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  1. Article ; Online: Phase Congruential White Noise Generator

    Aleksei F. Deon / Oleg K. Karaduta / Yulian A. Menyaev

    Algorithms, Vol 14, Iss 118, p

    2021  Volume 118

    Abstract: White noise generators can use uniform random sequences as a basis. However, such a technology may lead to deficient results if the original sequences have insufficient uniformity or omissions of random variables. This article offers a new approach for ... ...

    Abstract White noise generators can use uniform random sequences as a basis. However, such a technology may lead to deficient results if the original sequences have insufficient uniformity or omissions of random variables. This article offers a new approach for creating a phase signal generator with an improved matrix of autocorrelation coefficients. As a result, the generated signals of the white noise process have absolutely uniform intensities at the eigen Fourier frequencies. The simulation results confirm that the received signals have an adequate approximation of uniform white noise.
    Keywords pseudorandom number generator ; congruential stochastic sequences ; white noise ; stochastic Fourier spectrum ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Poisson Twister Generator by Cumulative Frequency Technology

    Aleksei F. Deon / Yulian A. Menyaev

    Algorithms, Vol 12, Iss 6, p

    2019  Volume 114

    Abstract: The widely known generators of Poisson random variables are associated with different modifications of the algorithm based on the convergence in probability of a sequence of uniform random variables to the created stochastic number. However, in some ... ...

    Abstract The widely known generators of Poisson random variables are associated with different modifications of the algorithm based on the convergence in probability of a sequence of uniform random variables to the created stochastic number. However, in some situations, this approach yields different discrete Poisson probability distributions and skipping in the generated numbers. This article offers a new approach for creating Poisson random variables based on the complete twister generator of uniform random variables, using cumulative frequency technology. The simulation results confirm that probabilistic and frequency distributions of the obtained stochastic numbers completely coincide with the theoretical Poisson distribution. Moreover, combining this new approach with the tuning algorithm of basic twister generation allows for a significant increase in length of the created sequences without using additional RAM of the computer.
    Keywords pseudorandom number generator ; stochastic sequences ; Poisson distribution ; twister generator ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 519
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Designing the Uniform Stochastic Photomatrix Therapeutic Systems

    Oleg K. Karaduta / Aleksei F. Deon / Yulian A. Menyaev

    Algorithms, Vol 13, Iss 2, p

    2020  Volume 41

    Abstract: Photomatrix therapeutic systems (PMTS) are widely used for the tasks of preventive, stimulating and rehabilitation medicine. They consist of low-intensity light-emitting diodes (LEDs) having the quasi-monochromatic irradiation properties. Depending on ... ...

    Abstract Photomatrix therapeutic systems (PMTS) are widely used for the tasks of preventive, stimulating and rehabilitation medicine. They consist of low-intensity light-emitting diodes (LEDs) having the quasi-monochromatic irradiation properties. Depending on the LED matrix structures, PMTS are intended to be used for local and large areas of bio-objects. However, in the case of non-uniform irradiation of biological tissues, there is a risk of an inadequate physiological response to this type of exposure. The proposed approach considers a novel technique for designing this type of biomedical technical systems, which use the capabilities of stochastic algorithms for LED switching. As a result, the use of stochastic photomatrix systems based on the technology of uniform twisting generation of random variables significantly expands the possibilities of their medical application.
    Keywords pseudorandom number generator ; stochastic sequences ; photomatrix therapeutic systems ; light-emitting diodes ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Towards rainbow portable Cytophone with laser diodes for global disease diagnostics

    Hind J. Jawad / Aayire C. Yadem / Yulian A. Menyaev / Mustafa Sarimollaoglu / Jillian N. Armstrong / Fumiya Watanabe / Alexandru S. Biris / Jason S. Stumhofer / Dmitry Nedosekin / James Y. Suen / Sunil Parikh / Vladimir P. Zharov

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 17

    Abstract: Abstract In vivo, Cytophone has demonstrated the capability for the early diagnosis of cancer, infection, and cardiovascular disorders through photoacoustic detection of circulating disease markers directly in the bloodstream with an unprecedented 1,000- ... ...

