation assay, and Transwell assays were performed to evaluate cell proliferation and invasion. qRT-PCR and immunohistochemistry were used to evaluate the expression of PROS1 in LGG. Results Various bioinformatics approaches revealed that PROS1 was a valuable prognostic marker and may influence tumour development via distinct mechanisms, including expression of DNA methyltransferase, RNA modification, and DNA mismatch repair system genes, copy number variation, single nucleotide variation frequency, genomic heterogeneity, cancer stemness, DNA methylation, and alternative PROS1 splicing. Our analyses indicated that the long non-coding RNA RP3-525N10.2 may “decoy” or “guide” the transcription factor NFKB1 and prevent its association with PROS1, thereby reducing PROS1 expression and improving poor LGG prognosis. PROS1 expression was also closely associated with tumour infiltration by immune cells, especially tumour-associated macrophages, as well as the expression of various immune checkpoint inhibitors, immunomodulators, and immune cell markers. Conclusion long non-coding RNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated PROS1 expression could serve as a ...
Keywords	Carcinogenesis ; Immunohistochemistry ; Long noncoding rna ; Transwell assays ; Macrophages ; Transcription factors ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mitochondrial Dysfunction in Cardiovascular Diseases

Jiaqi Yang / Qianyun Guo / Xunxun Feng / Yang Liu / Yujie Zhou

Frontiers in Cell and Developmental Biology, Vol

Potential Targets for Treatment

2022 Volume 10

Abstract: Cardiovascular diseases (CVDs) are serious public health issues and are responsible for nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the development of most CVDs. Mitochondria produce adenosine triphosphate through ... ...

Abstract	Cardiovascular diseases (CVDs) are serious public health issues and are responsible for nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the development of most CVDs. Mitochondria produce adenosine triphosphate through oxidative phosphorylation and inevitably generate reactive oxygen species (ROS). Excessive ROS causes mitochondrial dysfunction and cell death. Mitochondria can protect against these damages via the regulation of mitochondrial homeostasis. In recent years, mitochondria-targeted therapy for CVDs has attracted increasing attention. Various studies have confirmed that clinical drugs (β-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor-II blockers) against CVDs have mitochondrial protective functions. An increasing number of cardiac mitochondrial targets have shown their cardioprotective effects in experimental and clinical studies. Here, we briefly introduce the mechanisms of mitochondrial dysfunction and summarize the progression of mitochondrial targets against CVDs, which may provide ideas for experimental studies and clinical trials.
Keywords	cardiovascular diseases ; mitochondrial dysfunction ; reactive oxygen species ; mitophagy ; mitochondrial therapy ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimization of Sample Construction Based on NDVI for Cultivated Land Quality Prediction

Chengqiang Li / Junxiao Wang / Liang Ge / Yujie Zhou / Shenglu Zhou

International Journal of Environmental Research and Public Health, Vol 19, Iss 7781, p

2022 Volume 7781

Abstract: The integrated use of remote sensing technology and machine learning models to evaluate cultivated land quality (CLQ) quickly and efficiently is vital for protecting these lands. The effectiveness of machine-learning methods can be profoundly influenced ... ...

Abstract	The integrated use of remote sensing technology and machine learning models to evaluate cultivated land quality (CLQ) quickly and efficiently is vital for protecting these lands. The effectiveness of machine-learning methods can be profoundly influenced by training samples. However, in the existing research, samples have mainly been constructed by random point (RPO). Little attention has been devoted to the optimization of sample construction, which may affect the accuracy of evaluation results. In this study, we present two optimization methods for sample construction of random patch (RPA) and area sequence patch (ASP). Differing from RPO samples, it aims to include cultivated land area and its size into sample construction. Based on landsat-8 Operational Land Manager images and agricultural land grading data, the proposed sample construction methods were applied to the machine learning model to predict the CLQ in Dongtai City, Jiangsu Province, China. Four machine learning models (the backpropagation neural network, decision tree, random forest (RF), and support vector machine) were compared based on RPO samples to determine the accurate evaluation model. The best machine learning model was selected to compare RPA and ASP samples with RPO samples. Results determined that the RF model generated the highest accuracy. Meanwhile, a high correlation was noted between the cultivated land area and CLQ. Thus, incorporating cultivated land area in the sample construction attributes can improve the prediction accuracy of the model. Among the three sample construction methods, the ASP yielded the highest prediction accuracy, indicating that the use of a large, cultivated land patch as the sample unit can further elevate the model performance. This study provides a new sample construction method for predicting CLQ using a machine learning model, as well as providing a reference for related research.
Keywords	cultivated land quality ; sample construction ; machine learning ; NDVI ; Dongtai ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Platelet-lymphocyte ratio as a new predictor of in-hospital mortality in cardiac intensive care unit patients

