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Article ; Online: The influencer effect of Dexmedetomidine on radioiodine relevant to lacrimal gland impairment.

Şingar, Evin / Akbulut, Aylin / Koca, Gökhan / Yazihan, Nuray / Atilgan, Hasan İkbal / Yumuşak, Nihat / Demir, Ayten / Burcu, Ayse / Korkmaz, Meliha

International ophthalmology

2024 Volume 44, Issue 1, Page(s) 115

Abstract: Purpose: To assess the potential influencing effects of Dexmedetomidine on impaired lacrimal glands after high-dose radioiodine treatment (RAI).: Methods: Thirty-six rats were arbitrarily separated into 3 groups: Sham, RAI, and Dexmedetomidine. ... ...

Abstract	Purpose: To assess the potential influencing effects of Dexmedetomidine on impaired lacrimal glands after high-dose radioiodine treatment (RAI). Methods: Thirty-six rats were arbitrarily separated into 3 groups: Sham, RAI, and Dexmedetomidine. Dexmedetomidine group was given Dexmedetomidine and RAI, the Sham group was given the same millimeters of saline, and the RAI group was given RAI only. All forms of lacrimal glands, including harderian glands (HG), extraorbital (EG), and intraorbital (IG) lacrimal glands, were evaluated for immunohistochemical, histopathologic assessments and also for tissue cytokines, oxidant and antioxidant levels. Results: Dexmedetomidine significantly ameliorated histopathologic changes such as periacinar fibrosis, acinar atrophy, lymphocytic infiltration, ductal proliferation, lipofuscin-like accumulation, and nucleus changes caused by RAI in all lacrimal gland forms (p < 0.05 for all of the parameters). However, periductal fibrosis was improved significantly only in EG (p = 0.049), and mast cell infiltration was improved significantly only in IG (p = 0.038) in Dexmedetomidine groups. There was a significant decrease in the elevated caspase-3 and TUNEL levels after RAI administration in the Dexmedetomidine group in all lacrimal gland forms (p < 0.05 for all parameters). Dexmedetomidine attenuated NF-kb, TNF-α, and IL-6 levels significantly diminished total oxidant status and raised total antioxidant status levels (p < 0.05 for all parameters). Conclusions: The results of this study demonstrated that following RAI, Dexmedetomidine diminished inflammation, tissue cytokine levels, and apoptosis and ameliorated impaired histopathologic patterns of the lacrimal glands.
MeSH term(s)	Animals ; Rats ; Antioxidants/pharmacology ; Dexmedetomidine/pharmacology ; Iodine Radioisotopes ; Lacrimal Apparatus ; Cytokines ; Oxidants ; Fibrosis
Chemical Substances	Antioxidants ; Dexmedetomidine (67VB76HONO) ; Iodine Radioisotopes ; Cytokines ; Oxidants
Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-024-03052-6
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Article ; Online: Possible Neoplastic or Proliferative Effects of Intra-Tympanic Platelet-Rich Plasma on the MiddleEarMucosa: A Myth or a Fact to Consider?

Arslan, Necmi / Kargin Kaytez, Selda / Ocal, Ramazan / Yumusak, Nihat / Şenes, Mehmet / Ibas, Mustafa

The journal of international advanced otology

2022 Volume 18, Issue 3, Page(s) 252–256

Abstract: Background: Platelet-rich plasma is a frequently used plasma-derived material; however, a possible neoplastic or proliferative effect is one of the limiting issues in its use. The aim of our experimental study was to investigate the long-term ... ...