    Abstract Abstract In vivo, Cytophone has demonstrated the capability for the early diagnosis of cancer, infection, and cardiovascular disorders through photoacoustic detection of circulating disease markers directly in the bloodstream with an unprecedented 1,000-fold improvement in sensitivity. Nevertheless, a Cytophone with higher specificity and portability is urgently needed. Here, we introduce a novel Cytophone platform that integrates a miniature multispectral laser diode array, time-color coding, and high-speed time-resolved signal processing. Using two-color (808 nm/915 nm) laser diodes, we demonstrated spectral identification of white and red clots, melanoma cells, and hemozoin in malaria-infected erythrocytes against a blood background and artifacts. Data from a Plasmodium yoelii murine model and cultured human P. falciparum were verified in vitro with confocal photothermal and fluorescent microscopy. With these techniques, we detected infected cells within 4 h after invasion, which makes hemozoin promising as a spectrally selective marker at the earliest stages of malaria progression. Along with the findings from our previous application of Cytophone with conventional lasers for the diagnosis of melanoma, bacteremia, sickle anemia, thrombosis, stroke, and abnormal hemoglobin forms, this current finding suggests the potential for the development of a portable rainbow Cytophone with multispectral laser diodes for the identification of these and other diseases.
    Keywords Medicine ; R ; Science ; Q
    Subject code 290 ; 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Real-Time Label-Free Embolus Detection Using In Vivo Photoacoustic Flow Cytometry.

    Mazen A Juratli / Yulian A Menyaev / Mustafa Sarimollaoglu / Eric R Siegel / Dmitry A Nedosekin / James Y Suen / Alexander V Melerzanov / Tareq A Juratli / Ekaterina I Galanzha / Vladimir P Zharov

    PLoS ONE, Vol 11, Iss 5, p e

    2016  Volume 0156269

    Abstract: Thromboembolic events are one of the world's leading causes of death among patients. Embolus or clot formations have several etiologies including paraneoplastic, post-surgery, cauterization, transplantation, or extracorporeal circuits. Despite its ... ...

    Abstract Thromboembolic events are one of the world's leading causes of death among patients. Embolus or clot formations have several etiologies including paraneoplastic, post-surgery, cauterization, transplantation, or extracorporeal circuits. Despite its medical significance, little progress has been made in early embolus detection, screening and control. The aim of our study is to test the utility of the in vivo photoacoustic (PA) flow cytometry (PAFC) technique for non-invasive embolus detection in real-time. Using in vivo PAFC, emboli were non-invasively monitored in the bloodstream of two different mouse models. The tumor-free mouse model consisted of two groups, one in which the limbs were clamped to produce vessel stasis (7 procedures), and one where the mice underwent surgery (7 procedures). The melanoma-bearing mouse model also consisted of two groups, one in which the implanted tumor underwent compression (8 procedures), and one where a surgical excision of the implanted tumor was performed (8 procedures). We demonstrated that the PAFC can detect a single embolus, and has the ability to distinguish between erythrocyte-rich (red) and leukocyte/platelet-rich (white) emboli in small vessels. We show that, in tumor-bearing mice, the level of circulating emboli was increased compared to tumor-free mice (p = 0.0013). The number of circulating emboli temporarily increased in the tumor-free control mice during vessel stasis (p = 0.033) and after surgical excisions (signed-rank p = 0.031). Similar observations were noted during tumor compression (p = 0.013) and after tumor excisions (p = 0.012). For the first time, it was possible to detect unlabeled emboli in vivo non-invasively, and to confirm the presence of pigmented tumor cells within circulating emboli. The insight on embolus dynamics during cancer progression and medical procedures highlight the clinical potential of PAFC for early detection of cancer and surgery-induced emboli to prevent the fatal thromboembolic complications by well-timed therapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry

    Koonce, Nathan A / Charles M. Quick / Chengzhong Cai / Dmitry Nedosekin / Judith Dent / Mazen A. Juratli / Mustafa Sarimollaoglu / Robert J. Griffin / Ruud P.M. Dings / Vladimir Zharov / Yulian A. Menyaev

    Biochemical and biophysical research communications. 2017 Oct. 21, v. 492, no. 3

    2017  

    Abstract: Noninvasive biological readouts of tumor metastatic risk and therapeutic efficacy are needed as healthcare costs rise. CTCs are the source of metastasis in distant organs that are responsible for the majority of cancer-related deaths. Here we demonstrate ...