Guangyao Zhai / Jianlong Wang / Yuyang Liu / Yujie Zhou

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 12

Abstract: Abstract It has been discovered that both inflammation and platelet aggregation could cause crucial effect on the occurrence and development of cardiovascular diseases. As a combination of platelet and lymphocyte, platelet-lymphocyte ratio (PLR) was ... ...

Abstract	Abstract It has been discovered that both inflammation and platelet aggregation could cause crucial effect on the occurrence and development of cardiovascular diseases. As a combination of platelet and lymphocyte, platelet-lymphocyte ratio (PLR) was proved to be correlated with the severity as well as prognosis of cardiovascular diseases. Exploring the relationship between PLR and in-hospital mortality in cardiac intensive care unit (CICU) patients was the purpose of this study. PLR was calculated by dividing platelet count by lymphocyte count. All patients were grouped by PLR quartiles and the primary outcome was in-hospital mortality. The independent effect of PLR was determined by binary logistic regression analysis. The curve in line with overall trend was drawn by local weighted regression (Lowess). Subgroup analysis was used to determine the relationship between PLR and in-hospital mortality in different subgroups. We included 5577 CICU patients. As PLR quartiles increased, in-hospital mortality increased significantly (Quartile 4 vs. Quartile 1: 13.9 vs. 8.3, P < 0.001). After adjusting for confounding variables, PLR was proved to be independently associated with increased risk of in-hospital mortality (Quartile 4 vs. Quartile 1: OR 95% CI 1.55, 1.08–2.21, P = 0.016, P for trend < 0.001). The Lowess curves showed a positive relationship between PLR and in-hospital mortality. The subgroup analysis revealed that patients with low Acute Physiology and Chronic Health Evaluation IV (APACHE IV) or with less comorbidities had higher risk of mortality for PLR. Further, PLR quartiles had positive relation with length of CICU stay (Quartile 4 vs. Quartile 1: 2.7, 1.6–5.2 vs. 2.1, 1.3–3.9, P < 0.001), and the length of hospital stay (Quartile 4 vs. Quartile 1: 7.9, 4.6–13.1 vs. 5.8, 3.3–9.8, P < 0.001). PLR was independently associated with in-hospital mortality in CICU patients.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Functional Identification of Olfactory Receptors of Cnaphalocrocis medinalis (Lepidoptera

Jianjun Cheng / Jiawei Gui / Xiaoming Yao / Hong Zhao / Yujie Zhou / Yongjun Du

Insects, Vol 14, Iss 12, p

Crambidae) for Plant Odor

2023 Volume 930

Abstract: Cnaphalocrocis medinalis (Lepidoptera: Crambidae) is a migratory insect pest on rice crops. The migratory C. medinalis population in a particular location may be immigrants, local populations, emigrants, or a mix of these. Immigrants are strongly ... ...

