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  1. AU="Yumi Terakado"
  2. AU="Belal, Ahmed"
  3. AU="Prasher, Parteek"
  4. AU=Hasan Anamul
  5. AU="Janzic, Urska"
  6. AU="Moussavi-Baygi, Ruhollah"
  7. AU=Joffe Russell T
  8. AU="Szerencsés, Viktória"
  9. AU="Venkatesan, Vettriselvi"
  10. AU="Houzé, Sandrine"
  11. AU="Cox, Caitlin"
  12. AU="Sheng, Xin-Qing"
  13. AU="Marrink, Siewert J"
  14. AU="Boland, Fiona"
  15. AU="Semcesen, Liana N"
  16. AU="Beah, Peter Y"
  17. AU="Zakzuk, Josefina"
  18. AU="Buchner, Denise"
  19. AU="Xueting Feng"
  20. AU="Chen, Si-Rui"
  21. AU="Hoffmann, Sven"
  22. AU="Kang, Kyung Jun"
  23. AU="Brinks, Henriette L"

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  1. Artikel ; Online: Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach

    Nawaphat Jangphattananont / Hiroki Sato / Ryu Imamura / Katsuya Sakai / Yumi Terakado / Kazuhiro Murakami / Nick Barker / Hiroko Oshima / Masanobu Oshima / Junichi Takagi / Yukinari Kato / Seiji Yano / Kunio Matsumoto

    International Journal of Molecular Sciences, Vol 20, Iss 12, p

    2019  Band 2955

    Abstract: Hepatocyte growth factor (HGF) is secreted as an inactive single-chain HGF (scHGF); however, only proteolytically processed two-chain HGF (tcHGF) can activate the MET receptor. We investigated the localization of tcHGF and activated/phosphorylated MET ( ... ...

    Abstract Hepatocyte growth factor (HGF) is secreted as an inactive single-chain HGF (scHGF); however, only proteolytically processed two-chain HGF (tcHGF) can activate the MET receptor. We investigated the localization of tcHGF and activated/phosphorylated MET (pMET) using a tcHGF-specific antibody. In day 16.5 mouse embryos, total HGF (scHGF + tcHGF) was mainly localized in smooth muscle cells close to, but separate from, MET-positive epithelial cells in endodermal organs, including the stomach. In the adult stomach, total HGF was localized in smooth muscle cells, and tcHGF was mainly localized in the glandular base region. Immunostaining for pMET and Lgr5-driven green fluorescent protein (GFP) indicated that pMET localization overlapped with Lgr5 + gastric stem cells. HGF promoted organoid formation similar to EGF, indicating the potential for HGF to promote the survival and growth of gastric stem cells. pMET and tcHGF localizations changed during regeneration following gastric injury. These results indicate that MET is constantly activated in gastric stem cells and that the localization of pMET differs from the primary localization of precursor HGF but has a close relationship to tcHGF. Our results suggest the importance of the microenvironmental generation of tcHGF in the regulation of development, regeneration, and stem cell behavior.
    Schlagwörter HGF ; MET receptor ; regeneration ; smooth muscle cell ; stem cell ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

    Tsuneo Ikenoue / Yumi Terakado / Chi Zhu / Xun Liu / Tomoyuki Ohsugi / Daisuke Matsubara / Tomoki Fujii / Shigeru Kakuta / Sachiko Kubo / Takuma Shibata / Kiyoshi Yamaguchi / Yoichiro Iwakura / Yoichi Furukawa

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Band 9

    Abstract: Abstract F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed ... ...

    Abstract Abstract F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and Arg505) in the WD40 domain, which are critical for substrate recognition. To study the function of human FBXW7 R465C , the most frequent mutation in human malignancies, we generated a novel conditional knockin mouse line of murine Fbxw7 R468C corresponding to human FBXW7 R465C . Systemic heterozygous knockin of the Fbxw7 R468C mutation resulted in perinatal lethality due to defects in lung development, and occasionally caused an eyes-open at birth phenotype and cleft palate. Furthermore, mice carrying liver-specific heterozygous and homozygous Fbxw7 R468C alleles cooperated with an oncogenic Kras mutation to exhibit bile duct hyperplasia within 8 months of birth and cholangiocarcinoma-like lesions within 8 weeks of birth, respectively. In addition, the substrates affected by the mutant Fbxw7 differed between the embryos, embryonic fibroblasts, and adult liver. This novel conditional knockin Fbxw7 R468C line should be useful to gain a more profound understanding of carcinogenesis associated with mutation of FBXW7.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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