Article ; Online: Establishment of a novel mouse model of renal artery coiling-based chronic hypoperfusion-related kidney injury
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101607- (2024)
1481
Abstract: Renal artery stenosis-induced chronic renal ischemia is an important cause of renal dysfunction, especially in older adults, and its incidence is currently increasing. To elucidate the mechanisms underlying chronic renal hypoperfusion-induced kidney ... ...
| Abstract | Renal artery stenosis-induced chronic renal ischemia is an important cause of renal dysfunction, especially in older adults, and its incidence is currently increasing. To elucidate the mechanisms underlying chronic renal hypoperfusion-induced kidney damage, we developed a novel mouse model of renal artery coiling-based chronic hypoperfusion-related kidney injury. This model exhibits decreased renal blood flow and function, atrophy, and parenchymal injury in the coiled kidney, along with compensatory hypertrophy in the non-coiled kidney, without chronic hypertension. The availability of this mouse model, which can develop renal ischemia without genetic modification, will enhance kidney disease research by serving as a new tool to investigate the effects of acquired factors (e.g., obesity and aging) and genetic factors on renal artery stenosis-related renal parenchymal damage. |
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| Keywords | Renal hypoperfusion ; Chronic ischemia ; Artery coiling ; Animal model ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436 |
| Subject code | 616 |
| Language | English |
| Publishing date | 2024-03-01T00:00:00Z |
| Publisher | Elsevier |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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