Abstract	Background: Platelet-rich plasma is a frequently used plasma-derived material; however, a possible neoplastic or proliferative effect is one of the limiting issues in its use. The aim of our experimental study was to investigate the long-term histological effects of platelet-rich plasma on the middle ear mucosa. Methods: The rats were divided into 2 groups randomly (groups 1 and 2). Group 1 represented the control group and 8 rats were included in this group. To the left ear, 0.3 mL of normal saline solution was administered intra-tympanically. No injections were done to the right ears. Group 2 represented the platelet-rich plasma group and 11 rats were included. To the left ears, 0.3 mL of platelet-rich plasma and to the right ears 0.3 mL of normal saline solution was administered intra-tympanically. The intra-tympanic platelet-rich plasma injections were done twice with an interval of 1 week. All animals were sacrificed in the third month. The degree of mucosal thickness, the presence of metaplasia, atypical cells, myofibroblastic infiltration, angiogenesis, and acute or chronic inflammation were evaluated histopathologically. Results: Histopathological findings in the right and left ears in each group were compared in itself. The degree of inflammation and mucosal thickness were significantly higher in the perforated and saline administered side, in group 1 (P < .001). In group 2, the degree of angiogenesis was significantly higher in the platelet-rich plasma administered side (P < .001). The degree of mucosal thickness was significantly higher in the saline administered side (P < .001). Conclusion: Considering the anti-inflammatory and regenerative features and its safety, intra-tympanic-PRP may, in the future, be an alterna- tive to current intra-tympanic treatment modalities.
MeSH term(s)	Animals ; Ear, Middle ; Inflammation ; Platelet-Rich Plasma ; Rats ; Saline Solution ; Tympanic Membrane
Chemical Substances	Saline Solution
Language	English
Publishing date	2022-05-09
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2561231-1
ISSN	2148-3817 ; 1308-7649 ; 2148-3817
ISSN (online)	2148-3817
ISSN	1308-7649 ; 2148-3817
DOI	10.5152/iao.2022.20116
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Article: Protective role of melatonin and spirulina in aortic occlusion‐reperfusion model in rats

Sarı, Eyüp / Dilli, Dilek / Taşoğlu, İrfan / Akduman, Hasan / Yumuşak, Nıhat / Tümer, Naım Boran / Salar, Salıh

Journal of food biochemistry. 2022 Apr., v. 46, no. 4

2022

Abstract: The aim of this experiment was to investigate the role of melatonin and spirulina on multiorgan damage induced by ischemia/reperfusion injury (IR) in a rat model. A total of 32 male rats weighing 200–220 g were allocated into 4 groups (n = 8/group) (Sham, ...

Abstract	The aim of this experiment was to investigate the role of melatonin and spirulina on multiorgan damage induced by ischemia/reperfusion injury (IR) in a rat model. A total of 32 male rats weighing 200–220 g were allocated into 4 groups (n = 8/group) (Sham, Control‐IR [CIR], Melatonin‐IR [MIR], and Spirulina‐IR [SIR]). Sham group underwent midline laparotomy and dissection of the aorta without injury. In other groups, an IR model was established by clamping (ischemia) and releasing (reperfusion) the abdominal aorta at the supraceliac level for 20 min. All rats were given 3 ml/kg of distilled water by gavage for 14 days before and 7 days after the experiment. The treatment groups received either melatonin (50 mg/kg) or spirulina (50 mg/kg) by the same route. On the 21st day of the experiment, the rats were sacrificed. We found that melatonin and spirulina ameliorated the effects of IR at different levels of significance (ranging from p = .01 to p < .001), increasing total antioxidant capacity (TAC) and superoxide dismutase levels, and decreasing total oxidant status, oxidative stress index (OSI), myeloperoxidase, tumor necrosis factor‐alfa and malondialdehyde levels. When compared MIR and SIR groups, only TAC and OSI levels did differ in favor of melatonin between the groups (p < .05). Histopathological and immunohistochemical examinations showed that melatonin and spirulina similarly reduced IR‐related tissue damage and apoptosis. We concluded that melatonin and spirulina may have a protective role against oxidative tissue damage and apoptosis in the abdominal aortic IR animal model. PRACTICAL APPLICATIONS: Coarctation of aorta (CoA) and interrupted aortic arch (IAA) are serious cardiac defects with high morbidity and mortality if not diagnosed and treated early in life. Restoration of blood flow in CoA or IAA through prostaglandin E1 infusion, angioplasty or surgery can cause ischemia/reperfusion (IR) injury. This reperfusion period may be complicated IR injury at remote organs. It may be beneficial to increase antioxidant capacity in preventing stress‐induced tissue damage. Melatonin and spirulina are agents with strong antioxidant properties. In this animal research, protective role of these products on multiorgan damage induced by IR was investigated for the first time. We found that both melatonin and spirulina ameliorate the effects of IR to varying degrees. This study provides evidence that melatonin and spirulina may have preventive effects on oxidative tissue damage and apoptosis in the abdominal aortic IR animal model.
Keywords	Spirulina ; animal models ; animal research ; antioxidant activity ; antioxidants ; aorta ; apoptosis ; blood flow ; dissection ; histopathology ; immunohistochemistry ; ischemia ; laparotomy ; males ; malondialdehyde ; melatonin ; morbidity ; mortality ; myeloperoxidase ; necrosis ; neoplasms ; oxidants ; oxidative stress ; prostaglandins ; protective effect ; reperfusion injury ; superoxide dismutase
Language	English
Dates of publication	2022-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13926
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Article ; Online: The Effect of Oral Montelukast Administration in Cholesteatoma Development and Inflammation: An Experimental Animal Model.