    Abstract Noninvasive biological readouts of tumor metastatic risk and therapeutic efficacy are needed as healthcare costs rise. CTCs are the source of metastasis in distant organs that are responsible for the majority of cancer-related deaths. Here we demonstrate the acute and long-term effect of vascular disrupting therapies (high-dose radiotherapy and tumor necrosis factor-alpha (TNF)) on CTCs released from the primary tumor with a non-invasive real-time in vivo flow cytometry system. Using our innovative flow cytometry platform, we show here that radiation and nanodrug treatment can lead to short term release of CTC from the primary tumor. There was no increase in metastasis frequency or extent between control and TNF-treated mice; however, a significant reduction in lung metastasis was noted in the radiotherapy alone group. Mice treated with both TNF and radiotherapy had a slightly elevated metastatic profile between that of radiation alone and control (untreated) tumors. Possible mechanisms based on therapy specific vessel disruption and cell death are discussed. Overall, CTCs correlated with tumor progression and suggest CTC enumeration described herein may be useful in clinical management of solid tumor malignancies.
    Keywords cell death ; flow cytometry ; health care costs ; long term effects ; lungs ; metastasis ; mice ; monitoring ; neoplasms ; radiotherapy ; risk ; tumor necrosis factor-alpha
    Language English
    Dates of publication 2017-1021
    Size p. 507-512.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2017.08.053
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: In Vivo Long-Term Monitoring of Circulating Tumor Cells Fluctuation during Medical Interventions.

    Mazen A Juratli / Eric R Siegel / Dmitry A Nedosekin / Mustafa Sarimollaoglu / Azemat Jamshidi-Parsian / Chengzhong Cai / Yulian A Menyaev / James Y Suen / Ekaterina I Galanzha / Vladimir P Zharov

    PLoS ONE, Vol 10, Iss 9, p e

    2015  Volume 0137613

    Abstract: The goal of this research was to study the long-term impact of medical interventions on circulating tumor cell (CTC) dynamics. We have explored whether tumor compression, punch biopsy or tumor resection cause dissemination of CTCs into peripheral blood ... ...

    Abstract The goal of this research was to study the long-term impact of medical interventions on circulating tumor cell (CTC) dynamics. We have explored whether tumor compression, punch biopsy or tumor resection cause dissemination of CTCs into peripheral blood circulation using in vivo fluorescent flow cytometry and breast cancer-bearing mouse model inoculated with MDA-MB-231-Luc2-GFP cells in the mammary gland. Two weeks after tumor inoculation, three groups of mice were the subject of the following interventions: (1) tumor compression for 15 minutes using 400 g weight to approximate the pressure during mammography; (2) punch biopsy; or (3) surgery. The CTC dynamics were determined before, during and six weeks after these interventions. An additional group of tumor-bearing mice was used as control and did not receive an intervention. The CTC dynamics in all mice were monitored weekly for eight weeks after tumor inoculation. We determined that tumor compression did not significantly affect CTC dynamics, either during the procedure itself (P = 0.28), or during the 6-week follow-up. In the punch biopsy group, we observed a significant increase in CTC immediately after the biopsy (P = 0.02), and the rate stayed elevated up to six weeks after the procedure in comparison to the tumor control group. The CTCs in the group of mice that received a tumor resection disappeared immediately after the surgery (P = 0.03). However, CTC recurrence in small numbers was detected during six weeks after the surgery. In the future, to prevent these side effects of medical interventions, the defined dynamics of intervention-induced CTCs may be used as a basis for initiation of aggressive anti-CTC therapy at time-points of increasing CTC number.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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