Abstract	Cnaphalocrocis medinalis (Lepidoptera: Crambidae) is a migratory insect pest on rice crops. The migratory C. medinalis population in a particular location may be immigrants, local populations, emigrants, or a mix of these. Immigrants are strongly attracted to plant odor. We conducted research to identify the olfactory receptors in a floral scent mixture that is strongly attractive to C. medinalis . Through gene cloning, 12 olfactory receptor (OR) genes were amplified and expressed in Xenopus oocytes in vitro, and three of them were found to be responsive to plant foliar and floral volatiles. These were CmedOR31, a specific receptor for geraniol; CmedOR32, a broad-spectrum OR gene that responded to both foliar and floral odors; and CmedOR1, which strongly responded to 10 −4 M phenylacetaldehyde. The electrophysiological response to phenylacetaldehyde was extremely high, with a current of 3200 ± 86 nA and an extremely high sensitivity. We compared the phylogenetic tree and sequence similarity of CmedOR genes and found that CmedOR1 belonged to a uniquely conserved OR pedigree in the evolution of Glossata species, and the ORs of this pedigree strongly responded to phenylacetaldehyde. The expression of OR1 was significantly higher in the females than in the males. Localization of CmedOR1 in the antennae of C. medinalis by fluorescence in situ hybridization showed that CmedOR1 was expressed in both males and females. CmedOR1 may be an odor receptor used by females to locate food sources. The function of these ORs and their role in pest monitoring were discussed.
Keywords	functional identification ; Cnaphalocrocis medinalis ; floral odorant ; olfactory receptor ; Science ; Q
Subject code	590
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of scanning speeds on mechanical properties of CoCrNi medium entropy alloy prepared by laser additive manufacturing

Xu Kong / Yang Li / Na Tan / Lanrong Cai / Zichuan Lu / Qiu Li / Qiyao Deng / Yujie Zhou / Jia Wang / Dingchao Hu

Heliyon, Vol 10, Iss 1, Pp e23850- (2024)

1481

Abstract: Medium entropy alloy (MEA) is a hot spot in the field of material research in recent years. At present, the most widely used processing method of MEAs is “casting-rolling-heat treatment”, and the preparation of CoCrNi MEA by laser additive manufacturing ( ...

Abstract	Medium entropy alloy (MEA) is a hot spot in the field of material research in recent years. At present, the most widely used processing method of MEAs is “casting-rolling-heat treatment”, and the preparation of CoCrNi MEA by laser additive manufacturing (LAM) is still in primary stage. In this study, CoCrNi MEAs were fabricated with different scanning speeds by laser additive manufacturing, and the influence of scanning speed on its mechanical properties was investigated. The results show that higher scanning speed can significantly improve the mechanical properties of CoCrNi MEA. Compared with the low-speed laser additive manufacturing (LSLAM) MEA, the tensile strength of high-speed laser additive manufacturing (HSLAM) MEA is increased by 5.6 % and the fracture strain is increased by 60 %, which is mainly due to the entanglement of 1/6<112> and 1/2<110> dislocations and the defect structure at the grain boundary. LAM is a promising technology that can promote the development and application of MEAs in industry.
Keywords	Metals and alloys ; Additive manufacturing ; Laser processing ; Simulation and modelling ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	629
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives

Jinfeng Chen / Yimou Yang / Yujie Zhou / Yang Wei / Rui Zhu / Shaojun Zheng

Molecules, Vol 27, Iss 5570, p

2022 Volume 5570

Abstract: To search for efficient agricultural antifungal lead compounds, 39 Chimonanthus praecox derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by 1 H NMR, 13 C ... ...

Abstract	To search for efficient agricultural antifungal lead compounds, 39 Chimonanthus praecox derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by 1 H NMR, 13 C NMR, and MS spectra. The preliminary bioassays revealed that some compounds exhibited excellent antifungal activities in vitro. For example, the minimum inhibitory concentration (MIC) of compound b15 against Phytophthora infestans was 1.95 µg mL −1 , and the minimum inhibitory concentration (MIC) of compound b17 against Sclerotinia sclerotiorum was 1.95 µg mL −1 . Therefore, compounds b15 and b17 were identified as the most promising candidates for further study.
Keywords	Chimonanthus praecox derivative ; synthesis ; antifungal activity ; structure–activity relationship ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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