Ocal, Ramazan / Kargin Kaytez, Selda / Yumusak, Nihat / Akkoca, Ozlem / Celik, Hatice / Arslan, Necmi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2021 Volume 42, Issue 5, Page(s) e568–e572

Abstract: Hypothesis: We hypothesized that oral montelukast treatment could inhibit cholesteatoma formation in an experimental animal model.: Background: Inflammation and excessive proliferation have been described in the histopathology of cholesteatoma. The ... ...

Abstract	Hypothesis: We hypothesized that oral montelukast treatment could inhibit cholesteatoma formation in an experimental animal model. Background: Inflammation and excessive proliferation have been described in the histopathology of cholesteatoma. The aim of this study was to determine the effect of oral montelukast on cholesteatoma development. Methods: Eighteen healthy female Wistar albino rats weighing 250 g were chosen for the study. The animals were divided into two groups: group 1 received montelukast and group 2 was the control group. Intratympanic propylene glycol injection was administered into the left ears and physiologic serum was instilled into the right ears of the animals on the first, eighth, and fifteenth days. The effects of montelukast administration were evaluated by histological examination of the tympanic membrane and middle ear. Results: Group 1 (montelukast group) showed significant differences in terms of cholesteatoma formation, granulation, epithelial invagination, and inflammation. Cholesteatoma formation in the left ear was observed in 2 (22%) and 8 (89%) rats in groups 1 and 2, respectively (p = 0.015). Conclusion: Development of cholesteatoma and inflammation was significantly lower in the montelukast-administered group. Thus, oral montelukast was found effective in preventing cholesteatoma formation.
MeSH term(s)	Acetates ; Animals ; Cholesteatoma, Middle Ear ; Cyclopropanes ; Female ; Inflammation/drug therapy ; Models, Animal ; Quinolines ; Rats ; Rats, Wistar ; Sulfides
Chemical Substances	Acetates ; Cyclopropanes ; Quinolines ; Sulfides ; montelukast (MHM278SD3E)
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000003061
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Zs.A 1554: Show issues

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Article ; Online: Nasal mucociliary clearance after extremely low frequency by scintigraphic and histopathologic evaluation.

Aydinbelge-Dizdar, Nur / Akbulut, Aylin / Koca, Gokhan / Yumusak, Nihat / Canseven Kursun, Ayse Gulnihal / Billur, Deniz / Korkmaz, Meliha

The Laryngoscope

2022 Volume 133, Issue 9, Page(s) 2081–2089

Abstract: Objective: To investigate the effect of exposure to extremely low-frequency magnetic fields (ELF-MFs) on nasal mucociliary clearance (MCC) by rhinosintigrapic and histopathological evaluation.: Materials and methods: The rats were separated into ... ...

Abstract	Objective: To investigate the effect of exposure to extremely low-frequency magnetic fields (ELF-MFs) on nasal mucociliary clearance (MCC) by rhinosintigrapic and histopathological evaluation. Materials and methods: The rats were separated into three groups according to ELF-MFs intensity and control group. The exposure groups were standardized for the ELF-MFs of 1, 1.5, and 2 mT emitted by 3 Helmholtz coils for 4 h/day for 30 days. Rhinoscintigraphy was performed to measure nasal MCC. The nasal tissues were examined for edema, inflammation, hyperemia, necrosis, ciliary loss, goblet cell density, and fibroblast proliferation. The data were evaluated statistically (p < 0.05). Results: Nasal mucociliary clearance rates (NMCR) were calculated as 33.13 ± 5.91% in control, 27.78 ± 4.7% in 1 mT, 22.67 ± 5.43% in 1.5 mT, and 18.11 ± 6.33% in 2 mT. NMCR were decreased with increasing ELF-MFs, in 1.5 and 2 mT groups (p < 0.05) compared to control. Nasal mucociliary transport rate (NMTR) values were found to be 2.17 ± 0.33 mm/min in control, 1.82 ± 0.32 mm/min in 1 mT, 1.46 ± 0.34 mm/min in 1.5 mT and 1.24 ± 0.29 mm/min in 2 mT. NMTR was decreased in the groups exposed to 1.5 and 2 mT (p < 0.05) compared to control. The edema, hyperemia, inflammation, ciliary loss, and goblet cell density were statistically significant differences between control and groups exposed to 1.5 and 2 mT (p < 0.05). Conclusion: Our rat model has shown nasal mucosa damage and decreased NMCR and NMTR by rhinoscintigraphy as ELF-MFs intensity increases. It may be detrimental to nasal mucosa mucociliary function depending on the ELF-MFs intensity. Level of evidence: N/A Laryngoscope, 133:2081-2089, 2023.
MeSH term(s)	Rats ; Animals ; Mucociliary Clearance ; Hyperemia ; Nasal Mucosa ; Inflammation/diagnostic imaging ; Goblet Cells
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30490
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Ul II Zs.82: Show issues

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Article ; Online: Protective effect of osthole on testicular ischemia/reperfusion injury in rats.

Kocaman, Osman Hakan / Günendi, Tansel / Dörterler, Mustafa Erman / Koyuncu, Ismail / Çelik, Hakim / Yumuşak, Nihat / Böleken, Mehmet Emin

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2022 Volume 28, Issue 5, Page(s) 563–569

Abstract: Background: Testicular torsion is a urological emergency that requires urgent surgical intervention which results in testicular loss if not diagnosed and treated in a timely fashion. Ischemic tissue damage with oxygen deficiency, which starts with the ... ...

Title translation	Ostol'ün sıçanlarda testis iskemi/reperfüzyon hasarı üzerine koruyucu etkisi.
Abstract	Background: Testicular torsion is a urological emergency that requires urgent surgical intervention which results in testicular loss if not diagnosed and treated in a timely fashion. Ischemic tissue damage with oxygen deficiency, which starts with the decrease in blood flow to the tissue, continues to increase with the reoxygenation of the damaged tissues as soon as reperfusion is achieved. In various studies, osthole has also been shown to reduce cerebral, spinal cord, intestinal, renal, and myocardial ischemia/perfusion (I/R) damage. The aim of this study is to examine the effects of osthole on testicular I/R injury. Methods: 28 Wistar-albino rats were randomly divided into four experimental groups (n=7). Group 1 was the sham operation group. In Group 2 (I/R), 3-h ischemia was created by rotating the testis 720° clockwise, followed by 3 h of reperfusion. In Group 3 (I/R + single dose of Osthole), 20 mg/kg ostol was administered intraperitoneally half an hour before detorsion after 3 h of torsion. The testis was detorsioned. Three h of detorsion was applied. In Group 4 (I/R + twice doses of Osthole), 20 mg/kg ostol was administered intraperitoneally half an hour before detorsion, followed by 3-h torsion. The testis was released and detorsioned. Half an hour after the detorsion, an intraperitoneal dose of 20 mg/kg osthole was administered again. Detorsion was done for 3 h. All rats were sacrificed after 6 h and right orchiectomy was performed for blood for biochemical analysis and histopathological sample. Results: Glutathion, nuclear respiratory factor 2, Superoxide dismutase, and 8-hydroxydeoxyguanosine levels were decreased in I/R rats, while interleukin-6, malondialdehyde, and myeloperoxidase levels were increased. While caspase 3, caspase 8, caspase 9, and TUNEL showed moderate immunopositive tissues immunohistochemically in rats with I/R damage, mild immunopositive tissues were detected in Group 3 and Group 4. In the histochemical examination, degenerative tubule structure and separation of epithelial cells were observed in I/R rats, while partially healed testicular tissue was detected in Group 3 and Group 4. Conclusion: In our study, we observed that osthole reduced oxidative damage, suppressed the inflammatory process, prevented apoptosis, and reduced cell damage. We think that with repeated doses, cellular damage would gradually decline.
MeSH term(s)	Animals ; Coumarins ; Ischemia/pathology ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/drug therapy ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Testis/blood supply ; Testis/pathology
Chemical Substances	Coumarins ; osthol (XH1TI1759C)
Language	English
Publishing date	2022-04-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2021.43333
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Zs.A 6718: Show issues

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Article ; Online: Therapeutic Role of Astaxanthin and Resveratrol in an Experimental Rat Model of Supraceliac Aortic Ischemia-Reperfusion.

Dilli, Dilek / Taşoğlu, İrfan / Sarı, Eyüp / Akduman, Hasan / Yumuşak, Nihat / Tümer, Naim Boran / Salar, Salih

American journal of perinatology

2022

Abstract: Objective: The aim of the study is to investigate the therapeutic effects of astaxanthin (AST) and resveratrol (RVT) on multiorgan damage in an animal model of the supraceliac aortic ischemia-reperfusion (I/R).: Methods: In this study, 28 rats (: ...

Abstract	Objective: The aim of the study is to investigate the therapeutic effects of astaxanthin (AST) and resveratrol (RVT) on multiorgan damage in an animal model of the supraceliac aortic ischemia-reperfusion (I/R). Methods: In this study, 28 rats ( Results: We found that RVT increased total antioxidant status (TAS) and superoxide dismutase (SOD) levels, and decreased total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), and malondialdehyde (MDA) levels, while AST increased the levels of TAS, decreased TNF-α, MDA, TOS, and OSI ( Conclusion: Our study suggests that AST and RVT might show therapeutic effects against oxidative tissue damage and apoptosis in an animal model of aortic I/R. Further studies are required. Key points: · Major congenital heart diseases are at high risk of multiorgan damage.. · Re-establishment of blood flow may result in ischemia-reperfusion (I/R) injury.. · Astaxanthin and resveratrol may have therapeutic effects against I/R injury..
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0042-1748324
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Article ; Online: The Effect of Resveratrol on Radioiodine Therapy-Associated Lacrimal Gland Damage.

Koca, Gökhan / Singar, Evin / Akbulut, Aylin / Yazihan, Nuray / Yumuşak, Nihat / Demir, Ayten / Korkmaz, Meliha

Current eye research

2020 Volume 46, Issue 3, Page(s) 398–407

Abstract: Purpose: We have evaluated the potential radioprotective, antioxidant and anti-apoptotic effects of resveratrol (RSV) against high-dose radioactive iodine (RAI) therapy associated damage of the lacrimal glands by biochemical, histopathological and ... ...

Abstract	Purpose: We have evaluated the potential radioprotective, antioxidant and anti-apoptotic effects of resveratrol (RSV) against high-dose radioactive iodine (RAI) therapy associated damage of the lacrimal glands by biochemical, histopathological and immunohistochemical methods. Materials and methods: Thirty Wistar-albino rats were randomly divided into three groups; the control group received no treatment or medication, the RAI group received RAI but no medication and the RSV group received oral RAI and intraperitoneal RSV. RSV was started at day one, before RAI administration, and continued for 8 days. Bilateral intraorbital (IG), extraorbital (EG), and Harderian (HG) lacrimal glands were evaluated in all rats for histopathological, immunohistochemical, tissue cytokine and oxidant and antioxidant level assessment. Results: RSV group restored inflammation, fibrosis, vacuolization, change in nucleus characteristics, lipofuscin-like accumulation and cellular morphologic patterns were statistically significant in all lacrimal gland types, compared to the RAI group ( Conclusions: We conclude that with its anti-cancer effect as well as its antioxidant effect RSV has protected the histopathological pattern of the lacrimal glands from the damage, decreased inflammation in histopathologic assessments, and decreased tissue cytokine levels, apoptosis and DNA fragmentation on the lacrimal glands after RAI.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Disease Models, Animal ; Female ; Iodine Radioisotopes/adverse effects ; Iodine Radioisotopes/therapeutic use ; Lacrimal Apparatus/metabolism ; Lacrimal Apparatus/pathology ; Lacrimal Apparatus/radiation effects ; Lacrimal Apparatus Diseases/diagnosis ; Lacrimal Apparatus Diseases/drug therapy ; Lacrimal Apparatus Diseases/etiology ; Oxidative Stress ; Radiation Injuries, Experimental/complications ; Radiation Injuries, Experimental/diagnosis ; Radiation Injuries, Experimental/drug therapy ; Rats ; Rats, Wistar ; Resveratrol/pharmacology
Chemical Substances	Antioxidants ; Iodine Radioisotopes ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2020.1803920
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Zs.A 1775: Show issues

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Article ; Online: Effect of probiotics in experimental otitis media with effusion.

Kaytez, Selda Kargin / Ocal, Ramazan / Yumusak, Nihat / Celik, Hatiçe / Arslan, Necmi / Ibas, Mustafa

International journal of pediatric otorhinolaryngology

2020 Volume 132, Page(s) 109922

Abstract: Objectives: The article's aim was to investigate the effects of probiotics in the experimental otitis media with effusion.: Materials and methods: Twenty-four male Wistar albino rats were used. They were divided into four groups. Experimental otitis ... ...

Abstract	Objectives: The article's aim was to investigate the effects of probiotics in the experimental otitis media with effusion. Materials and methods: Twenty-four male Wistar albino rats were used. They were divided into four groups. Experimental otitis media with effusion was created by intratympanic histamine injection. The effusion was confirmed by otomicroscopic examination 24 h after injection. Group 1; did not receive any treatment, group 2; received probiotics for 7 days after the detection of effusion, group 3; received probiotics for 7 days prior to injection of histamine, group 4; received probiotics for 7 days before injection of histamine and 7 days after detection of effusion. After detection of effusion, animals were sacrificed. Otomicroscopic evaluation was done to determine the effusion. In histopathological examination neutrophil leukocyte counts were determined in 25 areas of the sub-mucosa of the temporal bulla. Results: The otomicroscopic ear effusions' healing rate in group 1 was 10%, in group 2 was 25%, in group 3 was 50%, and in group 4 was 100% (p < 0,013). The mean counts of submucosal neutrophil leukocyte from 25 areas of the temporal bulla of group 1 was 86,8 ± 24, group 2 was 66,5 ± 21, group 3 was 66,2 ± 16, and group 4 was 26,3 ± 6,5 (p < 0,001). Conclusion: Probiotics have a curative effect on the prevention and treatment of otitis media with effusion. This result may be related to their anti-inflammatory effects. Therefore, probiotics can be widely used in the age group at risk for otitis media with effusion as a complementary therapy by dietary supplements. Level of evidence: NA.
MeSH term(s)	Animals ; Disease Models, Animal ; Ear, Middle/immunology ; Histamine ; Male ; Neutrophils ; Otitis Media with Effusion/chemically induced ; Otitis Media with Effusion/immunology ; Otitis Media with Effusion/prevention & control ; Otitis Media with Effusion/therapy ; Probiotics/therapeutic use ; Rats ; Rats, Wistar
Chemical Substances	Histamine (820484N8I3)
Language	English
Publishing date	2020-02-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2020.109922
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evaluation of the effect of pitavastatin on motor deficit and functional recovery in sciatic nerve injury: A CatWalk study.

Mansız-Kaplan, Başak / Kotanoğlu, Mustafa Sırrı / Gürsoy, Koray / Vural, Seçil / Koca, Gökhan / Nacır, Barış / Yumuşak, Nihat / Kara, Halil / Yüksel, Selcen / Korkmaz, Meliha

Turkish journal of physical medicine and rehabilitation

2023 Volume 69, Issue 3, Page(s) 334–343

Abstract: Objectives: This study aims to investigate the electrophysiological, scintigraphic, and histopathological effects of pitavastatin and its impact on functional status in rats with sciatic nerve injury.: Materials and methods: A total of 30 Wistar ... ...

Abstract	Objectives: This study aims to investigate the electrophysiological, scintigraphic, and histopathological effects of pitavastatin and its impact on functional status in rats with sciatic nerve injury. Materials and methods: A total of 30 Wistar albino rats were divided into three equal groups including 10 rats in each group: sham group (no injury), control group (nerve injury induced), and pitavastatin group (nerve injury induced and 2 mg/kg of pitavastatin administered orally once a day for 21 days). Before and at the end of intervention, quantitative gait analysis with the CatWalk system and sciatic nerve conduction studies were performed. After the intervention, the gastrocnemius muscle was scintigraphically evaluated, and the sciatic nerve was histopathologically examined. Results: There was no significant difference in the sciatic nerve conduction before the intervention and Day 21 among the groups (p>0.05). According to the quantitative gait analysis, there were significant differences in the control group in terms of the individual, static, dynamic, and coordination parameters (p<0.05). The histopathological examination revealed a significant difference in the total myelinated axon count and mean axon diameter among the groups (p<0.001). Conclusion: Pitavastatin is effective in nerve regeneration and motor function recovery in rats with sciatic nerve injury.
Language	English
Publishing date	2023-06-11
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2712472-1
ISSN	2587-1250 ; 2587-1250 ; 1308-6316
ISSN (online)	2587-1250
ISSN	2587-1250 ; 1308-6316
DOI	10.5606/tftrd.2023.11002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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